IndraLab

Statements

Ubiquitin affects JOSD2
| 4
sparser
"The covalent complex between Josephin-2 and ubiquitin mimics the covalent thioester intermediate formed during the deubiquitination reaction ( xref )."
32647816
sparser
"Additionally, in the covalent complex of JOSD2 and ubiquitin, the ubiquitin molecule is covalently attached to cysteine-24, which moves side chain of this residue away from histine-125 and toward the binding site of the substrate."
32982735
sparser
"The crystal asymmetric unit contains a single copy of the ubiquitin-Josephin-2 complex."
32647816
sparser
"In order to form a Josephin-2-ubiquitin complex sufficiently stable for crystallization, we covalently linked the enzyme to its substrate using ubiquitin 1–75 -chloroethylamine, an active site-directed ubiquitin analog ( xref )."
32647816
TYSND1 affects JOSD2
3 |
TYSND1 binds JOSD2. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
TRAPPC2 affects JOSD2
3 |
TRAPPC2 binds JOSD2. 3 / 3
3 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19615732
JOSD2 affects TYSND1
3 |
TYSND1 binds JOSD2. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
JOSD2 affects TRAPPC2
3 |
TRAPPC2 binds JOSD2. 3 / 3
3 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19615732
JOSD2 affects AHCYL2
3 |
AHCYL2 binds JOSD2. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
JOSD2 affects AHCYL1
3 |
JOSD2 binds AHCYL1. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
AHCYL2 affects JOSD2
3 |
AHCYL2 binds JOSD2. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
AHCYL1 affects JOSD2
3 |
JOSD2 binds AHCYL1. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
Valproic acid affects JOSD2
2 |
Valproic acid methylates JOSD2.
1 |
Valproic acid methylates JOSD2. 1 / 1
1 |
ctd
No evidence text available
29154799
Valproic acid increases the amount of JOSD2.
1 |
Valproic acid increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
21427059
UBC affects JOSD2
2 |
UBC binds JOSD2. 2 / 2
2 |
biogrid
No evidence text available
23625928
biogrid
No evidence text available
21118805
SPRR3 affects JOSD2
2 |
SPRR3 binds JOSD2. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
PITX2 affects JOSD2
2 |
PITX2 decreases the amount of JOSD2. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
Niclosamide affects JOSD2
2 |
Niclosamide increases the amount of JOSD2. 2 / 2
2 |
ctd
No evidence text available
30165700
ctd
No evidence text available
31398420
MCEMP1 affects JOSD2
2 |
MCEMP1 binds JOSD2. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
JOSD2 affects runx1
| 2
JOSD2 inhibits runx1.
| 1
JOSD2 inhibits runx1. 1 / 1
| 1
reach
"Finally, JOSD2 decreases AML progression in vivo."
35836282
JOSD2 activates runx1.
| 1
JOSD2 activates runx1. 1 / 1
| 1
reach
"Taken together, we propose that JOSD2 blocks PKM2 nuclear localization and reduces AML progression."
35836282
JOSD2 affects glycolytic process
| 1 1
JOSD2 inhibits glycolytic process.
| 1
reach
"JOSD2 deficiency displays cytostatic effects and reduces glycolysis in a broad spectrum of tumor cells of distinct origin and its expression correlates with poor prognosis in non small cell lung cancer."
33082514
JOSD2 activates glycolytic process.
| 1
JOSD2 activates glycolytic process. 1 / 1
| 1
eidos
"JOSD2 deficiency displays cytostatic effects and reduces glycolysis in a broad spectrum of tumor cells of distinct origin and its expression correlates with poor prognosis in non-small cell lung cancer ."
33082514
JOSD2 affects UBC
2 |
UBC binds JOSD2. 2 / 2
2 |
biogrid
No evidence text available
23625928
biogrid
No evidence text available
21118805
JOSD2 affects SPRR3
2 |
SPRR3 binds JOSD2. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
JOSD2 affects MCEMP1
2 |
MCEMP1 binds JOSD2. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
JOSD2 inhibits Leukemia, Myeloid, Acute. 2 / 2
| 1 1
reach
"JOSD2 regulates PKM2 nuclear translocation and reduces acute myeloid leukemia progression."
35836282
eidos
"JOSD2 regulates PKM2 nuclear translocation and reduces acute myeloid leukemia progression ."
35836282
JOSD2 affects HBB
2 |
JOSD2 binds HBB. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
JOSD2 affects DUSP28
2 |
JOSD2 binds DUSP28. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
HBB affects JOSD2
2 |
JOSD2 binds HBB. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
ELK1 affects JOSD2
2 |
ELK1 decreases the amount of JOSD2. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
DUSP28 affects JOSD2
2 |
JOSD2 binds DUSP28. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
6-propyl-2-thiouracil decreases the amount of JOSD2. 2 / 2
2 |
ctd
No evidence text available
24780913
ctd
No evidence text available
25825206
2,3,7,8-tetrachlorodibenzodioxine increases the amount of JOSD2.
1 |
2,3,7,8-tetrachlorodibenzodioxine increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
26290441
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of JOSD2.
1 |
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
19465110
17alpha-ethynylestradiol increases the amount of JOSD2.
1 |
17alpha-ethynylestradiol increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
23129252
17alpha-ethynylestradiol decreases the amount of JOSD2.
1 |
17alpha-ethynylestradiol decreases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
28196854
Zinc atom affects JOSD2
1 |
Zinc atom increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
19071009
Topotecan affects JOSD2
1 |
Topotecan decreases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
25729387
Tetrachloromethane increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
31150632
Sodium arsenite affects JOSD2
1 |
Sodium arsenite increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
29361514
Oxaliplatin affects JOSD2
1 |
Oxaliplatin decreases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
25729387
Nefazodone affects JOSD2
1 |
Nefazodone increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
24136188
Methyl methanesulfonate increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
26011545
Glafenine affects JOSD2
1 |
Glafenine increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
24136188
Flutamide affects JOSD2
1 |
Flutamide increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
24136188
Decabromodiphenyl ether decreases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
24317228
Cyclosporin A affects JOSD2
1 |
Cyclosporin A increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
20106945
Coumarin affects JOSD2
1 |
Coumarin increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
18480146
Cobalt dichloride affects JOSD2
1 |
Cobalt dichloride decreases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
24386269
Cadmium dichloride increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
18804290
Atrazine affects JOSD2
1 |
Atrazine increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
25929836
Aluminium atom affects JOSD2
1 |
Aluminium atom decreases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
21298039
Aflatoxin B2 affects JOSD2
1 |
Aflatoxin B2 methylates JOSD2. 1 / 1
1 |
ctd
No evidence text available
30157460
Acetamide affects JOSD2
1 |
Acetamide increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
31881176
TFAP2C affects JOSD2
1 |
TFAP2C decreases the amount of JOSD2. 1 / 1
1 |
biopax:msigdb
No evidence text available
TFAP2A affects JOSD2
1 |
TFAP2A decreases the amount of JOSD2. 1 / 1
1 |
biopax:msigdb
No evidence text available
STUB1 affects JOSD2
1 |
STUB1 binds JOSD2. 1 / 1
1 |
biogrid
No evidence text available
23625928
SP3 affects JOSD2
1 |
SP3 decreases the amount of JOSD2. 1 / 1
1 |
biopax:msigdb
No evidence text available
SMARCA2 affects JOSD2
1 |
SMARCA2 binds JOSD2. 1 / 1
1 |
biogrid
No evidence text available
19615732
S-2-pentyl-4-pentynoic hydroxamic acid increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
21427059
RFX1 affects JOSD2
1 |
RFX1 decreases the amount of JOSD2. 1 / 1
1 |
biopax:msigdb
No evidence text available
PLA2G2A affects JOSD2
1 |
JOSD2 binds PLA2G2A. 1 / 1
1 |
biogrid
No evidence text available
22118674
PAX4 affects JOSD2
1 |
PAX4 decreases the amount of JOSD2. 1 / 1
1 |
biopax:msigdb
No evidence text available
PAX3 affects JOSD2
1 |
PAX3 decreases the amount of JOSD2. 1 / 1
1 |
biopax:msigdb
No evidence text available
NLRP3 affects JOSD2
| 1
JOSD2 binds NLRP3. 1 / 1
| 1
isi
"This was mediated by enhanced deubiquitination of NLRP3 via binding with deubiquitinases BRCC3 and JOSD2, which are highly expressed in myeloid cells."
32941940
NDUFA8 affects JOSD2
1 |
JOSD2 binds NDUFA8. 1 / 1
1 |
biogrid
No evidence text available
28514442
MEF2A affects JOSD2
1 |
MEF2A decreases the amount of JOSD2. 1 / 1
1 |
biopax:msigdb
No evidence text available
LRTOMT affects JOSD2
1 |
LRTOMT binds JOSD2. 1 / 1
1 |
biogrid
No evidence text available
28514442
K11 affects JOSD2
| 1
JOSD2 binds K11. 1 / 1
| 1
sparser
"The ubiquitin linkage types most readily cleaved by Josephin-2—K11, K48, and K63—are all abundant in cells ( xref , xref )."
32647816
JOSD2 affects nuclear localization PKM2
| 1
JOSD2 inhibits nuclear localization PKM2. 1 / 1
| 1
eidos
"We then found out that JOSD2 inhibits nuclear localization of PKM2 by reducing its K433 acetylation modification , accompanied by decreased downstream gene expression through non-glycolytic functions ."
35836282
JOSD2 affects localization
| 1
JOSD2 inhibits localization. 1 / 1
| 1
reach
"Taken together, we propose that JOSD2 blocks PKM2 nuclear localization and reduces AML progression."
35836282
reach
"The depletion of JOSD2 promoted YAP/TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in vivo ."
35024322
JOSD2 affects cell death
| 1
JOSD2 activates cell death. 1 / 1
| 1
reach
"Furthermore, in contrast to the control siRNA treated cells, siRNA depletion of JOSD2 caused selective cell death in high-PHGDH-expressing cells, but not in low expressing cell lines."
28614715
JOSD2 affects YAP1
| 1
JOSD2 inhibits YAP1. 1 / 1
| 1
reach
"The depletion of JOSD2 promoted YAP/TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in vivo ."
35024322
JOSD2 affects YAP TAZ proteasomal
| 1
JOSD2 activates YAP TAZ proteasomal. 1 / 1
| 1
eidos
"The depletion of JOSD2 promoted YAP / TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in vivo ."
35024322
JOSD2 affects Wnt pathway transduction
| 1
JOSD2 inhibits Wnt pathway transduction. 1 / 1
| 1
eidos
"Importantly , a mechanistic study revealed that JOSD2 binds to and decreases the ubiquitination level of catenin beta 1 ( CTNNB1 ) , a key component of Wnt signaling , thereby augmenting Wnt pathway transduction ."
35568970
JOSD2 affects TAFAZZIN
| 1
JOSD2 activates TAFAZZIN. 1 / 1
| 1
reach
"The depletion of JOSD2 promoted YAP/TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in vivo ."
35024322
JOSD2 affects STUB1
1 |
STUB1 binds JOSD2. 1 / 1
1 |
biogrid
No evidence text available
23625928
JOSD2 affects SMARCA2
1 |
SMARCA2 binds JOSD2. 1 / 1
1 |
biogrid
No evidence text available
19615732
JOSD2 affects PLA2G2A
1 |
JOSD2 binds PLA2G2A. 1 / 1
1 |
biogrid
No evidence text available
22118674
JOSD2 affects PKM2 nuclear localization
| 1
JOSD2 inhibits PKM2 nuclear localization. 1 / 1
| 1
eidos
"Taken together , we propose that JOSD2 blocks PKM2 nuclear localization and reduces AML progression ."
35836282
JOSD2 affects PKM
| 1
JOSD2 inhibits PKM. 1 / 1
| 1
reach
"Taken together, we propose that JOSD2 blocks PKM2 nuclear localization and reduces AML progression."
35836282
JOSD2 affects NLRP3
| 1
JOSD2 binds NLRP3. 1 / 1
| 1
isi
"This was mediated by enhanced deubiquitination of NLRP3 via binding with deubiquitinases BRCC3 and JOSD2, which are highly expressed in myeloid cells."
32941940
JOSD2 affects NDUFA8
1 |
JOSD2 binds NDUFA8. 1 / 1
1 |
biogrid
No evidence text available
28514442
JOSD2 affects LRTOMT
1 |
LRTOMT binds JOSD2. 1 / 1
1 |
biogrid
No evidence text available
28514442
JOSD2 affects K11
| 1
JOSD2 binds K11. 1 / 1
| 1
sparser
"The ubiquitin linkage types most readily cleaved by Josephin-2—K11, K48, and K63—are all abundant in cells ( xref , xref )."
32647816
JOSD2 affects FBN2
| 1
JOSD2 activates FBN2. 1 / 1
| 1
reach
"The depletion of JOSD2 promoted YAP/TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in vivo ."
35024322
JOSD2 affects FAM126A
| 1
JOSD2 activates FAM126A. 1 / 1
| 1
reach
"Furthermore, a series of rescue experiments confirmed the significance of CTNNB1 in the modulation of HCC progression by JOSD2."
35568970
reach
"Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression."
35024322
JOSD2 affects Cell Survival
| 1
reach
"Reconstitute of JOSD2 in AML cells significantly inhibit cell viability and induce cell apoptosis."
35836282
JOSD2 activates Carcinoma, Hepatocellular. 1 / 1
| 1
reach
"Deubiquitinating enzyme JOSD2 promotes hepatocellular carcinoma progression through interacting with and inhibiting CTNNB1 degradation."
35568970
JOSD2 affects CTNNB1
| 1
JOSD2 activates CTNNB1. 1 / 1
| 1
reach
"Deubiquitinating enzyme JOSD2 promotes hepatocellular carcinoma progression through interacting with and inhibiting CTNNB1 degradation."
35568970
JOSD2 affects COMMD3
1 |
COMMD3 binds JOSD2. 1 / 1
1 |
biogrid
No evidence text available
28514442
JOSD2 affects BRCC3
| 1
BRCC3 binds JOSD2. 1 / 1
| 1
isi
"This was mediated by enhanced deubiquitination of NLRP3 via binding with deubiquitinases BRCC3 and JOSD2, which are highly expressed in myeloid cells."
32941940
ICG 001 affects JOSD2
1 |
ICG 001 decreases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
26191083
GCM1 affects JOSD2
1 |
GCM1 decreases the amount of JOSD2. 1 / 1
1 |
biopax:msigdb
No evidence text available
GATA1 affects JOSD2
1 |
GATA1 decreases the amount of JOSD2. 1 / 1
1 |
biopax:msigdb
No evidence text available
COMMD3 affects JOSD2
1 |
COMMD3 binds JOSD2. 1 / 1
1 |
biogrid
No evidence text available
28514442
C646 compound affects JOSD2
1 |
C646 compound decreases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
26191083
BRCC3 affects JOSD2
| 1
BRCC3 binds JOSD2. 1 / 1
| 1
isi
"This was mediated by enhanced deubiquitination of NLRP3 via binding with deubiquitinases BRCC3 and JOSD2, which are highly expressed in myeloid cells."
32941940
AR affects JOSD2
1 |
AR decreases the amount of JOSD2. 1 / 1
1 |
biopax:msigdb
No evidence text available
(+)-JQ1 compound affects JOSD2
1 |
(+)-JQ1 compound decreases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
23086925
2,3',4,4',5-pentachlorobiphenyl increases the amount of JOSD2. 1 / 1
1 |
ctd
No evidence text available
31388691