IndraLab

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JOSD2 leads to the ubiquitination of NLRP3-R779C. 1 / 1
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reach
"Conversely, the downregulation of either BRCC3 or JOSD2 significantly inhibited the deubiquitination of NLRP3-R779C, suppressing IL-1β and IL-18 maturation and pyroptosis, thereby ameliorating acute colitis [76]."