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JOSD2 activates YAP1. 3 / 3
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"Another study revealed that JOSD2 promoted cholangiocarcinoma proliferation by deubiquitinating and stabilizing Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), two essential transcriptional co-activators of the Hippo pathway ."
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"As expected, JOSD2 shRNA greatly reduced both the YAP/TAZ transcriptional activities and protein abundance (Fig. 2F), suggesting that JOSD2 was required to optimally maintain the protein stabilities and transcriptional responses of YAP/TAZ."
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"In addition, we transfected β-TRCP and cullin 1, two subunits of E3 ligase SCF into RBE cells, and found that YAP/TAZ protein levels were down-regulated as expected; in the contrast, the exogenous introduction of JOSD2 abrogated SCF -mediated degradation of YAP/TAZ in a deubiquitinase activity-dependent manner (Fig. 2I)."
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