IndraLab
Statements
reach
"Contemporary research has demonstrated that JOSD2 can significantly impact metabolic and neoplastic diseases by modulating several signaling pathways by deubiquitinating different substrate proteins, such as sarcoplasmic/endoplasmic reticulum Ca ATPase 2a (SERCA2a), Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ), catenin beta-1 (CTNNB1), and a metabolic enzyme complex encompassing phosphoglycerate dehydrogenase, phosphofructokinase-1, and aldolase A16, 17, 18, 19."