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Mutated KRAS activates JOSD2. 2 / 2

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"KRAS mutants significantly upregulate JOSD2 by inhibiting the E3 ligase activity of CHIP."

40240366

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"Moreover, KRAS mutants remarkably upregulated the protein levels and prolonged the half-life of JOSD2-WT, while posed little effect on JOSD2-3KR, demonstrating KRAS mutants regulating JOSD2 levels and stability mainly through K48, K142, and K181 (Fig. 4j)."

40240366

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IndraLab

Statements

Mutated KRAS activates JOSD2. 2 / 2

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