IndraLab

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JOSD2 inhibits KRAS. 2 / 2
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"Aforementioned data suggested that JOSD2 interacts with KRAS and positively regulates KRAS turnover and activity in an enzymatic activity-dependent manner."
40240366
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"Given that JOSD2 has been shown to reverse the polyubiquitin chains of KRAS mediated by LZTR1, which is reported to promote K48, K63, and K33-linked ubiquitin chains as part of its function as a “RAS killer protein” and JOSD2 also can deubiquitinate K6-linked ubiquitination of LKB1 and affecting its kinase activity , so we next tested the effects of GST-JOSD2 on K6-, K33-, K48-, K63- and K48R-linked ubiquitin chains of KRAS."
40240366