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JOSD2 deubiquitinates IMPDH2. 3 / 3
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"Furthermore, JOSD2 exhibited an enhanced capacity to deubiquitinate IMPDH2 dose-dependently in HEK293T cells (Fig. 6B)."
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"The present study demonstrated that a DUB, JOSD2, alleviated colitis by deubiquitinating IMPDH2 and inhibiting IMPDH2 activity in macrophages."
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"Under colitis condition, in order to reduce inflammation, macrophages induce high expression of JOSD2, which then deubiquitinates IMPDH2 activity and inhibits IMPDH2–NF-κB inflammatory pathway."
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