IndraLab

Statements

USP20 is modified
42 | 2 47 14
USP20 is phosphorylated.
42 | 36 14
USP20 is phosphorylated. 10 / 37
| 23 14
rlimsp
"As shown in Figure 5D and Supplementary Figure S4C, ATR depletion compromised USP20 phosphorylation at the SQ/TQ motifs and resulted in USP20 downregulation, suggesting that ATR is the major kinase responsible for USP20 phosphorylation and upregulation following replication stress."
25355518
sparser
"Upon replication stress, ATR-mediated phosphorylation of USP20 promotes dissociation of HERC2 from USP20, stabilizes USP20 and its association with CLASPIN, thus increasing CALSPIN stability and ensuring CHK1 activation."
25326330
sparser
"USP20 phosphorylation by ATR does not affect its E3 ligase activity per se , suggesting that USP20 levels, but not catalytic activity, are subjected to ATR regulation."
25355518
sparser
"As shown in Figure xref and Supplementary Figure S4C, ATR depletion compromised USP20 phosphorylation at the SQ/TQ motifs and resulted in USP20 downregulation, suggesting that ATR is the major kinase responsible for USP20 phosphorylation and upregulation following replication stress."
25355518
sparser
"Similar to other DNA repair proteins, USP20 is phosphorylated post DNA damage, and its depletion sensitizes cancer cells to damaging agents that form blocks ahead of the replication forks."
24923443
rlimsp
"We found that individual mutation at these sites partially affected USP20 phosphorylation, while mutating all four sites (4 mut) abolished USP20 phosphorylation (Figure 5E and F)."
25355518
sparser
"This occurred in a phosphorylation-dependent manner, because only the non-phosphorylated USP20 was active."
26445063
sparser
"These suggest that ATR-mediated phosphorylation of USP20 promotes dissociation of USP20 from HERC2, and this dissociation would stabilize CLASPIN and promote CHK1 activation."
25326330
sparser
"Under replication stress, ATR-mediated phosphorylation of USP20 results in the disassociation of HERC2 from USP20."
25326330
rlimsp
"(D) USP20 was phosphorylated on its S/TQ motifs. 293T cells were transfected with FLAG-VEC, FLAG-USP20 or FLAG-USP20(4SA), in which all the four S/TQ sites within the USP20 polypeptide were mutated to AQ."
25326330
USP20 is phosphorylated on S132. 10 / 11
10 | 1
hprd
No evidence text available
20068231
sparser
"The post-prandial increase in insulin and glucose concentration stimulates mTORC1 to phosphorylate USP20 at S132 and S134; USP20 is recruited to the HMGCR complex and antagonizes its degradation."
33177714
hprd
No evidence text available
20068231
hprd
No evidence text available
17081983
hprd
No evidence text available
18669648
hprd
No evidence text available
18669648
hprd
No evidence text available
19651622
hprd
No evidence text available
19651622
hprd
No evidence text available
17081983
hprd
No evidence text available
18691976
USP20 is phosphorylated on S134. 10 / 11
10 | 1
hprd
No evidence text available
18669648
hprd
No evidence text available
18691976
hprd
No evidence text available
20068231
hprd
No evidence text available
19651622
hprd
No evidence text available
20068231
hprd
No evidence text available
18669648
hprd
No evidence text available
18691976
hprd
No evidence text available
17081983
hprd
No evidence text available
19651622
hprd
No evidence text available
17081983
USP20 is phosphorylated on S333. 10 / 11
| 11
sparser
"To determine whether USP20 Ser334 phosphorylation regulates pro-inflammatory signaling, we created USP20-S334A mice using CRISPR/Cas9-mediated gene editing."
37311534
sparser
"Reversible phosphorylation of USP20 at S333 could be a critical factor that determines the rate of down-regulation of β 2 ARs via autophagosomes during catecholamine stress [ xref ]."
28137506
sparser
"In this process, phosphorylation of USP20 at serine residue 333 is required for its activity providing an additional level of regulation [148]."
30126257
sparser
"The association of USP20 with its substrates triggers deubiquitinase activity; this association is regulated by phosphorylation of USP20 on Ser334 (mouse) or Ser333 (human)."
37311534
sparser
"In this process, phosphorylation of USP20 at serine residue 333 is required for its activity providing an additional level of regulation [ xref ]."
30126257
sparser
"Recent studies have shown that β 2 AR activation triggers site-specific phosphorylation of USP20 by the cAMP-activated protein kinase A (PKA) at serine 333 of USP20 [ xref ]."
28137506
sparser
"Our findings reveal novel mechanisms regulating IL-1β-induced pro-inflammatory signaling: by phosphorylating USP20 Ser334, IRAK1 diminishes the association of USP20 with TRAF6 and thus augments NFκB activation, SMC inflammation and neointimal hyperplasia."
37311534
sparser
"The association of USP20 with its substrates triggers deubiquitinase activity; this association is regulated by phosphorylation of USP20 on Ser334 (mouse) or Ser333 (human)."
37311534
sparser
"USP20 Ser333 phosphorylation was greater in SMCs of atherosclerotic segments of human arteries as compared with non-atherosclerotic segments."
37311534
sparser
"WT carotid SMCs showed substantial phosphorylation of USP20 Ser334, and WT carotids demonstrated greater NFκB activation, VCAM-1 expression, and SMC proliferation than USP20-S334A carotids."
37311534
USP20 is phosphorylated on S373. 4 / 4
4 |
hprd
No evidence text available
17081983
hprd
No evidence text available
17081983
hprd
No evidence text available
18669648
hprd
No evidence text available
18669648
USP20 is phosphorylated on S413. 4 / 4
4 |
hprd
No evidence text available
18669648
hprd
No evidence text available
18669648
hprd
No evidence text available
18691976
hprd
No evidence text available
18691976
USP20 is phosphorylated on S407. 4 / 4
4 |
hprd
No evidence text available
18669648
hprd
No evidence text available
18669648
hprd
No evidence text available
18691976
hprd
No evidence text available
18691976
USP20 is phosphorylated on T377. 2 / 2
2 |
hprd
No evidence text available
18669648
hprd
No evidence text available
18669648
USP20 is phosphorylated on T258. 2 / 2
2 |
hprd
No evidence text available
17081983
hprd
No evidence text available
17081983
USP20 is phosphorylated on S372. 2 / 2
2 |
hprd
No evidence text available
17081983
hprd
No evidence text available
17081983
USP20 is phosphorylated on S406. 2 / 2
2 |
hprd
No evidence text available
18669648
hprd
No evidence text available
18669648
USP20 is phosphorylated on S263. 2 / 2
2 |
hprd
No evidence text available
17081983
hprd
No evidence text available
17081983
USP20 is ubiquitinated.
| 2 10
USP20 is ubiquitinated. 10 / 12
| 2 10
sparser
"Additionally, USP20 could be ubiquitinated in a pVHL-dependent manner, inducing itself rapid degradation ( xref )."
28350092
sparser
"Data from the literature indicate that pVHL30 mediates the ubiquitination and degradation of both USP33 and USP20, in turn down-regulating the pathways controlled by these two proteins [ xref ]."
35205757
sparser
"Although pVHL functions as a master control for HIF-1alpha stabilization, as pVHL-E3 ligase mediates the ubiquitination of both HIF-1alpha and VDU2, the balance between the pVHL-mediated ubiquitination and VDU2-mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization."
15776016
reach
"The balance between the VHL mediated ubiquitination and VDU2 mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization."
22521794
sparser
"The HECT domain of WT HERC but not the catalytic inactive mutant (CA) ubiquitinated USP20 in vitro (Figure xref )."
25355518
sparser
"Finally, we demonstrate that VDU2 can also be ubiquitinated and degraded in a pVHL-dependent manner."
12056827
sparser
"As USP20 ubiquitination decreases following replication stress, we next studied whether the USP20-HERC2 interaction is subjected to regulation by the DDR pathway."
25355518
sparser
"We found that USP20 was ubiquitinated in unstressed cells and USP20 ubiquitination was dramatically decreased after UV or HU treatment (Figure xref ), suggesting that USP20 is regulated by the ubiquitin-proteasome pathway."
25355518
sparser
"On the other hand, when cells recover from DNA damage, HERC2 mediates USP20 ubiquitination, turning off the DDR signaling."
25355518
sparser
"Downregulation of HERC2 resulted in significant decrease in USP20 ubiquitination in vivo (Figure xref )."
25355518
USP20 is dephosphorylated.
| 1
USP20 is dephosphorylated. 1 / 1
| 1
sparser
"Only dephosphorylated USP20 shows robust activity for deubiquitinating the β 2 AR."
28137506
USP20 affects CLSPN
7 1 | 27 5
USP20 binds CLSPN.
7 | 4 5
USP20 binds CLSPN. 10 / 15
7 | 4 4
reach
"To determine whether the interaction between USP20 and Claspin is direct, we generated and purified recombinant USP20 and Claspin."
25355518
reach
"However, depletion of HERC2 did not affect the binding between USP20 and Claspin."
25355518
biogrid
No evidence text available
25326330
sparser
"We confirmed the USP20-Claspin interaction by Co-IP."
25355518
biogrid
No evidence text available
25355518
biogrid
No evidence text available
25355518
reach
"Co-immunoprecipitation assays revealed that both HERC2 and CLASPIN were present in the USP20 immunocomplex and both USP20 and CLASPIN were in the HERC2 immunocomplex, suggesting that HERC2, USP20 and CLASPIN form a complex."
25326330
biogrid
No evidence text available
25355518
reach
"As shown in Figure XREF_FIG, GST-USP20 was able to interact with His Claspin under cell-free conditions, suggesting a direct interaction between USP20 and Claspin."
25355518
sparser
"To determine whether the interaction between USP20 and Claspin is direct, we generated and purified recombinant USP20 and Claspin."
25355518
USP20 binds CLSPN and HERC2. 1 / 1
| 1
sparser
"Co-immunoprecipitation assays revealed that both HERC2 and CLASPIN were present in the USP20 immunocomplex (Figure xref ) and both USP20 and CLASPIN were in the HERC2 immunocomplex (Figure  xref ), suggesting that HERC2, USP20 and CLASPIN form a complex."
25326330
USP20 deubiquitinates CLSPN.
1 | 12
USP20 deubiquitinates CLSPN. 10 / 11
1 | 10
reach
"USP20 deubiquitinates and stabilizes Claspin."
25355518
reach
"USP20 deubiquitinates and stabilizes Claspin, which in turn facilitate the activation of cell-cycle checkpoint following DNA damage."
25355518
reach
"To determine whether USP20 directly deubiquitinates Claspin, we performed an in vitro deubiquitination assay."
25355518
reach
"CLASPIN was also deubiquitinated by bacterially produced GST-USP20, but not by the catalytically inactive mutant GST USP20 (C154S), in the in vitro deubiquitination assays."
25326330
reach
"These results revealed that USP20 mediated Claspin downregulation did not occur at the gene transcription level, just as the prior study reported that USP20 deubiquitinate and stabilize Claspin."
28350092
reach
"USP20 in turn deubiquitinates and stabilizes Claspin and enhances the activation of ATR-Chk1 signaling."
25355518
reach
"Next, we tested whether USP20 deubiquitinates Claspin."
25355518
reach
"These results suggest that USP20 deubiquitinates Claspin in cells."
25355518
reach
"Unbound USP20 is enzymatically active and mediates Claspin deubiquitination and stabilization, this way promoting Chk1 activation [49,50]."
28942358
ubibrowser
"USP20 in turn deubiquitinates and stabilizes Claspin and enhances the activation of ATR-Chk1 signaling."
25355518
USP20-C154S deubiquitinates CLSPN. 1 / 1
| 1
reach
"CLASPIN was also deubiquitinated by bacterially produced GST-USP20, but not by the catalytically inactive mutant GST USP20 (C154S), in the in vitro deubiquitination assays."
25326330
USP20 deubiquitinates ubiquitinated CLSPN. 1 / 1
| 1
reach
"USP20 in turn deubiquitinates K48-linked-polyubiquitinated CLASPIN, stabilizing CLASPIN and ultimately promoting CHK1 phosphorylation and CHK1 directed checkpoint activation."
25326330
USP20 activates CLSPN.
| 3
USP20 activates CLSPN. 3 / 9
| 3
reach
"USP20 promotes CLASPIN stability through deubiquitination."
25326330
reach
"Given that HERC2 is a component of the replication complex, our data shown in this report suggest that HERC2 and USP20 coordinately modulate CLASPIN stability during S-phase and in response to replication stress."
25326330
reach
"These results revealed that USP20 mediated Claspin downregulation did not occur at the gene transcription level, just as the prior study reported that USP20 deubiquitinate and stabilize Claspin."
28350092
USP20 increases the amount of CLSPN.
| 3
USP20 increases the amount of CLSPN. 1 / 2
| 1
reach
"Furthermore, reconstitution of WT USP20 but not catalytically inactive mutant of USP20 (USP20CA) in USP20 depleted cells restored Claspin protein levels."
25355518
Modified USP20 increases the amount of CLSPN. 1 / 1
| 1
reach
"As shown in XREF_FIG, overexpression of USP20 increased the protein level of Claspin without the change of mRNA level."
28350092
Mutated USP20 increases the amount of CLSPN. 1 / 1
| 1
reach
"Furthermore, reconstitution of WT USP20 but not catalytically inactive mutant of USP20 (USP20CA) in USP20 depleted cells restored Claspin protein levels."
25355518
USP20 ubiquitinates CLSPN.
| 2
USP20 ubiquitinates CLSPN. 2 / 2
| 2
reach
"Conversely, knocking-down USP20 increased polyubiquitination of Claspin."
25355518
reach
"As shown in Figure XREF_FIG, overexpressing USP20 resulted in a significant decrease in polyubiquitination of Claspin, while overexpressing USP20CA mutant had no such effect."
25355518
USP20 inhibits CLSPN.
| 2
USP20-C154S inhibits CLSPN. 1 / 1
| 1
reach
"Concomitantly, expression of the catalytically inactive mutant FLAG USP20 (C154S) reduced the half-life of CLASPIN."
25326330
USP20 inhibits CLSPN. 1 / 1
| 1
reach
"Furthermore, downregulation of USP20 blocked UV induced Claspin upregulation."
25355518
USP20 decreases the amount of CLSPN.
| 1
USP20 decreases the amount of CLSPN. 1 / 1
| 1
reach
"Prior studies have demonstrated that USP20 regulate the cell proliferation through the ATK-Claspin-CHK signaling pathway, and downregulation of USP20, could reduce the expression of Claspin through the ubiquitin-proteasome degradation and promote the DNA synthesis, suggesting a defect in the intra-S-phase checkpoint."
28350092
HERC2 affects USP20
7 1 | 20 16
HERC2 binds USP20.
7 | 12 14
USP20 binds HERC2. 10 / 32
7 | 12 13
reach
"As shown in Figure XREF_FIG, the interaction between HERC2 and USP20 decreased at early time point following DNA damage and then increased at later time point."
25355518
reach
"In unstressed cells, HERC2 binds USP20 to maintain a low basal level of USP20 in cells."
25355518
reach
"Co-immunoprecipitation assays revealed that both HERC2 and CLASPIN were present in the USP20 immunocomplex and both USP20 and CLASPIN were in the HERC2 immunocomplex, suggesting that HERC2, USP20 and CLASPIN form a complex."
25326330
sparser
"We found that treating cells with the pan PIKK inhibitor caffeine blocked the disassociation of USP20 and HERC2 after UV treatment (Figure xref ), suggesting that PIKKs might be involved in the regulation of USP20-HERC2 interaction."
25355518
biogrid
No evidence text available
25326330
reach
"We found that the presence of USP20 in the HERC2 immunocomplex decreased upon HU treatment, so did the presence of HERC2 in the FALG-USP20 immunocomplex, whereas the interaction between USP20 (4SA) and HERC2 did not decrease in response to HU treatment."
25326330
sparser
"We next studied how HERC2-USP20 interaction is regulated by the DDR pathway."
25355518
reach
"We confirmed the interaction between USP20 and HERC2 by endogenous Co-IP."
25355518
reach
"One is that USP20 phosphorylation itself affects the binding between USP20 and HERC2."
25355518
sparser
"On the other hand, USP20 is phosphorylated by ATR, which disrupts the interaction between USP20 and HERC2, resulting in USP20 stabilization."
25355518
USP20 binds CLSPN and HERC2. 1 / 1
| 1
sparser
"Co-immunoprecipitation assays revealed that both HERC2 and CLASPIN were present in the USP20 immunocomplex (Figure xref ) and both USP20 and CLASPIN were in the HERC2 immunocomplex (Figure  xref ), suggesting that HERC2, USP20 and CLASPIN form a complex."
25326330
HERC2 ubiquitinates USP20.
1 | 3 2
HERC2 ubiquitinates USP20. 6 / 7
1 | 3 2
sparser
"To determine whether HERC2 directly ubiquitinates USP20, we performed an in vitro ubiquitination assay."
25355518
reach
"Under unperturbed condition, HERC2 ubiquitinates USP20 and promotes ubiquitination mediated proteasomal degradation of USP20, regulating the status of K48 linked polyubiquitination of CLASPIN and ensuring appropriate protein levels of CLASPIN during the S-phase."
25326330
reach
"To determine whether HERC2 directly ubiquitinates USP20, we performed an in vitro ubiquitination assay."
25355518
ubibrowser
"UbiNet 2.0"
25355518
sparser
"Under unperturbed condition, HERC2 ubiquitinates USP20 and promotes ubiquitination-mediated proteasomal degradation of USP20, regulating the status of K48-linked polyubiquitination of CLASPIN and ensuring appropriate protein levels of CLASPIN during the S-phase."
25326330
reach
"On the other hand, when cells recover from DNA damage, HERC2 mediates USP20 ubiquitination, turning off the DDR signaling."
25355518
HERC2 inhibits USP20.
| 4
HERC2 inhibits USP20. 4 / 4
| 4
reach
"Here we found that HERC2 antagonized USP20 function and negatively regulated the replication stress signaling pathway."
25355518
reach
"In HERC2 depleted cells, USP20 and its substrates Claspin were significantly upregulated and the phosphorylation of CHK1 is more sustained, even at later time points."
25355518
reach
"Taken together, these results suggested that HERC2 functions as an E3 ligase of USP20 and negatively regulates USP20 in unstressed cells."
25355518
reach
"HERC2 promotes USP20 degradation."
25326330
HERC2 increases the amount of USP20.
| 1
HERC2 increases the amount of USP20. 1 / 1
| 1
reach
"As shown in Figure XREF_FIG and XREF_FIG, downregulation of HERC2 resulted in upregulation of USP20 levels and protein stability."
25355518
USP20 affects USP33
2 | 5 15
USP20 binds USP33.
2 | 4 15
USP20 binds USP33. 10 / 11
2 | 4 4
biogrid
No evidence text available
23486064
reach
"In the current studies and together with our previous report [30], we have demonstrated that both VDU1 and VDU2 also bind to the beta-domain of pVHL and several naturally occurring mutations in the be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
sparser
"Moreover, pVHL30 is also known to interact with both USP33 and USP20, two enzymes belonging to the USP protein family, whose USP7 is a further member [ xref ]."
35205757
sparser
"Two DUBs, USP33 (or VDU-1) and USP20 (or VDU-2), interact with and regulate D2 [ xref ]."
29892818
biogrid
No evidence text available
23486064
reach
"The interactions with USP20/33 are most likely direct because (1) bacterially expressed GST-USP33 and USP20 bind to in vitro translated CP110 in binding assays (XREF_SUPPLEMENTARY) and (2) Neurl4 depletion does not affect the binding between USP33 and CP110 (XREF_SUPPLEMENTARY)."
23486064
sparser
"Like VDU1, VDU2 interacts with pVHL beta-domain and these two proteins can compete with each other to bind to pVHL."
12056827
reach
"Together, our results suggest that VDU1 and VDU2 might be relevent to pVHL related tumorigenesis.In conclusion, our previously published results and current data indicate that the interaction between [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"Further investigations are warranted to probe the biochemical and biological functions of the interaction between pVHL and VDU1 and VDU2 and to dissect functional and physiological differences between[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
sparser
"In the current studies and together with our previous report [30] , we have demonstrated that both VDU1 and VDU2 also bind to the β-domain of pVHL and several naturally occurring mutations in the β-d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
USP20 binds USP33 and groL2. 4 / 4
| 4
sparser
"Similar to our previous demonstration with hSP56 and VDU1 interactions (14), VDU2 (red fluorescence from anti-HA/anti-mouse IgG-Texas Red) and hSP56 (green fluorescence from hSP56-EGFP) overlapped in the cytoplasm ( xref D)."
24874852
sparser
"HSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"HSP56 was co-immunoprecipitated specifically with either VDU1-HA or VDU2-HA using anti-HA antibody, but not using normal mouse IgG ( xref C), confirming that hSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"We investigated the interactions of hSP56 with VDU1 and VDU2 further by co-immunoprecipitation."
24874852
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP20 binds VHL and USP33. 2 / 2
| 2
sparser
"In conclusion, our previously published results and current data indicate that the interaction between pVHL and VDU1 or VDU2 mediates the ubiquitination and degradation of these two proteins."
12056827
sparser
"Based on their amino acid sequence homology and functional interaction with pVHL, VDU1 and VDU2 define a subfamily of ubiquitin specific processing proteases."
12056827
USP20 binds USP33 and AR. 1 / 1
| 1
sparser
"Because carvedilol enhanced β 2 AR ubiquitination and degradation independently of the known β 2 AR E3 ligase Nedd4, we reasoned that carvedilol might diminish β 2 AR deubiquitination by reducing the association of the β 2 AR with USP20 and/or USP33."
23166351
USP20 binds USP33 and CCP110. 1 / 1
| 1
sparser
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
USP20 binds USP33 and ARs. 1 / 1
| 1
sparser
"Plasma membrane-localized β 2 ARs can bind to two closely related DUBs, USP33 and USP20 (also known as VDU2)."
23764054
USP20 activates USP33.
| 1
USP20 activates USP33. 1 / 1
| 1
reach
"The closely related DUBs, USP20 and USP33, deubiquitylate activated beta-adrenergic receptors as well as the adaptor and signalling protein beta-arrestin (in the case of USP33), to favour recycling from endosomes, despite largely being associated with the secretory pathway 75, 76, 77."
28064438
ATR affects USP20
1 | 9 9 3
ATR phosphorylates USP20.
| 8 9 3
ATR phosphorylates USP20. 10 / 21
| 8 9 3
rlimsp
"Taken together, these data demonstrated that USP20 is phosphorylated by ATR in response to HU-induced replication stress."
25326330
rlimsp
"ATR-mediated phosphorylation of USP20 promotes its dissociation from HERC2."
25326330
reach
"USP20 phosphorylation by ATR is important for its stabilization and checkpoint activation."
25355518
sparser
"USP20 phosphorylation by ATR is important for its stabilization and checkpoint activation."
25355518
sparser
"Upon DNA damage, ATR phosphorylates USP20, a deubiquitinating enzyme which is a degradation target of HERC2 ( xref A)."
32580485
sparser
"Besides, ATR phosphorylates and also stabilizes USP20 by unbinding it from HERC2."
31447701
reach
"USP20 phosphorylation by ATR does not affect its E3 ligase activity per se, suggesting that USP20 levels, but not catalytic activity, are subjected to ATR regulation."
25355518
rlimsp
"(B and C) USP20 was phosphorylated by ATR in response to HU treatment."
25326330
reach
"Mechanistically, the phosphorylation of USP20 by ATR disrupts the interaction between HERC2 and USP20 and is responsible for USP20 upregulation following the DDR."
25355518
sparser
"Taken together, these data demonstrated that USP20 is phosphorylated by ATR in response to HU-induced replication stress."
25326330
ATR binds USP20.
1 |
USP20 binds ATR. 1 / 1
1 |
biogrid
No evidence text available
25326330
ATR activates USP20.
| 1
ATR activates USP20. 1 / 1
| 1
reach
"Since USP20 is upregulated after replication stress, we sought to determine whether USP20 is modulated by ATR in response to replication stress."
25326330
VHL affects USP20
4 2 | 11 5
VHL binds USP20.
4 | 7 3
USP20 binds VHL. 10 / 12
4 | 7 1
biogrid
No evidence text available
12056827
reach
"This mutation did not affect the interaction between hVDU2 and pVHL as predicted.VDU1 and VDU2 exhibit a very high homology at their N-terminal and C-terminal region as shown in Fig. 1, and both prote[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
sparser
"The proteasome has both ubiquitin ligases and DUBs that associate with it (Crosas et al., 2006) , and several DUB-ligase pairs interact directly, including BRCC36-BRCA1, BAP1-BRCA1, USP4-Ro52, USP7-MDM2, USP8-GRAIL, USP20-pVHL, USP33-pVHL and USP44-APC (Kee and Huibregtse, 2007; Marfany and Denuc, 2008; Ventii and Wilkinson, 2008) ."
19571111
reach
"In the current studies and together with our previous report [30], we have demonstrated that both VDU1 and VDU2 also bind to the beta-domain of pVHL and several naturally occurring mutations in the be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"The interaction between hVDU2 and pVHL was also tested by in vivo co-immunoprecipitation."
12056827
reach
"PVHL was precipitated by an anti-GFP antibody due to the interaction between hVDU2 and pVHL."
12056827
biogrid
No evidence text available
12056827
reach
"Our data have demonstrated that several naturally occurring mutations in the pVHL beta-domain disrupt the interaction between hVDU2 and pVHL, which underscores the functional relevance of this interac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"Further investigations are warranted to probe the biochemical and biological functions of the interaction between pVHL and VDU1 and VDU2 and to dissect functional and physiological differences between[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"Together, our results suggest that VDU1 and VDU2 might be relevent to pVHL related tumorigenesis.In conclusion, our previously published results and current data indicate that the interaction between [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
USP20 binds VHL and USP33. 2 / 2
| 2
sparser
"In conclusion, our previously published results and current data indicate that the interaction between pVHL and VDU1 or VDU2 mediates the ubiquitination and degradation of these two proteins."
12056827
sparser
"Based on their amino acid sequence homology and functional interaction with pVHL, VDU1 and VDU2 define a subfamily of ubiquitin specific processing proteases."
12056827
VHL ubiquitinates USP20.
2 | 4 2
VHL ubiquitinates USP20. 8 / 8
2 | 4 2
reach
"To test whether hVDU2 can be ubiquitinated by pVHL E3 ubiquitin ligase complex, we performed ubiquitination assay in vitro and in vivo."
12056827
reach
"These results suggest that like hVDU1, the ubiquitination of hVDU2 is dependent on the presence of pVHL.To test whether hVDU2 ubiquitination mediated by pVHL could result in rapid turnover of hVDU2 pr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
ubibrowser
"In this report we show that another uncharacterized deubiquitinating enzyme, named VDU2 (pVHL-interacting deubiquitinating enzyme-2), is a substrate of pVHL"
12056827
reach
"Moreover, VHL can ubiquitinate USP20 in return and target it for degradation [XREF_BIBR]."
33466790
sparser
"Moreover, VHL can ubiquitinate USP20 in return and target it for degradation [78]."
33466790
ubibrowser
"Although pVHL functions as a master control for HIF-1alpha stabilization, as pVHL-E3 ligase mediates the ubiquitination of both HIF-1alpha and VDU2, the balance between the pVHL-mediated ubiquitination and VDU2-mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization"
15776016
sparser
"Moreover, VHL can ubiquitinate USP20 in return and target it for degradation [ xref ]."
33466790
reach
"Although pVHL functions as a master control for HIF-1alpha stabilization, as pVHL-E3 ligase mediates the ubiquitination of both HIF-1alpha and VDU2, the balance between the pVHL mediated ubiquitination and VDU2 mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization."
15776016
USP33 affects USP20
2 | 4 15
USP20 binds USP33. 10 / 11
2 | 4 4
biogrid
No evidence text available
23486064
reach
"In the current studies and together with our previous report [30], we have demonstrated that both VDU1 and VDU2 also bind to the beta-domain of pVHL and several naturally occurring mutations in the be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
sparser
"Moreover, pVHL30 is also known to interact with both USP33 and USP20, two enzymes belonging to the USP protein family, whose USP7 is a further member [ xref ]."
35205757
sparser
"Two DUBs, USP33 (or VDU-1) and USP20 (or VDU-2), interact with and regulate D2 [ xref ]."
29892818
biogrid
No evidence text available
23486064
reach
"The interactions with USP20/33 are most likely direct because (1) bacterially expressed GST-USP33 and USP20 bind to in vitro translated CP110 in binding assays (XREF_SUPPLEMENTARY) and (2) Neurl4 depletion does not affect the binding between USP33 and CP110 (XREF_SUPPLEMENTARY)."
23486064
sparser
"Like VDU1, VDU2 interacts with pVHL beta-domain and these two proteins can compete with each other to bind to pVHL."
12056827
reach
"Together, our results suggest that VDU1 and VDU2 might be relevent to pVHL related tumorigenesis.In conclusion, our previously published results and current data indicate that the interaction between [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"Further investigations are warranted to probe the biochemical and biological functions of the interaction between pVHL and VDU1 and VDU2 and to dissect functional and physiological differences between[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
sparser
"In the current studies and together with our previous report [30] , we have demonstrated that both VDU1 and VDU2 also bind to the β-domain of pVHL and several naturally occurring mutations in the β-d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
USP20 binds USP33 and groL2. 4 / 4
| 4
sparser
"Similar to our previous demonstration with hSP56 and VDU1 interactions (14), VDU2 (red fluorescence from anti-HA/anti-mouse IgG-Texas Red) and hSP56 (green fluorescence from hSP56-EGFP) overlapped in the cytoplasm ( xref D)."
24874852
sparser
"HSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"HSP56 was co-immunoprecipitated specifically with either VDU1-HA or VDU2-HA using anti-HA antibody, but not using normal mouse IgG ( xref C), confirming that hSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"We investigated the interactions of hSP56 with VDU1 and VDU2 further by co-immunoprecipitation."
24874852
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP20 binds VHL and USP33. 2 / 2
| 2
sparser
"In conclusion, our previously published results and current data indicate that the interaction between pVHL and VDU1 or VDU2 mediates the ubiquitination and degradation of these two proteins."
12056827
sparser
"Based on their amino acid sequence homology and functional interaction with pVHL, VDU1 and VDU2 define a subfamily of ubiquitin specific processing proteases."
12056827
USP20 binds USP33 and AR. 1 / 1
| 1
sparser
"Because carvedilol enhanced β 2 AR ubiquitination and degradation independently of the known β 2 AR E3 ligase Nedd4, we reasoned that carvedilol might diminish β 2 AR deubiquitination by reducing the association of the β 2 AR with USP20 and/or USP33."
23166351
USP20 binds USP33 and CCP110. 1 / 1
| 1
sparser
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
USP20 binds USP33 and ARs. 1 / 1
| 1
sparser
"Plasma membrane-localized β 2 ARs can bind to two closely related DUBs, USP33 and USP20 (also known as VDU2)."
23764054
USP20 affects HIF1A
3 1 | 11 3
USP20 binds HIF1A.
3 | 3 3
USP20 binds HIF1A. 9 / 10
3 | 3 3
reach
"For example, VHL interacting deubiquitinating enzyme 2 (VDU2) interacts with HIF-1alpha and specifically deubiquitinates and stabilizes HIF-1alpha [XREF_BIBR]."
22521794
sparser
"In contrast to VDU2 which directly interacts with HIF-1α, USP28 forms a ternary complex with HIF-1α via its association with HIF-1α bound Fbw7 (Flügel et al., xref )."
26942179
sparser
"According to those findings, USP20 binds to and stabilizes HIF-1α."
31208103
reach
"Molecular and cellular experiments showed that VDU2 interacted with HIF-1alpha in order to induce the expression of HIF-1 downstream genes, such as VEGF, through the deubiquitination and stabilization of HIF-1alpha."
29285833
biogrid
No evidence text available
15776016
sparser
"However, by using in vitro pull down assays with GST-HIF-1α (amino acid 530–826) and co-immunoprecipitation experiments in COS-7 cells it was shown that only VDU2 but not VDU1 could interact with HIF-1α (Li et al., xref )."
26942179
biogrid
No evidence text available
15776016
biogrid
No evidence text available
15776016
reach
"The interaction between HIF-1alpha and VDU2 was shown using an immunoprecipitation assay."
29285833
USP20 deubiquitinates HIF1A.
1 | 4
USP20 deubiquitinates HIF1A. 5 / 5
1 | 4
ubibrowser
"USP20 stabilizes HIF-1α by abolishing von Hippel-Lindau protein (pVHL)-E3 ligase complex-mediated HIF-1α degradation."
23750477
reach
"VDU2 can specifically deubiquitinate and stabilize HIF-1alpha and, therefore, increase expression of HIF-1alpha targeted genes, such as vascular endothelial growth factor (VEGF)."
15776016
reach
"In addition, VDU2, but not VDU1, is able to interact with and deubiquitinate HIF1alpha, and rescue it from proteasome mediated degradation."
25605410
reach
"In addition, it was shown that VDU2 but not VDU1 can deubiquitylate HIF-1alpha and increase it 's half-life."
26942179
reach
"One of them, USP-20, deubiquitinates HIF-1alpha and therefore tends to stabilize it [46] by preventing its proteasomal degradation."
26899267
USP20 activates HIF1A.
| 2
USP20 activates HIF1A. 2 / 4
| 2
reach
"Up-regulation of Usp20, a deubiquitinase that acts on Hif1a and other proteins 24, should reduce degradation of Hif1a."
28779178
reach
"Therefore, targeting USP20 can induce degradation of HIF-1alpha and be a potential drug target for human cancer."
22649774
USP20 increases the amount of HIF1A.
| 2
Modified USP20 increases the amount of HIF1A. 1 / 1
| 1
reach
"Thus, overexpression of VDU2 increases expression of HIF-1alpha targeted genes, such as VEGF."
22521794
USP20 increases the amount of HIF1A. 1 / 1
| 1
reach
"The previous study has shown that Usp20 increases the expression of HIF1A XREF_BIBR, XREF_BIBR, which is reported as a metabolic switch for an early stage of iPSC 20."
28839133
CLSPN affects USP20
7 | 5 5
CLSPN binds USP20.
7 | 4 5
USP20 binds CLSPN. 10 / 15
7 | 4 4
reach
"To determine whether the interaction between USP20 and Claspin is direct, we generated and purified recombinant USP20 and Claspin."
25355518
reach
"However, depletion of HERC2 did not affect the binding between USP20 and Claspin."
25355518
biogrid
No evidence text available
25326330
sparser
"We confirmed the USP20-Claspin interaction by Co-IP."
25355518
biogrid
No evidence text available
25355518
biogrid
No evidence text available
25355518
reach
"Co-immunoprecipitation assays revealed that both HERC2 and CLASPIN were present in the USP20 immunocomplex and both USP20 and CLASPIN were in the HERC2 immunocomplex, suggesting that HERC2, USP20 and CLASPIN form a complex."
25326330
biogrid
No evidence text available
25355518
reach
"As shown in Figure XREF_FIG, GST-USP20 was able to interact with His Claspin under cell-free conditions, suggesting a direct interaction between USP20 and Claspin."
25355518
sparser
"To determine whether the interaction between USP20 and Claspin is direct, we generated and purified recombinant USP20 and Claspin."
25355518
USP20 binds CLSPN and HERC2. 1 / 1
| 1
sparser
"Co-immunoprecipitation assays revealed that both HERC2 and CLASPIN were present in the USP20 immunocomplex (Figure xref ) and both USP20 and CLASPIN were in the HERC2 immunocomplex (Figure  xref ), suggesting that HERC2, USP20 and CLASPIN form a complex."
25326330
CLSPN activates USP20.
| 1
CLSPN activates USP20. 1 / 1
| 1
reach
"Nevertheless, in USP20 knockdown cells, reconstitution of Claspin was able to rescue phospho-CHK1 levels and significantly suppress tumorigenesis, even if Rad17 levels was decreased, suggesting that Claspin is an important target of USP20 in mediating checkpoint activation and tumor suppression."
25355518
USP20 affects VHL
4 | 8 3
USP20 binds VHL.
4 | 7 3
USP20 binds VHL. 10 / 12
4 | 7 1
biogrid
No evidence text available
12056827
reach
"This mutation did not affect the interaction between hVDU2 and pVHL as predicted.VDU1 and VDU2 exhibit a very high homology at their N-terminal and C-terminal region as shown in Fig. 1, and both prote[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
sparser
"The proteasome has both ubiquitin ligases and DUBs that associate with it (Crosas et al., 2006) , and several DUB-ligase pairs interact directly, including BRCC36-BRCA1, BAP1-BRCA1, USP4-Ro52, USP7-MDM2, USP8-GRAIL, USP20-pVHL, USP33-pVHL and USP44-APC (Kee and Huibregtse, 2007; Marfany and Denuc, 2008; Ventii and Wilkinson, 2008) ."
19571111
reach
"In the current studies and together with our previous report [30], we have demonstrated that both VDU1 and VDU2 also bind to the beta-domain of pVHL and several naturally occurring mutations in the be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"The interaction between hVDU2 and pVHL was also tested by in vivo co-immunoprecipitation."
12056827
reach
"PVHL was precipitated by an anti-GFP antibody due to the interaction between hVDU2 and pVHL."
12056827
biogrid
No evidence text available
12056827
reach
"Our data have demonstrated that several naturally occurring mutations in the pVHL beta-domain disrupt the interaction between hVDU2 and pVHL, which underscores the functional relevance of this interac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"Further investigations are warranted to probe the biochemical and biological functions of the interaction between pVHL and VDU1 and VDU2 and to dissect functional and physiological differences between[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"Together, our results suggest that VDU1 and VDU2 might be relevent to pVHL related tumorigenesis.In conclusion, our previously published results and current data indicate that the interaction between [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
USP20 binds VHL and USP33. 2 / 2
| 2
sparser
"In conclusion, our previously published results and current data indicate that the interaction between pVHL and VDU1 or VDU2 mediates the ubiquitination and degradation of these two proteins."
12056827
sparser
"Based on their amino acid sequence homology and functional interaction with pVHL, VDU1 and VDU2 define a subfamily of ubiquitin specific processing proteases."
12056827
USP20 deubiquitinates VHL.
| 1
USP20 deubiquitinates ubiquitinated VHL. 1 / 1
| 1
reach
"Can VDU1 or VDU2 deubiquitinate the ubiquitinated pVHL to salvage it from degradation on certain conditions?"
12056827
USP20 affects ULK1
1 | 7 6
USP20 binds ULK1.
| 5 6
ULK1 binds USP20. 10 / 11
| 5 6
sparser
"USP20 can bind, de-ubiquitinate and stabilize ULK1 at a basal level and plays an important role in autophagy initiation."
32887506
reach
"USP20 interacts with and deubiquitinates ULK1, thus protecting it from degradation."
30126257
reach
"However, the interaction between ULK1 and USP20 is weakened upon prolonged induction of autophagy (4 to 8 h), leading to a reduction of the level of ULK1 protein while its ubiquitinated form accumulates [XREF_BIBR]."
30126257
sparser
"However, the interaction between ULK1 and USP20 is weakened upon prolonged induction of autophagy (4 to 8 h), leading to a reduction of the level of ULK1 protein while its ubiquitinated form accumulates [64]."
30126257
reach
"Under prolonged starvation, the binding of USP20 to ULK1 is diminished, leading to autophagy inhibition [43]."
31630678
sparser
"Under prolonged starvation, the binding of USP20 to ULK1 is diminished, leading to autophagy inhibition [ xref ]."
31630678
reach
"At basal state, USP20 binds to and stabilizes ULK1 by removing the ubiquitin moiety, thereby interfering with the lysosomal degradation of ULK1."
29487085
sparser
"However, the interaction between ULK1 and USP20 is weakened upon prolonged induction of autophagy (4 to 8 h), leading to a reduction of the level of ULK1 protein while its ubiquitinated form accumulates [ xref ]."
30126257
sparser
"During prolonged starvation, NEDD4L catalyzes the K27 and K29 ubiquitination on ULK1 [ xref ], whereas the interaction between USP20 and ULK1 is attenuated [ xref ]."
31630678
reach
"During prolonged starvation, NEDD4L catalyzes the K27 and K29 ubiquitination on ULK1 [58], whereas the interaction between USP20 and ULK1 is attenuated [43]."
31630678
USP20 deubiquitinates ULK1.
1 | 1
USP20 deubiquitinates ULK1. 2 / 2
1 | 1
reach
"USP20 interacts with and deubiquitinates ULK1, thus protecting it from degradation."
30126257
ubibrowser
"The deubiquitination of ULK1 by USP20 allows for its stabilization and promotion of autophagy induction."
30126257
USP20 ubiquitinates ULK1.
| 1
USP20 leads to the ubiquitination of ULK1. 1 / 1
| 1
reach
"The degradable ULK1 ubiquitination is reversed by USP20."
31630678
USP20 affects TRAF6
4 1 | 9
USP20 deubiquitinates TRAF6.
1 | 8
USP20 deubiquitinates TRAF6. 9 / 9
1 | 8
reach
"For example, Junichiro et al. demonstrated that USP21 constitutively deubiquitinates RIP1 in vitro and in vivo [40]; and a previous study has reported that USP20 deubiquitinates TRAF6 and Tax in vivo [40]."
24260525
reach
"For example, USP11 negatively regulates TNFα-induced NF-κB activation associated with IκBα and attenuates IκBα degradation [34]; USP20 deubiquitinates TRAF6 and suppresses interleukin 1β (IL-1β)- and Tax-induced NF-κB activation [40]; Katrin et al. showed that USP15 regulates IκBα/NF-κB by deubiquitinylation IκBα[44]; and USP31 inhibits TNFα, CD40, TRAF2, TRAF6 and IKKβ-mediated NF-κB activation [45]."
24260525
reach
"For example, Junichiro et al. demonstrated that USP21 constitutively deubiquitinates RIP1 in vitro and in vivo [XREF_BIBR]; and a previous study has reported that USP20 deubiquitinates TRAF6 and Tax in vivo [XREF_BIBR]."
24260525
reach
"We report that two ubiquitin specific peptidases, USP20 and USP33, deubiquitinate TRAF6 and suppress IL-1beta-induced NF-kappaB activation."
| PMC
reach
"Here, we report that ubiquitin specific peptidase USP20 deubiquitinates TRAF6 and Tax and suppresses interleukin 1beta (IL-1beta) - and Tax induced NF-kappaB activation."
21525354
reach
"54 Ubiquitinated beta-arrestin2 promotes NF-kappaB signaling in SMCs, whereas deubiquitinated beta-arrestin2 attenuates NF-kappaB signaling by scaffolding the deubiquitinase USP20, that in turn deubiquitinates TRAF6, which blocks the NF-kappaB signaling cascade."
28328745
reach
"TRAF6 activity can be impeded by deubiquitinating enzymes like ubiquitin specific protease 20 (USP20), which can reverse TRAF6 autoubiquitination, and by association with the multifunctional adaptor protein beta-arrestin2."
26839314
ubibrowser
"With purified proteins and in intact cells, our protein interaction studies showed that TRAF6/USP20 association and subsequent USP20-mediated TRAF6 deubiquitination were β-arrestin2-dependent."
26839314
reach
"For example, USP11 negatively regulates TNFalpha induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [XREF_BIBR]; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta (IL-1beta) - and Tax induced NF-kappaB activation [XREF_BIBR]; Katrin et al. showed that USP15 regulates IkappaBalpha and NF-kappaB by deubiquitinylation IkappaBalpha [XREF_BIBR]; and USP31 inhibits TNFalpha, CD40, TRAF2, TRAF6 and IKKbeta mediated NF-kappaB activation [XREF_BIBR]."
24260525
USP20 binds TRAF6.
4 |
TRAF6 binds USP20. 4 / 4
4 |
biogrid
No evidence text available
26839314
biogrid
No evidence text available
21525354
biogrid
No evidence text available
21525354
biogrid
No evidence text available
26839314
USP20 activates TRAF6.
| 1
USP20 activates TRAF6. 1 / 1
| 1
reach
"For example, USP17 and USP20 were found to target RIG-I and TRAF6 respectively, thereby functioning as novel regulators of antiviral innate immune responses [XREF_BIBR, XREF_BIBR]."
24260525
USP20 affects SQSTM1
| 1 12 1
SQSTM1 binds USP20. 10 / 13
| 1 12
sparser
"This is the first report that reveals the molecular mechanism of the USP20-p62 axis regarding NF-κB-mediated cell survival."
32354117
sparser
"Immunoprecipitation assays supported the endogenous interactions between USP20 and p62 upon TNFα treatment in HeLa cells ( xref B)."
32354117
sparser
"These findings strongly suggest that the USP20-p62 axis plays an essential role in NF-κB-mediated cell survival induced by the TNFα-atypical PKCζ signaling pathway."
32354117
sparser
"Our finding that USP20 stabilizes the p62 protein prompted us to examine whether USP20 directly binds to p62."
32354117
sparser
"USP20 specifically binds to p62 and acts as a positive regulator for NF-κB activation by TNFα through deubiquitinating lysine 48 (K48)-linked polyubiquitination, eventually contributing to cell survival."
32354117
sparser
"Based on this speculation, our current experiments provide evidence that the p62-USP20 axis is required for PKCζ-mediated NF-κB activation upon TNFα treatment."
32354117
sparser
"This time point coincided with the timing of endogenous p62 interaction with USP20 ( xref B)."
32354117
sparser
"Co-immunoprecipitation assays revealed the direct interaction of USP20 with p62 when plasmids encoding HA-USP20 and Flag-p62 were ectopically expressed in HeLa cells ( xref A)."
32354117
sparser
"Based on this finding, we next examined the endogenous interaction of USP20 with p62 upon TNFα treatment."
32354117
sparser
"Herein, we find that USP20 binds to p62 at 5 min upon TNFα treatment and thus stabilizes it through removing the lysine 48 (K48)-linked polyubiquitin chains."
32354117
SQSTM1 binds USP20. 1 / 1
| 1
isi
"USP20 specifically binds to p62 and acts as a positive regulator for NF-kappaB activation by TNFalpha through deubiquitinating lysine 48 (K48)-linked polyubiquitination, eventually contributing to cell survival."
32354117
USP20 affects STING1
2 1 | 1 5 4
USP20 binds STING1.
2 | 4
USP18 binds USP20 and STING1. 4 / 4
| 4
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
34901390
sparser
"Collectively, these results showed that USP18 and USP20 interact with STING and that a deficiency of either USP18 or USP20 affects the stability of STING in SCC9 cells."
34901390
sparser
"Immunoprecipitation revealed that both USP18 and USP20 interacted with the N-terminal region of the STING protein."
33138315
sparser
"We found that USP18 and USP20 both interact with STING in SCC9 cells."
34901390
USP20 binds STING1. 2 / 2
2 |
biogrid
No evidence text available
27801882
biogrid
No evidence text available
27801882
USP20 inhibits STING1.
| 1 3
USP20 inhibits STING1. 4 / 4
| 1 3
eidos
"On the other hand , OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation , thus maintain the stability of STING and promote activation of STING pathway ( 87 ) ( 88 ) ( 89 ) ."
35603197
reach
"On the other hand, OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation, thus maintain the stability of STING and promote activation of STING pathway (87) (88) (89) ."
35603197
reach
"On the other hand, OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation, thus maintain the stability of STING and promote activation of STING pathway (87–89)."
35603197
reach
"USP18 deficiency or knockdown of USP20 resulted in enhanced K48 linked ubiquitination and accelerated degradation of STING, and impaired activation of IRF3 and NF-kappaB as well as induction of downstream genes after infection with DNA virus HSV-1 or transfection of various DNA ligands."
27801882
USP20 activates STING1.
| 2
USP20 activates STING1. 2 / 2
| 2
reach
"On the other hand, OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation, thus maintain the stability of STING and promote activation of STING pathway (87–89)."
35603197
reach
"On the other hand, OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation, thus maintain the stability of STING and promote activation of STING pathway (87) (88) (89) ."
35603197
USP20 deubiquitinates STING1.
1 |
USP20 deubiquitinates STING1. 1 / 1
1 |
ubibrowser
"USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA"
27801882
USP20 affects USP18
| 10
USP18 binds USP20. 6 / 8
| 6
sparser
"Immunoprecipitation revealed that STING, USP18 and USP20 are arranged as USP20-USP18-STING, but both USP20 and USP18 were associated with the N-terminus of STING [ xref ]."
31208841
sparser
"USP18-USP20 mediated the accumulation of STING that regulates oHSV-1 T1012G viral lytic replication in SCC9 cells."
34901390
sparser
"In 2016, Zhang et al. [61] reported that USP18 interacts with the deubiquitinase USP20 and recruits it to stimulator of interferon genes (STING)."
30126853
sparser
"Immunoprecipitation revealed that STING, USP18 and USP20 are arranged as USP20-USP18-STING, but both USP20 and USP18 were associated with the N-terminus of STING [41]."
31208841
sparser
"All the above results indicate that USP18-USP20 mediated the accumulation of STING function with limited oHSV-1 T1012G virus yields in SCC9 cells."
34901390
sparser
"In 2016, Zhang et al. [ xref ] reported that USP18 interacts with the deubiquitinase USP20 and recruits it to stimulator of interferon genes (STING)."
30126853
USP18 binds USP20 and STING1. 4 / 4
| 4
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
34901390
sparser
"Collectively, these results showed that USP18 and USP20 interact with STING and that a deficiency of either USP18 or USP20 affects the stability of STING in SCC9 cells."
34901390
sparser
"Immunoprecipitation revealed that both USP18 and USP20 interacted with the N-terminal region of the STING protein."
33138315
sparser
"We found that USP18 and USP20 both interact with STING in SCC9 cells."
34901390
USP20 affects CHEK1
| 8
USP20 activates CHEK1.
| 4
USP20 activates CHEK1. 4 / 8
| 4
reach
"USP20 promotes CHK1 activation in response to replication stress or UV radiation."
25326330
reach
"Taken together, these results indicate that USP20 promotes CHK1 activation in response to HU induced replication stress or UV irradiation."
25326330
reach
"To test if USP20 mediated stability of CLASPIN promotes CHK1 activation upon replication stress, we expressed wild-type FLAG-CLASPIN in USP20 depleted cells."
25326330
reach
"Upon replication stress, ATR mediated phosphorylation of USP20 promotes dissociation of HERC2 from USP20, stabilizes USP20 and its association with CLASPIN, thus increasing CALSPIN stability and ensuring CHK1 activation."
25326330
USP20 inhibits CHEK1.
| 2
USP20 inhibits CHEK1. 1 / 1
| 1
reach
"In a candidate screen of ubiquitin specific processing proteases (USPs) for modulating CHK1 activation, we revealed that inhibition of USP20 expression in 293T cells delayed HU induced CHK1 activation, whereas expression of siRNA resistant form of FLAG-USP20res in the endogenous USP20 depleted cells restored HU induced CHK1 activation kinetics."
25326330
USP20-C154S inhibits CHEK1. 1 / 1
| 1
reach
"Concomitantly, expression of the catalytically inactive mutant FLAG USP20 (C154S) attenuated HU induced CHK1 activation."
25326330
USP20 dephosphorylates CHEK1.
| 2
USP20 leads to the dephosphorylation of CHEK1. 2 / 2
| 2
reach
"As shown in Figure XREF_FIG, depletion of USP20 in cells dramatically reduced Chk1 phosphorylation following DNA damage."
25355518
reach
"Furthermore, depletion of USP20 can not further reduce Chk1 phosphorylation in Claspin knocking-down cells."
25355518
USP18 affects USP20
| 10
USP18 binds USP20. 6 / 8
| 6
sparser
"Immunoprecipitation revealed that STING, USP18 and USP20 are arranged as USP20-USP18-STING, but both USP20 and USP18 were associated with the N-terminus of STING [ xref ]."
31208841
sparser
"USP18-USP20 mediated the accumulation of STING that regulates oHSV-1 T1012G viral lytic replication in SCC9 cells."
34901390
sparser
"In 2016, Zhang et al. [61] reported that USP18 interacts with the deubiquitinase USP20 and recruits it to stimulator of interferon genes (STING)."
30126853
sparser
"Immunoprecipitation revealed that STING, USP18 and USP20 are arranged as USP20-USP18-STING, but both USP20 and USP18 were associated with the N-terminus of STING [41]."
31208841
sparser
"All the above results indicate that USP18-USP20 mediated the accumulation of STING function with limited oHSV-1 T1012G virus yields in SCC9 cells."
34901390
sparser
"In 2016, Zhang et al. [ xref ] reported that USP18 interacts with the deubiquitinase USP20 and recruits it to stimulator of interferon genes (STING)."
30126853
USP18 binds USP20 and STING1. 4 / 4
| 4
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
34901390
sparser
"Collectively, these results showed that USP18 and USP20 interact with STING and that a deficiency of either USP18 or USP20 affects the stability of STING in SCC9 cells."
34901390
sparser
"Immunoprecipitation revealed that both USP18 and USP20 interacted with the N-terminal region of the STING protein."
33138315
sparser
"We found that USP18 and USP20 both interact with STING in SCC9 cells."
34901390
ULK1 affects USP20
| 5 6
ULK1 binds USP20. 10 / 11
| 5 6
sparser
"USP20 can bind, de-ubiquitinate and stabilize ULK1 at a basal level and plays an important role in autophagy initiation."
32887506
reach
"USP20 interacts with and deubiquitinates ULK1, thus protecting it from degradation."
30126257
reach
"However, the interaction between ULK1 and USP20 is weakened upon prolonged induction of autophagy (4 to 8 h), leading to a reduction of the level of ULK1 protein while its ubiquitinated form accumulates [XREF_BIBR]."
30126257
sparser
"However, the interaction between ULK1 and USP20 is weakened upon prolonged induction of autophagy (4 to 8 h), leading to a reduction of the level of ULK1 protein while its ubiquitinated form accumulates [64]."
30126257
reach
"Under prolonged starvation, the binding of USP20 to ULK1 is diminished, leading to autophagy inhibition [43]."
31630678
sparser
"Under prolonged starvation, the binding of USP20 to ULK1 is diminished, leading to autophagy inhibition [ xref ]."
31630678
reach
"At basal state, USP20 binds to and stabilizes ULK1 by removing the ubiquitin moiety, thereby interfering with the lysosomal degradation of ULK1."
29487085
sparser
"However, the interaction between ULK1 and USP20 is weakened upon prolonged induction of autophagy (4 to 8 h), leading to a reduction of the level of ULK1 protein while its ubiquitinated form accumulates [ xref ]."
30126257
sparser
"During prolonged starvation, NEDD4L catalyzes the K27 and K29 ubiquitination on ULK1 [ xref ], whereas the interaction between USP20 and ULK1 is attenuated [ xref ]."
31630678
reach
"During prolonged starvation, NEDD4L catalyzes the K27 and K29 ubiquitination on ULK1 [58], whereas the interaction between USP20 and ULK1 is attenuated [43]."
31630678
GroL2 affects USP20
| 3 7
USP20 binds groL2. 6 / 6
| 3 3
reach
"HSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"We previously identified pVHL-interacting deubiquitinating enzyme 1 (VDU1) as a protein interacting with hSP56 xref , thus extended this finding to examine whether hSP56 interacts also with VDU2, a closely related isoform of VDU1."
24874852
reach
"We previously identified pVHL interacting deubiquitinating enzyme 1 (VDU1) as a protein interacting with hSP56 XREF_BIBR, thus extended this finding to examine whether hSP56 interacts also with VDU2, a closely related isoform of VDU1."
24874852
sparser
"Interestingly, we observed a stronger interaction between VDU2 and hSP56 than between VDU1 and hSP56 ( xref B)."
24874852
sparser
"These results suggest that the interaction of hSP56 with VDU2 is relevant."
24874852
reach
"Interestingly, we observed a stronger interaction between VDU2 and hSP56 than between VDU1 and hSP56 (XREF_FIG B)."
24874852
USP20 binds USP33 and groL2. 4 / 4
| 4
sparser
"Similar to our previous demonstration with hSP56 and VDU1 interactions (14), VDU2 (red fluorescence from anti-HA/anti-mouse IgG-Texas Red) and hSP56 (green fluorescence from hSP56-EGFP) overlapped in the cytoplasm ( xref D)."
24874852
sparser
"HSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"HSP56 was co-immunoprecipitated specifically with either VDU1-HA or VDU2-HA using anti-HA antibody, but not using normal mouse IgG ( xref C), confirming that hSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"We investigated the interactions of hSP56 with VDU1 and VDU2 further by co-immunoprecipitation."
24874852
USP20 affects NFkappaB
| 1 6 1 1
USP20 inhibits NFkappaB.
| 1 4 1
USP20 inhibits NFkappaB. 6 / 6
| 1 4 1
reach
"Silencing USP20 in SMCs with siRNA (small interfering RNA) augmented NFkappaB activation by = ~ 50% in response to either TNF or IL-1beta (interleukin-1beta)."
30354204
reach
"USP18 deficiency or knockdown of USP20 resulted in enhanced K48 linked ubiquitination and accelerated degradation of STING, and impaired activation of IRF3 and NF-kappaB as well as induction of downstream genes after infection with DNA virus HSV-1 or transfection of various DNA ligands."
27801882
reach
"XREF_BIBR USP20 inhibits NF-kappaB activation via Toll like receptor (TLR) 4, XREF_BIBR IL-1R, and the TNF XREF_BIBR inflammatory pathway in VSMCs."
33664994
reach
"XREF_BIBR This study showed that USP18 or USP20 deficiency significantly inhibited HSV-I or cytosolic DNA activation of both NF-kappaB and IRF3, and type-I IFN and proinflammatory cytokine expression."
30989105
sparser
"USPs are the most abundant DUBs, with approximately 60 proteases in humans. xref USP20 inhibits NF-κB activation via Toll-like receptor (TLR)4, xref IL-1R, and the TNF xref inflammatory pathway in VSMCs."
33664994
eidos
"Ubiquitin-specific peptidase 20 ( USP20 ) reduces NFkappaB activation triggered by pro-inflammatory stimuli , and USP20 activity attenuates atherosclerosis in mice ."
37311534
USP20 activates NFkappaB.
| 2
USP20 activates NFkappaB. 2 / 3
| 2
reach
"USP20 is downregulated in HTLV-1 infected cell lines, presumably to promote high levels of NF-kappaB activation, although the exact mechanism is unclear [XREF_BIBR]."
25341660
reach
"Coimmunoprecipitation experiments revealed that USP20 associates with several components of the TNFR1 (TNF receptor-1) signaling pathway, including RIPK1 (receptor interacting protein kinase 1), a critical checkpoint in TNF induced NFkappaB activation and inflammation."
30354204
USP20 binds NFkappaB.
| 1
NFkappaB binds USP20. 1 / 1
| 1
isi
"USP20 specifically binds to p62 and acts as a positive regulator for NF-kappaB activation by TNFalpha through deubiquitinating lysine 48 (K48)-linked polyubiquitination, eventually contributing to cell survival."
32354117
PKA affects USP20
| 4 5 1
PKA phosphorylates USP20.
| 4 4 1
PKA phosphorylates USP20. 9 / 9
| 4 4 1
reach
"PKA dependent phosphorylation of the DUB USP20 was recently shown to perturb post-endocytic trafficking of the beta-andregenic receptor under cellular stress conditions."
26690337
reach
"Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of beta2 adrenergic receptors to autophagosomes during physiological stress."
25666616
rlimsp
"Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress."
25666616
sparser
"Most recently, it was described that upon physiological stress, USP20 is phosphorylated by protein kinase A and this process regulates trafficking of β 2 AR to autophagosomes [ xref ]."
28448471
sparser
"Phosphorylation of USP20 by protein kinase A has been reported to regulate β2 adrenergic receptors intracellular trafficking ( xref )."
33400290
sparser
"PKA-dependent phosphorylation of the DUB USP20 was recently shown to perturb post-endocytic trafficking of the β-andregenic receptor under cellular stress conditions."
26690337
reach
"Phosphorylation of USP20 by protein kinase A has been reported to regulate β2 adrenergic receptors intracellular trafficking (Yu et al., 2019)."
33400290
reach
"Most recently, it was described that upon physiological stress, USP20 is phosphorylated by protein kinase A and this process regulates trafficking of beta 2 AR to autophagosomes [XREF_BIBR]."
28448471
sparser
"This process requires the protein kinase A-dependent phosphorylation and deactivation of the deubiquitinating enzyme USP20, allowing for the ubiquitination of β2AR to persist and act as a sorting signal to autophagosomes [ xref ]."
30353650
PKA inhibits USP20.
| 1
PKA inhibits USP20. 1 / 1
| 1
sparser
"Concomitant inhibition of the deubiquitinase USP20 (Ubiquitin-specific-processing protease 20) by PKA favors ubiquitylation and degradation of the receptor by NEDD4 ( xref ; xref )."
26388770
HIF1A affects USP20
3 | 3 3
USP20 binds HIF1A. 9 / 10
3 | 3 3
reach
"For example, VHL interacting deubiquitinating enzyme 2 (VDU2) interacts with HIF-1alpha and specifically deubiquitinates and stabilizes HIF-1alpha [XREF_BIBR]."
22521794
sparser
"In contrast to VDU2 which directly interacts with HIF-1α, USP28 forms a ternary complex with HIF-1α via its association with HIF-1α bound Fbw7 (Flügel et al., xref )."
26942179
sparser
"According to those findings, USP20 binds to and stabilizes HIF-1α."
31208103
reach
"Molecular and cellular experiments showed that VDU2 interacted with HIF-1alpha in order to induce the expression of HIF-1 downstream genes, such as VEGF, through the deubiquitination and stabilization of HIF-1alpha."
29285833
biogrid
No evidence text available
15776016
sparser
"However, by using in vitro pull down assays with GST-HIF-1α (amino acid 530–826) and co-immunoprecipitation experiments in COS-7 cells it was shown that only VDU2 but not VDU1 could interact with HIF-1α (Li et al., xref )."
26942179
biogrid
No evidence text available
15776016
biogrid
No evidence text available
15776016
reach
"The interaction between HIF-1alpha and VDU2 was shown using an immunoprecipitation assay."
29285833
USP20 inhibits cell population proliferation. 5 / 5
| 5
reach
"Silencing of USP20 increases proliferation in GC cells."
28350092
reach
"In HTLV-1-transformed cells, the transcription of USP20 is reduced compared with HTLV-1-negative T cells, and ectopic USP20 expression was found to inhibit the proliferation of an HTLV-1-transformed cell line, MT4."
| PMC
reach
"In line with the clinical outcomes, we found that the overexpression of USP20 could, on one hand, suppress cell proliferation and delay G1-S cell cycle transition, and on the other hand, enhance autophagy in GC cells."
28350092
reach
"Since overexpression of USP20 inhibits the proliferation of ATL cells, it raises the possibility that induction of USP20 could be used to inhibit HTLV induced oncogenesis."
22029515
reach
"Experimentally, small interfering RNA mediated knockdown of USP20 expression significantly promoted cell proliferation, accelerated G1-S phase transition and attenuated the autophagy activity."
28350092
reach
"USP20 was shown to promote breast tumor metastasis, and proliferation of oral squamous carcinoma cells."
36874086
reach
"These finding revealed that USP20 could modulate GC cell proliferation."
28350092
reach
"Depletion of several DUBs caused either resistance or hypersensitivity to HU treatment; among them, USP20 knockdown showed most significant hypersensitivity to HU treatment, while knockdown of USP20 slightly decreased cell proliferation in untreated cells."
25355518
USP20 affects RAD17
4 1 | 2 1
USP20 binds RAD17.
4 | 1
USP20 binds RAD17. 5 / 5
4 | 1
biogrid
No evidence text available
24923443
sparser
"We demonstrate that USP20 and Rad17 interact, and that this interaction is enhanced by UV exposure."
24923443
biogrid
No evidence text available
24923443
biogrid
No evidence text available
24923443
biogrid
No evidence text available
19615732
USP20 increases the amount of RAD17.
| 2
Modified USP20 increases the amount of RAD17. 1 / 1
| 1
reach
"It was also noted that inhibition of USP20 expression decreased RAD17 protein levels."
25326330
USP20 increases the amount of RAD17. 1 / 1
| 1
reach
"Consistent with this report, we found knockdown of USP20 in cells decreased Rad17 levels."
25355518
USP20 deubiquitinates RAD17.
1 |
USP20 deubiquitinates RAD17. 1 / 1
1 |
ubibrowser
"Similar to Chk1 and Rad17, which enhance recombinational repair of collapsed replication forks, we demonstrate that USP20 depletion impairs DNA double strand break repair by homologous recombination."
24923443
USP20 affects CCP110
2 | 1 4
USP20 binds CCP110. 4 / 5
2 | 1 1
biogrid
No evidence text available
23486064
sparser
"The interactions with USP20/33 are most likely direct because (1) bacterially expressed GST-USP33 and USP20 bind to in vitro translated CP110 in binding assays ( xref ) and (2) Neurl4 depletion does not affect the binding between USP33 and CP110 ( xref )."
23486064
biogrid
No evidence text available
23486064
reach
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP20 binds USP33 and CCP110. 1 / 1
| 1
sparser
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
USP20 affects MAPK6
2 1 | 3
USP20 binds MAPK6.
2 | 1
USP20 binds MAPK6. 3 / 3
2 | 1
reach
"USP20 interacts with and deubiquitinates ERK3 both in vitro and in intact cells."
28167606
biogrid
No evidence text available
28167606
biogrid
No evidence text available
28167606
USP20 deubiquitinates MAPK6.
1 | 1
USP20 deubiquitinates MAPK6. 2 / 2
1 | 1
ubibrowser
"In this study, we carried out an unbiased functional loss-of-function screen of the human deubiquitinating enzyme (DUB) family and identified ubiquitin-specific protease 20 (USP20) as a novel ERK3 regulator.| USP20 interacts with and deubiquitinates ERK3 both in vitro and in intact cells."
28167606
reach
"USP20 interacts with and deubiquitinates ERK3 both in vitro and in intact cells."
28167606
USP20 decreases the amount of MAPK6.
| 1
USP20 decreases the amount of MAPK6. 1 / 1
| 1
reach
"The overexpression of USP20 results in the stabilization and accumulation of the ERK3 protein, whereas USP20 depletion reduces the levels of ERK3."
28167606
STING1 affects USP20
2 | 4
USP18 binds USP20 and STING1. 4 / 4
| 4
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
34901390
sparser
"Collectively, these results showed that USP18 and USP20 interact with STING and that a deficiency of either USP18 or USP20 affects the stability of STING in SCC9 cells."
34901390
sparser
"Immunoprecipitation revealed that both USP18 and USP20 interacted with the N-terminal region of the STING protein."
33138315
sparser
"We found that USP18 and USP20 both interact with STING in SCC9 cells."
34901390
USP20 binds STING1. 2 / 2
2 |
biogrid
No evidence text available
27801882
biogrid
No evidence text available
27801882
RAD17 affects USP20
4 | 1 1
RAD17 binds USP20.
4 | 1
USP20 binds RAD17. 5 / 5
4 | 1
biogrid
No evidence text available
24923443
sparser
"We demonstrate that USP20 and Rad17 interact, and that this interaction is enhanced by UV exposure."
24923443
biogrid
No evidence text available
24923443
biogrid
No evidence text available
24923443
biogrid
No evidence text available
19615732
RAD17 activates USP20.
| 1
RAD17 activates USP20. 1 / 1
| 1
reach
"Nevertheless, in USP20 knockdown cells, reconstitution of Claspin was able to rescue phospho-CHK1 levels and significantly suppress tumorigenesis, even if Rad17 levels was decreased, suggesting that Claspin is an important target of USP20 in mediating checkpoint activation and tumor suppression."
25355518
USP20 activates inflammatory response.
| 3
USP20 activates inflammatory response. 3 / 3
| 3
reach
"Our findings reveal novel mechanisms regulating IL-1β-induced pro-inflammatory signaling: by phosphorylating USP20 Ser334, IRAK1 diminishes the association of USP20 with TRAF6 and thus augments NFκB activation, SMC inflammation and neointimal hyperplasia."
37311534
reach
"Coimmunoprecipitation experiments revealed that USP20 associates with several components of the TNFR1 (TNF receptor-1) signaling pathway, including RIPK1 (receptor interacting protein kinase 1), a critical checkpoint in TNF induced NFkappaB activation and inflammation."
30354204
reach
"Phosphorylation of USP20 on Ser334 by IRAK-1 Promotes IL-1β-evoked Signaling in Vascular Smooth Muscle Cells and Vascular Inflammation."
37311534
USP20 inhibits inflammatory response.
| 1 1
USP20 inhibits inflammatory response. 2 / 2
| 1 1
reach
"USP20 (Ubiquitin Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis."
30354204
sparser
"Thus, USP20 inhibits SMC inflammation in response to the atherogenic cytokine IL-1β, as it does to the atherogenic activation of TLR4. xref "
30354204
USP20 affects autophagy
| 5
USP20 activates autophagy. 4 / 4
| 4
reach
"Experimentally, small interfering RNA mediated knockdown of USP20 expression significantly promoted cell proliferation, accelerated G1-S phase transition and attenuated the autophagy activity."
28350092
reach
"Our result found that silencing of USP20 could inhibit autophagy, not singly but in pairs, the overexpression of USP33, which is the homology of USP20, could deubiquitinate RALB at Lys 47, and then regulate assembly of the RALB, EXO84, and beclin1 complex that initiated autophagy."
28350092
reach
"Thus, whether the autophagy caused by USP20 could contribute to the inhibition of tumor growth is worthy of investigation in a further study."
28350092
reach
"On the contrary, autophagy activity was enhanced by the USP20 overexpression (XREF_FIG)."
28350092
USP20 bound to ULK1 activates autophagy. 1 / 1
| 1
reach
"Under prolonged starvation, the binding of USP20 to ULK1 is diminished, leading to autophagy inhibition [43]."
31630678
USP20 affects USP20
| 1 4
USP20 inhibits USP20.
| 2
USP20 inhibits USP20. 2 / 2
| 2
reach
"Under unperturbed condition, HERC2 ubiquitinates USP20 and promotes ubiquitination mediated proteasomal degradation of USP20, regulating the status of K48 linked polyubiquitination of CLASPIN and ensuring appropriate protein levels of CLASPIN during the S-phase."
25326330
reach
"Our findings reveal novel mechanisms regulating IL-1β-induced pro-inflammatory signaling: by phosphorylating USP20 Ser334, IRAK1 diminishes the association of USP20 with TRAF6 and thus augments NFκB activation, SMC inflammation and neointimal hyperplasia."
37311534
USP20 activates USP20.
| 1 1
USP20 activates USP20. 2 / 2
| 1 1
eidos
"] Although deubiquitinating STING alone , USP20 can be recruited by USP18 , thus causing USP20 to remove K48-linked polyubiquitin chains more efficiently , even at a low dose ."
33511009
reach
"These suggest that ATR mediated phosphorylation of USP20 promotes dissociation of USP20 from HERC2, and this dissociation would stabilize CLASPIN and promote CHK1 activation."
25326330
USP20 phosphorylates USP20.
| 1
USP20 phosphorylates USP20 on S132. 1 / 1
| 1
reach
"Lu et al. demonstrated the post-prandial increase in insulin and the glucose concentration stimulates mTORC1 to phosphorylate the deubiquitylase ubiquitin-specific peptidase 20 (USP20) at S132 and S134, which is recruited to the HMGCR complex and antagonizes its degradation (Lu et al., 2020)."
34658858
USP20 affects Tax
| 5
USP20 deubiquitinates Tax. 5 / 5
| 5
reach
"Here, we report that ubiquitin specific peptidase USP20 deubiquitinates TRAF6 and Tax and suppresses interleukin 1beta (IL-1beta) - and Tax induced NF-kappaB activation."
21525354
reach
"We find that USP20 deubiquitinates Tax and inhibits Tax induced NF-kappaB activation, consistent with Tax being a substrate of USP20."
| PMC
reach
"For example, Junichiro et al. demonstrated that USP21 constitutively deubiquitinates RIP1 in vitro and in vivo [XREF_BIBR]; and a previous study has reported that USP20 deubiquitinates TRAF6 and Tax in vivo [XREF_BIBR]."
24260525
reach
"In further support of this, the deubiquitinating enzyme (DUB) USP20 deubiquitinates Tax to negatively regulate activation of IKK [XREF_BIBR]."
27082114
reach
"For example, Junichiro et al. demonstrated that USP21 constitutively deubiquitinates RIP1 in vitro and in vivo [40]; and a previous study has reported that USP20 deubiquitinates TRAF6 and Tax in vivo [40]."
24260525
USP20 affects TNF
| 4 1
USP20 inhibits TNF.
| 4
USP20 inhibits TNF. 4 / 4
| 4
reach
"USP20 (Ubiquitin Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis."
30354204
reach
"XREF_BIBR USP20 inhibits NF-kappaB activation via Toll like receptor (TLR) 4, XREF_BIBR IL-1R, and the TNF XREF_BIBR inflammatory pathway in VSMCs."
33664994
reach
"Silencing USP20 in SMCs with siRNA (small interfering RNA) augmented NFkappaB activation by = ~ 50% in response to either TNF or IL-1beta (interleukin-1beta)."
30354204
reach
"Conclusions- USP20 attenuates TNF- and IL-1beta-evoked atherogenic signaling in SMCs, by deubiquitinating RIPK1, among other signaling intermediates."
30354204
USP20 binds TNF.
| 1
TNF binds USP20. 1 / 1
| 1
sparser
"Co-immunoprecipitation experiments revealed that USP20 associates with several components of the TNF receptor-1 signaling pathway including receptor-interacting protein kinase 1 (RIPK1), a critical checkpoint in TNF-induced NFκB activation and inflammation."
30354204
USP20 affects RIPK1
2 | 1 2
USP20 deubiquitinates RIPK1.
2 | 1
USP20 deubiquitinates RIPK1. 3 / 3
2 | 1
ubibrowser
"RIPK1 was deubiquitinated by purified USP20 in vitro."
30354204
ubibrowser
"Conclusions- USP20 attenuates TNF- and IL-1β-evoked atherogenic signaling in SMCs, by deubiquitinating RIPK1, among other signaling intermediates."
30354204
reach
"TNF evoked = ~ 2-fold more RIPK1 ubiquitination in SMC-DN-USP20-transgenic than in control SMCs, and RIPK1 was deubiquitinated by purified USP20 in vitro."
30354204
USP20 ubiquitinates RIPK1.
| 1
USP20 ubiquitinates RIPK1. 1 / 1
| 1
sparser
"Antagonizing USP20 activity in SMCs by low-level overexpression of DN-USP20 augmented TNF-induced RIPK1 ubiquitination ( xref )."
30354204
USP20 binds RIPK1.
| 1
RIPK1 binds USP20, ARRB2, and NFKBIA. 1 / 1
| 1
sparser
"In addition, USP20 associated with RIPK1, IκBα, and β-arrestin2 ( xref )."
30354204
USP20 affects NEURL4
3 | 2
USP20 binds NEURL4. 3 / 3
3 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23486064
biogrid
No evidence text available
23486064
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP20 affects ARRB2
| 3 2
USP20 deubiquitinates ARRB2.
| 2
USP20 deubiquitinates ARRB2. 2 / 2
| 2
reach
"Importantly, a double knockdown of USP20 and USP33 enhances the extent of beta-arrestin-2 ubiquitination and increases beta 2 AR degradation."
24292830
reach
"54 Ubiquitinated beta-arrestin2 promotes NF-kappaB signaling in SMCs, whereas deubiquitinated beta-arrestin2 attenuates NF-kappaB signaling by scaffolding the deubiquitinase USP20, that in turn deubiquitinates TRAF6, which blocks the NF-kappaB signaling cascade."
28328745
USP20 binds ARRB2.
| 2
RIPK1 binds USP20, ARRB2, and NFKBIA. 1 / 1
| 1
sparser
"In addition, USP20 associated with RIPK1, IκBα, and β-arrestin2 ( xref )."
30354204
USP20 binds ARRB2. 1 / 1
| 1
sparser
"The association of USP20 with β-arrestin2 was augmented when β-arrestin2 ubiquitination was prevented and reduced when β-arrestin2 ubiquitination was rendered constitutive."
26839314
USP20 ubiquitinates ARRB2.
| 1
USP20 leads to the ubiquitination of ARRB2. 1 / 1
| 1
reach
"Importantly, a knockdown of USP20 and USP33 enhances beta-arrestin2 ubiquitination and increases beta 2 AR degradation [XREF_BIBR, XREF_BIBR]."
24680432
NEURL4 affects USP20
3 | 2
USP20 binds NEURL4. 3 / 3
3 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23486064
biogrid
No evidence text available
23486064
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
GroL2 affects USP33
| 4
USP20 binds USP33 and groL2. 4 / 4
| 4
sparser
"Similar to our previous demonstration with hSP56 and VDU1 interactions (14), VDU2 (red fluorescence from anti-HA/anti-mouse IgG-Texas Red) and hSP56 (green fluorescence from hSP56-EGFP) overlapped in the cytoplasm ( xref D)."
24874852
sparser
"HSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"HSP56 was co-immunoprecipitated specifically with either VDU1-HA or VDU2-HA using anti-HA antibody, but not using normal mouse IgG ( xref C), confirming that hSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"We investigated the interactions of hSP56 with VDU1 and VDU2 further by co-immunoprecipitation."
24874852
USP20 affects SOX4
| 1 2 1
USP20 binds SOX4.
| 1 1
SOX4 binds USP20. 2 / 2
| 1 1
sparser
"The interaction between USP20 and SOX4 was notarized through Co-IP assay."
35405623
reach
"The interaction between USP20 and SOX4 was notarized through Co-IP assay."
35405623
USP20 increases the amount of SOX4.
| 1
USP20 increases the amount of SOX4. 1 / 1
| 1
reach
"USP20 was found to modulate SOX4 protein expression."
35405623
USP20 activates SOX4.
| 1
USP20 activates SOX4. 1 / 1
| 1
eidos
"Finally , through rescue assays , we revealed that USP20 mediated SOX4 expression to accelerate CRC progression ."
35405623
USP20 affects PKM
1 | 1 2
USP20 binds PKM.
| 1 2
USP20 binds PKM. 3 / 3
| 1 2
reach
"USP20 interaction with PKM2 was suggested to apparently enhance its protein stability."
29468140
sparser
"Apart from interacting with E3 ubiquitin ligases, PKM2 does also bind the deubiquitin enzyme USP20 (ubiquitin-specific protease, a deubiquitin enzyme)."
29468140
sparser
"USP20 interaction with PKM2 was suggested to apparently enhance its protein stability ( xref )."
29468140
USP20 deubiquitinates PKM.
1 |
USP20 deubiquitinates PKM. 1 / 1
1 |
ubibrowser
"From this evidence, it is expected that USP20 would be associated with the metabolic pathway through the regulation of PKM2 ubiquitination."
25708858
USP18 affects STING1
| 4
USP18 binds USP20 and STING1. 4 / 4
| 4
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
34901390
sparser
"Collectively, these results showed that USP18 and USP20 interact with STING and that a deficiency of either USP18 or USP20 affects the stability of STING in SCC9 cells."
34901390
sparser
"Immunoprecipitation revealed that both USP18 and USP20 interacted with the N-terminal region of the STING protein."
33138315
sparser
"We found that USP18 and USP20 both interact with STING in SCC9 cells."
34901390
TRAF6 affects USP20
4 |
TRAF6 binds USP20. 4 / 4
4 |
biogrid
No evidence text available
26839314
biogrid
No evidence text available
21525354
biogrid
No evidence text available
21525354
biogrid
No evidence text available
26839314
STING1 affects USP18, and USP20
| 4
USP18 binds USP20 and STING1. 4 / 4
| 4
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
34901390
sparser
"Collectively, these results showed that USP18 and USP20 interact with STING and that a deficiency of either USP18 or USP20 affects the stability of STING in SCC9 cells."
34901390
sparser
"Immunoprecipitation revealed that both USP18 and USP20 interacted with the N-terminal region of the STING protein."
33138315
sparser
"We found that USP18 and USP20 both interact with STING in SCC9 cells."
34901390
MAPK6 affects USP20
2 | 2
MAPK6 binds USP20.
2 | 1
USP20 binds MAPK6. 3 / 3
2 | 1
reach
"USP20 interacts with and deubiquitinates ERK3 both in vitro and in intact cells."
28167606
biogrid
No evidence text available
28167606
biogrid
No evidence text available
28167606
MAPK6 activates USP20.
| 1
MAPK6 activates USP20. 1 / 1
| 1
reach
"Mechanistically, ERK3 expression level in cancer cells was shown to be upregulated by BRAF (through increasing ERK3 mRNA) 11, BMI1 (by suppressing let-7i which targets ERK3 mRNA) 12 and USP20 (by deubiquitinating and stabilizing ERK3 protein) 13."
29101390
Pirinixic acid affects USP20
3 |
Pirinixic acid increases the amount of USP20. 3 / 3
3 |
ctd
No evidence text available
23811191
ctd
No evidence text available
18301758
ctd
No evidence text available
21318169
VAPB affects USP20
3 |
USP20 binds VAPB. 3 / 3
3 |
biogrid
No evidence text available
25416956
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
VAPA affects USP20
3 |
USP20 binds VAPA. 3 / 3
3 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
USP33 affects CCP110
| 3
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP20 binds USP33 and CCP110. 1 / 1
| 1
sparser
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
USP20 affects VAPB
3 |
USP20 binds VAPB. 3 / 3
3 |
biogrid
No evidence text available
25416956
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
USP20 affects VAPA
3 |
USP20 binds VAPA. 3 / 3
3 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
USP20 affects TNFRSF1A
| 3
sparser
"Thus, it appears that USP20 constitutively associates with components of the TNFR1 signaling complex to regulate NFκB signaling and inflammation."
30354204
sparser
"Coimmunoprecipitation experiments revealed that USP20 associates with several components of the TNFR1 (TNF receptor-1) signaling pathway, including RIPK1 (receptor-interacting protein kinase 1), a critical checkpoint in TNF-induced NFκB activation and inflammation."
30354204
TNFRSF1A binds USP20, BIRC3, and IKBKG. 1 / 1
| 1
sparser
"Of these USP20-associating proteins, only β-arrestin2 has previously been described. xref In contrast, we could not detect specific association of USP20 with TNFR1, cIAP2, or IKKγ ( xref )."
30354204
USP20 activates Neoplasm Metastasis. 3 / 3
| 3
reach
"USP20 was shown to promote breast tumor metastasis, and proliferation of oral squamous carcinoma cells."
36874086
reach
"Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2."
32943575
reach
"USP20 enhances CRC cells metastasis and is associated with immune infiltration, immune checkpoints, and chemotherapy resistance."
36874086
USP20 affects NFKBIA
| 1 2
USP20 binds NFKBIA.
| 2
RIPK1 binds USP20, ARRB2, and NFKBIA. 1 / 1
| 1
sparser
"In addition, USP20 associated with RIPK1, IκBα, and β-arrestin2 ( xref )."
30354204
USP20 binds NFKBIA. 1 / 1
| 1
sparser
"For example, both β-arrestin2 xref and USP20 ( xref ) associate with IκBα; therefore, it is possible that a ternary complex of USP20, β-arrestin2 and IκBα facilitates deubiquitination of IκBα—a possibility made more plausible by the observation that β-arrestin2 and its homolog β-arrestin1 can inhibit IκBα degradation and NFκB signaling downstream of TNFR1. xref "
30354204
USP20 phosphorylates NFKBIA.
| 1
USP20 leads to the phosphorylation of NFKBIA. 1 / 1
| 1
reach
"Deletion of USP20 accelerates HSV-1-induced degradation of MITA and impairs phosphorylation of IRF3 and IkappaBalpha as well as subsequent induction of type I IFNs and proinflammatory cytokines after HSV-1 infection or cytoplasmic DNA challenge."
30814308
USP20 affects IRF3
| 3
USP20 inhibits IRF3.
| 2
USP20 inhibits IRF3. 2 / 2
| 2
reach
"XREF_BIBR This study showed that USP18 or USP20 deficiency significantly inhibited HSV-I or cytosolic DNA activation of both NF-kappaB and IRF3, and type-I IFN and proinflammatory cytokine expression."
30989105
reach
"USP18 deficiency or knockdown of USP20 resulted in enhanced K48 linked ubiquitination and accelerated degradation of STING, and impaired activation of IRF3 and NF-kappaB as well as induction of downstream genes after infection with DNA virus HSV-1 or transfection of various DNA ligands."
27801882
USP20 phosphorylates IRF3.
| 1
USP20 leads to the phosphorylation of IRF3. 1 / 1
| 1
reach
"Deletion of USP20 accelerates HSV-1-induced degradation of MITA and impairs phosphorylation of IRF3 and IkappaBalpha as well as subsequent induction of type I IFNs and proinflammatory cytokines after HSV-1 infection or cytoplasmic DNA challenge."
30814308
USP20 affects DIO2
1 1 1 |
USP20 binds DIO2.
1 1 |
USP20 binds DIO2. 2 / 2
1 1 |
hprd
No evidence text available
12865408
biogrid
No evidence text available
12865408
USP20 deubiquitinates DIO2.
1 |
USP20 deubiquitinates DIO2. 1 / 1
1 |
ubibrowser
"Ubiquitinated D2 can be either targeted to proteasomal degradation or reactivated by deubiquitination, a process that is mediated by the deubiquitinases USP20/33 and is important in adaptive thermogenesis."
22967761
USP20 affects Atherosclerosis
| 2 1
USP20 inhibits Atherosclerosis. 3 / 3
| 2 1
eidos
"Ubiquitin-specific peptidase 20 ( USP20 ) reduces NFkappaB activation triggered by pro-inflammatory stimuli , and USP20 activity attenuates atherosclerosis in mice ."
37311534
reach
"Ubiquitin-specific peptidase 20 (USP20) reduces NFκB activation triggered by pro-inflammatory stimuli, and USP20 activity attenuates atherosclerosis in mice."
37311534
eidos
"147 In addition , USP20 attenuated atherosclerosis in an LDLr - / - mouse model by inhibiting NF-kappaB activation in vivo.148 Therefore , increased expression / activity of USP20 may offer protection against inflammatory pathways in patients with ISR ."
33664994
USP20 affects AR
| 2 1
USP20 ubiquitinates AR.
| 1
USP20 leads to the ubiquitination of AR. 1 / 1
| 1
reach
"Ubiquitination of the beta 2 AR is reversed by the deubiquitinases USP20 and USP33, which tonically associate with the beta 2 AR."
23166351
USP20 deubiquitinates AR.
| 1
USP20 leads to the deubiquitination of AR. 1 / 1
| 1
reach
"104 Two DUBs USP20 and USP33 have been shown to mediate deubiquitination of beta 2 AR."
26055058
USP20 binds AR.
| 1
USP20 binds USP33 and AR. 1 / 1
| 1
sparser
"Because carvedilol enhanced β 2 AR ubiquitination and degradation independently of the known β 2 AR E3 ligase Nedd4, we reasoned that carvedilol might diminish β 2 AR deubiquitination by reducing the association of the β 2 AR with USP20 and/or USP33."
23166351
USP20 affects ADRB2
2 1 |
USP20 binds ADRB2.
2 |
USP20 binds ADRB2. 2 / 2
2 |
biogrid
No evidence text available
25666616
biogrid
No evidence text available
23166351
USP20 deubiquitinates ADRB2.
1 |
USP20 deubiquitinates ADRB2. 1 / 1
1 |
TNFRSF1A affects USP20
| 3
sparser
"Thus, it appears that USP20 constitutively associates with components of the TNFR1 signaling complex to regulate NFκB signaling and inflammation."
30354204
sparser
"Coimmunoprecipitation experiments revealed that USP20 associates with several components of the TNFR1 (TNF receptor-1) signaling pathway, including RIPK1 (receptor-interacting protein kinase 1), a critical checkpoint in TNF-induced NFκB activation and inflammation."
30354204
TNFRSF1A binds USP20, BIRC3, and IKBKG. 1 / 1
| 1
sparser
"Of these USP20-associating proteins, only β-arrestin2 has previously been described. xref In contrast, we could not detect specific association of USP20 with TNFR1, cIAP2, or IKKγ ( xref )."
30354204
PKM affects USP20
| 1 2
USP20 binds PKM. 3 / 3
| 1 2
reach
"USP20 interaction with PKM2 was suggested to apparently enhance its protein stability."
29468140
sparser
"Apart from interacting with E3 ubiquitin ligases, PKM2 does also bind the deubiquitin enzyme USP20 (ubiquitin-specific protease, a deubiquitin enzyme)."
29468140
sparser
"USP20 interaction with PKM2 was suggested to apparently enhance its protein stability ( xref )."
29468140
CCP110 affects USP33
| 3
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP20 binds USP33 and CCP110. 1 / 1
| 1
sparser
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
VSX2 affects USP20
2 |
USP20 binds VSX2. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
VHL affects USP33
| 2
USP20 binds VHL and USP33. 2 / 2
| 2
sparser
"In conclusion, our previously published results and current data indicate that the interaction between pVHL and VDU1 or VDU2 mediates the ubiquitination and degradation of these two proteins."
12056827
sparser
"Based on their amino acid sequence homology and functional interaction with pVHL, VDU1 and VDU2 define a subfamily of ubiquitin specific processing proteases."
12056827
USP33 affects NEURL4
| 2
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP21 affects USP20
2 |
USP20 binds USP21. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22626734
reach
"Genetic deletion or pharmacological inhibition of USP20 markedly decreases diet induced body weight gain, reduces lipid levels in the serum and liver, improves insulin sensitivity and increases energy expenditure."
33177714
reach
"USP20 links feeding induced cholesterol synthesis and energy expenditure."
33420925
USP20 affects cell cycle
| 2
USP20 inhibits cell cycle. 2 / 2
| 2
reach
"As shown in XREF_FIG, the silencing of USP20 expression accelerated the G1-S cell cycle transition which is accompanied by decrease in the percentage of G1 cells (down to 54.05%) and increase in the percentage of cells in the S phase (up to 37.62%), and the tendency was also consistent with MKN45-siUSP20 cells and BGC-823-siUSP20 cells (P < 0.05; XREF_FIG and XREF_FIG)."
28350092
reach
"In line with the clinical outcomes, we found that the overexpression of USP20 could, on one hand, suppress cell proliferation and delay G1-S cell cycle transition, and on the other hand, enhance autophagy in GC cells."
28350092
USP20 affects VSX2
2 |
USP20 binds VSX2. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP20 affects USP33, and VHL
| 2
USP20 binds VHL and USP33. 2 / 2
| 2
sparser
"In conclusion, our previously published results and current data indicate that the interaction between pVHL and VDU1 or VDU2 mediates the ubiquitination and degradation of these two proteins."
12056827
sparser
"Based on their amino acid sequence homology and functional interaction with pVHL, VDU1 and VDU2 define a subfamily of ubiquitin specific processing proteases."
12056827
USP20 affects USP21
2 |
USP20 binds USP21. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22626734
USP20 affects Stomach Neoplasms
| 2
USP20 inhibits Stomach Neoplasms.
| 1
USP20 inhibits Stomach Neoplasms. 1 / 1
| 1
reach
"Silencing of USP20 increases proliferation in GC cells."
28350092
USP20 activates Stomach Neoplasms.
| 1
USP20 activates Stomach Neoplasms. 1 / 1
| 1
reach
"These finding revealed that USP20 could modulate GC cell proliferation."
28350092
USP20 affects MCL1
| 1 1
USP20 deubiquitinates MCL1.
| 1
USP20 leads to the deubiquitination of MCL1. 1 / 1
| 1
reach
"In addition, depletion of USP20 could increase the polyubiquitination of MCL1, thereby increasing the conversion rate of MCL1 and the sensitivity of cells to chemotherapy."
35063767
USP20 binds MCL1.
| 1
USP20 binds MCL1. 1 / 1
| 1
sparser
"Overall, our findings indicate that the USP20-MCL1 axis might play a key role in the apoptotic signaling pathway."
35063767
USP20 affects K33-
| 2
USP20 deubiquitinates K33- on K48. 2 / 2
| 2
reach
"USP20 deubiquitinated K33- or K48 linked ubiquitin of STING [XREF_BIBR]."
31208841
reach
"USP20 deubiquitinated K33- or K48-linked ubiquitin of STING [41]."
31208841
USP20 affects IL1B
| 1 1
USP20 inhibits IL1B. 2 / 2
| 1 1
eidos
"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."
24260525
reach
"Silencing USP20 in SMCs with siRNA (small interfering RNA) augmented NFkappaB activation by = ~ 50% in response to either TNF or IL-1beta (interleukin-1beta)."
30354204
USP20 affects IKKalpha beta phosphorylation
| 2
USP20 activates IKKalpha beta phosphorylation. 2 / 2
| 2
eidos
"In addition , USP20 depletion significantly decreased IKKalpha / beta phosphorylation and delayed IkappaBalpha degradation , resulting in the reduction of NF-kappaB-mediated cell survival ."
32354117
eidos
"Furthermore , USP20 depletion significantly reduced IKKalpha / beta phosphorylation and delayed IkappaBalpha degradation in the presence of TNFalpha ( Figure 3E ) , which was similarly observed in p62-depleted HeLa cells ( Figure S1 ) ."
32354117
USP20 affects IFN-I
| 1 1
USP20 activates IFN-I. 2 / 2
| 1 1
eidos
"Among the DUBs that interact with STING , five members , namely CYLD , OTUD5 , USP18 ( also termed UBP43 ) , USP20 , and USP44 , have been demonstrated to promote IFN-I production and antiviral responses ."
34707613
reach
"Among the DUBs that interact with STING, five members, namely CYLD, OTUD5, USP18 (also termed UBP43), USP20, and USP44, have been demonstrated to promote IFN-I production and antiviral responses."
34707613
USP20 affects HSPA2
| 2
USP20 binds HSPA2. 2 / 2
| 2
sparser
"Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice."
36636478
sparser
"The downregulation of the USP20-HSPA2 axis in diet-induced obese mice following SG improved lipid dysmetabolism, indicating that USP20-HSPA2 axis was a noninvasive therapeutic target to be investigated in the future."
36636478
USP20 affects DBNL
2 |
USP20 binds DBNL. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
reach
"USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells."
34901390
reach
"USP20 was shown to promote breast tumor metastasis, and proliferation of oral squamous carcinoma cells."
36874086
USP20 affects CNTN2
| 2
USP20 deubiquitinates CNTN2.
| 1
USP20 deubiquitinates CNTN2. 1 / 1
| 1
reach
"The ubiquitin specific peptidase USP20 (ubiquitin specific peptidase) deubiquitinates Tax-1 and suppresses IL-1beta- and Tax-1-induced NF-kappaB activation XREF_BIBR."
25116307
USP20 binds CNTN2.
| 1
USP20 binds CNTN2. 1 / 1
| 1
reach
"Tax-1 interacts with NRP and optineurin and TAX1BP1, and with the ubiquitin specific peptidase USP20."
24058363
USP20 affects CBX7
2 |
USP20 binds CBX7. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
USP20 affects APBA2
2 |
USP20 binds APBA2. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
SOX4 affects USP20
| 1 1
SOX4 binds USP20. 2 / 2
| 1 1
sparser
"The interaction between USP20 and SOX4 was notarized through Co-IP assay."
35405623
reach
"The interaction between USP20 and SOX4 was notarized through Co-IP assay."
35405623
PTEN affects USP20
| 1 1
PTEN binds USP20.
| 1
USP20 binds PTEN. 1 / 1
| 1
sparser
"Mechanistically, we found that USP20 directly interacted with PTEN."
34953448
PTEN activates USP20.
| 1
PTEN activates USP20. 1 / 1
| 1
reach
"Notably, suppressing PTEN with its specific inhibitor dramatically abolished the function of USP20 to ameliorate neuroinflammation and neuron death induced by OGD/R."
34953448
PRKACA affects USP20
1 1 |
PRKACA phosphorylates USP20.
1 |
PRKACA phosphorylates USP20 on S333. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKACA binds USP20.
1 |
USP20 binds PRKACA. 1 / 1
1 |
biogrid
No evidence text available
25666616
NFKBIA affects USP20
| 2
RIPK1 binds USP20, ARRB2, and NFKBIA. 1 / 1
| 1
sparser
"In addition, USP20 associated with RIPK1, IκBα, and β-arrestin2 ( xref )."
30354204
USP20 binds NFKBIA. 1 / 1
| 1
sparser
"For example, both β-arrestin2 xref and USP20 ( xref ) associate with IκBα; therefore, it is possible that a ternary complex of USP20, β-arrestin2 and IκBα facilitates deubiquitination of IκBα—a possibility made more plausible by the observation that β-arrestin2 and its homolog β-arrestin1 can inhibit IκBα degradation and NFκB signaling downstream of TNFR1. xref "
30354204
NEURL4 affects USP33
| 2
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
IRAK1 affects USP20
| 2
IRAK1 phosphorylates USP20 on S333. 1 / 1
| 1
sparser
"Phosphorylation of USP20 on Ser334 by IRAK-1 Promotes IL-1β-evoked Signaling in Vascular Smooth Muscle Cells and Vascular Inflammation."
37311534
IRAK1 phosphorylates USP20 on S333. 1 / 1
| 1
sparser
"Phosphorylation of USP20 on Ser334 by IRAK-1 Promotes IL-1β-evoked Signaling in Vascular Smooth Muscle Cells and Vascular Inflammation."
37311534
HSPA2 affects USP20
| 2
USP20 binds HSPA2. 2 / 2
| 2
sparser
"Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice."
36636478
sparser
"The downregulation of the USP20-HSPA2 axis in diet-induced obese mice following SG improved lipid dysmetabolism, indicating that USP20-HSPA2 axis was a noninvasive therapeutic target to be investigated in the future."
36636478
DIO2 affects USP20
1 1 |
USP20 binds DIO2. 2 / 2
1 1 |
hprd
No evidence text available
12865408
biogrid
No evidence text available
12865408
DBNL affects USP20
2 |
USP20 binds DBNL. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
CCP110 affects NEURL4, USP20, and USP33
| 2
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
CBX7 affects USP20
2 |
USP20 binds CBX7. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
Ataxia Telangiectasia phosphorylates USP20. 1 / 1
| 1
rlimsp
"Upon β2AR activation, a specific isoform of the second messenger cAMP-dependent protein kinase A (PKAα) rapidly phosphorylates USP20 on serine 333 located in its unique insertion domain. This phosphorylation of USP20 correlates with a characteristic SDS-PAGE mobility shift of the protein, blocks its deubiquitinase activity, promotes its dissociation from the activated β2AR complex, and facilitates trafficking of the ubiquitinated β2AR to autophagosomes, which fuse with lysosomes to form autolysosomes where receptors are degraded."
25666616
Ataxia Telangiectasia phosphorylates USP20 on S333. 1 / 1
| 1
rlimsp
"Upon β2AR activation, a specific isoform of the second messenger cAMP-dependent protein kinase A (PKAα) rapidly phosphorylates USP20 on serine 333 located in its unique insertion domain."
25666616
ARRB2 affects USP20
| 2
RIPK1 binds USP20, ARRB2, and NFKBIA. 1 / 1
| 1
sparser
"In addition, USP20 associated with RIPK1, IκBα, and β-arrestin2 ( xref )."
30354204
USP20 binds ARRB2. 1 / 1
| 1
sparser
"The association of USP20 with β-arrestin2 was augmented when β-arrestin2 ubiquitination was prevented and reduced when β-arrestin2 ubiquitination was rendered constitutive."
26839314
APBA2 affects USP20
2 |
USP20 binds APBA2. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
ADRB2 affects USP20
2 |
USP20 binds ADRB2. 2 / 2
2 |
biogrid
No evidence text available
25666616
biogrid
No evidence text available
23166351
3,4-methylenedioxymethamphetamine increases the amount of USP20.
1 |
3,4-methylenedioxymethamphetamine increases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
20188158
3,4-methylenedioxymethamphetamine decreases the amount of USP20.
1 |
3,4-methylenedioxymethamphetamine decreases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
26251327
Urethane affects USP20
1 |
Urethane increases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
28818685
Tetrachloromethane decreases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
25270620
Sodium arsenite affects USP20
1 |
Sodium arsenite increases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
29361514
Silicon dioxide affects USP20
1 |
Silicon dioxide decreases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
25895662
Protein kinase A-alpha affects USP20
| 1
Protein kinase A-alpha phosphorylates USP20 on S333. 1 / 1
| 1
reach
"beta1AR induced phosphorylation of USP20 Ser333 by protein kinase A-alpha (PKAalpha) was required for optimal USP20 mediated regulation of beta1AR lysosomal trafficking."
30538132
Progesterone affects USP20
1 |
Progesterone increases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
23012394
Potassium chromate increases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
22714537
Phenobarbital affects USP20
1 |
Phenobarbital increases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
19482888
Methapyrilene affects USP20
1 |
Methapyrilene demethylates USP20. 1 / 1
1 |
ctd
No evidence text available
30157460
Methamphetamine affects USP20
1 |
Methamphetamine increases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
26307267
MTORC1 affects USP20
| 1
MTORC1 phosphorylates USP20. 1 / 1
| 1
sparser
"In contrast to ubiquitination, HMGCR is deubiquitinated by mTORC1-phosphorylated USP20, which preferentially hydrolyzes K48 and K63 linkages, and stabilized HMGCR increases cholesterol synthesis in the feeding state (Lu et al., 2020)."
35386193
Lipopolysaccharide increases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
25613284
Leflunomide affects USP20
1 |
Leflunomide decreases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
28988120
Interaction affects USP20
| 1
Interaction activates USP20. 1 / 1
| 1
eidos
"As a consequence of this interaction , USP20 induces the expression of HIF-1alpha target genes , such as vascular endothelial growth factor ( VEGF ) ."
31208103
Hydroperoxide affects USP20
1 |
Hydroperoxide decreases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
26846883
Hsa-miR-26b-5p affects USP20
1 |
Hsa-miR-26b-5p decreases the amount of USP20. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19088304
Genistein affects USP20
1 |
Genistein decreases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
16705744
Flutamide affects USP20
1 |
Flutamide increases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
24136188
Ethoxyimino H-indeno b pyrazine-2 dicarbonitrile affects USP20
| 1
Ethoxyimino H-indeno b pyrazine-2 dicarbonitrile inhibits USP20. 1 / 1
| 1
eidos
"For example , 8-mercapto-N - ( ( tetrahydro-3-furanyl ) methyl ) -4 - quinoline carboxamide , LND-57444 , VLX1570 , ML323 , ( ADC-01 , ADC-03 , HBX41108 , HBX19818 , P5091 , P22077 ) , 9 - ( ethoxyimino ) -9 H-indeno ( 1,2 - b ) pyrazine-2 ,3 - dicarbonitrile , WP1130 , Mitoxantrone and GSK2643943A are able to inhibit PSMD14 , UCHL1 , UCHL5 and USP14 , USP1 , USP7 , USP8 , USP9X , USP11 and USP20 , respectively ."
33906413
Carbon nanotube affects USP20
1 |
Carbon nanotube decreases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
25554681
Caffeine affects USP20
| 1
Caffeine leads to the dephosphorylation of USP20. 1 / 1
| 1
reach
"Using an antibody against consensus ATM and ATR phosphorylation sites (anti-phospho-SQ/TQ), we found that phosphorylation of USP20 at SQ/TQ motifs following HU or UV treatment and USP20 phosphorylation was blocked by caffeine."
25355518
Bisphenol A affects USP20
1 |
Bisphenol A decreases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
25181051
Bis(2-ethylhexyl) phthalate increases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
21318169
Benzo[e]pyrene affects USP20
1 |
Benzo[e]pyrene demethylates USP20. 1 / 1
1 |
ctd
No evidence text available
30157460
Benzo[a]pyrene affects USP20
1 |
Benzo[a]pyrene increases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
22228805
All-trans-retinoic acid increases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
23724009
sparser
"USP20 is also associated with β2 adrenergic receptor recycling."
23750477
ZNF770 affects USP20
1 |
USP20 binds ZNF770. 1 / 1
1 |
biogrid
No evidence text available
19615732
WP1130 affects USP20
| 1
WP1130 inhibits USP20. 1 / 1
| 1
eidos
"For example , 8-mercapto-N - ( ( tetrahydro-3-furanyl ) methyl ) -4 - quinoline carboxamide , LND-57444 , VLX1570 , ML323 , ( ADC-01 , ADC-03 , HBX41108 , HBX19818 , P5091 , P22077 ) , 9 - ( ethoxyimino ) -9 H-indeno ( 1,2 - b ) pyrazine-2 ,3 - dicarbonitrile , WP1130 , Mitoxantrone and GSK2643943A are able to inhibit PSMD14 , UCHL1 , UCHL5 and USP14 , USP1 , USP7 , USP8 , USP9X , USP11 and USP20 , respectively ."
33906413
USP33 affects ARs
| 1
USP20 binds USP33 and ARs. 1 / 1
| 1
sparser
"Plasma membrane-localized β 2 ARs can bind to two closely related DUBs, USP33 and USP20 (also known as VDU2)."
23764054
USP33 affects AR
| 1
USP20 binds USP33 and AR. 1 / 1
| 1
sparser
"Because carvedilol enhanced β 2 AR ubiquitination and degradation independently of the known β 2 AR E3 ligase Nedd4, we reasoned that carvedilol might diminish β 2 AR deubiquitination by reducing the association of the β 2 AR with USP20 and/or USP33."
23166351
USP28 affects USP20
1 |
USP20 binds USP28. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP20
1 |
USP20 binds USP20. 1 / 1
1 |
biogrid
No evidence text available
23486064
USP20 affects ubiquitinated HIF-1alpha
| 1
USP20 activates ubiquitinated HIF-1alpha. 1 / 1
| 1
reach
"These findings suggest that ubiquitination of HIF-1alpha is a dynamic process and that ubiquitinated HIF-1alpha might be rescued from degradation by VDU2 through deubiquitination."
15776016
USP20 affects type I IFNs
| 1
USP20 inhibits type I IFNs. 1 / 1
| 1
reach
"Consistently, Usp20 -/- mice produce decreased type I IFNs and proinflammatory cytokines, exhibit increased susceptibility to lethal HSV-1 infection, and aggravated HSV-1 replication compared with Usp20 +/+ mice."
30814308
USP20 affects stability STING
| 1
USP20 activates stability STING. 1 / 1
| 1
eidos
"Mechanistically , USP20 is recruited by USP18 to deconjugate K48-linked ubiquitination chains from STING and thus promotes the stability of STING and the expression of type I IFNs and proinflammatory cytokines after DNA virus infection ( 91 ) ."
34707613
USP20 affects signaling
| 1
USP20 inhibits signaling. 1 / 1
| 1
sparser
"Thus, RIPK1 itself appears to be a substrate of USP20—and, by directly deubiquitinating RIPK1, USP20 can inhibit TNFR1-triggered NFκB signaling."
30354204
USP20 affects signaling complex composed p62 PKCzeta RIPK1
| 1
USP20 activates signaling complex composed p62 PKCzeta RIPK1. 1 / 1
| 1
eidos
"To validate this possibility , we examined whether USP20 depletion disrupts formation of the signaling complex composed of p62 , PKCzeta and RIPK1 upon TNFalpha treatment ."
32354117
USP20 affects severity cerebral ischemic stroke
| 1
USP20 inhibits severity cerebral ischemic stroke. 1 / 1
| 1
eidos
"Notably , suppressing PTEN with its specific inhibitor dramatically abolished the function of USP20 to ameliorate neuroinflammation and neuron death induced by OGD / R. Collectively , our results illustrated that USP20 could effectively mitigate the severity of cerebral ischemic stroke and improve behavior deficits in MCAO-operated mice , and identified the USP20 / PTEN axis as a promising therapeutic target for ischemic stroke treatment ."
34953448
USP20 affects sensitivity cells chemotherapy
| 1
USP20 inhibits sensitivity cells chemotherapy. 1 / 1
| 1
eidos
"In addition , depletion of USP20 could increase the polyubiquitination of MCL1 , thereby increasing the conversion rate of MCL1 and the sensitivity of cells to chemotherapy ."
35063767
USP20 affects post-endocytic trafficking autophagosomes
| 1
USP20 activates post-endocytic trafficking autophagosomes. 1 / 1
| 1
eidos
"However , solely USP20 was shown to promote the deubiquitination of beta2-ARs and their post-endocytic trafficking to autophagosomes ."
30126257
USP20 affects polyubiquitination MCL1
| 1
USP20 inhibits polyubiquitination MCL1. 1 / 1
| 1
eidos
"In addition , depletion of USP20 could increase the polyubiquitination of MCL1 , thereby increasing the conversion rate of MCL1 and the sensitivity of cells to chemotherapy ."
35063767
USP20 affects pVHL-E3 ligase
| 1
USP20 deubiquitinates pVHL-E3 ligase. 1 / 1
| 1
reach
"Can VDU1 and VDU2 deubiquitinate the ubiquitinated downstream targets of pVHL-E3 ligase, such as HIF-1alpha, therefore, counteract or modify the ubiquitinating function of VCB-E3 ligase?"
12056827
USP20 affects p62 protein
| 1
USP20 activates p62 protein. 1 / 1
| 1
eidos
"USP20 depletion did not affect the levels of p62 mRNA ( Figure 1A ) , but significantly decreased the expression of p62 protein ( Figure 1B ) ."
32354117
USP20 affects neointimal hyperplasia caused carotid endothelial denudation transgenic mice model
| 1
USP20 inhibits neointimal hyperplasia caused carotid endothelial denudation transgenic mice model. 1 / 1
| 1
eidos
"Intriguingly , USP20 impedes TLR4-induced NF-kappaB activation by deubiquitinating TNF receptor-associated factor 6,147 whereas it inhibits IL-1R and TNF-triggered NF-kappaB activation by deubiquitinating receptor-interacting protein kinase 1.148 Consistent with the results of the in vitro experiments , USP20 decreased neointimal hyperplasia caused by carotid endothelial denudation in a transgenic mice model ."
33664994
USP20 affects ischemic stroke mice
| 1
USP20 inhibits ischemic stroke mice. 1 / 1
| 1
eidos
"USP20 mitigates ischemic stroke in mice by suppressing neuroinflammation and neuron death via regulating PTEN signal ."
34953448
reach
"VDU1 and VDU2, a closely related isoform, have been shown to increase half-life of type 2 iodothyronine deiodinase by their deubiquitinating activity [23]."
19118533
reach
"USP20 also deubiquitinates hypoxia inducible factor-1 alpha (HIF-1alpha), promoting HIF-1alpha stability and consequently the expression of its target genes."
25326330
USP20 affects deubiquitination beta2-ARs
| 1
USP20 activates deubiquitination beta2-ARs. 1 / 1
| 1
eidos
"However , solely USP20 was shown to promote the deubiquitination of beta2-ARs and their post-endocytic trafficking to autophagosomes ."
30126257
USP20 affects conversion MCL1
| 1
USP20 inhibits conversion MCL1. 1 / 1
| 1
eidos
"In addition , depletion of USP20 could increase the polyubiquitination of MCL1 , thereby increasing the conversion rate of MCL1 and the sensitivity of cells to chemotherapy ."
35063767
USP20 affects cleaved caspase-8 caspase-3 PARP TNFalpha CHX compared control HeLa cells causing basal cleaved proteins
| 1
USP20 inhibits cleaved caspase-8 caspase-3 PARP TNFalpha CHX compared control HeLa cells causing basal cleaved proteins. 1 / 1
| 1
eidos
"In addition , immunoblot analysis showed that USP20 depletion increases the expression of cleaved caspase-8 , caspase-3 and PARP in the presence of TNFalpha / CHX , compared to control HeLa cells , as well as causing increased basal levels of these cleaved proteins without TNFalpha / CHX ( Figure 4D ) ."
32354117
USP20 affects cholesterol
| 1
USP20 activates cholesterol. 1 / 1
| 1
reach
"USP20 links feeding induced cholesterol synthesis and energy expenditure."
33420925
USP20 affects cell migration invasion breast cancer
| 1
USP20 activates cell migration invasion breast cancer. 1 / 1
| 1
eidos
"USP4 and USP20 can promote the cell migration and invasion activities in breast cancer by inhibiting NFkappaB activation via deubiquitination of TRAF2 and TRAF6 [ 74 ] ."
31133011
USP20 affects cell growth
| 1
USP20 inhibits cell growth. 1 / 1
| 1
reach
"As shown in XREF_FIG, silencing of USP20 significantly promoted cell growth in monolayer culture, and further experimental results revealed that the proliferation ability of MGC-803-USP20 cells were lower than that of MGC-803-NC cells (XREF_FIG)."
28350092
USP20 affects cell death
| 1
USP20 inhibits cell death. 1 / 1
| 1
eidos
"Because our results suggest that the USP20-p62 axis is responsible for PKCzeta-mediated NF-kappaB activation for cell survival , USP20 depletion may promote cell death ."
32354117
USP20 affects cell death pathways
| 1
USP20 inhibits cell death pathways. 1 / 1
| 1
eidos
"Based on our data that USP20 is responsible for NF-kappaB-mediated cell survival through stabilizing p62 , we also suggest that USP20 depletion causes the blockade of TNFalpha-induced NF-kappaB activation regarding PKCzeta and thus may accelerate cell death pathways ."
32354117
USP20 affects beta2AR
| 1
USP20 activates beta2AR. 1 / 1
| 1
reach
"Conversely, depletion of both USP33 and USP20 was shown to increase downregulation of the beta2AR, suggesting a specific role of these DUBs in regulating recycling of this GPCR, in a manner similar to that described for AMSH on the EGFR."
20854416
USP20 affects beta2-ARs
| 1
USP20 leads to the deubiquitination of beta2-ARs. 1 / 1
| 1
reach
"However, solely USP20 was shown to promote the deubiquitination of beta2-ARs and their post-endocytic trafficking to autophagosomes."
30126257
USP20 affects beta-arrestins
| 1
USP20 leads to the deubiquitination of beta-arrestins. 1 / 1
| 1
reach
"Deubiquitination of beta-arrestins is also regulated by agonist activation of the beta2AR and other GPCRs and is mediated by USP20 and USP33 and is important for beta, arrestin, and beta2AR complex disassembly, lysosomal sorting and signaling [XREF_BIBR, XREF_BIBR] (XREF_FIG)."
30353650
USP20 affects beta-arrestin
| 1
USP20 activates beta-arrestin. 1 / 1
| 1
reach
"The closely related DUBs, USP20 and USP33, deubiquitylate activated beta-adrenergic receptors as well as the adaptor and signalling protein beta-arrestin (in the case of USP33), to favour recycling from endosomes, despite largely being associated with the secretory pathway 75, 76, 77."
28064438
USP20 affects beta-andregenic receptor
| 1
USP20 inhibits beta-andregenic receptor. 1 / 1
| 1
reach
"PKA dependent phosphorylation of the DUB USP20 was recently shown to perturb post-endocytic trafficking of the beta-andregenic receptor under cellular stress conditions."
26690337
USP20 affects behavior
| 1
USP20 inhibits behavior. 1 / 1
| 1
eidos
"Notably , suppressing PTEN with its specific inhibitor dramatically abolished the function of USP20 to ameliorate neuroinflammation and neuron death induced by OGD / R. Collectively , our results illustrated that USP20 could effectively mitigate the severity of cerebral ischemic stroke and improve behavior deficits in MCAO-operated mice , and identified the USP20 / PTEN axis as a promising therapeutic target for ischemic stroke treatment ."
34953448
USP20 affects atypical PKCzeta-RIPK1-p62 complex required NF-kappaB activation
| 1
USP20 activates atypical PKCzeta-RIPK1-p62 complex required NF-kappaB activation. 1 / 1
| 1
eidos
"Furthermore , depletion of USP20 disrupts formation of the atypical PKCzeta-RIPK1-p62 complex required for TNFalpha-mediated NF-kappaB activation and significantly increases the apoptosis induced by TNFalpha plus cycloheximide or TNFalpha plus TAK1 inhibitor ."
32354117
USP20 affects apoptosis induced cycloheximide TNFalpha TAK1
| 1
USP20 activates apoptosis induced cycloheximide TNFalpha TAK1. 1 / 1
| 1
eidos
"Furthermore , depletion of USP20 disrupts formation of the atypical PKCzeta-RIPK1-p62 complex required for TNFalpha-mediated NF-kappaB activation and significantly increases the apoptosis induced by TNFalpha plus cycloheximide or TNFalpha plus TAK1 inhibitor ."
32354117
USP20 affects antiviral responses
| 1
USP20 activates antiviral responses. 1 / 1
| 1
eidos
"Among the DUBs that interact with STING , five members , namely CYLD , OTUD5 , USP18 ( also termed UBP43 ) , USP20 , and USP44 , have been demonstrated to promote IFN-I production and antiviral responses ."
34707613
sparser
"USP20 is also associated with β2 adrenergic receptor recycling."
23750477
USP20 affects activity
| 1
USP20 inhibits activity. 1 / 1
| 1
sparser
"To identify potential substrates of USP20 and elucidate mechanisms by which USP20 inhibits TNF-evoked NFκB activity, we immunoprecipitated HA-tagged USP20 from HEK-293 cells and immunoblotted for endogenous proteins that constitute TNFR1-activated signaling intermediates."
30354204
USP20 affects activation
| 1
USP20 inhibits activation. 1 / 1
| 1
sparser
"Furthermore, host DUBs that interact with HTLV-1Tax oncoprotein were investigated, and consequently ubiquitin-specific peptidase USP20 was found to deubiquitinate Tax and inhibit Tax-induced NF-κB activation [ xref ]."
23151130
USP20 affects activation STING pathway
| 1
USP20 activates activation STING pathway. 1 / 1
| 1
eidos
"On the other hand , OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation , thus maintain the stability of STING and promote activation of STING pathway ( 87 ) ( 88 ) ( 89 ) ."
35603197
USP20 affects ZNF770
1 |
USP20 binds ZNF770. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects USP28
1 |
USP20 binds USP28. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP20 affects USP18-induced deubiquitination STING knockdown
| 1
USP20 activates USP18-induced deubiquitination STING knockdown. 1 / 1
| 1
eidos
"Subsequently , they searched for DUBs that interact with USP18 and found that knockdown of USP20 inhibited USP18-induced deubiquitination of STING and knockdown of USP18 inhibited USP20-induced deubiquitination of STING [ 41 ] ."
31208841
USP20 affects USP15
1 |
USP15 binds USP20. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP20 affects UCHL3
1 |
UCHL3 binds USP20. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects Tax-induced NF-kappaB activation
| 1
USP20 inhibits Tax-induced NF-kappaB activation. 1 / 1
| 1
eidos
"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."
24260525
USP20 affects TRIM23
1 |
USP20 binds TRIM23. 1 / 1
1 |
biogrid
No evidence text available
25416956
USP20 affects TRAF2
| 1
TRAF2 binds USP20. 1 / 1
| 1
sparser
"With these co-immunoprecipitation assays, we found that USP20 associated with the ubiquitin E3 ligases TRAF2, cIAP1, and two components of LUBAC xref : HOIL-1-interacting protein (HOIP, or RNF31) and SHARPIN (also known as SIPL1) ( xref )."
30354204
USP20 affects TNFalpha-mediated
| 1
TNFalpha-mediated binds USP20. 1 / 1
| 1
isi
"Furthermore, depletion of USP20 disrupts formation of the atypical PKCzeta-RIPK1-p62 complex required for TNFalpha-mediated NF-kappaB activation and significantly increases the apoptosis induced by TNFalpha plus cycloheximide or TNFalpha plus TAK1 inhibitor."
32354117
USP20 affects TNFalpha-induced NF-kappaB activation regarding PKCzeta
| 1
USP20 activates TNFalpha-induced NF-kappaB activation regarding PKCzeta. 1 / 1
| 1
eidos
"Based on our data that USP20 is responsible for NF-kappaB-mediated cell survival through stabilizing p62 , we also suggest that USP20 depletion causes the blockade of TNFalpha-induced NF-kappaB activation regarding PKCzeta and thus may accelerate cell death pathways ."
32354117
USP20 affects TLR4-induced NF-kappaB
| 1
USP20 inhibits TLR4-induced NF-kappaB. 1 / 1
| 1
eidos
"Intriguingly , USP20 impedes TLR4-induced NF-kappaB activation by deubiquitinating TNF receptor-associated factor 6,147 whereas it inhibits IL-1R and TNF-triggered NF-kappaB activation by deubiquitinating receptor-interacting protein kinase 1.148 Consistent with the results of the in vitro experiments , USP20 decreased neointimal hyperplasia caused by carotid endothelial denudation in a transgenic mice model ."
33664994
USP20 affects Signaling
| 1
USP20 inhibits Signaling. 1 / 1
| 1
sparser
"USP20 Inhibits IL-1R-evoked Inflammatory Signaling in SMCs."
30354204
USP20 affects SYTL4
1 |
USP20 binds SYTL4. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects SUN2
1 |
USP20 binds SUN2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects SPRY2
1 |
SPRY2 binds USP20. 1 / 1
1 |
biogrid
No evidence text available
25416956
USP20 affects SNAI2
| 1
USP20 activates SNAI2. 1 / 1
| 1
reach
"Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2."
32943575
USP20 activates Reperfusion Injury. 1 / 1
| 1
reach
"All these effects mediated by USP20 during cerebral I/R injury were confirmed in the cultured primary microglial cells and cortical neurons stimulated by oxygen-glucose deprivation and reoxygenation (OGD/R)."
34953448
USP20 affects RGPD5
1 |
USP20 binds RGPD5. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects RFC4
1 |
USP20 binds RFC4. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects RFC3
1 |
USP20 binds RFC3. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects RFC2
1 |
USP20 binds RFC2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects PTEN
| 1
USP20 binds PTEN. 1 / 1
| 1
sparser
"Mechanistically, we found that USP20 directly interacted with PTEN."
34953448
USP20 affects PSMD7
1 |
USP20 binds PSMD7. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects PSMD6
1 |
USP20 binds PSMD6. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects PSMD12
1 |
USP20 binds PSMD12. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects PSMD11
1 |
USP20 binds PSMD11. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects PRKCI
1 |
USP20 binds PRKCI. 1 / 1
1 |
hprd
No evidence text available
17350623
USP20 affects PRKACA
1 |
USP20 binds PRKACA. 1 / 1
1 |
biogrid
No evidence text available
25666616
USP20 affects POLDIP3
1 |
USP20 binds POLDIP3. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects PLK1
1 |
USP20 binds PLK1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects PLEKHA7
1 |
USP20 binds PLEKHA7. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects PLEC
1 |
USP20 binds PLEC. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects PLA2G2A
1 |
USP20 binds PLA2G2A. 1 / 1
1 |
biogrid
No evidence text available
22118674
USP20 affects PKCzeta-RIPK1-p62
| 1
PKCzeta-RIPK1-p62 binds USP20. 1 / 1
| 1
isi
"Furthermore, depletion of USP20 disrupts formation of the atypical PKCzeta-RIPK1-p62 complex required for TNFalpha-mediated NF-kappaB activation and significantly increases the apoptosis induced by TNFalpha plus cycloheximide or TNFalpha plus TAK1 inhibitor."
32354117
USP20 affects PJA1
1 |
USP20 binds PJA1. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP20 affects Neoplasms
| 1
USP20 activates Neoplasms. 1 / 1
| 1
reach
"USP20 can support progression of variety of tumors."
36874086
USP20 affects NUP153
1 |
USP20 binds NUP153. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects NFASC
| 1
USP20 activates NFASC. 1 / 1
| 1
reach
"Our findings reveal novel mechanisms regulating IL-1β-induced pro-inflammatory signaling: by phosphorylating USP20 Ser334, IRAK1 diminishes the association of USP20 with TRAF6 and thus augments NFκB activation, SMC inflammation and neointimal hyperplasia."
37311534
USP20 affects NF-kappaB-mediated target
| 1
USP20 activates NF-kappaB-mediated target. 1 / 1
| 1
eidos
"In addition , quantitative real-time RT-PCR analysis revealed that USP20 depletion decreases expression of NF-kappaB-mediated target genes such as BFL1 and cFLIP , which are related to cell survival , upon TNFalpha treatment ( Figure 3D ) ."
32354117
USP20 affects N4BP3
1 |
USP20 binds N4BP3. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects Mice
| 1
USP20 inhibits Mice. 1 / 1
| 1
reach
"Ubiquitin-specific peptidase 20 (USP20) reduces NFκB activation triggered by pro-inflammatory stimuli, and USP20 activity attenuates atherosclerosis in mice."
37311534
USP20 affects MYO1C
1 |
USP20 binds MYO1C. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects MYO1A
1 |
USP20 binds MYO1A. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects MDFI
1 |
USP20 binds MDFI. 1 / 1
1 |
biogrid
No evidence text available
25416956
USP20 affects MCAO-operated mice
| 1
USP20 inhibits MCAO-operated mice. 1 / 1
| 1
eidos
"Notably , suppressing PTEN with its specific inhibitor dramatically abolished the function of USP20 to ameliorate neuroinflammation and neuron death induced by OGD / R. Collectively , our results illustrated that USP20 could effectively mitigate the severity of cerebral ischemic stroke and improve behavior deficits in MCAO-operated mice , and identified the USP20 / PTEN axis as a promising therapeutic target for ischemic stroke treatment ."
34953448
USP20 affects MCAO-induced ischemic brain injury
| 1
USP20 activates MCAO-induced ischemic brain injury. 1 / 1
| 1
eidos
"We then found that promoting USP20 expression remarkably ameliorated MCAO-induced ischemic brain injury , along with significantly reduced infarct volume , neurological scores and brain water contents ."
34953448
USP20 affects MAP7D2
1 |
USP20 binds MAP7D2. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP20 affects MAP7D1
1 |
USP20 binds MAP7D1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects MAGEA11
1 |
USP20 binds MAGEA11. 1 / 1
1 |
biogrid
No evidence text available
25416956
USP20 affects LRRC59
1 |
USP20 binds LRRC59. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects LMNA
1 |
USP20 binds LMNA. 1 / 1
1 |
biogrid
No evidence text available
24623722
USP20 affects K48-linked deubiquitination STING
| 1
USP20 activates K48-linked deubiquitination STING. 1 / 1
| 1
eidos
"On the other hand , OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation , thus maintain the stability of STING and promote activation of STING pathway ( 87 ) ( 88 ) ( 89 ) ."
35603197
USP20 affects K48-
| 1
USP20 activates K48-. 1 / 1
| 1
reach
"The DUB USP20 mediates removal of both K48- and K63 linked polyubiquitin chains."
25326330
USP20 affects Interferon
| 1
USP20 inhibits Interferon. 1 / 1
| 1
reach
"XREF_BIBR This study showed that USP18 or USP20 deficiency significantly inhibited HSV-I or cytosolic DNA activation of both NF-kappaB and IRF3, and type-I IFN and proinflammatory cytokine expression."
30989105
USP20 affects Infections
| 1
USP20 inhibits Infections. 1 / 1
| 1
reach
"The complementation of STING into Usp20 (-/-) cells remarkably restores HSV-1-triggered signaling and inhibits HSV-1 infection (92)."
34707613
USP20 affects INS
| 1
USP20 activates INS. 1 / 1
| 1
reach
"Genetic deletion or pharmacological inhibition of USP20 markedly decreases diet induced body weight gain, reduces lipid levels in the serum and liver, improves insulin sensitivity and increases energy expenditure."
33177714
USP20 affects IL1
| 1
USP20 activates IL1. 1 / 1
| 1
reach
"Phosphorylation of USP20 on Ser334 by IRAK-1 Promotes IL-1β-evoked Signaling in Vascular Smooth Muscle Cells and Vascular Inflammation."
37311534
USP20 affects IKBKG
| 1
TNFRSF1A binds USP20, BIRC3, and IKBKG. 1 / 1
| 1
sparser
"Of these USP20-associating proteins, only β-arrestin2 has previously been described. xref In contrast, we could not detect specific association of USP20 with TNFR1, cIAP2, or IKKγ ( xref )."
30354204
USP20 affects IFNs proinflammatory cytokines
| 1
USP20 activates IFNs proinflammatory cytokines. 1 / 1
| 1
eidos
"Mechanistically , USP20 is recruited by USP18 to deconjugate K48-linked ubiquitination chains from STING and thus promotes the stability of STING and the expression of type I IFNs and proinflammatory cytokines after DNA virus infection ( 91 ) ."
34707613
USP20 affects Hyperplasia
| 1
USP20 activates Hyperplasia. 1 / 1
| 1
reach
"Our findings reveal novel mechanisms regulating IL-1β-induced pro-inflammatory signaling: by phosphorylating USP20 Ser334, IRAK1 diminishes the association of USP20 with TRAF6 and thus augments NFκB activation, SMC inflammation and neointimal hyperplasia."
37311534
USP20 affects HMGCR
| 1
Phosphorylated USP20 deubiquitinates HMGCR. 1 / 1
| 1
reach
"In contrast to ubiquitination, HMGCR is deubiquitinated by mTORC1-phosphorylated USP20, which preferentially hydrolyzes K48 and K63 linkages, and stabilized HMGCR increases cholesterol synthesis in the feeding state (Lu et al., 2020)."
35386193
USP20 affects HIF-1alpha target
| 1
USP20 activates HIF-1alpha target. 1 / 1
| 1
eidos
"As a consequence of this interaction , USP20 induces the expression of HIF-1alpha target genes , such as vascular endothelial growth factor ( VEGF ) ."
31208103
USP20 affects HIF-1alpha [
| 1
USP20 binds HIF-1alpha [. 1 / 1
| 1
reach
"For example, VHL interacting deubiquitinating enzyme 2 (VDU2) interacts with HIF-1alpha and specifically deubiquitinates and stabilizes HIF-1alpha [XREF_BIBR]."
22521794
USP20 affects HIF)-1alpha
| 1
USP20 deubiquitinates HIF)-1alpha. 1 / 1
| 1
reach
"Indeed, USP20 deubiquitinates and stabilizes its associated protein, hypoxia inducible factor (HIF)-1alpha, resulting in the promotion of cancer cell proliferation, invasion, and metastasis [XREF_BIBR, XREF_BIBR]."
27058415
USP20 affects HERC2P2
1 |
USP20 binds HERC2P2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 activates Genomic Instability. 1 / 1
| 1
reach
"USP20 promotes genome stability and suppresses xenograft tumor growth."
25326330
USP20 affects GTF2IRD1
1 |
USP20 binds GTF2IRD1. 1 / 1
1 |
biogrid
No evidence text available
26275350
USP20 affects GPT2
1 |
USP20 binds GPT2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects GCGR
| 1
USP20 deubiquitinates GCGR. 1 / 1
| 1
reach
"USP20, which regulates β - and β -ARs (18, 19), also does not deubiquitinate GCGR, because in cells with USP20 knockdown, the extent of glucagon-induced deubiquitination is identical to cells with control knockdown (Fig. S4, C and D)."
32967969
USP20 affects FECH
1 |
USP20 binds FECH. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects FATE1
1 |
USP20 binds FATE1. 1 / 1
1 |
biogrid
No evidence text available
25416956
USP20 affects EIF3E
1 |
USP20 binds EIF3E. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects EIF3C
1 |
USP20 binds EIF3C. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects ECI2
1 |
USP20 binds ECI2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects Deubiquitinase
| 1
reach
"The association of USP20 with its substrates triggers deubiquitinase activity; this association is regulated by phosphorylation of USP20 on Ser334 (mouse) or Ser333 (human)."
37311534
USP20 phosphorylates DNA damage response, detection of DNA damage. 1 / 1
| 1
sparser
"These results establish the important role of USP20 phosphorylation in ATR-dependent DDR."
25355518
USP20 affects DDX58
| 1
USP20 activates DDX58. 1 / 1
| 1
reach
"For example, USP17 and USP20 were found to target RIG-I and TRAF6 respectively, thereby functioning as novel regulators of antiviral innate immune responses [XREF_BIBR, XREF_BIBR]."
24260525
USP20 affects Cellular Antiviral Responses
| 1
USP20 activates Cellular Antiviral Responses. 1 / 1
| 1
reach
"USP20 Promotes Cellular Antiviral Responses via Deconjugating K48 Linked Ubiquitination of MITA."
30814308
USP20 affects Cell Survival
| 1
USP20 activates Cell Survival. 1 / 1
| 1
reach
"Furthermore, reconstitution of WT USP20 but not USP20-4 mut rescued the cell viability after UV treatment and restored UV or HU induced intra-S-phase checkpoint."
25355518
USP20 affects CTNNB1
| 1
USP20 leads to the deubiquitination of CTNNB1. 1 / 1
| 1
reach
"Moreover, knockdown of USP20 increases beta-catenin polyubiquitination, which enhances beta-catenin turnover and cell sensitivity to chemotherapy."
29867130
USP20 affects CRAMP1
1 |
USP20 binds CRAMP1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP20 affects CLAPSIN
| 1
USP20 binds CLAPSIN. 1 / 1
| 1
reach
"We then wanted to determine the functional significance of the interaction between USP20 and CLAPSIN."
25326330
USP20 affects CI
| 1
USP20 binds CI. 1 / 1
| 1
sparser
"After plasmids encoding Flag-p62 and HA-ubiquitin (HA-Ubi) were co-transfected into HeLa cells, together with wild-type (WT) USP20 or catalytically inactive mutant USP20 (USP20-CI), immunoprecipitation and immunoblot assays were performed."
32354117
USP20 affects CCDC36
1 |
USP20 binds CCDC36. 1 / 1
1 |
biogrid
No evidence text available
25416956
USP20 affects CALM1
1 |
USP20 binds CALM1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects Breast Neoplasms
| 1
USP20 activates Breast Neoplasms. 1 / 1
| 1
reach
"USP20 was shown to promote breast tumor metastasis, and proliferation of oral squamous carcinoma cells."
36874086
USP20 affects BIRC3
| 1
TNFRSF1A binds USP20, BIRC3, and IKBKG. 1 / 1
| 1
sparser
"Of these USP20-associating proteins, only β-arrestin2 has previously been described. xref In contrast, we could not detect specific association of USP20 with TNFR1, cIAP2, or IKKγ ( xref )."
30354204
USP20 affects BEND7
1 |
USP20 binds BEND7. 1 / 1
1 |
biogrid
No evidence text available
25416956
USP20 affects BEND5
1 |
USP20 binds BEND5. 1 / 1
1 |
biogrid
No evidence text available
25416956
USP20 affects BCAM
| 1
USP20 activates BCAM. 1 / 1
| 1
reach
"Lu et al. demonstrated the post-prandial increase in insulin and the glucose concentration stimulates mTORC1 to phosphorylate the deubiquitylase ubiquitin-specific peptidase 20 (USP20) at S132 and S134, which is recruited to the HMGCR complex and antagonizes its degradation (Lu et al., 2020)."
34658858
USP20 affects Ala-Pro
| 1
USP20 activates Ala-Pro. 1 / 1
| 1
reach
"In contrast, the overexpression of Usp26 decreased the number of AP + colonies, while overexpression of Usp20 increased the number of AP + colonies."
28839133
USP20 affects ATR-Chk1 [
| 1
USP20 activates ATR-Chk1 [. 1 / 1
| 1
reach
"USP20 serves as a novel regulator of ATR dependent DNA damage checkpoint signaling through the deubiquitination and stabilization of claspin and enhances the activation of ATR-Chk1 [XREF_BIBR]."
25972356
USP20 affects ATR-CLASPIN-CHK1
| 1
USP20 activates ATR-CLASPIN-CHK1. 1 / 1
| 1
reach
"Our results demonstrated that USP20 positively regulates the ATR-CLASPIN-CHK1 signaling during replication stress."
25326330
USP20 affects ATR
1 |
USP20 binds ATR. 1 / 1
1 |
biogrid
No evidence text available
25326330
USP20 affects ATP6AP2
1 |
USP20 binds ATP6AP2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects ATAD3B
1 |
USP20 binds ATAD3B. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP20 affects ARs
| 1
USP20 binds USP33 and ARs. 1 / 1
| 1
sparser
"Plasma membrane-localized β 2 ARs can bind to two closely related DUBs, USP33 and USP20 (also known as VDU2)."
23764054
USP20 affects ALAS1
1 |
USP20 binds ALAS1. 1 / 1
1 |
biogrid
No evidence text available
25416956
USP20 affects ADRB1
| 1
USP20 inhibits ADRB1. 1 / 1
| 1
reach
"For example, ubiquitin carboxyl-terminal hydrolase 20 (USP20) knockout reduces beta1-adrenergic receptor (beta1AR)-induced cardiac contractility and relaxation."
32494592
USP20 affects ACADM
1 |
USP20 binds ACADM. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP15 affects USP20
1 |
USP15 binds USP20. 1 / 1
1 |
biogrid
No evidence text available
22626734
UCHL3 affects USP20
1 |
UCHL3 binds USP20. 1 / 1
1 |
biogrid
No evidence text available
19615732
TRIM23 affects USP20
1 |
USP20 binds TRIM23. 1 / 1
1 |
biogrid
No evidence text available
25416956
TRAF2 affects USP20
| 1
TRAF2 binds USP20. 1 / 1
| 1
sparser
"With these co-immunoprecipitation assays, we found that USP20 associated with the ubiquitin E3 ligases TRAF2, cIAP1, and two components of LUBAC xref : HOIL-1-interacting protein (HOIP, or RNF31) and SHARPIN (also known as SIPL1) ( xref )."
30354204
TNFalpha-mediated affects USP20
| 1
TNFalpha-mediated binds USP20. 1 / 1
| 1
isi
"Furthermore, depletion of USP20 disrupts formation of the atypical PKCzeta-RIPK1-p62 complex required for TNFalpha-mediated NF-kappaB activation and significantly increases the apoptosis induced by TNFalpha plus cycloheximide or TNFalpha plus TAK1 inhibitor."
32354117
TNFRSF1A affects IKBKG
| 1
TNFRSF1A binds USP20, BIRC3, and IKBKG. 1 / 1
| 1
sparser
"Of these USP20-associating proteins, only β-arrestin2 has previously been described. xref In contrast, we could not detect specific association of USP20 with TNFR1, cIAP2, or IKKγ ( xref )."
30354204
TNF affects USP20
| 1
TNF binds USP20. 1 / 1
| 1
sparser
"Co-immunoprecipitation experiments revealed that USP20 associates with several components of the TNF receptor-1 signaling pathway including receptor-interacting protein kinase 1 (RIPK1), a critical checkpoint in TNF-induced NFκB activation and inflammation."
30354204
TINCR affects USP20
| 1
TINCR activates USP20. 1 / 1
| 1
reach
"Furthermore, in the cytoplasm, TINCR potentially acts as a molecular sponge of miR-199a-5p and upregulates the stability of USP20 mRNA through a competing endogenous RNA (ceRNA) regulatory mechanism, thus promoting PD-L1 expression by decreasing its ubiquitination level."
36725842
SYTL4 affects USP20
1 |
USP20 binds SYTL4. 1 / 1
1 |
biogrid
No evidence text available
19615732
SUN2 affects USP20
1 |
USP20 binds SUN2. 1 / 1
1 |
biogrid
No evidence text available
19615732
SPRY2 affects USP20
1 |
SPRY2 binds USP20. 1 / 1
1 |
biogrid
No evidence text available
25416956
RIPK1 affects USP20
| 1
RIPK1 binds USP20, ARRB2, and NFKBIA. 1 / 1
| 1
sparser
"In addition, USP20 associated with RIPK1, IκBα, and β-arrestin2 ( xref )."
30354204
RGPD5 affects USP20
1 |
USP20 binds RGPD5. 1 / 1
1 |
biogrid
No evidence text available
19615732
RFC4 affects USP20
1 |
USP20 binds RFC4. 1 / 1
1 |
biogrid
No evidence text available
19615732
RFC3 affects USP20
1 |
USP20 binds RFC3. 1 / 1
1 |
biogrid
No evidence text available
19615732
RFC2 affects USP20
1 |
USP20 binds RFC2. 1 / 1
1 |
biogrid
No evidence text available
19615732
PSMD7 affects USP20
1 |
USP20 binds PSMD7. 1 / 1
1 |
biogrid
No evidence text available
19615732
PSMD6 affects USP20
1 |
USP20 binds PSMD6. 1 / 1
1 |
biogrid
No evidence text available
19615732
PSMD12 affects USP20
1 |
USP20 binds PSMD12. 1 / 1
1 |
biogrid
No evidence text available
19615732
PSMD11 affects USP20
1 |
USP20 binds PSMD11. 1 / 1
1 |
biogrid
No evidence text available
19615732
PRKCI affects USP20
1 |
USP20 binds PRKCI. 1 / 1
1 |
hprd
No evidence text available
17350623
POLDIP3 affects USP20
1 |
USP20 binds POLDIP3. 1 / 1
1 |
biogrid
No evidence text available
19615732
PLK1 affects USP20
1 |
USP20 binds PLK1. 1 / 1
1 |
biogrid
No evidence text available
19615732
PLEKHA7 affects USP20
1 |
USP20 binds PLEKHA7. 1 / 1
1 |
biogrid
No evidence text available
19615732
PLEC affects USP20
1 |
USP20 binds PLEC. 1 / 1
1 |
biogrid
No evidence text available
19615732
PLA2G2A affects USP20
1 |
USP20 binds PLA2G2A. 1 / 1
1 |
biogrid
No evidence text available
22118674
PKCzeta-RIPK1-p62 affects USP20
| 1
PKCzeta-RIPK1-p62 binds USP20. 1 / 1
| 1
isi
"Furthermore, depletion of USP20 disrupts formation of the atypical PKCzeta-RIPK1-p62 complex required for TNFalpha-mediated NF-kappaB activation and significantly increases the apoptosis induced by TNFalpha plus cycloheximide or TNFalpha plus TAK1 inhibitor."
32354117
PJA1 affects USP20
1 |
USP20 binds PJA1. 1 / 1
1 |
biogrid
No evidence text available
22626734
P22077 affects USP20
| 1
P22077 inhibits USP20. 1 / 1
| 1
eidos
"P22077 inhibited only USP7 , USP9x , USP10 and USP20 appreciably at 1 muM ( USP47 was not tested ) ."
26852935
Niclosamide affects USP20
1 |
Niclosamide increases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
31398420
NUP153 affects USP20
1 |
USP20 binds NUP153. 1 / 1
1 |
biogrid
No evidence text available
19615732
NFkappaB affects USP20
| 1
NFkappaB binds USP20. 1 / 1
| 1
isi
"USP20 specifically binds to p62 and acts as a positive regulator for NF-kappaB activation by TNFalpha through deubiquitinating lysine 48 (K48)-linked polyubiquitination, eventually contributing to cell survival."
32354117
NFKBIA affects RIPK1
| 1
RIPK1 binds USP20, ARRB2, and NFKBIA. 1 / 1
| 1
sparser
"In addition, USP20 associated with RIPK1, IκBα, and β-arrestin2 ( xref )."
30354204
N4BP3 affects USP20
1 |
USP20 binds N4BP3. 1 / 1
1 |
biogrid
No evidence text available
19615732
reach
"Our experiments showed that hVDU2 protein was extremely stable in the group without co-transfection of pVHL during cycloheximide treatment, and MG132 did not significantly increase the level of VDU2 p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
MYO1C affects USP20
1 |
USP20 binds MYO1C. 1 / 1
1 |
biogrid
No evidence text available
19615732
MYO1A affects USP20
1 |
USP20 binds MYO1A. 1 / 1
1 |
biogrid
No evidence text available
19615732
MDFI affects USP20
1 |
USP20 binds MDFI. 1 / 1
1 |
biogrid
No evidence text available
25416956
MCL1 affects USP20
| 1
USP20 binds MCL1. 1 / 1
| 1
sparser
"Overall, our findings indicate that the USP20-MCL1 axis might play a key role in the apoptotic signaling pathway."
35063767
MAP7D2 affects USP20
1 |
USP20 binds MAP7D2. 1 / 1
1 |
biogrid
No evidence text available
28514442
MAP7D1 affects USP20
1 |
USP20 binds MAP7D1. 1 / 1
1 |
biogrid
No evidence text available
19615732
MAGEA11 affects USP20
1 |
USP20 binds MAGEA11. 1 / 1
1 |
biogrid
No evidence text available
25416956
LRRC59 affects USP20
1 |
USP20 binds LRRC59. 1 / 1
1 |
biogrid
No evidence text available
19615732
LMNA affects USP20
1 |
USP20 binds LMNA. 1 / 1
1 |
biogrid
No evidence text available
24623722
IL1B affects USP20
| 1
IL1B phosphorylates USP20 on S333. 1 / 1
| 1
sparser
"Using in vitro phosphorylation with purified IRAK1 and siRNA-mediated gene silencing of IRAK1 in SMCs, we identified IRAK1 as a novel kinase for IL-1β-induced USP20 Ser334 phosphorylation."
37311534
IKBKG affects USP20
| 1
TNFRSF1A binds USP20, BIRC3, and IKBKG. 1 / 1
| 1
sparser
"Of these USP20-associating proteins, only β-arrestin2 has previously been described. xref In contrast, we could not detect specific association of USP20 with TNFR1, cIAP2, or IKKγ ( xref )."
30354204
HIF-1alpha [ affects USP20
| 1
USP20 binds HIF-1alpha [. 1 / 1
| 1
reach
"For example, VHL interacting deubiquitinating enzyme 2 (VDU2) interacts with HIF-1alpha and specifically deubiquitinates and stabilizes HIF-1alpha [XREF_BIBR]."
22521794
HERC2P2 affects USP20
1 |
USP20 binds HERC2P2. 1 / 1
1 |
biogrid
No evidence text available
19615732
HERC2 affects CLSPN
| 1
USP20 binds CLSPN and HERC2. 1 / 1
| 1
sparser
"Co-immunoprecipitation assays revealed that both HERC2 and CLASPIN were present in the USP20 immunocomplex (Figure xref ) and both USP20 and CLASPIN were in the HERC2 immunocomplex (Figure  xref ), suggesting that HERC2, USP20 and CLASPIN form a complex."
25326330
GTF2IRD1 affects USP20
1 |
USP20 binds GTF2IRD1. 1 / 1
1 |
biogrid
No evidence text available
26275350
GSK2643943A affects USP20
| 1
GSK2643943A inhibits USP20. 1 / 1
| 1
eidos
"For example , 8-mercapto-N - ( ( tetrahydro-3-furanyl ) methyl ) -4 - quinoline carboxamide , LND-57444 , VLX1570 , ML323 , ( ADC-01 , ADC-03 , HBX41108 , HBX19818 , P5091 , P22077 ) , 9 - ( ethoxyimino ) -9 H-indeno ( 1,2 - b ) pyrazine-2 ,3 - dicarbonitrile , WP1130 , Mitoxantrone and GSK2643943A are able to inhibit PSMD14 , UCHL1 , UCHL5 and USP14 , USP1 , USP7 , USP8 , USP9X , USP11 and USP20 , respectively ."
33906413
GPT2 affects USP20
1 |
USP20 binds GPT2. 1 / 1
1 |
biogrid
No evidence text available
19615732
FECH affects USP20
1 |
USP20 binds FECH. 1 / 1
1 |
biogrid
No evidence text available
19615732
FATE1 affects USP20
1 |
USP20 binds FATE1. 1 / 1
1 |
biogrid
No evidence text available
25416956
EIF3E affects USP20
1 |
USP20 binds EIF3E. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3C affects USP20
1 |
USP20 binds EIF3C. 1 / 1
1 |
biogrid
No evidence text available
19615732
ECI2 affects USP20
1 |
USP20 binds ECI2. 1 / 1
1 |
biogrid
No evidence text available
19615732
E3_Ub_ligase affects USP20
| 1
E3_Ub_ligase ubiquitinates USP20. 1 / 1
| 1
reach
"To test whether hVDU2 can be ubiquitinated by pVHL E3 ubiquitin ligase complex, we performed ubiquitination assay in vitro and in vivo."
12056827
CRAMP1 affects USP20
1 |
USP20 binds CRAMP1. 1 / 1
1 |
biogrid
No evidence text available
28514442
CNTN2 affects USP20
| 1
USP20 binds CNTN2. 1 / 1
| 1
reach
"Tax-1 interacts with NRP and optineurin and TAX1BP1, and with the ubiquitin specific peptidase USP20."
24058363
CLSPN affects HERC2, and USP20
| 1
USP20 binds CLSPN and HERC2. 1 / 1
| 1
sparser
"Co-immunoprecipitation assays revealed that both HERC2 and CLASPIN were present in the USP20 immunocomplex (Figure xref ) and both USP20 and CLASPIN were in the HERC2 immunocomplex (Figure  xref ), suggesting that HERC2, USP20 and CLASPIN form a complex."
25326330
CLAPSIN affects USP20
| 1
USP20 binds CLAPSIN. 1 / 1
| 1
reach
"We then wanted to determine the functional significance of the interaction between USP20 and CLAPSIN."
25326330
CI affects USP20
| 1
USP20 binds CI. 1 / 1
| 1
sparser
"After plasmids encoding Flag-p62 and HA-ubiquitin (HA-Ubi) were co-transfected into HeLa cells, together with wild-type (WT) USP20 or catalytically inactive mutant USP20 (USP20-CI), immunoprecipitation and immunoblot assays were performed."
32354117
CHEK1 affects USP20
| 1
CHEK1 activates USP20. 1 / 1
| 1
sparser
"We found that overexpression of FLAG-CLASPIN corrected the delay of USP20 depletion-induced CHK1 activation in response to HU treatment (Figure xref )."
25326330
CCP110 affects USP20, and USP33
| 1
USP20 binds USP33 and CCP110. 1 / 1
| 1
sparser
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
CCDC36 affects USP20
1 |
USP20 binds CCDC36. 1 / 1
1 |
biogrid
No evidence text available
25416956
CALM1 affects USP20
1 |
USP20 binds CALM1. 1 / 1
1 |
biogrid
No evidence text available
19615732
BIRC3 affects USP20
| 1
TNFRSF1A binds USP20, BIRC3, and IKBKG. 1 / 1
| 1
sparser
"Of these USP20-associating proteins, only β-arrestin2 has previously been described. xref In contrast, we could not detect specific association of USP20 with TNFR1, cIAP2, or IKKγ ( xref )."
30354204
BEND7 affects USP20
1 |
USP20 binds BEND7. 1 / 1
1 |
biogrid
No evidence text available
25416956
BEND5 affects USP20
1 |
USP20 binds BEND5. 1 / 1
1 |
biogrid
No evidence text available
25416956
Arrestins affects USP20
| 1
Arrestins deubiquitinates USP20. 1 / 1
| 1
reach
"Arrestins also recruit deubiquitinating enzymes USP33 and USP20, important for recycling and resensitisation to the beta2-adrenergic receptor."
20412604
AZM551248 affects USP20
1 |
AZM551248 decreases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
22323515
ATP6AP2 affects USP20
1 |
USP20 binds ATP6AP2. 1 / 1
1 |
biogrid
No evidence text available
19615732
ATAD3B affects USP20
1 |
USP20 binds ATAD3B. 1 / 1
1 |
biogrid
No evidence text available
19615732
ARs affects USP33
| 1
USP20 binds USP33 and ARs. 1 / 1
| 1
sparser
"Plasma membrane-localized β 2 ARs can bind to two closely related DUBs, USP33 and USP20 (also known as VDU2)."
23764054
ARRB2 affects RIPK1
| 1
RIPK1 binds USP20, ARRB2, and NFKBIA. 1 / 1
| 1
sparser
"In addition, USP20 associated with RIPK1, IκBα, and β-arrestin2 ( xref )."
30354204
AR affects USP33
| 1
USP20 binds USP33 and AR. 1 / 1
| 1
sparser
"Because carvedilol enhanced β 2 AR ubiquitination and degradation independently of the known β 2 AR E3 ligase Nedd4, we reasoned that carvedilol might diminish β 2 AR deubiquitination by reducing the association of the β 2 AR with USP20 and/or USP33."
23166351
ALAS1 affects USP20
1 |
USP20 binds ALAS1. 1 / 1
1 |
biogrid
No evidence text available
25416956
ACADM affects USP20
1 |
USP20 binds ACADM. 1 / 1
1 |
biogrid
No evidence text available
19615732
2-hydroxypropanoic acid decreases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
30851411
17alpha-ethynylestradiol decreases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
23129252
(R)-noradrenaline affects USP20
| 1
(R)-noradrenaline activates USP20. 1 / 1
| 1
reach
"VDU1, but not VDU2, is markedly increased in brown adipocytes by norepinephrine or cold exposure, further amplifying the increase in D2 activity that results from catecholamine stimulated de novo synthesis."
12865408
(+)-JQ1 compound affects USP20
1 |
(+)-JQ1 compound increases the amount of USP20. 1 / 1
1 |
ctd
No evidence text available
24796395