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USP20 inhibits Atherosclerosis. 5 / 5
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"Ubiquitin-specific peptidase 20 (USP20) reduces NFkappaB activation triggered by proinflammatory stimuli, and USP20 activity attenuates atherosclerosis in mice."
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"147 In addition , USP20 attenuated atherosclerosis in an LDLr - / - mouse model by inhibiting NF-kappaB activation in vivo.148 Therefore , increased expression / activity of USP20 may offer protection against inflammatory pathways in patients with ISR ."
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"Ubiquitin-specific peptidase 20 ( USP20 ) reduces NFkappaB activation triggered by pro-inflammatory stimuli , and USP20 activity attenuates atherosclerosis in mice ."
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"Considering that vascular inflammation contributes to the pathogenesis of atherosclerosis, USP20 in smooth muscle cells is likely to attenuate the incidence of atherosclerosis."
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"Moreover, ectopic expression of Usp20 in smooth muscle cells significantly reduced aortic atherosclerosis in LdlrKO mice, while the introduction of the dominant negative form of USP20 increased atherosclerotic plaques [216]."
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