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JOSD2 inhibits IMPDH2. 4 / 4
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"Under colitis condition, in order to reduce inflammation, macrophages induce high expression of JOSD2, which then deubiquitinates IMPDH2 activity and inhibits IMPDH2–NF-κB inflammatory pathway."
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"The present work shows that JOSD2 directly interacts with IMPDH2 and, via K63-linked deubiquitination, reduces IMPDH2 activity in macrophages."
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"Furthermore, compared to the wide-type IMPDH2, the ubiquitination level of IMPDH2-K134R mutant was significantly reduced and JOSD2 failed to further deubiquitinate IMPDH2-K134R mutant, indicating that K134 in IMPDH2 is essential for ubiquitination and JOSD2-mediated deubiquitination (Fig. S9B).3.7 JOSD2 inhibits the activity of IMPDH2 to suppress downstream NF-kappaB activation."
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"Overall, these results suggest that IMPDH2 K134R reverses JOSD2-mediated IMPDH2 and NF-κB activities.3.8 Therapeutic effects of restoring JOSD2 expression against DSS-induced colitis in mice."
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