IndraLab

Statements

VHL ubiquitinates USP20. 9 / 9
1 | 6 2
reach
"Moreover, VHL can ubiquitinate USP20 in return and target it for degradation [XREF_BIBR]."
33466790
reach
"Because pVHL can ubiquitylate both HIF-1α and VDU2, cellular HIF-1α levels might be determined by the balance between the pVHL-mediated ubiquitylation and VDU2-mediated de-ubiquitylation."
18809331
reach
"VDU2 itself can be ubiquitylated and degraded by the pVHL E3 ligase complex [32] ."
18809331
ubibrowser
"Although <span class="match term0">pVHL</span> functions as a master control for HIF-1alpha stabilization, as <span class="match term0">pVHL</span>-E3 ligase mediates the ubiquitination of both HIF-1alpha and <span class="match term1">VDU2</span>, the balance between the <span class="match term0">pVHL</span>-mediated ubiquitination and <span class="match term1">VDU2</span>-mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization"
15776016
sparser
"Moreover, VHL can ubiquitinate USP20 in return and target it for degradation [ xref ]."
33466790
reach
"These results suggest that like hVDU1, the ubiquitination of hVDU2 is dependent on the presence of pVHL.To test whether hVDU2 ubiquitination mediated by pVHL could result in rapid turnover of hVDU2 pr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"To test whether hVDU2 can be ubiquitinated by pVHL E3 ubiquitin ligase complex, we performed ubiquitination assay in vitro and in vivo."
12056827
sparser
"Because pVHL can ubiquitylate both HIF-1α and VDU2, cellular HIF-1α levels might be determined by the balance between the pVHL-mediated ubiquitylation and VDU2-mediated de-ubiquitylation."
18809331
reach
"Although pVHL functions as a master control for HIF-1alpha stabilization, as pVHL-E3 ligase mediates the ubiquitination of both HIF-1alpha and VDU2, the balance between the pVHL mediated ubiquitination and VDU2 mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization."
15776016