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JOSD2 binds IMPDH2 and K63. 1 / 1

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"Mechanistically, JOSD2 binds to the C-terminal of inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) and preferentially cleaves K63-linked polyubiquitin chains at the K134 site, suppressing IMPDH2 activity and preventing activation of nuclear factor kappa B (NF-kappaB) and inflammation in macrophages."

40177575

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IndraLab

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JOSD2 binds IMPDH2 and K63. 1 / 1

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