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JOSD2 inhibits PKM2. 3 / 3
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"Moreover, acute myeloid leukemia progression is inhibited by the Josephin domain containing 2 blocking PKM2 nuclear localization."
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"Taken together, we propose that JOSD2 blocks PKM2 nuclear localization and reduces AML progression."
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"However, JOSD2 did not affect PKM2 protein level (Fig. 1h), but immunofluorescence showed that JOSD2 overexpression could significantly inhibit PKM2 nuclear localization in HL60 and primary AML cells (Fig. 1i, j and Additional file 1: Fig. S3a)."
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