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PR619 inhibits JOSD2. 1 / 1

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"As shown in Supporting Information Fig. S4A, PR619 greatly abolished the deubiquitinating efficiency of JOSD2 on YAP, as indicated by the reversal of loss of poly-ubiquitin chains on YAP in PR619 treated cells.Collectively, these results demonstrate that JOSD2 stabilizes YAP/TAZ through the cleavage of poly-ubiquitin chains from YAP/TAZ, which confirm its regulation on YAP/TAZ as a DUB.3.5 JOSD2 is essential for the growth of CCA xenograft and positively correlated with YAP in CCA patients."

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PR619 inhibits JOSD2. 1 / 1

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