IndraLab

Statements

USP20 is ubiquitinated. 12 / 12
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"Additionally, USP20 could be ubiquitinated in a pVHL-dependent manner, inducing itself rapid degradation ( xref )."
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"Data from the literature indicate that pVHL30 mediates the ubiquitination and degradation of both USP33 and USP20, in turn down-regulating the pathways controlled by these two proteins [ xref ]."
35205757
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"Although pVHL functions as a master control for HIF-1alpha stabilization, as pVHL-E3 ligase mediates the ubiquitination of both HIF-1alpha and VDU2, the balance between the pVHL-mediated ubiquitination and VDU2-mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization."
15776016
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"The balance between the VHL mediated ubiquitination and VDU2 mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization."
22521794
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"The HECT domain of WT HERC but not the catalytic inactive mutant (CA) ubiquitinated USP20 in vitro (Figure xref )."
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"Finally, we demonstrate that VDU2 can also be ubiquitinated and degraded in a pVHL-dependent manner."
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"As USP20 ubiquitination decreases following replication stress, we next studied whether the USP20-HERC2 interaction is subjected to regulation by the DDR pathway."
25355518
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"We found that USP20 was ubiquitinated in unstressed cells and USP20 ubiquitination was dramatically decreased after UV or HU treatment (Figure xref ), suggesting that USP20 is regulated by the ubiquitin-proteasome pathway."
25355518
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"On the other hand, when cells recover from DNA damage, HERC2 mediates USP20 ubiquitination, turning off the DDR signaling."
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"Downregulation of HERC2 resulted in significant decrease in USP20 ubiquitination in vivo (Figure xref )."
25355518
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"To confirm this, we examined the ubiquitination of USP20 in cells depleted of HERC2."
25355518
reach
"Although pVHL functions as a master control for HIF-1alpha stabilization, as pVHL-E3 ligase mediates the ubiquitination of both HIF-1alpha and VDU2, the balance between the pVHL mediated ubiquitination and VDU2 mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization."
15776016