IndraLab
Statements
reach
"Together with data showing that co-expression of the USP-46, WDR-48, and WDR-20 complex reduces levels of ubiquitinated GLR-1, these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo."
sparser
"Recent structural work revealed how the WD-repeat protein UAF1 interacted with the catalytic domain of USP46 and USP12, which is facilitated predominantly through the “fingers” subdomain of the USP core, mediating long-range allosteric interactions eventually leading to enhanced enzyme efficiency ( xref , xref )."
WDR48 binds MTBMA_c15380, USP12, and USP46. 1 / 1
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1
reach
"These findings indicate that Usp46, and its allosteric regulators Uaf1 and Wdr20, promote Wingless signaling in target cells in the wing imaginal disc.We further characterized Usp46 mutant cells in the wing disc that were generated by combining CRISPR-based mutagenesis with tissue-specific expression of Cas9 and Usp46 guide RNAs."
reach
"Together with data showing that co-expression of the USP-46, WDR-48, and WDR-20 complex reduces levels of ubiquitinated GLR-1, these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo."
sparser
"Recent structural work revealed how the WD-repeat protein UAF1 interacted with the catalytic domain of USP46 and USP12, which is facilitated predominantly through the “fingers” subdomain of the USP core, mediating long-range allosteric interactions eventually leading to enhanced enzyme efficiency ( xref , xref )."
WDR48 binds MTBMA_c15380, USP12, and USP46. 1 / 1
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"It raises the possibility that a targeted knockout of Uaf1 in granulosa cells might lead to infertility in female mice, which could provide further insights into UAF1’s specific functions in female reproductive biology.UAF1 acts as a cofactor for USP1, USP12, and USP46, enhancing their deubiquitinase activity by forming stable UAF1/USP protein complexes.14 18 Defective spermiogenesis in Uaf1 sKO mice necessitated the identification of a DUB critical for this process."
reach
"H. Model : UAF1 mediates the interaction between USP1 and RAD51AP1.of USP12 and USP46, 2 DUBs that also associate with UAF1,26 did not significantly affect the RAD51AP1 stability, suggesting that the effect is specific to the USP1-UAF1 complex.Mapping of the UAF1 interacting region of RAD51AP1In order to specifically determine the functional significance of the UAF1-RAD51AP1 interaction, we sought to identify the residues within RAD51AP1 required for interacting with UAF1."
reach
"Although the PHLLP1 and PHLLP2 phosphatases have been reported to be components of the USP46 and USP12 complexes, they were not detectably associated with EBNA3 complexes, likely because these phosphatases are predominantly membrane associated [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
sparser
"Recent structural work revealed how the WD-repeat protein UAF1 interacted with the catalytic domain of USP46 and USP12, which is facilitated predominantly through the “fingers” subdomain of the USP core, mediating long-range allosteric interactions eventually leading to enhanced enzyme efficiency ( xref , xref )."
sparser
"Although the exact function of p80/Uaf1 in viral DNA replication remains unclear, this WD40 repeats-containing protein is known to interact with the de-ubiquitinating enzymes Usp1, Usp12 and Usp46, whose substrates include PCNA, histones H2A and H2B and Fanconi anaemia complementation group D type 2, a component of the Fanconi anaemia pathway [ xref , xref ]."
WDR48 binds MTBMA_c15380, USP12, and USP46. 1 / 1
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1
reach
"H. Model : UAF1 mediates the interaction between USP1 and RAD51AP1.of USP12 and USP46, 2 DUBs that also associate with UAF1,26 did not significantly affect the RAD51AP1 stability, suggesting that the effect is specific to the USP1-UAF1 complex.Mapping of the UAF1 interacting region of RAD51AP1In order to specifically determine the functional significance of the UAF1-RAD51AP1 interaction, we sought to identify the residues within RAD51AP1 required for interacting with UAF1."
reach
"Although the PHLLP1 and PHLLP2 phosphatases have been reported to be components of the USP46 and USP12 complexes, they were not detectably associated with EBNA3 complexes, likely because these phosphatases are predominantly membrane associated [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
sparser
"Recent structural work revealed how the WD-repeat protein UAF1 interacted with the catalytic domain of USP46 and USP12, which is facilitated predominantly through the “fingers” subdomain of the USP core, mediating long-range allosteric interactions eventually leading to enhanced enzyme efficiency ( xref , xref )."
sparser
"Although the exact function of p80/Uaf1 in viral DNA replication remains unclear, this WD40 repeats-containing protein is known to interact with the de-ubiquitinating enzymes Usp1, Usp12 and Usp46, whose substrates include PCNA, histones H2A and H2B and Fanconi anaemia complementation group D type 2, a component of the Fanconi anaemia pathway [ xref , xref ]."
WDR48 binds MTBMA_c15380, USP12, and USP46. 1 / 1
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"Recently, a proteomic study on deubiquitinating enzymes and their associated protein complexes demonstrated that USP46 interacts with PHLPP and SCOP (PH-domain leucine rich repeat protein phosphatase and suprachiasmatic nucleus circadian oscillatory protein), which are members of the of Ser/Thr family of protein phosphatases XREF_BIBR."
USP46 affects Delta-actitoxin-Avd1a
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Delta-actitoxin-Avd1a binds USP46. 10 / 30
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sparser
"In this study, we found that several lncRNAs, including FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, ENSG00000271020, AC112220.2, AC018647.2, AC015922.2, MID1IP1-AS1, AL731577.2 and AL450326.1 were co-expressed with VHL, and their expression were positively correlated with VHL expression."
sparser
"Moreover, results of the log-rank test showed that high expression groups of AC112220.2, AL391121.1, USP46-AS1, AL450326.1, SUCLG2-AS1, RAP2C-AS1, FGD5-AS1, AC018647.2 and AC015922.2 had significantly longer OS than their respective low expression groups, and high AC112220.2, USP46-AS1, AL450326.1, SUCLG2-AS1, FGD5-AS1, AC018647.2 and AC015922.2 expression groups had remarkably longer DFS than their respective low expression groups."
sparser
"Similarly, KAT2B , VWA1 , CX3CL1 , MLYCD , NR2F2 , USP46-AS1 , miR6724-4 , and LINC01257 were identified in the serum of chemo-nonresponsive patients as compared with responsive ones. xref KAT2B gene was one of the most dysregulated genes detected in RB specific sEV which corroborated with the treatment responsive RB. xref As part of further validation, we aimed to investigate the immunolocalization of EV markers alongside and Rb-specific markers in RB tissue."
USP46 binds Delta-actitoxin-Avd1a and SUCLG2. 2 / 2
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sparser
"Lower expression of FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 were associated with advanced tumor stage (Figure xref A); lower expression of RAP2C-AS1 was related to lymphatic invasion (Figure xref B); lower expression of RAP2C-AS1, USP46-AS1, AC112220.2 and AC015922.2 tended to promote tumor metastasis (Figure xref C); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 expression levels were correlated with higher pathological stage (Figure xref D); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2 and AC015922.2 expression levels were also correlated with higher histological grade (Figure xref E)."
sparser
"In this study, we found that several lncRNAs, including FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, ENSG00000271020, AC112220.2, AC018647.2, AC015922.2, MID1IP1-AS1, AL731577.2 and AL450326.1 were co-expressed with VHL, and their expression were positively correlated with VHL expression."
PON2 binds Delta-actitoxin-Avd1a and USP46. 1 / 1
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sparser
"In this study, we explored the association between ncRNA expression and glioma OS, and obtained a prognostic signature containing three ncRNAs, including USP46‐AS1 , PON2 and LOC441179 , based on which we could accurately separate glioma patients with better prognosis from those with a worse prognosis."
reach
"Recently, a proteomic study on deubiquitinating enzymes and their associated protein complexes demonstrated that USP46 interacts with PHLPP and SCOP (PH-domain leucine rich repeat protein phosphatase and suprachiasmatic nucleus circadian oscillatory protein), which are members of the of Ser/Thr family of protein phosphatases XREF_BIBR."
USP46 affects cell population proliferation
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26
USP46 inhibits cell population proliferation.
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USP46 activates cell population proliferation.
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7
USP46 activates cell population proliferation. 7 / 7
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"As shown in Supplementary Fig. 6e, the depletion of USP46 in genetically engineered human immortalized melanocytes (hTERT/CDK4 /p53 ) expressing NRAS Q61R induced a significant reduction of cell proliferation as assessed by Ki67 staining, and a significant increase of apoptotic cell death as assessed by cleaved caspase-3 staining."
reach
"Herein, we demonstrate that the USP46 complex is required for Wnt signaling in cultured human cells, Xenopus embryos, zebrafish embryos, and mouse intestinal organoids, indicating evolutionary conservation of function.We show that in response to Wnt pathway activation, the USP46 complex is recruited to and deubiquitylates cell surface LRP6, blocking its turnover."
reach
"Furthermore, the depletion of USP46 in SK-MEL-103, SK-MEL-30 and SK-MEL-2 cells significantly suppressed levels of p-AKT and p-ERK, cellular proliferation, migration and invasion abilities along with increased cellular sensitivity to DTIC, whereas the reconstitution of NRAS Q61R/K, NRAS Q61R-K135R + K147R or NRAS Q61R-K135R + K147L in USP46-deficient cells markedly rescue such effects (Fig. 5i–l and Supplementary Figs."
reach
"Compared to control cells (shScramble), the depletion of USP46 in SK-MEL-103 cells expressing FLAG-NRAS Q61R markedly decreased the protein level of the NRAS mutant, inhibited the activation of downstream pathways assessed by p-AKT and p-ERK, reduced cell proliferation, and increased cellular sensitivity to DTIC."
USP46 is modified
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USP46 affects Neoplasm Metastasis
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USP46 activates Neoplasm Metastasis.
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10
USP46 inhibits Neoplasm Metastasis.
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sparser
"Immunoprecipitation of endogenous cellular Cdt2 coimmunoprecipitated cellular USP46 and E6 only from HeLa cell lysates (that contain HPV E6) but not from U2OS cell lysates (that do not contain E6) ( xref ; xref ), suggesting that E6 is necessary to promote the interaction of Cdt2 with USP46."
reach
"These include : (a) overexpression of Nedd4-1 in neurons, which enhances GluA1 ubiquitination, causes a reduction in the number of AMPARs on the plasma membrane; (b) shRNA mediated knockdown of Nedd4-1 increases the rate of GluA1 internalization; (c) overexpression of USP46, which downregulates GluA1 ubiquitination, decreases the accumulation of internalized GluA1 in neurons; and (d) overexpression of GluA1-4KR ubiquitin deficient mutants (where all four C-terminal lysine residues have been substituted with arginines) blocks AMPA induced GluA1 internalization."
reach
"By deubiquitinating K63 ubiquitinated glutaminergic AMPARs (α-amino-3-hydroxy-5methyl-4-isoxazolepropionic acid) receptors GluA1 and GluA2, which are considered to mediate most of the excitatory synaptic transmission in the brain, USP46 upregulates the intracellular trafficking, cell surface density, and signal intensity of AMPARs [116,117]."
reach
"These functions of CYLD were implied in a study on another K63-DUB, USP46, which can cleave K63-linked ubiquitination chains from AMPARs and modulate AMPAR internalization and turnover in cultured rat cortical and hippocampal neurons; in this way, USP46 is thought to regulate AMPAR-mediated excitatory synaptic transmission (Huo et al., 2015)."
sparser
"Immunoprecipitation of endogenous cellular Cdt2 coimmunoprecipitated cellular USP46 and E6 only from HeLa cell lysates (that contain HPV E6) but not from U2OS cell lysates (that do not contain E6) ( xref ; xref ), suggesting that E6 is necessary to promote the interaction of Cdt2 with USP46."
sparser
"Recent structural work revealed how the WD-repeat protein UAF1 interacted with the catalytic domain of USP46 and USP12, which is facilitated predominantly through the “fingers” subdomain of the USP core, mediating long-range allosteric interactions eventually leading to enhanced enzyme efficiency ( xref , xref )."
WDR48 binds MTBMA_c15380, USP12, and USP46. 1 / 1
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sparser
"The substrate is cradled between the fingers and the inner palm/thumb regions. xref Moreover, a Zintegrated by 4 conserved Cys residues stabilizes the USP46 subdomain of the tip of the fingers, and the active-site adopts a catalytically favorable conformation. xref The USP46:ubiquitin interface buries 1,825A ° 2 of surface area on each protein."
sparser
"Recent structural work revealed how the WD-repeat protein UAF1 interacted with the catalytic domain of USP46 and USP12, which is facilitated predominantly through the “fingers” subdomain of the USP core, mediating long-range allosteric interactions eventually leading to enhanced enzyme efficiency ( xref , xref )."
WDR48 binds MTBMA_c15380, USP12, and USP46. 1 / 1
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sparser
"The substrate is cradled between the fingers and the inner palm/thumb regions. xref Moreover, a Zintegrated by 4 conserved Cys residues stabilizes the USP46 subdomain of the tip of the fingers, and the active-site adopts a catalytically favorable conformation. xref The USP46:ubiquitin interface buries 1,825A ° 2 of surface area on each protein."
sparser
"Although the exact function of p80/Uaf1 in viral DNA replication remains unclear, this WD40 repeats-containing protein is known to interact with the de-ubiquitinating enzymes Usp1, Usp12 and Usp46, whose substrates include PCNA, histones H2A and H2B and Fanconi anaemia complementation group D type 2, a component of the Fanconi anaemia pathway [ xref , xref ]."
USP46 affects Neoplasm Invasiveness
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8
USP46 inhibits Neoplasm Invasiveness.
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5
USP46 activates Neoplasm Invasiveness.
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sparser
"Although the exact function of p80/Uaf1 in viral DNA replication remains unclear, this WD40 repeats-containing protein is known to interact with the de-ubiquitinating enzymes Usp1, Usp12 and Usp46, whose substrates include PCNA, histones H2A and H2B and Fanconi anaemia complementation group D type 2, a component of the Fanconi anaemia pathway [ xref , xref ]."
USP46 affects Histone_H2B
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8
sparser
"Recent structural work revealed how the WD-repeat protein UAF1 interacted with the catalytic domain of USP46 and USP12, which is facilitated predominantly through the “fingers” subdomain of the USP core, mediating long-range allosteric interactions eventually leading to enhanced enzyme efficiency ( xref , xref )."
USP46 affects apoptotic process
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USP46 activates apoptotic process.
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USP46 inhibits apoptotic process.
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USP46 inhibits apoptotic process. 3 / 3
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"As shown in Supplementary Fig. 6e, the depletion of USP46 in genetically engineered human immortalized melanocytes (hTERT/CDK4 /p53 ) expressing NRAS Q61R induced a significant reduction of cell proliferation as assessed by Ki67 staining, and a significant increase of apoptotic cell death as assessed by cleaved caspase-3 staining."
CK1δ affects USP46
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USP46 affects Wingless
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6
USP46 activates Wingless.
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3
USP46 inhibits Wingless.
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2
USP46 increases the amount of Wingless.
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"Furthermore, depletion of Usp46, Wdr20 or Uaf1 did not inhibit wingless expression, indicating that the observed reduction in Sens was not due to decreased Wingless levels, but instead resulted from impaired reception of the Wingless ligand or downstream defects in the Wingless signaling pathway (Fig. S3)."
USP46 affects ILC3
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sparser
"Although the exact function of p80/Uaf1 in viral DNA replication remains unclear, this WD40 repeats-containing protein is known to interact with the de-ubiquitinating enzymes Usp1, Usp12 and Usp46, whose substrates include PCNA, histones H2A and H2B and Fanconi anaemia complementation group D type 2, a component of the Fanconi anaemia pathway [ xref , xref ]."
sparser
"Although the exact function of p80/Uaf1 in viral DNA replication remains unclear, this WD40 repeats-containing protein is known to interact with the de-ubiquitinating enzymes Usp1, Usp12 and Usp46, whose substrates include PCNA, histones H2A and H2B and Fanconi anaemia complementation group D type 2, a component of the Fanconi anaemia pathway [ xref , xref ]."
Particulate Matter affects USP46
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Particulate Matter decreases the amount of USP46.
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Particulate Matter increases the amount of USP46.
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ILC3 affects USP46
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Δ affects USP46
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Bisphenol A affects USP46
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Bisphenol A increases the amount of USP46.
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Bisphenol A methylates USP46.
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Bisphenol A decreases the amount of USP46.
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sparser
"We could not determine whether the E6 translocated USP46 to the nucleus of the cancer cells, because contrary to the well-known cytoplasmic localization of USP46 in cell lines in culture, IHC with the USP46 antibody revealed that USP46 is nuclear in both normal and malignant areas of cervical squamous epithelium ( xref )."
Air Pollutants affects USP46
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Air Pollutants increases the amount of USP46.
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Air Pollutants decreases the amount of USP46.
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Valproic acid affects USP46
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reach
"Thus, Wnt signaling induced a physical alteration of the USP46 complex in the cytoplasm.Because the association of the USP46 complex with LRP6 was enhanced in the presence of Wnt stimulation (Fig. 3E, F), we tested whether the USP46 complex interacted with LRP6 receptor aggregates in signalosomes that could be readily detected in sucrose density gradients ."
WDR proteins affects USP46
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USP46 affects WDR proteins
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sparser
"As shown in Fig. xref , purified GST-USP46 interacted with the NRAS Q61R and NRAS Q61K mutant more strongly than NRAS WT and Q61L. We also modeled the structure of ubiquitinated NRAS in complex with USP46 using protein-protein docking (Schrödinger, LLC, New York, NY, 2023) based on the USP46-UB complex structure (PDB ID: 5CVM) and NRAS Q61K (PDB ID: 8VM2)."
reach
"By deubiquitinating K63 ubiquitinated glutaminergic AMPARs (α-amino-3-hydroxy-5methyl-4-isoxazolepropionic acid) receptors GluA1 and GluA2, which are considered to mediate most of the excitatory synaptic transmission in the brain, USP46 upregulates the intracellular trafficking, cell surface density, and signal intensity of AMPARs [116,117]."
USP46 affects CK1δ
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sparser
"As shown in Fig. xref , purified GST-USP46 interacted with the NRAS Q61R and NRAS Q61K mutant more strongly than NRAS WT and Q61L. We also modeled the structure of ubiquitinated NRAS in complex with USP46 using protein-protein docking (Schrödinger, LLC, New York, NY, 2023) based on the USP46-UB complex structure (PDB ID: 5CVM) and NRAS Q61K (PDB ID: 8VM2)."
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2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP46.
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2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP46.
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MiR-27a-3p affects USP46
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Hsa-miR-873-5p affects USP46
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Hsa-miR-6893-3p affects USP46
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Hsa-miR-6765-3p affects USP46
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Hsa-miR-5585-5p affects USP46
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Hsa-miR-548ax affects USP46
2
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Hsa-miR-548ao-5p affects USP46
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Hsa-miR-4797-5p affects USP46
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Hsa-miR-4722-5p affects USP46
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Hsa-miR-370-3p affects USP46
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Hsa-miR-3622b-3p affects USP46
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Hsa-miR-3622a-3p affects USP46
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Gamma-aminobutyric acid affects USP46
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Gamma-aminobutyric acid activates USP46. 1 / 1
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Gamma-aminobutyric acid activates mutated USP46. 1 / 1
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All-trans-retinoic acid affects USP46
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All-trans-retinoic acid increases the amount of USP46.
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All-trans-retinoic acid decreases the amount of USP46.
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Aflatoxin B1 affects USP46
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Aflatoxin B1 methylates USP46.
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Aflatoxin B1 demethylates USP46.
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USP46 affects δ
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2
USP46 affects mHTT
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USP46 affects glycolytic process
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2
reach
"https://doi.org/10.3892/mmr.2021.12024.The images for Figure 4A, sh-LINC01260 and sh-Control have been duplicated with the images for Figure 3A, NC and miR-613 mimics, respectively, from Luo et al, 2021.Images for Figure 4F have been duplicated with images for Figure 1D from Xu L, Zhang B, Li W. Downregulated expression levels of USP46 promote the resistance of ovarian cancer to cisplatin and are regulated by PUM2."
USP46 affects cell migration
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2
USP46 inhibits cell migration.
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USP46 inhibits cell migration. 1 / 1
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USP46 activates cell migration.
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USP46 activates cell migration. 1 / 1
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USP46 affects cell growth
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USP46 inhibits cell growth.
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USP46 inhibits cell growth. 1 / 1
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USP46 activates cell growth.
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USP46 activates cell growth. 1 / 1
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reach
"It raises the possibility that a targeted knockout of Uaf1 in granulosa cells might lead to infertility in female mice, which could provide further insights into UAF1’s specific functions in female reproductive biology.UAF1 acts as a cofactor for USP1, USP12, and USP46, enhancing their deubiquitinase activity by forming stable UAF1/USP protein complexes.14 18 Defective spermiogenesis in Uaf1 sKO mice necessitated the identification of a DUB critical for this process."
USP46 binds Delta-actitoxin-Avd1a and SUCLG2. 2 / 2
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sparser
"Lower expression of FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 were associated with advanced tumor stage (Figure xref A); lower expression of RAP2C-AS1 was related to lymphatic invasion (Figure xref B); lower expression of RAP2C-AS1, USP46-AS1, AC112220.2 and AC015922.2 tended to promote tumor metastasis (Figure xref C); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 expression levels were correlated with higher pathological stage (Figure xref D); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2 and AC015922.2 expression levels were also correlated with higher histological grade (Figure xref E)."
sparser
"In this study, we found that several lncRNAs, including FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, ENSG00000271020, AC112220.2, AC018647.2, AC015922.2, MID1IP1-AS1, AL731577.2 and AL450326.1 were co-expressed with VHL, and their expression were positively correlated with VHL expression."
USP46 affects Phosphatase
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USP46 binds Phosphatase. 2 / 2
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reach
"Furthermore, the depletion of USP46 in SK-MEL-103, SK-MEL-30 and SK-MEL-2 cells significantly suppressed levels of p-AKT and p-ERK, cellular proliferation, migration and invasion abilities along with increased cellular sensitivity to DTIC, whereas the reconstitution of NRAS Q61R/K, NRAS Q61R-K135R + K147R or NRAS Q61R-K135R + K147L in USP46-deficient cells markedly rescue such effects (Fig. 5i–l and Supplementary Figs."
USP46 affects Cell Survival
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USP46 affects Carcinoma, Hepatocellular
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USP46 inhibits Carcinoma, Hepatocellular. 2 / 2
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reach
"Usp46 inactivation in Wingless-responding cells destabilizes Arrow, reduces cytoplasmic accumulation of the transcriptional coactivator Armadillo/beta-catenin, and attenuates or abolishes Wingless target gene activation, which prevents the concentration-dependent regulation of signaling strength."
sparser
"Although the exact function of p80/Uaf1 in viral DNA replication remains unclear, this WD40 repeats-containing protein is known to interact with the de-ubiquitinating enzymes Usp1, Usp12 and Usp46, whose substrates include PCNA, histones H2A and H2B and Fanconi anaemia complementation group D type 2, a component of the Fanconi anaemia pathway [ xref , xref ]."
USP46 binds Delta-actitoxin-Avd1a and SUCLG2. 2 / 2
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sparser
"Lower expression of FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 were associated with advanced tumor stage (Figure xref A); lower expression of RAP2C-AS1 was related to lymphatic invasion (Figure xref B); lower expression of RAP2C-AS1, USP46-AS1, AC112220.2 and AC015922.2 tended to promote tumor metastasis (Figure xref C); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 expression levels were correlated with higher pathological stage (Figure xref D); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2 and AC015922.2 expression levels were also correlated with higher histological grade (Figure xref E)."
sparser
"In this study, we found that several lncRNAs, including FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, ENSG00000271020, AC112220.2, AC018647.2, AC015922.2, MID1IP1-AS1, AL731577.2 and AL450326.1 were co-expressed with VHL, and their expression were positively correlated with VHL expression."
Proteasome affects USP46
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Proteasome inhibits USP46.
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Proteasome inhibits USP46. 1 / 1
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Proteasome activates USP46.
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Proteasome activates USP46. 1 / 1
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Phosphatase affects USP46
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USP46 binds Phosphatase. 2 / 2
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Delta-actitoxin-Avd1a affects SUCLG2, and USP46
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USP46 binds Delta-actitoxin-Avd1a and SUCLG2. 2 / 2
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2
sparser
"Lower expression of FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 were associated with advanced tumor stage (Figure xref A); lower expression of RAP2C-AS1 was related to lymphatic invasion (Figure xref B); lower expression of RAP2C-AS1, USP46-AS1, AC112220.2 and AC015922.2 tended to promote tumor metastasis (Figure xref C); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 expression levels were correlated with higher pathological stage (Figure xref D); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2 and AC015922.2 expression levels were also correlated with higher histological grade (Figure xref E)."
sparser
"In this study, we found that several lncRNAs, including FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, ENSG00000271020, AC112220.2, AC018647.2, AC015922.2, MID1IP1-AS1, AL731577.2 and AL450326.1 were co-expressed with VHL, and their expression were positively correlated with VHL expression."
ΔK92 affects USP46
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1
Vinclozolin affects USP46
1
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Titanium dioxide affects USP46
1
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Testosterone affects USP46
1
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Sodium arsenite affects USP46
1
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SiRNA-mediated wdr48 affects USP46
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1
Potassium dichromate affects USP46
1
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Polyubiquitin chains affects USP46
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1
Permethrin affects USP46
1
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Oxaliplatin affects USP46
1
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Mono(2-ethylhexyl) phthalate affects USP46
1
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MiR-34a affects USP46
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1
reach
"Our study is the first to show that an anti-tumorous microRNA, miR-34a suppresses viral E6 protein (which in turn excludes USP46 from nucleus) and destabilizes overexpressed oncoprotein Cdt2 in HPV positive cell lines and stops their proliferation eventually killing these cancerous cells (Fig. 6), while no effect is seen on HPV negative cells."
Methylmercury chloride affects USP46
1
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Methyl methanesulfonate affects USP46
1
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Methimazole affects USP46
1
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Leucine affects USP46
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1
reach
"Recently, a proteomic study on deubiquitinating enzymes and their associated protein complexes demonstrated that USP46 interacts with PHLPP and SCOP (PH-domain leucine rich repeat protein phosphatase and suprachiasmatic nucleus circadian oscillatory protein), which are members of the of Ser/Thr family of protein phosphatases XREF_BIBR."
Hsa-mir-4457 affects USP46
1
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Hsa-mir-4303 affects USP46
1
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Hsa-mir-4294 affects USP46
1
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Hsa-mir-4282 affects USP46
1
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Hsa-mir-4280 affects USP46
1
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Hsa-mir-3920 affects USP46
1
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Hsa-miR-6815-3p affects USP46
1
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Hsa-miR-6807-5p affects USP46
1
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Hsa-miR-6751-3p affects USP46
1
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Hsa-miR-513c-3p affects USP46
1
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Hsa-miR-513b-5p affects USP46
1
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Hsa-miR-513a-5p affects USP46
1
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Hsa-miR-513a-3p affects USP46
1
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Hsa-miR-489-3p affects USP46
1
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Hsa-miR-4795-3p affects USP46
1
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Hsa-miR-4766-3p affects USP46
1
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Hsa-miR-4670-3p affects USP46
1
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Hsa-miR-4459 affects USP46
1
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Hsa-miR-4433b-3p affects USP46
1
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Hsa-miR-3688-3p affects USP46
1
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Hsa-miR-3681-3p affects USP46
1
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Hsa-miR-3606-3p affects USP46
1
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Hsa-miR-338-5p affects USP46
1
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Hsa-miR-3065-5p affects USP46
1
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Hsa-miR-3064-3p affects USP46
1
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Hsa-miR-27b-3p affects USP46
1
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Hsa-miR-216a-3p affects USP46
1
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Hsa-miR-16-2-3p affects USP46
1
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Hsa-miR-128-3p affects USP46
1
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Hsa-miR-125b-2-3p affects USP46
1
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Hsa-miR-1199-5p affects USP46
1
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Hsa-miR-106b-5p affects USP46
1
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Hexabromocyclododecane affects USP46
1
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HUAF1 affects USP46
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1
reach
"These may suggested that the activation of USP1 upon binding to UAF1 may be due to an increase in k cat with no drastic change in the K M, that was similar to what were observed on activation of human USP12 and USP46 binding to hUAF1 [XREF_BIBR] Besides hUSP1, hUAF1 stimulates hUSP12 and hUSP46 activity as well."
Folic acid affects USP46
1
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Endosulfan affects USP46
1
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Deltamethrin affects USP46
1
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Crocidolite asbestos affects USP46
1
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Cobalt dichloride affects USP46
1
|
Circ-NNT affects USP46
|
1
Cholesterol affects USP46
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1
Cholesterol binds USP46. 1 / 1
|
1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
Calcitriol affects USP46
1
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Cadmium dichloride affects USP46
1
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Bortezomib affects USP46
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1
Bortezomib activates USP46. 1 / 1
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1
Bisphenol F affects USP46
1
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Bis(2-ethylhexyl) phthalate affects USP46
1
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Benzo[a]pyrene affects USP46
1
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Arsenous acid affects USP46
1
|
Arsenic atom affects USP46
1
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Antirheumatic drug affects USP46
1
|
Albumin affects USP46
|
1
WDR48 affects MTBMA_c15380
|
1
WDR protein affects USP46
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1
WD40-repeat-containing protein affects USP46
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1
WD40-repeat protein WDR-20 affects USP46
|
1
WD40-repeat (WDR) proteins affects USP46
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1
USP46-PHLPP affects USP46
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1
USP46 affects ΔK92
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1
USP46 affects ubiquitinated receptors
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1
USP46 affects tissue homeostasis
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1
USP46 activates tissue homeostasis. 1 / 1
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1
USP46 affects resistance ovarian cancer cisplatin
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1
USP46 affects pyroptosis
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1
USP46 activates pyroptosis. 1 / 1
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1
USP46 affects proteolysis
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1
USP46 inhibits proteolysis. 1 / 1
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1
USP46 affects protein stabilization
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1
USP46 activates protein stabilization. 1 / 1
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1
USP46 affects polyubiquitin chains
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1
USP46 affects pevonedistat
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1
USP46 activates pevonedistat. 1 / 1
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1
USP46 affects nodes lung metastasis ESCC
|
1
USP46 affects migration invasion ESCC cells
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1
USP46 affects localization
|
1
USP46 activates localization. 1 / 1
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1
USP46 affects leucine
|
1
reach
"Recently, a proteomic study on deubiquitinating enzymes and their associated protein complexes demonstrated that USP46 interacts with PHLPP and SCOP (PH-domain leucine rich repeat protein phosphatase and suprachiasmatic nucleus circadian oscillatory protein), which are members of the of Ser/Thr family of protein phosphatases XREF_BIBR."
USP46 affects homeostatic process
|
1
USP46 activates homeostatic process. 1 / 1
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1
USP46 affects hUAF1
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1
reach
"These may suggested that the activation of USP1 upon binding to UAF1 may be due to an increase in k cat with no drastic change in the K M, that was similar to what were observed on activation of human USP12 and USP46 binding to hUAF1 [XREF_BIBR] Besides hUSP1, hUAF1 stimulates hUSP12 and hUSP46 activity as well."
USP46 affects gamma-aminobutyric acid
|
1
USP46 activates gamma-aminobutyric acid. 1 / 1
|
1
USP46 affects endocytosis
|
1
USP46 activates endocytosis. 1 / 1
|
1
USP46 affects cholesterol
|
1
Cholesterol binds USP46. 1 / 1
|
1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
USP46 affects cellular senescence
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1
USP46 activates cellular senescence. 1 / 1
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1
USP46 affects cell division
|
1
USP46 inhibits cell division. 1 / 1
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1
USP46 affects cell apoptosis
|
1
USP46 affects albumin
|
1
USP46 affects ZNFR3
|
1
USP46 affects Wnt co-receptor
|
1
USP46 affects Wingless target gene
|
1
reach
"Usp46 inactivation in Wingless-responding cells destabilizes Arrow, reduces cytoplasmic accumulation of the transcriptional coactivator Armadillo/beta-catenin, and attenuates or abolishes Wingless target gene activation, which prevents the concentration-dependent regulation of signaling strength."
USP46 affects WDR protein
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1
USP46 affects WD40-repeat protein WDR-20
|
1
USP46 affects WD40-repeat (WDR) proteins
|
1
USP46 affects Ser351
|
1
USP46 affects Reperfusion Injury
|
1
USP46 activates Reperfusion Injury. 1 / 1
|
1
USP46 affects RSPO
|
1
PON2 binds Delta-actitoxin-Avd1a and USP46. 1 / 1
|
1
sparser
"In this study, we explored the association between ncRNA expression and glioma OS, and obtained a prognostic signature containing three ncRNAs, including USP46‐AS1 , PON2 and LOC441179 , based on which we could accurately separate glioma patients with better prognosis from those with a worse prognosis."
USP46 affects MTBMA_c15380
|
1
"Moreover, <span class="match term0">USP46</span> acts as a deubiquitinating enzyme of <span class="match term1">MST1</span> to potentiate <span class="match term1">MST1</span> kinase activity to suppress tumor growth and metastasis, indicating that <span class="match term0">USP46</span> activation may represent a potential treatment strategy for HCC."
USP46 affects MIR mice
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1
USP46 affects LRP6 receptors
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1
sparser
"These functions of CYLD were implied in a study on another K63-DUB, USP46, which can cleave K63-linked ubiquitination chains from AMPARs and modulate AMPAR internalization and turnover in cultured rat cortical and hippocampal neurons; in this way, USP46 is thought to regulate AMPAR-mediated excitatory synaptic transmission ( xref )."
USP46 affects Infarction
|
1
USP46 activates Infarction. 1 / 1
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1
reach
"In contrast, re-expression of the catalytically inactive USP12 or USP46 mutants, in which the catalytic site cysteine was substituted for serine (Li et al, 2016; Yin et al, 2015), were unable to restore the Itgb1 levels indicating that USP12/46 require the DUB activity to maintain the 125 kDa mature Itgb1 levels (Figs."
USP46 affects ISC
|
1
reach
"We conclude that the Usp46 complex restricts ISC proliferation but is dispensable for asymmetric stem cell division, properties shared with known positive regulators in the Wingless signaling pathway.In the adult posterior midgut, the ability of enterocytes to non-autonomously restrict the proliferation of neighboring ISCs requires Wingless signaling ."
USP46 affects Hypertrophy
|
1
USP46 activates Hypertrophy. 1 / 1
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1
USP46 affects Fibrinogen
|
1
USP46 binds Fibrinogen. 1 / 1
|
1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
USP46 affects ESCC
|
1
USP46 affects Carcinoma, Endometrioid
|
1
USP46 activates Carcinoma, Endometrioid. 1 / 1
|
1
USP46 affects Carcinogenesis
|
1
USP46 activates Carcinogenesis. 1 / 1
|
1
USP46 affects CK1delta
|
1
USP46 affects Arm/β-catenin
|
1
USP46 affects AMPA receptors
|
1
USP46 affects 293T
|
1
USP12 affects MTBMA_c15380
|
1
UAF1 elusive affects USP46
|
1
reach
"https://doi.org/10.3892/mmr.2021.12024.The images for Figure 4A, sh-LINC01260 and sh-Control have been duplicated with the images for Figure 3A, NC and miR-613 mimics, respectively, from Luo et al, 2021.Images for Figure 4F have been duplicated with images for Figure 1D from Xu L, Zhang B, Li W. Downregulated expression levels of USP46 promote the resistance of ovarian cancer to cisplatin and are regulated by PUM2."
Ser351 affects USP46
|
1
Rimonabant affects USP46
1
|
Reperfusion Injury affects USP46
|
1
Reperfusion Injury increases the amount of USP46. 1 / 1
|
1
RNAi affects USP46
|
1
PON2 binds Delta-actitoxin-Avd1a and USP46. 1 / 1
|
1
sparser
"In this study, we explored the association between ncRNA expression and glioma OS, and obtained a prognostic signature containing three ncRNAs, including USP46‐AS1 , PON2 and LOC441179 , based on which we could accurately separate glioma patients with better prognosis from those with a worse prognosis."
PHLPP1 affects leucine
|
1
reach
"Recently, a proteomic study on deubiquitinating enzymes and their associated protein complexes demonstrated that USP46 interacts with PHLPP and SCOP (PH-domain leucine rich repeat protein phosphatase and suprachiasmatic nucleus circadian oscillatory protein), which are members of the of Ser/Thr family of protein phosphatases XREF_BIBR."
PHLPP1 affects 293T
|
1
reach
"These include : (a) overexpression of Nedd4-1 in neurons, which enhances GluA1 ubiquitination, causes a reduction in the number of AMPARs on the plasma membrane; (b) shRNA mediated knockdown of Nedd4-1 increases the rate of GluA1 internalization; (c) overexpression of USP46, which downregulates GluA1 ubiquitination, decreases the accumulation of internalized GluA1 in neurons; and (d) overexpression of GluA1-4KR ubiquitin deficient mutants (where all four C-terminal lysine residues have been substituted with arginines) blocks AMPA induced GluA1 internalization."
N,N-diethyl-m-toluamide affects USP46
1
|
MTBMA_c15380 affects WDR48
|
1
"Microarray profiling uncovers multiple targets of the family, including the cyclin-dependent kinase inhibitor p21/CDKN1A. (See supplemental Table 1: Supplementary Table 1. miR-106b family signature. A consensus set of genes that were significantly down-regulated by miR-106a, miR-106b, miR-17-5p, and miR-20)"
"Microarray profiling uncovers multiple targets of the family, including the cyclin-dependent kinase inhibitor p21/CDKN1A. (See supplemental Table 1: Supplementary Table 1. miR-106b family signature. A consensus set of genes that were significantly down-regulated by miR-106a, miR-106b, miR-17-5p, and miR-20)"
LRP6 receptors affects USP46
|
1
sparser
"These functions of CYLD were implied in a study on another K63-DUB, USP46, which can cleave K63-linked ubiquitination chains from AMPARs and modulate AMPAR internalization and turnover in cultured rat cortical and hippocampal neurons; in this way, USP46 is thought to regulate AMPAR-mediated excitatory synaptic transmission ( xref )."
Fibrinogen affects USP46
|
1
USP46 binds Fibrinogen. 1 / 1
|
1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
EBNA3 proteins affects USP46
|
1
Dietary Fats affects USP46
1
|
Delta-actitoxin-Avd1a affects PON2, and USP46
|
1
PON2 binds Delta-actitoxin-Avd1a and USP46. 1 / 1
|
1
sparser
"In this study, we explored the association between ncRNA expression and glioma OS, and obtained a prognostic signature containing three ncRNAs, including USP46‐AS1 , PON2 and LOC441179 , based on which we could accurately separate glioma patients with better prognosis from those with a worse prognosis."
Circ-NNT affects USP46
|
1
Caenorhabditis elegans homologs WDR20 WDR48 known UAF1 affects USP46
|
1
CK1delta affects USP46
|
1
Alzheimer Disease affects USP46
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1
Alzheimer Disease decreases the amount of USP46. 1 / 1
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1
Acrylamide affects USP46
1
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4-hydroxyphenyl retinamide affects USP46
1
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1
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293T affects USP46
|
1
2,6-dinitrotoluene affects USP46
1
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1
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