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JOSD2 activates KITLG. 1 / 1
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"In addition, we transfected β-TRCP and cullin 1, two subunits of E3 ligase SCF into RBE cells, and found that YAP/TAZ protein levels were down-regulated as expected; in the contrast, the exogenous introduction of JOSD2 abrogated SCF -mediated degradation of YAP/TAZ in a deubiquitinase activity-dependent manner (Fig. 2I)."