IndraLab

Statements

USP20 binds PTEN. 5 / 5
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"Together, these results suggested that USP20 could interact with PTEN to regulate neuroinflammation and neuronal death in microglia and cortical neurons, respectively."
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"Among the numerous USP members, USP20 interacts with PTEN and affects neuroinflammation via Toll-like receptor signaling pathway (Pan et al. xref ; Jean-Charles et al. xref )."
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"Here, in our study, we found that USP20 over-expression promoted PTEN expression, and importantly USP20 could directly bind to PTEN."
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"Notably, mechanistic analysis indicated that USP20 directly interacted with PTEN, thereafter reducing inflammatory response in microglial cells and mitigating neuronal death in cortical neurons upon O[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These findings indicated that USP20 interacted with PTEN in cells."
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