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"In addition, to better consolidate our conclusion that JOSD2 regulated LKB1 activity by removing K6-ub but not K63-ub, we also investigated the effects of JOSD2 on K63-ub of LKB1, as shown in supplementary Fig. S4f, g, neither overexpression nor depletion of JOSD2 posed effects on LKB1 K63-ub, suggested that as a DUB for LKB1, JOSD2 preferentially cleaved K6 linkage but not K63 linkage.Hence, these results indicated that JOSD2 was a bona fide DUB for LKB1, as JOSD2 bound to LKB1 and removed the K6-linked polyubiquitination on LKB1."