IndraLab

Statements

USP20 activates CHEK1. 4 / 8
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"USP20 promotes CHK1 activation in response to replication stress or UV radiation."
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"Taken together, these results indicate that USP20 promotes CHK1 activation in response to HU induced replication stress or UV irradiation."
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"To test if USP20 mediated stability of CLASPIN promotes CHK1 activation upon replication stress, we expressed wild-type FLAG-CLASPIN in USP20 depleted cells."
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"Upon replication stress, ATR mediated phosphorylation of USP20 promotes dissociation of HERC2 from USP20, stabilizes USP20 and its association with CLASPIN, thus increasing CALSPIN stability and ensuring CHK1 activation."
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