IndraLab

Statements

VHL binds USP20. 10 / 14
4 | 8 2
sparser
"Meanwhile, the structural basis for the interactions between USP20 DUSPs and its functional relevant proteins such as D2 and pVHL have not been elucidated yet."
33529762
sparser
"The proteasome has both ubiquitin ligases and DUBs that associate with it (Crosas et al., 2006) , and several DUB-ligase pairs interact directly, including BRCC36-BRCA1, BAP1-BRCA1, USP4-Ro52, USP7-MDM2, USP8-GRAIL, USP20-pVHL, USP33-pVHL and USP44-APC (Kee and Huibregtse, 2007; Marfany and Denuc, 2008; Ventii and Wilkinson, 2008) ."
19571111
reach
"Interestingly, several naturally occurring mutations in the VDU-binding domain of pVHL were found to disrupt the interaction between VDU1/VDU2 and pVHL, thus suggesting a functional relevance in pVHL-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17961905
reach
"The interaction between hVDU2 and pVHL was also tested by in vivo co-immunoprecipitation."
12056827
reach
"PVHL was precipitated by an anti-GFP antibody due to the interaction between hVDU2 and pVHL."
12056827
reach
"This mutation did not affect the interaction between hVDU2 and pVHL as predicted.VDU1 and VDU2 exhibit a very high homology at their N-terminal and C-terminal region as shown in Fig. 1, and both prote[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"Our data have demonstrated that several naturally occurring mutations in the pVHL beta-domain disrupt the interaction between hVDU2 and pVHL, which underscores the functional relevance of this interac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"In the current studies and together with our previous report [30], we have demonstrated that both VDU1 and VDU2 also bind to the beta-domain of pVHL and several naturally occurring mutations in the be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"Together, our results suggest that VDU1 and VDU2 might be relevent to pVHL related tumorigenesis.In conclusion, our previously published results and current data indicate that the interaction between [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"Further investigations are warranted to probe the biochemical and biological functions of the interaction between pVHL and VDU1 and VDU2 and to dissect functional and physiological differences between[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827