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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

Phosphorylated USP20 deubiquitinates HMGCR. 1 / 1

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"In contrast to ubiquitination, HMGCR is deubiquitinated by mTORC1-phosphorylated USP20, which preferentially hydrolyzes K48 and K63 linkages, and stabilized HMGCR increases cholesterol synthesis in the feeding state (Lu et al., 2020)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...