IndraLab

Statements

USP20 activates inflammatory response. 3 / 3
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"Our findings reveal novel mechanisms regulating IL-1β-induced pro-inflammatory signaling: by phosphorylating USP20 Ser334, IRAK1 diminishes the association of USP20 with TRAF6 and thus augments NFκB activation, SMC inflammation and neointimal hyperplasia."
37311534
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"Coimmunoprecipitation experiments revealed that USP20 associates with several components of the TNFR1 (TNF receptor-1) signaling pathway, including RIPK1 (receptor interacting protein kinase 1), a critical checkpoint in TNF induced NFkappaB activation and inflammation."
30354204
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"Phosphorylation of USP20 on Ser334 by IRAK-1 Promotes IL-1β-evoked Signaling in Vascular Smooth Muscle Cells and Vascular Inflammation."
37311534