IndraLab

Statements

Mutated KRAS leads to the deubiquitination of JOSD2. 1 / 1

| 1

reach

"Reciprocally, the stabilized KRAS mutants inhibit the ubiquitination of JOSD2 by suppressing its bona fide E3 ubiquitin ligase CHIP, thus forming a JOSD2/KRAS positive feedback circuit that robustly accelerates proliferation in KRAS-mutant CRC cells."

40240366

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

Mutated KRAS leads to the deubiquitination of JOSD2. 1 / 1

INDRA sources:

Databases

Reading