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JOSD2 inhibits Colitis. 3 / 3
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"It was also shown that JOSD2 knockout significantly exacerbated increased azoxymethane (AOM)/DSS-induced CRC, and AAV6-mediated JOSD2 overexpression in macrophages prevented the development of colitis in mice."
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"It was further found that deficiency of JOSD2 in myeloid cells exacerbated intestinal inflammation and IBD pathology in dextran sodium sulfate (DSS)-challenged mice, while overexpression of JOSD2 prevented colitis in mice caused by DSS."
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"In summary, these findings indicate that the use of AAV6 to increase the expression of JOSD2 provides protection against colitis produced by DSS in mice.3.9 JOSD2 deficiency exacerbates the development of AOM/DSS-induced CRC in mice."
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