IndraLab

Statements

USP20 activates autophagy. 10 / 10
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"USP20 promotes autophagy at multiple steps."
38705724
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"Our result found that silencing of USP20 could inhibit autophagy, not singly but in pairs, the overexpression of USP33, which is the homology of USP20, could deubiquitinate RALB at Lys 47, and then regulate assembly of the RALB, EXO84, and beclin1 complex that initiated autophagy."
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"These findings strongly indicate that knockdown of USP20 inhibits autophagy flux."
38705724
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"USP20 facilitates RETREG1-VAPB association and enhances early autophagy protein recruitment for reticulophagy."
38705724
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"While the deubiquitinating enzyme USP20 and STAMBP/AMSH promote autophagy initiation by stabilizing ULK1 [21, 46], USP24 was found to negatively regulate autophagy and the stability of ULK1 [47]."
37607937
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"Experimentally, small interfering RNA mediated knockdown of USP20 expression significantly promoted cell proliferation, accelerated G1-S phase transition and attenuated the autophagy activity."
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"Thus, whether the autophagy caused by USP20 could contribute to the inhibition of tumor growth is worthy of investigation in a further study."
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"USP20 induces autophagy by stabilizing ULK1 [41]."
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"Similarly, the kinase ULK1 is stabilized by USP20, which is necessary to initiate autophagy ."
30705402
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"On the contrary, autophagy activity was enhanced by the USP20 overexpression (XREF_FIG)."
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