IndraLab

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CGAS binds JOSD2. 7 / 7
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"Finally, our study focused on macrophages as key mediators of the JOSD2-cGAS axis; however, other innate immune cells, particularly conventional type 1 dendritic cells (cDC1), which are crucial for T cell priming and also depend on the cGAS-STING pathway, xref were not examined."
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"The results, as shown in xref , indicate that JOSD2 binds to cGAS in the in vitro system."
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"Further molecular mechanism studies revealed that JOSD2 interacts with cGAS and cleaves ubiquitin chains in an enzymatic activity-dependent manner without affecting cGAS protein stability but critically regulates its enzymatic function."
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"Exogenous cGAS bound endogenous JOSD2 ( xref ), and vice versa ( xref )."
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"Co-IP assays revealed specific interaction between JOSD2 and cGAS ( xref )."
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"JOSD2 interacts with cGAS proteins."
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"Interestingly, endogenous Co-IP in untransfected cells confirmed the physiological interaction between cGAS and JOSD2 ( xref )."
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