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STUB1 inhibits JOSD2. 2 / 2
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"As shown in Fig. 4q, KRAS mutants significantly upregulated JOSD2 levels, but failed to pose similar effects in CHIP-depleted cells, indicating that KRAS mutants upregulated JOSD2 relying on CHIP.Given that JOSD2 functions as a DUB, we further investigate whether JOSD2 exhibits auto-DUB activity."
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"Reciprocally, KRAS mutations prevented CHIP-mediated degradation of JOSD2, thus forming a JOSD2/KRAS positive feedback circuit to fuel malignant proliferation of KRAS-mutant CRC cells, and rendering these cells vulnerable to JOSD2 inhibition (Fig. 7f)."
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