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USP20 activates Neoplasms. 7 / 7
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"Animal studies demonstrated that USP20 depletion significantly inhibited tumor growth and increased the antitumor efficacy of OXA."
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"Third, the mechanism by which USP20 promotes tumor progression in this review has been elucidated in a few types of cancer cells, but the mechanism is unclear in most cancer cell lines that highly express USP20."
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"USP20 may promote tumor metastasis and is associated with immune infiltration and drug resistance in CRC."
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"USP20 can support progression of variety of tumors."
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"It is found that knockdown of USP20 significantly reduced tumor growth and increased the antitumor efficacy of OXA (5 mg/kg, twice a week) 20 in vivo (Figure S2D)."
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"It has been confirmed that USP20 can cause D2, HIF-1α, β2-AR, TRAF6, Tax and PKM2 to deubiquitinate, thereby regulating thyroid hormone activation, cell cycle regulation, inflammatory response, tumori[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We speculate that USP20 may promote tumor progression by promoting lymph node metastasis."
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