IndraLab

Statements

ATR phosphorylates USP20. 20 / 21
| 8 9 3
rlimsp
"Taken together, these data demonstrated that USP20 is phosphorylated by ATR in response to HU-induced replication stress."
25326330
rlimsp
"ATR-mediated phosphorylation of USP20 promotes its dissociation from HERC2."
25326330
reach
"USP20 phosphorylation by ATR is important for its stabilization and checkpoint activation."
25355518
sparser
"USP20 phosphorylation by ATR is important for its stabilization and checkpoint activation."
25355518
sparser
"Upon DNA damage, ATR phosphorylates USP20, a deubiquitinating enzyme which is a degradation target of HERC2 ( xref A)."
32580485
sparser
"Besides, ATR phosphorylates and also stabilizes USP20 by unbinding it from HERC2."
31447701
reach
"USP20 phosphorylation by ATR does not affect its E3 ligase activity per se, suggesting that USP20 levels, but not catalytic activity, are subjected to ATR regulation."
25355518
rlimsp
"(B and C) USP20 was phosphorylated by ATR in response to HU treatment."
25326330
reach
"Mechanistically, the phosphorylation of USP20 by ATR disrupts the interaction between HERC2 and USP20 and is responsible for USP20 upregulation following the DDR."
25355518
sparser
"Taken together, these data demonstrated that USP20 is phosphorylated by ATR in response to HU-induced replication stress."
25326330
sparser
"Mechanistically, the phosphorylation of USP20 by ATR disrupts the interaction between HERC2 and USP20 and is responsible for USP20 upregulation following the DDR."
25355518
reach
"Taken together, these data demonstrated that USP20 is phosphorylated by ATR in response to HU induced replication stress."
25326330
sparser
"Upon replication stress, ATR phosphorylates USP20 promoting its dissociation from the complex."
28942358
sparser
"USP20 phosphorylation by ATR does not affect its E3 ligase activity per se , suggesting that USP20 levels, but not catalytic activity, are subjected to ATR regulation."
25355518
reach
"USP20 itself is phosphorylated by ATR, resulting in its stabilization and further activating ATR-Chk1 signaling following replication stress."
25355518
sparser
"On the other hand, USP20 is phosphorylated by ATR, which disrupts the interaction between USP20 and HERC2, resulting in USP20 stabilization."
25355518
reach
"USP20 is phosphorylated by ATR, resulting in disassociation of the E3 ubiquitin ligase HERC2 from USP20 and USP20 stabilization."
25355518
sparser
"USP20 is phosphorylated by ATR, resulting in disassociation of the E3 ubiquitin ligase HERC2 from USP20 and USP20 stabilization."
25355518
reach
"Upon replication stress, ATR phosphorylates USP20 promoting its dissociation from the complex."
28942358
reach
"On the other hand, USP20 is phosphorylated by ATR, which disrupts the interaction between USP20 and HERC2, resulting in USP20 stabilization."
25355518