IndraLab

Statements

JOSD2 deubiquitinates IMPDH2. 3 / 3
| 3
reach
"Under colitis condition, in order to reduce inflammation, macrophages induce high expression of JOSD2, which then deubiquitinates IMPDH2 activity and inhibits IMPDH2–NF-κB inflammatory pathway."
40177575
reach
"Furthermore, JOSD2 exhibited an enhanced capacity to deubiquitinate IMPDH2 dose-dependently in HEK293T cells (Fig. 6B)."
40177575
reach
"The present study demonstrated that a DUB, JOSD2, alleviated colitis by deubiquitinating IMPDH2 and inhibiting IMPDH2 activity in macrophages."
40177575