IndraLab

Statements

JOSD2 increases the amount of KRAS. 4 / 4
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"As shown in Supplementary Fig. 3i, depletion of JOSD2 significantly downregulated intratumor KRAS levels, indicating JOSD2 inhibition is capable of suppressing KRAS turnover in vitro and in vivo.To further investigate the contribution of JOSD2 in KRAS-mutant CRC growth in preclinical settings, we conducted KRAS-mutant CRC patient-derived cells (PDCs) and patient-derived xenografts (PDX) models (Fig. 3a)."
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"Further intratumor protein analysis shown that depletion of JOSD2 significantly downregulated intratumor KRAS levels, and the effects on KRAS mutants is significantly stronger than KRAS wild-type (Fig. 5h and Supplementary Fig. 6a)."
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"We found overexpression of JOSD2, but not JOSD1, significantly upregulated KRAS levels (Fig. 1d)."
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"Correspondingly, depletion of JOSD2, but not JOSD1, significantly downregulated KRAS levels (Fig. 1e and Supplementary Fig. 1b, c), indicating JOSD2 positively regulates KRAS abundance."
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