IndraLab

Statements


USP20 inhibits TNF. 4 / 4
| 4

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"USP20 (Ubiquitin Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis."

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"Conclusions- USP20 attenuates TNF- and IL-1beta-evoked atherogenic signaling in SMCs, by deubiquitinating RIPK1, among other signaling intermediates."

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"XREF_BIBR USP20 inhibits NF-kappaB activation via Toll like receptor (TLR) 4, XREF_BIBR IL-1R, and the TNF XREF_BIBR inflammatory pathway in VSMCs."

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"Silencing USP20 in SMCs with siRNA (small interfering RNA) augmented NFkappaB activation by = ~ 50% in response to either TNF or IL-1beta (interleukin-1beta)."