IndraLab

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JOSD2 activates STK11. 3 / 3
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"Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity."
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"Further cellular assays revealed that both HY041004 and HY04071 robustly blocked the loss of K6-linked polyubiquitination on LKB1 caused by JOSD2 (Fig. 7c), suggesting that these two compounds not only inhibit the in vitro deubiquitinating activity of JOSD2, but also efficiently suppress its catalytic activity in the cells."
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"To pinpoint the specific lysine linkage on LKB1 mediated by JOSD2, we performed a cell-based ubiquitination assay using WT-Ub and seven mutant forms of ubiquitin: ubiquitin-K6, ubiquitin-K11, ubiquitin-K27, ubiquitin-K29, ubiquitin-K33, ubiquitin-K48 and ubiquitin-K63, each links to the substrate in a distinctive manner."
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