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JOSD2 inhibits Mice. 3 / 3
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"Taken together, these data suggest that JOSD2 deficiency significantly exacerbates DSS-induced colon injuries.3.3 JOSD2 deficiency increases the production of inflammatory cytokines in DSS-challenged mice."
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"Conversely, the specific overexpression of JOSD2 in renal tubular epithelial cells effectively prevented renal tubular injury and inflammation induced in AKI mice."
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"Similarly, compared with the AAV6-NC group, AAV6-mediated JOSD2 overexpression significantly inhibited DSS-induced colon shortening and colon epithelial damage in mice, as seen in Fig. 8C–F. Moreover, AAV6-mediated JOSD2 overexpression markedly reduced the expression of proinflammatory cytokine and chemokine genes compared with the AAV6-NC-injected group (Fig. 8G)."
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