IndraLab

Statements

USP20 deubiquitinates CLSPN. 11 / 11
1 | 10
reach
"USP20 deubiquitinates and stabilizes Claspin."
25355518
reach
"USP20 deubiquitinates and stabilizes Claspin, which in turn facilitate the activation of cell-cycle checkpoint following DNA damage."
25355518
reach
"To determine whether USP20 directly deubiquitinates Claspin, we performed an in vitro deubiquitination assay."
25355518
reach
"CLASPIN was also deubiquitinated by bacterially produced GST-USP20, but not by the catalytically inactive mutant GST USP20 (C154S), in the in vitro deubiquitination assays."
25326330
reach
"These results revealed that USP20 mediated Claspin downregulation did not occur at the gene transcription level, just as the prior study reported that USP20 deubiquitinate and stabilize Claspin."
28350092
reach
"USP20 in turn deubiquitinates and stabilizes Claspin and enhances the activation of ATR-Chk1 signaling."
25355518
reach
"Next, we tested whether USP20 deubiquitinates Claspin."
25355518
reach
"These results suggest that USP20 deubiquitinates Claspin in cells."
25355518
reach
"Unbound USP20 is enzymatically active and mediates Claspin deubiquitination and stabilization, this way promoting Chk1 activation [49,50]."
28942358
ubibrowser
"USP20 in turn deubiquitinates and stabilizes Claspin and enhances the activation of ATR-Chk1 signaling."
25355518
reach
"Taken together, these results suggest that USP20 deubiquitinates Claspin both in vitro and in vivo."
25355518