IndraLab
Statements
USP20 is modified
42
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2
158
16
USP20 is phosphorylated.
42
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147
16
USP20 is ubiquitinated.
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2
10
reach
"Although pVHL functions as a master control for HIF-1alpha stabilization, as pVHL-E3 ligase mediates the ubiquitination of both HIF-1alpha and VDU2, the balance between the pVHL mediated ubiquitination and VDU2 mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization."
sparser
"Although pVHL functions as a master control for HIF-1alpha stabilization, as pVHL-E3 ligase mediates the ubiquitination of both HIF-1alpha and VDU2, the balance between the pVHL-mediated ubiquitination and VDU2-mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization."
USP20 is dephosphorylated.
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1
"USP20 is regulated by HERC2 following DNA damage or replication stress.The HECT domain of WT HERC but not the catalytic inactive mutant (CA) ubiquitinated USP20 in vitro (Figure (Figure4G).4G). Taken together, these results suggested that HERC2 functions as an E3 ligase of USP20 and negatively regulates USP20 in unstressed cells."
"HERC2 promotes USP20 degradation.|Under unperturbed condition, HERC2 ubiquitinates USP20 and promotes ubiquitination mediated proteasomal degradation of USP20, regulating the status of K48 linked polyubiquitination of CLASPIN and ensuring appropriate protein levels of CLASPIN during the S-phase."
"USP20 is regulated by HERC2 following DNA damage or replication stress.The HECT domain of WT HERC but not the catalytic inactive mutant (CA) ubiquitinated USP20 in vitro (Figure (Figure4G).4G). Taken together, these results suggested that HERC2 functions as an E3 ligase of USP20 and negatively regulates USP20 in unstressed cells."
"HERC2 promotes USP20 degradation.|Under unperturbed condition, HERC2 ubiquitinates USP20 and promotes ubiquitination mediated proteasomal degradation of USP20, regulating the status of K48 linked polyubiquitination of CLASPIN and ensuring appropriate protein levels of CLASPIN during the S-phase."
"With purified proteins and in intact cells, our protein interaction studies showed that <span class="match term1">TRAF6</span>/<span class="match term0">USP20</span> association and subsequent <span class="match term0">USP20</span>-mediated <span class="match term1">TRAF6</span> deubiquitination were beta-arrestin2-dependent."
reach
"For example, USP11 negatively regulates TNFalpha induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [XREF_BIBR]; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta (IL-1beta) - and Tax induced NF-kappaB activation [XREF_BIBR]; Katrin et al. showed that USP15 regulates IkappaBalpha and NF-kappaB by deubiquitinylation IkappaBalpha [XREF_BIBR]; and USP31 inhibits TNFalpha, CD40, TRAF2, TRAF6 and IKKbeta mediated NF-kappaB activation [XREF_BIBR]."
sparser
"The serine/threonine kinase IRAK1 is a key mediator of TRAF6 activation downstream of TLR4 and the IL-1R. Therefore, IRAK1 could not only promote TRAF6 activation but also prevent TRAF6 inactivation (deubiquitination)—if, indeed, IRAK1 phosphorylates USP20 on Ser334 (and thereby reduces the association of USP20 with TRAF6)."
sparser
"Thus, IRAK1 not only transduces IL-1R signaling ( xref ) but also prevents its termination: phosphorylation of USP20 on Ser334 reduces USP20’s binding to TRAF6 and thereby diminishes (a) USP20-mediated deubiquitination/deactivation of TRAF6 and (b) consequent attenuation of downstream NFκB activation."
reach
"Thus, IRAK1 not only transduces IL-1R signaling (1) but also prevents its termination: phosphorylation of USP20 on Ser334 reduces USP20’s binding to TRAF6 and thereby diminishes (a) USP20-mediated deubiquitination/deactivation of TRAF6 and (b) consequent attenuation of downstream NFκB activation.USP20 is a member of the USP subfamily of DUBs, which are endowed with protein interaction domains that also participate in the activation process of these enzymes (31)."
sparser
"The proteasome has both ubiquitin ligases and DUBs that associate with it (Crosas et al., 2006) , and several DUB-ligase pairs interact directly, including BRCC36-BRCA1, BAP1-BRCA1, USP4-Ro52, USP7-MDM2, USP8-GRAIL, USP20-pVHL, USP33-pVHL and USP44-APC (Kee and Huibregtse, 2007; Marfany and Denuc, 2008; Ventii and Wilkinson, 2008) ."
"Although <span class="match term0">pVHL</span> functions as a master control for HIF-1alpha stabilization, as <span class="match term0">pVHL</span>-E3 ligase mediates the ubiquitination of both HIF-1alpha and <span class="match term1">VDU2</span>, the balance between the <span class="match term0">pVHL</span>-mediated ubiquitination and <span class="match term1">VDU2</span>-mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization"
reach
"Although pVHL functions as a master control for HIF-1alpha stabilization, as pVHL-E3 ligase mediates the ubiquitination of both HIF-1alpha and VDU2, the balance between the pVHL mediated ubiquitination and VDU2 mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization."
"VDU1 and VDU2 could be important substrates of pVHL E3 ligase complex. Finally, we demonstrate that VDU2 can also be ubiquitinated and degraded in a pVHL-dependent manner.pVHL mediates the degradation of hVDU2 by proteasome. we have demonstrated that both VDU1 and VDU2 also bind to the β-domain of pVHL and several naturally occurring mutations in the β-domain disrupt the interaction between VDU1/VDU2 and pVHL. If pVHL is mutated either in the α-domain or β-domain, VDU1 and VDU2 would not be ubiquitinated and degraded properly. This could lead to accumulation of these two proteins in the cells. Together, our results suggest that VDU1 and VDU2 might be relevent to pVHL-related tumorigenesis."
USP20 affects cell population proliferation
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20
USP20 activates cell population proliferation.
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11
USP20 activates cell population proliferation. 10 / 12
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11
reach
"Altogether, these findings and Figure 4 suggest that phosphorylation of USP20 on Ser334 augments neointimal hyperplasia primarily by increasing inflammatory signaling and associated proliferation of SMCs.To model neointimal hyperplasia in vitro (16, 17), we assessed proliferation and migration of SMCs derived from WT and USP20-S334A mice."
USP20 inhibits cell population proliferation.
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9
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
sparser
"The proteasome has both ubiquitin ligases and DUBs that associate with it (Crosas et al., 2006) , and several DUB-ligase pairs interact directly, including BRCC36-BRCA1, BAP1-BRCA1, USP4-Ro52, USP7-MDM2, USP8-GRAIL, USP20-pVHL, USP33-pVHL and USP44-APC (Kee and Huibregtse, 2007; Marfany and Denuc, 2008; Ventii and Wilkinson, 2008) ."
sparser
"Recently, it was reported that USP20 directly interacts with xCT and cleaves K48‐linked polyubiquitinated xCT at K30 and K37. [ xref ] TRIM3, an E3 ubiquitin ligase, promoted xCT proteasome‐dependent degradation by catalyzing K11‐linked ubiquitination of xCT at K37. [ xref ] Notably, no reports have identified any E3 ligase‐mediated ubiquitination of the xCT protein at K4 or K12, leaving an open question regarding the identification of another antagonistic regulator responsible for ferroptosis sensitivity and ubiquitination modification of xCT at K4 or K12 in BLCA in future studies."
reach
"Thus, the inhibition of Hippo-YAP1 pathway-related DUBs may directly enhance the ubiquitination and degradation of the YAP1 protein, which could be a promising strategy to disrupt the function of the Hippo-YAP1 pathway and inhibit the progression of BC.Our siRNA screening assay identified USP20 as a critical USP that regulates YAP1 stability and the malignant phenotype of BC."
USP20 affects Neoplasm Metastasis
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13
USP20 activates Neoplasm Metastasis. 10 / 13
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13
reach
"USP20 also promotes metastasis of CRC cells and is closely correlated with several immune checkpoint genes, including ADORA2A (adenosine A2a receptor), CD160 (cluster of differentiation 160), CD27 (cluster of differentiation 27), and TNFRSF25 (TNF receptor superfamily member 25)[79]."
reach
"This observation suggests that alternative
regulatory mechanisms may be involved in mediating TBBPA’s
effects on hepatic lipid metabolism.Our findings reveal a previously
unrecognized mechanism underlying
TBBPA-induced dyslipidemia, centered on post-transcriptional regulation
of cholesterol synthesis through USP20-mediated HMGCR stabilization."
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
USP20 affects inflammatory response
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9
1
USP20 inhibits inflammatory response.
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5
1
USP20 activates inflammatory response.
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4
USP20 affects ferroptosis
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10
USP20 inhibits ferroptosis.
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5
USP20 activates ferroptosis.
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5
USP20 phosphorylates USP20.
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4
reach
"Lu et al. demonstrated the post-prandial increase in insulin and the glucose concentration stimulates mTORC1 to phosphorylate the deubiquitylase ubiquitin-specific peptidase 20 (USP20) at S132 and S134, which is recruited to the HMGCR complex and antagonizes its degradation (Lu et al., 2020)."
USP20 inhibits USP20.
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3
USP20 activates USP20.
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1
1
USP20 increases the amount of USP20.
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1
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
reach
"Huh‐7, Hep3B, and HCC primary cell line were treated with increasing concentration of a glutamate–cystine antiporter system Xc− inhibitor (erastin), and found that USP20 depletion inhibited the viability of HCC cells, and cells depleted with USP20 were more sensitive to ferroptosis induced by erastin treatment (Figures 2A–C and S2E)."
reach
"We then stably expressed USP20 WT, S132A/368A, and S132D/S368D in HCC primary cell line (from sample T7 with low USP20 expression) to examine the functions of USP20 phosphorylation in HCC cells,. Overexpression the wild type and S132D/S368D of USP20 decreased the sensitivity of the HCC primary cell line to OXA, while USP20 S132A/368A almost had no effect (Figure S8)."
sparser
"The serine/threonine kinase IRAK1 is a key mediator of TRAF6 activation downstream of TLR4 and the IL-1R. Therefore, IRAK1 could not only promote TRAF6 activation but also prevent TRAF6 inactivation (deubiquitination)—if, indeed, IRAK1 phosphorylates USP20 on Ser334 (and thereby reduces the association of USP20 with TRAF6)."
sparser
"Thus, IRAK1 not only transduces IL-1R signaling ( xref ) but also prevents its termination: phosphorylation of USP20 on Ser334 reduces USP20’s binding to TRAF6 and thereby diminishes (a) USP20-mediated deubiquitination/deactivation of TRAF6 and (b) consequent attenuation of downstream NFκB activation."
"Here, we conducted comprehensive gain- and loss-of-function screens using a human DUB cDNA library of 65 genes and an siRNA library of 98 genes, and identified <span class="match term0">USP20</span> as a deubiquitinase (DUB) that regulates <span class="match term1">SNAI2</span> ubiquitination and stability"
USP20 affects Atherosclerosis
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2
6
USP20 inhibits Atherosclerosis.
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2
3
USP20 activates Atherosclerosis.
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3
reach
"They found that elevated postprandial blood glucose and insulin levels activate mTORC1 (mechanistic target of rapamycin complex 1), which stabilizes HMGCR (3-hydroxy-methylglutaryl coenzyme A reductase), phosphorylates USP20 (ubiquitin-specific peptidase 20), and upregulates cholesterol biosynthesis."
USP20 affects Neoplasm Invasiveness
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7
eidos
"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."
sparser
"To further assess the therapeutic potential of targeting the USP20‐CTSL axis, mice inoculated with tumour cells via tail vein injection were treated with the small‐molecule USP20 inhibitor G‐3A. As illustrated in the experimental scheme (Figure xref ), compared with the control group, G‐3A significantly reduced the frequency and size of lung metastases, whereas CTSL overexpression partially restored the metastatic burden (Figure xref )."
sparser
"To further assess the therapeutic potential of targeting the USP20‐CTSL axis, mice inoculated with tumour cells via tail vein injection were treated with the small‐molecule USP20 inhibitor G‐3A. As illustrated in the experimental scheme (Figure xref ), compared with the control group, G‐3A significantly reduced the frequency and size of lung metastases, whereas CTSL overexpression partially restored the metastatic burden (Figure xref )."
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6
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6
USP20 activates cholesterol biosynthetic process.
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5
USP20 inhibits cholesterol biosynthetic process.
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1
USP20 inhibits cholesterol biosynthetic process. 1 / 1
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1
reach
"They found that elevated postprandial blood glucose and insulin levels activate mTORC1 (mechanistic target of rapamycin complex 1), which stabilizes HMGCR (3-hydroxy-methylglutaryl coenzyme A reductase), phosphorylates USP20 (ubiquitin-specific peptidase 20), and upregulates cholesterol biosynthesis."
5
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USP20 is inactive.
4
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"HERC2 promotes USP20 degradation.|Under unperturbed condition, HERC2 ubiquitinates USP20 and promotes ubiquitination mediated proteasomal degradation of USP20, regulating the status of K48 linked polyubiquitination of CLASPIN and ensuring appropriate protein levels of CLASPIN during the S-phase."
"USP20 is regulated by HERC2 following DNA damage or replication stress.The HECT domain of WT HERC but not the catalytic inactive mutant (CA) ubiquitinated USP20 in vitro (Figure (Figure4G).4G). Taken together, these results suggested that HERC2 functions as an E3 ligase of USP20 and negatively regulates USP20 in unstressed cells."
"VDU1 and VDU2 could be important substrates of pVHL E3 ligase complex. Finally, we demonstrate that VDU2 can also be ubiquitinated and degraded in a pVHL-dependent manner.pVHL mediates the degradation of hVDU2 by proteasome. we have demonstrated that both VDU1 and VDU2 also bind to the β-domain of pVHL and several naturally occurring mutations in the β-domain disrupt the interaction between VDU1/VDU2 and pVHL. If pVHL is mutated either in the α-domain or β-domain, VDU1 and VDU2 would not be ubiquitinated and degraded properly. This could lead to accumulation of these two proteins in the cells. Together, our results suggest that VDU1 and VDU2 might be relevent to pVHL-related tumorigenesis."
USP20 is active.
1
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sparser
"We next performed validation of the mass spectrometry by immunoprecipitation and found that USP20 interacts with STAT3 in heart tissues and neonatal rat cardiomyocytes (NRCMs) following Ang II treatment (Figure xref ), suggesting that USP20 directly binds to the STAT3 protein in cardiomyocytes."
USP20 affects Cell Survival
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5
sparser
"We next performed validation of the mass spectrometry by immunoprecipitation and found that USP20 interacts with STAT3 in heart tissues and neonatal rat cardiomyocytes (NRCMs) following Ang II treatment (Figure xref ), suggesting that USP20 directly binds to the STAT3 protein in cardiomyocytes."
reach
"They found that elevated postprandial blood glucose and insulin levels activate mTORC1 (mechanistic target of rapamycin complex 1), which stabilizes HMGCR (3-hydroxy-methylglutaryl coenzyme A reductase), phosphorylates USP20 (ubiquitin-specific peptidase 20), and upregulates cholesterol biosynthesis."
USP20 affects reticulophagy
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4
USP20 activates reticulophagy. 4 / 4
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4
reach
"The results demonstrated that in USP20 knockdown cells, the expression of wild-type USP20 or RETREG1 fully restored reticulophagy function, whereas expression of the catalytically inactive mutant USP20 or the FFAT1/2-deleted mutant USP20[ΔFFAT1/2] failed to initiate reticulophagy (Figure 7A-B)."
USP20 affects cell migration
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4
USP20 affects Carcinogenesis
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3
USP20 affects CS
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4
USP20 affects Body Weight
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4
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4
USP20 activates 4-(ethoxymethylene)-2-phenyloxazol-5-one.
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3
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1
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
TINCR affects USP20
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4
reach
"Then we extended the processing time and confirmed that IFN-γ Stimulation can indeed downregulate the expression of miR-199a-5p.This is the first study to clarify the mechanism by which TINCR upregulates USP20 and PD-L1 through the dual role of ceRNA interaction and miR-199a-5p transcription inhibition."
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
CS affects USP20
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4
Pirinixic acid affects USP20
3
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VAP affects USP20
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3
USP20 affects β-arrestin2
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3
USP20 affects apoptotic process
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3
USP20 affects VAP
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3
sparser
"Recently, it was reported that USP20 directly interacts with xCT and cleaves K48‐linked polyubiquitinated xCT at K30 and K37. [ xref ] TRIM3, an E3 ubiquitin ligase, promoted xCT proteasome‐dependent degradation by catalyzing K11‐linked ubiquitination of xCT at K37. [ xref ] Notably, no reports have identified any E3 ligase‐mediated ubiquitination of the xCT protein at K4 or K12, leaving an open question regarding the identification of another antagonistic regulator responsible for ferroptosis sensitivity and ubiquitination modification of xCT at K4 or K12 in BLCA in future studies."
"Upon β2AR activation, a specific isoform of the second messenger cAMP-dependent protein kinase A (PKAα) rapidly phosphorylates USP20 on serine 333 located in its unique insertion domain. This phosphorylation of USP20 correlates with a characteristic SDS-PAGE mobility shift of the protein, blocks its deubiquitinase activity, promotes its dissociation from the activated β2AR complex, and facilitates trafficking of the ubiquitinated β2AR to autophagosomes, which fuse with lysosomes to form autolysosomes where receptors are degraded."
"Upon β2AR activation, a specific isoform of the second messenger cAMP-dependent protein kinase A (PKAα) rapidly phosphorylates USP20 on serine 333 located in its unique insertion domain. This phosphorylation of USP20 correlates with a characteristic SDS-PAGE mobility shift of the protein, blocks its deubiquitinase activity, promotes its dissociation from the activated β2AR complex, and facilitates trafficking of the ubiquitinated β2AR to autophagosomes, which fuse with lysosomes to form autolysosomes where receptors are degraded."
OGD/R affects USP20
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3
E3_Ub_ligase affects USP20
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2
1
E3_Ub_ligase ubiquitinates USP20.
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2
E3_Ub_ligase ubiquitinates USP20. 2 / 2
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2
E3_Ub_ligase binds USP20.
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1
E3_Ub_ligase binds USP20. 1 / 1
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1
Sodium arsenite affects USP20
2
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USP20 affects signal transduction
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2
USP20 affects lipid biosynthetic process
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2
USP20 affects glutathione
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2
USP20 affects cholesterol
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2
USP20 decreases the amount of cholesterol.
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1
USP20 decreases the amount of cholesterol. 1 / 1
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1
USP20 activates cholesterol.
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1
USP20 activates cholesterol. 1 / 1
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1
USP20 affects cell death
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1
1
USP20 affects cell cycle
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2
USP20 inhibits cell cycle. 2 / 2
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2
reach
"As shown in XREF_FIG, the silencing of USP20 expression accelerated the G1-S cell cycle transition which is accompanied by decrease in the percentage of G1 cells (down to 54.05%) and increase in the percentage of cells in the S phase (up to 37.62%), and the tendency was also consistent with MKN45-siUSP20 cells and BGC-823-siUSP20 cells (P < 0.05; XREF_FIG and XREF_FIG)."
USP20 affects Weight Gain
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2
USP20 activates Weight Gain. 2 / 2
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2
USP20 affects Stomach Neoplasms
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2
USP20 inhibits Stomach Neoplasms.
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1
USP20 inhibits Stomach Neoplasms. 1 / 1
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1
USP20 activates Stomach Neoplasms.
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1
USP20 activates Stomach Neoplasms. 1 / 1
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1
USP20 affects Reactive Oxygen Species
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2
USP20 affects OGD/R
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2
sparser
"For example, both β-arrestin2 xref and USP20 ( xref ) associate with IκBα; therefore, it is possible that a ternary complex of USP20, β-arrestin2 and IκBα facilitates deubiquitination of IκBα—a possibility made more plausible by the observation that β-arrestin2 and its homolog β-arrestin1 can inhibit IκBα degradation and NFκB signaling downstream of TNFR1. xref "
USP20 affects IKKalpha beta phosphorylation
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2
USP20 affects Hyperplasia
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2
USP20 activates Hyperplasia. 2 / 2
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2
reach
"Altogether, these findings and Figure 4 suggest that phosphorylation of USP20 on Ser334 augments neointimal hyperplasia primarily by increasing inflammatory signaling and associated proliferation of SMCs.To model neointimal hyperplasia in vitro (16, 17), we assessed proliferation and migration of SMCs derived from WT and USP20-S334A mice."
USP20 affects Deubiquitinase
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2
GSK2643943A affects USP20
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1
1
eidos
"For example , 8-mercapto-N - ( ( tetrahydro-3-furanyl ) methyl ) -4 - quinoline carboxamide , LND-57444 , VLX1570 , ML323 , ( ADC-01 , ADC-03 , HBX41108 , HBX19818 , P5091 , P22077 ) , 9 - ( ethoxyimino ) -9 H-indeno ( 1,2 - b ) pyrazine-2 ,3 - dicarbonitrile , WP1130 , Mitoxantrone and GSK2643943A are able to inhibit PSMD14 , UCHL1 , UCHL5 and USP14 , USP1 , USP7 , USP8 , USP9X , USP11 and USP20 , respectively ."
DNA Damage affects USP20
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2
Trichloroethene affects USP20
1
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Tetrachloromethane affects USP20
1
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Protein kinase A-alpha affects USP20
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1
Potassium chromate affects USP20
1
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Phenobarbital affects USP20
1
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Perfluorooctane-1-sulfonic acid affects USP20
1
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Methamphetamine affects USP20
1
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Hydrogen peroxide affects USP20
1
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Hydrogen cyanide affects USP20
1
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Hsa-miR-26b-5p affects USP20
1
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Folic acid affects USP20
1
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Cholesterol affects USP20
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1
Cholesterol inhibits USP20. 1 / 1
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1
Bisphenol A affects USP20
1
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Bis(2-ethylhexyl) phthalate affects USP20
1
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Benzo[e]pyrene affects USP20
1
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Benzo[a]pyrene affects USP20
1
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Vehicle Emissions affects USP20
1
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UbV.20D2 affects USP20
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1
USP33 affects ARs
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1
USP20 affects β2-adrenergic receptor
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1
USP20 affects β2-AR
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1
USP20 affects β2 adrenergic receptors
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1
USP20 affects β -adrenergic receptor
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1
reach
"The Ser334 phosphorylation status of USP20 affects neither the binding of USP20 to the active-site directed probe Ub-VME nor USP20-mediated deubiquitination per se: whereas phosphorylation of USP20 on Ser334 reduces USP20-mediated deubiquitination of the β -adrenergic receptor, it increases USP20-mediated deubiquitination of the β -adrenergic receptor (10, 11)."
USP20 affects ubiquitin-proteasome
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1
USP20 affects type I IFNs
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1
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1
USP20 activates smooth muscle cell proliferation. 1 / 1
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1
USP20 affects signaling
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1
USP20 affects signaling complex composed p62 PKCzeta RIPK1
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1
USP20 affects response to xenobiotic stimulus
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1
USP20 activates response to xenobiotic stimulus. 1 / 1
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1
USP20 affects regulation of cell cycle
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1
USP20 inhibits regulation of cell cycle. 1 / 1
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1
USP20 affects post-endocytic trafficking autophagosomes
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1
USP20 affects oxaliplatin
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1
USP20 activates oxaliplatin. 1 / 1
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1
USP20 affects neointimal hyperplasia caused carotid endothelial denudation transgenic mice model
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1
USP20 inhibits neointimal hyperplasia caused carotid endothelial denudation transgenic mice model. 1 / 1
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1
eidos
"Intriguingly , USP20 impedes TLR4-induced NF-kappaB activation by deubiquitinating TNF receptor-associated factor 6,147 whereas it inhibits IL-1R and TNF-triggered NF-kappaB activation by deubiquitinating receptor-interacting protein kinase 1.148 Consistent with the results of the in vitro experiments , USP20 decreased neointimal hyperplasia caused by carotid endothelial denudation in a transgenic mice model ."
USP20 affects navitoclax
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1
USP20 inhibits navitoclax. 1 / 1
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1
USP20 affects localization
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1
USP20 inhibits localization. 1 / 1
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1
USP20 affects ischemic stroke mice
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1
USP20 affects heat generation
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1
USP20 activates heat generation. 1 / 1
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1
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1
USP20 activates establishment of protein localization. 1 / 1
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1
USP20 affects deubiquitination beta2-ARs
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1
USP20 affects cell migration invasion breast cancer
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1
USP20 affects cell growth
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1
USP20 inhibits cell growth. 1 / 1
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1
USP20 affects cell cycle checkpoint signaling
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1
USP20 activates cell cycle checkpoint signaling. 1 / 1
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1
USP20 affects beta-arrestins
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1
eidos
"Notably , suppressing PTEN with its specific inhibitor dramatically abolished the function of USP20 to ameliorate neuroinflammation and neuron death induced by OGD / R. Collectively , our results illustrated that USP20 could effectively mitigate the severity of cerebral ischemic stroke and improve behavior deficits in MCAO-operated mice , and identified the USP20 / PTEN axis as a promising therapeutic target for ischemic stroke treatment ."
USP20 affects apoptosis induced cycloheximide TNFalpha TAK1
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1
USP20 affects activity
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1
USP20 affects activation
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1
USP20 affects actin cytoskeleton organization
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1
USP20 activates actin cytoskeleton organization. 1 / 1
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1
USP20 affects UbV.20D2
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1
USP20 affects Tax-induced NF-kappaB activation
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1
eidos
"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."
USP20 affects TNFalpha-mediated
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USP20 binds TNFalpha-mediated. 1 / 1
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USP20 affects TNFalpha-induced NF-kappaB activation regarding PKCzeta
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USP20 affects Plaque, Atherosclerotic
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USP20 inhibits Plaque, Atherosclerotic. 1 / 1
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USP20 affects PKCzeta-RIPK1-p62
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1
USP20 binds PKCzeta-RIPK1-p62. 1 / 1
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1
USP20 affects PD-L1 inhibitors
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1
USP20 affects NF-κBp65 subunit
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sparser
"Employing a stable cell line expressing FLAG-GFP-RETREG1 and utilizing FLAG for pulldown of the conjugated ubiquitin signal, we observed an increase in the conjugated ubiquitin signal on RETREG1 upon USP20 knockdown ( xref ), aligning with the data obtained from treating cells with the USP20 inhibitor GSK2643943A. Moreover, the immunoprecipitation assay demonstrated an interaction between MYC-USP20 and FLAG-RETREG1, indicating their potential binding capability ( xref )."
USP20 affects MCAO-operated mice
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1
eidos
"Notably , suppressing PTEN with its specific inhibitor dramatically abolished the function of USP20 to ameliorate neuroinflammation and neuron death induced by OGD / R. Collectively , our results illustrated that USP20 could effectively mitigate the severity of cerebral ischemic stroke and improve behavior deficits in MCAO-operated mice , and identified the USP20 / PTEN axis as a promising therapeutic target for ischemic stroke treatment ."
USP20 affects LC3-II
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USP20 affects K48-
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USP20 affects Interferon
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USP20 inhibits Interferon. 1 / 1
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USP20 affects Infections
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USP20 inhibits Infections. 1 / 1
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USP20 affects HIF-1alpha target
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1
USP20 affects HIF-1alpha [
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1
USP20 affects HIF)-1alpha
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1
USP20 affects Genomic Instability
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1
USP20 activates Genomic Instability. 1 / 1
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sparser
"Chip‐qPCR showed an association of Foxp1 with the promoter of Usp20 (Figure xref ; Table xref , Supporting Information) and luciferase assay confirmed that Foxp1 expression vector could dose‐dependently repress the promoter of Usp20 (Figure xref ) containing FXOP1 binding sites in NIH‐3T3 cells."
USP20 affects E3_Ub_ligase
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E3_Ub_ligase binds USP20. 1 / 1
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1
USP20 affects DNA damage checkpoint signaling
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1
USP20 activates DNA damage checkpoint signaling. 1 / 1
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1
USP20 affects CLAPSIN
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1
USP20 affects Breast Neoplasms
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USP20 activates Breast Neoplasms. 1 / 1
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reach
"Lu et al. demonstrated the post-prandial increase in insulin and the glucose concentration stimulates mTORC1 to phosphorylate the deubiquitylase ubiquitin-specific peptidase 20 (USP20) at S132 and S134, which is recruited to the HMGCR complex and antagonizes its degradation (Lu et al., 2020)."
USP20 affects BC
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USP20 affects Ala-Pro zwitterion
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USP20 activates Ala-Pro zwitterion. 1 / 1
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1
USP20 affects ATR-CLASPIN-CHK1
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1
USP20 affects ARs
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1
TNFalpha-mediated affects USP20
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1
USP20 binds TNFalpha-mediated. 1 / 1
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Si-Usp20-1 affects USP20
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1
Particulate Matter affects USP20
1
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PKCzeta-RIPK1-p62 affects USP20
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1
USP20 binds PKCzeta-RIPK1-p62. 1 / 1
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1
reach
"Moreover, ubiquitin specific peptidase 20 (USP20) improved FTO level through inhibiting FTO degradation while PDIA3 increased FTO level by enhancing USP20 phosphorylation during osteogenic differentiation of MC3T3-E1 cells, suggesting a positive feedback regulatory loop between PDIA3 and FTO."
sparser
"For example, both β-arrestin2 xref and USP20 ( xref ) associate with IκBα; therefore, it is possible that a ternary complex of USP20, β-arrestin2 and IκBα facilitates deubiquitination of IκBα—a possibility made more plausible by the observation that β-arrestin2 and its homolog β-arrestin1 can inhibit IκBα degradation and NFκB signaling downstream of TNFR1. xref "
sparser
"Employing a stable cell line expressing FLAG-GFP-RETREG1 and utilizing FLAG for pulldown of the conjugated ubiquitin signal, we observed an increase in the conjugated ubiquitin signal on RETREG1 upon USP20 knockdown ( xref ), aligning with the data obtained from treating cells with the USP20 inhibitor GSK2643943A. Moreover, the immunoprecipitation assay demonstrated an interaction between MYC-USP20 and FLAG-RETREG1, indicating their potential binding capability ( xref )."
HIF-1alpha [ affects USP20
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1
Gentamicins affects USP20
1
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Gastrectomy affects USP20
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1
Gastrectomy decreases the amount of USP20. 1 / 1
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sparser
"Chip‐qPCR showed an association of Foxp1 with the promoter of Usp20 (Figure xref ; Table xref , Supporting Information) and luciferase assay confirmed that Foxp1 expression vector could dose‐dependently repress the promoter of Usp20 (Figure xref ) containing FXOP1 binding sites in NIH‐3T3 cells."
CLAPSIN affects USP20
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1
Arrestins affects USP20
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1
ATM/ATR affects USP20
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1
ARs affects USP33
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1
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2-hydroxypropanoic acid affects USP20
1
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17alpha-ethynylestradiol affects USP20
1
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1,2-dimethylhydrazine affects USP20
1
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(R)-noradrenaline affects USP20
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1
(R)-noradrenaline activates USP20. 1 / 1
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