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"Moreover, CHIP positively regulated the K48-linked polyubiquitination levels of JOSD2 (Fig. 4m, n and Supplementary Fig. 4l–n), indicating CHIP binds to JOSD2 and regulates the latter’s ubiquitination levels.To further demonstrate that CHIP functions as an E3 ligase regulating JOSD2, we next examined the effect of CHIP on JOSD2 protein levels."