IndraLab

Statements


USP20 deubiquitinates RIPK1. 3 / 3
1 | 2

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"TNF evoked = ~ 2-fold more RIPK1 ubiquitination in SMC-DN-USP20-transgenic than in control SMCs, and RIPK1 was deubiquitinated by purified USP20 in vitro."

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"USP20 reduces atherogenic signaling in smooth muscle cells by deubiquitinating RIPK1 (receptor interacting serine/threonine kinase 1) in response to TNF (tumor necrosis factor) and IL1B (interleukin 1 beta) stimulation [51]."

"TNF evoked -2-fold more <span class="match term1">RIPK1</span> ubiquitination in SMC-DN-<span class="match term0">USP20</span>-Tg than in control SMCs, and <span class="match term1">RIPK1</span> was deubiquitinated by purified <span class="match term0">USP20</span> in vitro."