IndraLab

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JOSD2 increases the amount of YAP1. 3 / 3
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"The results indicated that JOSD2 increased the protein level of YAP and significantly enhanced the nuclear/cytoplasm ratio of YAP (Fig. 2G)."
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"Deletion of endogenous JOSD2 by two specific shRNA substantially reduced YAP/TAZ protein levels (Fig. 2C)."
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"Moreover, over-expression of JOSD2-WT, but not the catalytically inactive C24A mutant, robustly up-regulated YAP/TAZ protein levels, indicting a deubiquitinase activity-dependent manner was involved (Fig. 2D)."
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