IndraLab

Statements

JOSD2 is ubiquitinated. 3 / 3
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"Moreover, EGF stimulation induced KRAS activation also posed a similar effect (Supplementary Fig.  xref ), demonstrating the regulation of KRAS on JOSD2 ubiquitination depending on KRAS activity."
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"Considering that E3 ligases are key proteins regulating the ubiquitination levels of substrates, we guessed whether KRAS mutants regulate JOSD2 ubiquitination through their E3 ligases."
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"Reciprocally, the stabilized KRAS mutants inhibit the ubiquitination of JOSD2 by suppressing its bona fide E3 ubiquitin ligase CHIP, thus forming a JOSD2/KRAS positive feedback circuit that robustly accelerates proliferation in KRAS-mutant CRC cells."
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