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JOSD2 activates glycolytic process. 4 / 4
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"JOSD2 deficiency inhibits tumor cell proliferation by reducing glycolysis, and its mRNA expression is related to the worst prognosis in NSCLC (Krassikova et al., 2021)."
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"JOSD2 deficiency displays cytostatic effects and reduces glycolysis in a broad spectrum of tumor cells of distinct origin and its expression correlates with poor prognosis in non-small cell lung cancer ."
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"In addition, Krassikova et al. also demonstrated that JOSD2 promoted glycolysis in tumor cells through deubiquitination and stabilization of three important enzymes involved in glucose metabolism, namely PHGDH, PFK-1 and Aldolase A."
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"Krassikova et al. also demonstrated that JOSD2 promoted glycolysis in tumor cells through deubiquitination and stabilization of three important enzymes involved in glucose metabolism, namely PHGDH, PFK-1 and Aldolase A."
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