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USP20 activates inflammatory response. 4 / 4
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"Coimmunoprecipitation experiments revealed that USP20 associates with several components of the TNFR1 (TNF receptor-1) signaling pathway, including RIPK1 (receptor interacting protein kinase 1), a critical checkpoint in TNF induced NFkappaB activation and inflammation."
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"Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1beta-evoked signaling in vascular smooth muscle cells and vascular inflammation."
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"Our findings reveal novel mechanisms regulating IL-1beta-induced proinflammatory signaling: by phosphorylating USP20 Ser334, IRAK1 diminishes the association of USP20 with TRAF6 and thus augments NFkappaB activation, SMC inflammation, and neointimal hyperplasia."
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"It has been confirmed that USP20 can cause D2, HIF-1α, β2-AR, TRAF6, Tax and PKM2 to deubiquitinate, thereby regulating thyroid hormone activation, cell cycle regulation, inflammatory response, tumori[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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