IndraLab

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JOSD2 deubiquitinates PHGDH. 4 / 4
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"A recent study found that JOSD2 promoted glucose metabolism by deubiquitinating and stabilizing the metabolic enzyme complex, namely phosphoglycerate dehydrogenase (PHGDH), phosphofructokinase-1 (PFK-1), and Aldolase A ."
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"Josephin-2, a new DUB, deubiquitinates PHGDH in HCC to promote its stem cell phenotype [130]."
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"Recently, Norberg's group25 26 reported that JOSD2 deubiquitinates and stabilizes 3 important components (aldolase A, phosphofructokinase-1 and phosphoglycerate dehydrogenase) of glucose metabolic enzyme complex, leading to enhanced glycolytic rate and lung adenocarcinomas progression."
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"In NSCLC, JOSD2 also deubiquitinates and stabilizes phosphoglycerate dehydrogenase, a key enzyme that drives the first committed step in de novo serine biosynthesis [5]."
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