IndraLab

Statements

JOSD2 activates NSCLC. 3 / 3
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"JOSD2 promotes NSCLC growth via regulating LKB1."
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"Depletion of JOSD2 significantly impeded NSCLC growth in both cell/patient-derived xenografts in vivo."
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"Nonetheless, in LKB1-null cells, silencing JOSD2 still exhibited a certain inhibitory effect on the proliferation, suggesting that other protein substrates in addition to LKB1, might also be involved in JOSD2-driven NSCLC proliferation and cannot be excluded.To further demonstrate that the tumor-promoting effect of JOSD2 depends on LKB1, LKB1-WT and LKB1-3KR were introduced to LKB-null NCI-H460 cells."
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