IndraLab

Statements

VHL ubiquitinates USP20. 8 / 8
2 | 4 2
reach
"To test whether hVDU2 can be ubiquitinated by pVHL E3 ubiquitin ligase complex, we performed ubiquitination assay in vitro and in vivo."
12056827
reach
"These results suggest that like hVDU1, the ubiquitination of hVDU2 is dependent on the presence of pVHL.To test whether hVDU2 ubiquitination mediated by pVHL could result in rapid turnover of hVDU2 pr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
ubibrowser
"In this report we show that another uncharacterized deubiquitinating enzyme, named VDU2 (pVHL-interacting deubiquitinating enzyme-2), is a substrate of pVHL"
12056827
reach
"Moreover, VHL can ubiquitinate USP20 in return and target it for degradation [XREF_BIBR]."
33466790
sparser
"Moreover, VHL can ubiquitinate USP20 in return and target it for degradation [78]."
33466790
ubibrowser
"Although pVHL functions as a master control for HIF-1alpha stabilization, as pVHL-E3 ligase mediates the ubiquitination of both HIF-1alpha and VDU2, the balance between the pVHL-mediated ubiquitination and VDU2-mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization"
15776016
sparser
"Moreover, VHL can ubiquitinate USP20 in return and target it for degradation [ xref ]."
33466790
reach
"Although pVHL functions as a master control for HIF-1alpha stabilization, as pVHL-E3 ligase mediates the ubiquitination of both HIF-1alpha and VDU2, the balance between the pVHL mediated ubiquitination and VDU2 mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization."
15776016