IndraLab

Statements

USP20 deubiquitinates ULK1. 4 / 5
1 | 4
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"USP20 has previously been shown to regulate autophagy by deubiquitinating and stabilizing ULK1, thus promoting autophagy [36]."
38705724
reach
"These observations are consistent with previously published data, which have established that USP20 deubiquitylates ULK1, safeguarding it from lysosomal degradation and enabling this kinase to effectively initiate the autophagic process [22]."
38570483
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"USP20 mediates ULK1 deubiquitination in the basal state, thus interfering with lysosome-dependent degradation of ULK1 and playing a key role in autophagy initiation [76]."
35806307
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"USP20 interacts with and deubiquitinates ULK1, thus protecting it from degradation."
30126257