IndraLab

Statements

WDR48 affects USP46
14 | 63 45
WDR48 binds USP46.
14 | 42 40
USP46 binds WDR48. 10 / 63
14 | 35 14
reach
"hUSP1 and hUAF1 shares similar mode of interaction with USP46 and UAF1 complex [XREF_BIBR]."
29091922
sparser
"Similar to USP1, human USP46 forms a complex with UAF1 and the activity of USP46 is stimulated by UAF1 ( xref )."
22118673
reach
"Additionally, the study also found out that the UAF1/USP12 and UAF1/USP46 complexes increase p65 expression, which promotes NF-κB activation and increases NLRP3 and IL-1β expression levels."
| PMC
reach
"As stated earlier, UAF1 interacts with two other USPs, USP12 and USP46."
23797609
biogrid
No evidence text available
24850727
reach
"Recent structural insights into the USP46 and UAF1 complex and the USP12, UAF1, and WDR20 complex revealed that the activators interact with surfaces remote from the catalytic center and mediate activation via long-range allosteric mechanisms."
27591049
sparser
"In addition, WDR48 3X interaction with USP46 was partially restored by the USP46 E186K charge-reversal mutant."
26388029
reach
"This motif, and a homologous amino acid segment that mediates USP46 binding to UAF1, map to the Fingers sub-domain of these DUBs."
25744535
sparser
"This motif, and a homologous amino acid segment that mediates USP46 binding to UAF1, map to the Fingers sub-domain of these DUBs."
25744535
reach
"USP12 and USP46 exhibit the conserved USP fold structure comprised of Fingers, Palm and Thumb subdomains, with the catalytic triad of cysteine, histidine and aspartic acid, nestled in between the Palm and Thumb FIGURE 1 | Model of USP46 bound to WDR48 and WDR20."
29302259
WDR20 binds USP46 and WDR48. 10 / 11
| 7 4
sparser
"These results indicate that USP46 does not associate with its accessory factor UAF1 or WDR20 when interacting with or deubiquitinating Cdt2 in high risk E6 transformed cells."
30415951
sparser
"USP46 is normally associated with its accessory proteins UAF1 and WDR20."
30415951
sparser
"Figure 1: Model of USP46 bound to WDR48 and WDR20."
29302259
reach
"Together with data showing that co-expression of the USP-46, WDR-48, and WDR-20 complex reduces levels of ubiquitinated GLR-1, these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo."
29302259
reach
"Because USP46 and USP12 are highly homologous (~ 90% identity) and we could confirm a robust association with USP46 by Western blotting (discussed below), we chose to focus our subsequent attention on the USP46, WDR48, and WDR20 complex."
25855980
reach
"Total levels of WDR48 and USP46 were unchanged upon 4HT withdrawal (XREF_FIG) thus increased signal in the WDR48 ChIP at the p14 was not attributable to increased expression of the constituents of the USP46, WDR48, and WDR20 complex by EBNA3C."
25855980
sparser
"USP12 and USP46 exhibit the conserved USP fold structure comprised of Fingers, Palm and Thumb subdomains, with the catalytic triad of cysteine, histidine and aspartic acid, nestled in between the Palm and Thumb FIGURE 1 | Model of USP46 bound to WDR48 and WDR20."
29302259
reach
"These recent structural and biochemical studies complement in vivo studies of the USP-46, WDR-48, and WDR-20 complex in C. elegans."
29302259
reach
"Together with data showing that co-expression of the USP-46/WDR-48/WDR-20 complex reduces levels of ubiquitinated GLR-1 (Dahlberg and Juo, 2014), these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo.Interestingly, Huo et al. (2015) showed that knock-down of mammalian USP46 has a greater effect on reducing surface GluA1 (42% decrease) and mEPSC amplitude (32% decrease) than overexpression of USP46 (18%–20% increase in surface GluA1 and mEPSC amplitudes; Huo et al., 2015)."
29302259
reach
"Because our TAP lysis procedure extracted both nuclear and cytoplasmic proteins (XREF_SUPPLEMENTARY), we wanted to ensure that the USP46, WDR48, and WDR20 complex subcellular localization was compatible with formation of a complex with EBNA3 proteins."
25855980
USP46 binds USP12 and WDR48. 9 / 9
| 9
sparser
"In addition to USP1, two other DUBs, USP12 and USP46 interact with UAF1 [ xref ], but the UAF1-binding sites in these DUBs have not yet been mapped."
25744535
sparser
"In C. elegans , USP46 and USP12 both bind to USP1-associated factor 1 (UAF1/WDR48) and the binding dramatically enhances the activity of USP12 and USP46 ( xref , xref ; xref )."
26077708
sparser
"UAF1 also binds and activates two other DUBs, USP12 and USP46 ( xref ), and studies that reveal how UAF1 binds and activates USP12 and USP46 suggest that UAF1 will bind to USP1 in an analogous manner ( xref , xref )."
30456385
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"UAF1 also interacts with DUBs USP12 and USP46 ( García-Santisteban et al., 2013 ) and, thus, both genes also could be involved in senescence."
27160904
sparser
"Recent crystallographic studies demonstrate that UAF1 binds to a distinct site on USP12 or USP46 and, through an allosteric interaction, stimulates DUB activity ( xref ; xref )."
30576655
sparser
"The mode of interaction of USP12 and USP46 with UAF1 is still unclear."
23797609
sparser
"Recent structural work revealed how the WD-repeat protein UAF1 interacted with the catalytic domain of USP46 and USP12, which is facilitated predominantly through the “fingers” subdomain of the USP core, mediating long-range allosteric interactions eventually leading to enhanced enzyme efficiency ( xref , xref )."
27591049
sparser
"P65 interacted with USP12, USP46 and UAF1 in both resting and LPS-stimulated macrophages, but exhibited no association with USP1 (Fig.  xref )."
33247121
USP1 binds USP46, USP12, and WDR48. 5 / 5
| 5
sparser
"For example, WDR48 interacts with USP1, USP12, and USP46 to activate their DUB activity ( Cohn et al., 2009; Yin et al., 2015 )."
27880911
sparser
"HPV E1 helicase, which possesses DNA unwinding activity and enhances viral DNA replication, could form a complex with UAF1 and any one of USP1, USP12 and USP46."
35283827
sparser
"For example, WDR48 interacts with USP1, USP12 and USP46 to activate their DUB activity ( xref ; xref )."
27880911
sparser
"UAF1 constitutively binds to USP1, USP12, and USP46, and this binding greatly enhances their deubiquitinase activity."
33247121
sparser
"For example, USP1, USP12 and USP46 can interact with WD40-repeat protein USP1-associated factor 1 (UAF1), and UAF1 stimulates the catalytic activity of human USP1 through the formation of a tight complex [ xref ]."
29386062
Ubiquitin binds USP46 and WDR48. 3 / 3
| 3
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB enzyme ( xref and xref )."
27373336
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB (Figures 2A and 2B) ."
27373336
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB (A and 2B)."
27373336
WDR20 binds USP46, USP12, and WDR48. 2 / 2
| 2
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., xref ; Kee et al., xref ) and further enhances their catalytic activity in vitro (Kee et al., xref ; Faesen et al., xref )."
29302259
USP1 binds USP46 and WDR48. 2 / 2
| 2
sparser
"Homologous amino acid motifs, mapping to the Fingers sub-domain, mediate binding of USP1 and USP46 to UAF1."
25744535
sparser
"Also, UAF1 can interact with USP1 and USP46 in addition to USP12 [ xref ]."
33498168
USP46 binds USP12, WDR48, and USPs. 1 / 1
| 1
sparser
"As stated earlier, UAF1 interacts with two other USPs, USP12 and USP46."
23797609
WDR48 activates USP46.
| 20 5
WDR48 activates USP46. 10 / 24
| 19 5
reach
"WDR48 stimulates the activity of three DUBs, USP12, USP46 and USP1, a DUB which regulates the Fanconi anemia DNA damage pathway."
29302259
reach
"Although mammalian USP46 and USP12 DUB activity can be stimulated by two proteins UAF-1 and WDR20, the C. elegans homologs of these genes have not yet been identified."
21273419
reach
"The WD-repeat protein WDR48 (USP1 associated factor UAF-1) stimulates activity of ubiquitin specific proteases USP1, USP12, and USP46."
26388029
reach
"WDR48 stimulates the activity of three DUBs, USP12, USP46 and USP1, a DUB which regulates the Fanconi anemia DNA damage pathway (Cohn et al., 2007 (Cohn et al., , 2009 Faesen et al., 2011) ."
29302259
reach
"Therefore, this suggests that for some USPs the KG FP reagent may be a better substrate, and provide more relevant kinetic parameters.This study confirmed that the modulator UAF1 activates USP1, USP12[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22195557
reach
"For example, USP1, USP12, and USP46 are activated by the WD40-repeat containing UAF1, and USP7 is activated by GMPS (Cohn et al., 2007, 2009; Faesen et al., 2011; van der Knaap et al., 2005)."
22195557
reach
"Together, UAF1 and WDR20 are able to synergistically stimulate the enzymatic activities of USP12 and USP46 to a peak level."
27373336
sparser
"However, a structural comparison of the enzyme in these two post-reaction forms revealed few conformational differences, leaving the mechanism of USP46 activation by UAF1 elusive."
27373336
reach
"WDR48 and UAF1 is an activator of USP1 and more recently has been shown to activate USP12 and USP46."
19615732
sparser
"UAF1 also binds and activates two other DUBs, USP12 and USP46 ( xref ), and studies that reveal how UAF1 binds and activates USP12 and USP46 suggest that UAF1 will bind to USP1 in an analogous manner ( xref , xref )."
30456385
WDR48 bound to WDR20 activates USP46. 1 / 1
| 1
reach
"We and others previously showed that the WD40-repeat proteins WDR-48 and WDR-20 bind to and stimulate the catalytic activity of USP-46."
33622778
WDR48 deubiquitinates USP46.
| 1
WDR48 deubiquitinates USP46. 1 / 1
| 1
reach
"The E1 protein from anogenital HPV types interacts with the UAF1 associated deubiquitinating enzymes USP1, USP12, and USP46 to stimulate replication of the viral genome."
25833051
USP46 affects WDR48
14 | 43 40
USP46 binds WDR48.
14 | 42 40
USP46 binds WDR48. 10 / 63
14 | 35 14
reach
"hUSP1 and hUAF1 shares similar mode of interaction with USP46 and UAF1 complex [XREF_BIBR]."
29091922
sparser
"Similar to USP1, human USP46 forms a complex with UAF1 and the activity of USP46 is stimulated by UAF1 ( xref )."
22118673
reach
"Additionally, the study also found out that the UAF1/USP12 and UAF1/USP46 complexes increase p65 expression, which promotes NF-κB activation and increases NLRP3 and IL-1β expression levels."
| PMC
reach
"As stated earlier, UAF1 interacts with two other USPs, USP12 and USP46."
23797609
biogrid
No evidence text available
24850727
reach
"Recent structural insights into the USP46 and UAF1 complex and the USP12, UAF1, and WDR20 complex revealed that the activators interact with surfaces remote from the catalytic center and mediate activation via long-range allosteric mechanisms."
27591049
sparser
"In addition, WDR48 3X interaction with USP46 was partially restored by the USP46 E186K charge-reversal mutant."
26388029
reach
"This motif, and a homologous amino acid segment that mediates USP46 binding to UAF1, map to the Fingers sub-domain of these DUBs."
25744535
sparser
"This motif, and a homologous amino acid segment that mediates USP46 binding to UAF1, map to the Fingers sub-domain of these DUBs."
25744535
reach
"USP12 and USP46 exhibit the conserved USP fold structure comprised of Fingers, Palm and Thumb subdomains, with the catalytic triad of cysteine, histidine and aspartic acid, nestled in between the Palm and Thumb FIGURE 1 | Model of USP46 bound to WDR48 and WDR20."
29302259
WDR20 binds USP46 and WDR48. 10 / 11
| 7 4
sparser
"These results indicate that USP46 does not associate with its accessory factor UAF1 or WDR20 when interacting with or deubiquitinating Cdt2 in high risk E6 transformed cells."
30415951
sparser
"USP46 is normally associated with its accessory proteins UAF1 and WDR20."
30415951
sparser
"Figure 1: Model of USP46 bound to WDR48 and WDR20."
29302259
reach
"Together with data showing that co-expression of the USP-46, WDR-48, and WDR-20 complex reduces levels of ubiquitinated GLR-1, these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo."
29302259
reach
"Because USP46 and USP12 are highly homologous (~ 90% identity) and we could confirm a robust association with USP46 by Western blotting (discussed below), we chose to focus our subsequent attention on the USP46, WDR48, and WDR20 complex."
25855980
reach
"Total levels of WDR48 and USP46 were unchanged upon 4HT withdrawal (XREF_FIG) thus increased signal in the WDR48 ChIP at the p14 was not attributable to increased expression of the constituents of the USP46, WDR48, and WDR20 complex by EBNA3C."
25855980
sparser
"USP12 and USP46 exhibit the conserved USP fold structure comprised of Fingers, Palm and Thumb subdomains, with the catalytic triad of cysteine, histidine and aspartic acid, nestled in between the Palm and Thumb FIGURE 1 | Model of USP46 bound to WDR48 and WDR20."
29302259
reach
"These recent structural and biochemical studies complement in vivo studies of the USP-46, WDR-48, and WDR-20 complex in C. elegans."
29302259
reach
"Together with data showing that co-expression of the USP-46/WDR-48/WDR-20 complex reduces levels of ubiquitinated GLR-1 (Dahlberg and Juo, 2014), these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo.Interestingly, Huo et al. (2015) showed that knock-down of mammalian USP46 has a greater effect on reducing surface GluA1 (42% decrease) and mEPSC amplitude (32% decrease) than overexpression of USP46 (18%–20% increase in surface GluA1 and mEPSC amplitudes; Huo et al., 2015)."
29302259
reach
"Because our TAP lysis procedure extracted both nuclear and cytoplasmic proteins (XREF_SUPPLEMENTARY), we wanted to ensure that the USP46, WDR48, and WDR20 complex subcellular localization was compatible with formation of a complex with EBNA3 proteins."
25855980
USP46 binds USP12 and WDR48. 9 / 9
| 9
sparser
"In addition to USP1, two other DUBs, USP12 and USP46 interact with UAF1 [ xref ], but the UAF1-binding sites in these DUBs have not yet been mapped."
25744535
sparser
"In C. elegans , USP46 and USP12 both bind to USP1-associated factor 1 (UAF1/WDR48) and the binding dramatically enhances the activity of USP12 and USP46 ( xref , xref ; xref )."
26077708
sparser
"UAF1 also binds and activates two other DUBs, USP12 and USP46 ( xref ), and studies that reveal how UAF1 binds and activates USP12 and USP46 suggest that UAF1 will bind to USP1 in an analogous manner ( xref , xref )."
30456385
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"UAF1 also interacts with DUBs USP12 and USP46 ( García-Santisteban et al., 2013 ) and, thus, both genes also could be involved in senescence."
27160904
sparser
"Recent crystallographic studies demonstrate that UAF1 binds to a distinct site on USP12 or USP46 and, through an allosteric interaction, stimulates DUB activity ( xref ; xref )."
30576655
sparser
"The mode of interaction of USP12 and USP46 with UAF1 is still unclear."
23797609
sparser
"Recent structural work revealed how the WD-repeat protein UAF1 interacted with the catalytic domain of USP46 and USP12, which is facilitated predominantly through the “fingers” subdomain of the USP core, mediating long-range allosteric interactions eventually leading to enhanced enzyme efficiency ( xref , xref )."
27591049
sparser
"P65 interacted with USP12, USP46 and UAF1 in both resting and LPS-stimulated macrophages, but exhibited no association with USP1 (Fig.  xref )."
33247121
USP1 binds USP46, USP12, and WDR48. 5 / 5
| 5
sparser
"For example, WDR48 interacts with USP1, USP12, and USP46 to activate their DUB activity ( Cohn et al., 2009; Yin et al., 2015 )."
27880911
sparser
"HPV E1 helicase, which possesses DNA unwinding activity and enhances viral DNA replication, could form a complex with UAF1 and any one of USP1, USP12 and USP46."
35283827
sparser
"For example, WDR48 interacts with USP1, USP12 and USP46 to activate their DUB activity ( xref ; xref )."
27880911
sparser
"UAF1 constitutively binds to USP1, USP12, and USP46, and this binding greatly enhances their deubiquitinase activity."
33247121
sparser
"For example, USP1, USP12 and USP46 can interact with WD40-repeat protein USP1-associated factor 1 (UAF1), and UAF1 stimulates the catalytic activity of human USP1 through the formation of a tight complex [ xref ]."
29386062
Ubiquitin binds USP46 and WDR48. 3 / 3
| 3
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB enzyme ( xref and xref )."
27373336
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB (Figures 2A and 2B) ."
27373336
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB (A and 2B)."
27373336
WDR20 binds USP46, USP12, and WDR48. 2 / 2
| 2
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., xref ; Kee et al., xref ) and further enhances their catalytic activity in vitro (Kee et al., xref ; Faesen et al., xref )."
29302259
USP1 binds USP46 and WDR48. 2 / 2
| 2
sparser
"Homologous amino acid motifs, mapping to the Fingers sub-domain, mediate binding of USP1 and USP46 to UAF1."
25744535
sparser
"Also, UAF1 can interact with USP1 and USP46 in addition to USP12 [ xref ]."
33498168
USP46 binds USP12, WDR48, and USPs. 1 / 1
| 1
sparser
"As stated earlier, UAF1 interacts with two other USPs, USP12 and USP46."
23797609
USP46 deubiquitinates WDR48.
| 1
USP46 deubiquitinates WDR48. 1 / 1
| 1
reach
"Usp12 and Usp46 deubiquitinate both H2A and H2B and Uaf-1 is required for this reaction [XREF_BIBR]."
25962961
USP12 affects USP46
2 | 15 34
USP12 binds USP46.
2 | 12 34
USP46 binds USP12. 10 / 25
2 | 12 11
reach
"The more distantly related USP1 is also regulated by WDR48, but WDR20 is unique to USP12 and USP46 complexes."
25855980
sparser
"BIAcore SPR studies demonstrated a dose dependent binding of galeterone to USP12 and USP46 (Figure xref )."
29861848
reach
"Conversely, in the CWR22Rv1 cell line silencing AR FL alone decreased galeterone efficiency by 4 fold compared to SCR control and silencing USP12 or USP12 and USP46 complex members had no significant effect on galeterone efficacy."
29861848
sparser
"The unique binding mode elucidated here thus provides a framework to guide further exploration into the role of the larger USP1 insertions and the particular interactions of USP12 and USP46 in mediati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26388029
reach
"Similarly galeterone inhibition did not have a significant effect on transcript levels of USP12 and USP46 complex members UAF1 (adj. p = 0.4) and WDR20 (adj. p = 0.25)."
29861848
sparser
"UAF1 also binds and activates two other DUBs, USP12 and USP46 ( xref ), and studies that reveal how UAF1 binds and activates USP12 and USP46 suggest that UAF1 will bind to USP1 in an analogous manner ( xref , xref )."
30456385
sparser
"Biochemical and proteomic studies showed that two WDR proteins, WDR48 (also known as USP1-associated factor, UAF1) and WDR20, interact with USP46 and USP12 (Cohn et al., 2009; Sowa et al., 2009; Kee et al., 2010)."
29302259
reach
"Our data demonstrates a proof-of-principle for USP12 and USP46 complex targeting in PC and uncovers additional mechanisms of galeterone activity."
29861848
sparser
"Together, these structural studies suggest that binding of the WDR proteins to USP12 or USP46 relatively far from the active site results in the rearrangement of several structural elements, which propagates to the catalytic triad increasing enzyme catalysis."
29302259
reach
"We therefore tested C527 for its ability to inhibit the purified USP12 and USP46 complex or other DUBs."
24130053
USP46 binds USP12 and WDR48. 9 / 9
| 9
sparser
"In addition to USP1, two other DUBs, USP12 and USP46 interact with UAF1 [ xref ], but the UAF1-binding sites in these DUBs have not yet been mapped."
25744535
sparser
"In C. elegans , USP46 and USP12 both bind to USP1-associated factor 1 (UAF1/WDR48) and the binding dramatically enhances the activity of USP12 and USP46 ( xref , xref ; xref )."
26077708
sparser
"UAF1 also binds and activates two other DUBs, USP12 and USP46 ( xref ), and studies that reveal how UAF1 binds and activates USP12 and USP46 suggest that UAF1 will bind to USP1 in an analogous manner ( xref , xref )."
30456385
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"UAF1 also interacts with DUBs USP12 and USP46 ( García-Santisteban et al., 2013 ) and, thus, both genes also could be involved in senescence."
27160904
sparser
"Recent crystallographic studies demonstrate that UAF1 binds to a distinct site on USP12 or USP46 and, through an allosteric interaction, stimulates DUB activity ( xref ; xref )."
30576655
sparser
"The mode of interaction of USP12 and USP46 with UAF1 is still unclear."
23797609
sparser
"Recent structural work revealed how the WD-repeat protein UAF1 interacted with the catalytic domain of USP46 and USP12, which is facilitated predominantly through the “fingers” subdomain of the USP core, mediating long-range allosteric interactions eventually leading to enhanced enzyme efficiency ( xref , xref )."
27591049
sparser
"P65 interacted with USP12, USP46 and UAF1 in both resting and LPS-stimulated macrophages, but exhibited no association with USP1 (Fig.  xref )."
33247121
USP1 binds USP46, USP12, and WDR48. 5 / 5
| 5
sparser
"For example, WDR48 interacts with USP1, USP12, and USP46 to activate their DUB activity ( Cohn et al., 2009; Yin et al., 2015 )."
27880911
sparser
"HPV E1 helicase, which possesses DNA unwinding activity and enhances viral DNA replication, could form a complex with UAF1 and any one of USP1, USP12 and USP46."
35283827
sparser
"For example, WDR48 interacts with USP1, USP12 and USP46 to activate their DUB activity ( xref ; xref )."
27880911
sparser
"UAF1 constitutively binds to USP1, USP12, and USP46, and this binding greatly enhances their deubiquitinase activity."
33247121
sparser
"For example, USP1, USP12 and USP46 can interact with WD40-repeat protein USP1-associated factor 1 (UAF1), and UAF1 stimulates the catalytic activity of human USP1 through the formation of a tight complex [ xref ]."
29386062
WDR20 binds USP46, USP12, and WDR48. 2 / 2
| 2
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., xref ; Kee et al., xref ) and further enhances their catalytic activity in vitro (Kee et al., xref ; Faesen et al., xref )."
29302259
USP1 binds USP46 and USP12. 2 / 2
| 2
sparser
"UAF1 is a WD40 repeat protein, which binds and activates three important DUBs, USP1, USP12 and USP46."
27650958
sparser
"Although the exact function of p80/Uaf1 in viral DNA replication remains unclear, this WD40 repeats-containing protein is known to interact with the de-ubiquitinating enzymes Usp1, Usp12 and Usp46, whose substrates include PCNA, histones H2A and H2B and Fanconi anaemia complementation group D type 2, a component of the Fanconi anaemia pathway [ xref , xref ]."
23615820
WDR20 binds USP46 and USP12. 2 / 2
| 2
sparser
"Further analysis showed that WDR20 associates exclusively with USP12 and USP46, not with USP1."
20147737
sparser
"WDR20 binding to USP12 and USP46 showed a significant increase in the catalytic activity in vitro [ xref , xref ]."
32512887
USP46 binds USP12, WDR48, and USPs. 1 / 1
| 1
sparser
"As stated earlier, UAF1 interacts with two other USPs, USP12 and USP46."
23797609
USP46 binds USP12 and DMWD. 1 / 1
| 1
sparser
"Experimentally, we first confirmed that DMWD binds both USP12 and USP46 through direct co-immunoprecipitation of epitope-tagged proteins."
33844468
TBK1 binds USP46 and USP12. 1 / 1
| 1
sparser
"In addition, USP12 and USP46 were not associated with TBK1 ( xref )."
29138248
USP12 activates USP46.
| 2
USP12 activates USP46. 1 / 1
| 1
reach
"Identification of Usp12 as a modifier of HD suggested that Usp12 could rescue neurodegeneration in related disorders, such as amyotrophic lateral sclerosis (ALS) and Parkinson 's disease (PD) that are characterized by proteotoxic stress."
30266909
USP12 bound to WDR48 activates USP46. 1 / 1
| 1
reach
"In C. elegans, USP46 and USP12 both bind to USP1 associated factor 1 (UAF1 and WDR48) and the binding dramatically enhances the activity of USP12 and USP46."
26077708
USP12 inhibits USP46.
| 1
USP12 inhibits USP46. 1 / 1
| 1
reach
"We propose a mechanism by which Usp12 suppresses HD related neurodegeneration via induction of autophagy."
30266909
USP46 affects USP12
2 | 13 34
USP46 binds USP12.
2 | 12 34
USP46 binds USP12. 10 / 25
2 | 12 11
reach
"The more distantly related USP1 is also regulated by WDR48, but WDR20 is unique to USP12 and USP46 complexes."
25855980
sparser
"BIAcore SPR studies demonstrated a dose dependent binding of galeterone to USP12 and USP46 (Figure xref )."
29861848
reach
"Conversely, in the CWR22Rv1 cell line silencing AR FL alone decreased galeterone efficiency by 4 fold compared to SCR control and silencing USP12 or USP12 and USP46 complex members had no significant effect on galeterone efficacy."
29861848
sparser
"The unique binding mode elucidated here thus provides a framework to guide further exploration into the role of the larger USP1 insertions and the particular interactions of USP12 and USP46 in mediati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26388029
reach
"Similarly galeterone inhibition did not have a significant effect on transcript levels of USP12 and USP46 complex members UAF1 (adj. p = 0.4) and WDR20 (adj. p = 0.25)."
29861848
sparser
"UAF1 also binds and activates two other DUBs, USP12 and USP46 ( xref ), and studies that reveal how UAF1 binds and activates USP12 and USP46 suggest that UAF1 will bind to USP1 in an analogous manner ( xref , xref )."
30456385
sparser
"Biochemical and proteomic studies showed that two WDR proteins, WDR48 (also known as USP1-associated factor, UAF1) and WDR20, interact with USP46 and USP12 (Cohn et al., 2009; Sowa et al., 2009; Kee et al., 2010)."
29302259
reach
"Our data demonstrates a proof-of-principle for USP12 and USP46 complex targeting in PC and uncovers additional mechanisms of galeterone activity."
29861848
sparser
"Together, these structural studies suggest that binding of the WDR proteins to USP12 or USP46 relatively far from the active site results in the rearrangement of several structural elements, which propagates to the catalytic triad increasing enzyme catalysis."
29302259
reach
"We therefore tested C527 for its ability to inhibit the purified USP12 and USP46 complex or other DUBs."
24130053
USP46 binds USP12 and WDR48. 9 / 9
| 9
sparser
"In addition to USP1, two other DUBs, USP12 and USP46 interact with UAF1 [ xref ], but the UAF1-binding sites in these DUBs have not yet been mapped."
25744535
sparser
"In C. elegans , USP46 and USP12 both bind to USP1-associated factor 1 (UAF1/WDR48) and the binding dramatically enhances the activity of USP12 and USP46 ( xref , xref ; xref )."
26077708
sparser
"UAF1 also binds and activates two other DUBs, USP12 and USP46 ( xref ), and studies that reveal how UAF1 binds and activates USP12 and USP46 suggest that UAF1 will bind to USP1 in an analogous manner ( xref , xref )."
30456385
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"UAF1 also interacts with DUBs USP12 and USP46 ( García-Santisteban et al., 2013 ) and, thus, both genes also could be involved in senescence."
27160904
sparser
"Recent crystallographic studies demonstrate that UAF1 binds to a distinct site on USP12 or USP46 and, through an allosteric interaction, stimulates DUB activity ( xref ; xref )."
30576655
sparser
"The mode of interaction of USP12 and USP46 with UAF1 is still unclear."
23797609
sparser
"Recent structural work revealed how the WD-repeat protein UAF1 interacted with the catalytic domain of USP46 and USP12, which is facilitated predominantly through the “fingers” subdomain of the USP core, mediating long-range allosteric interactions eventually leading to enhanced enzyme efficiency ( xref , xref )."
27591049
sparser
"P65 interacted with USP12, USP46 and UAF1 in both resting and LPS-stimulated macrophages, but exhibited no association with USP1 (Fig.  xref )."
33247121
USP1 binds USP46, USP12, and WDR48. 5 / 5
| 5
sparser
"For example, WDR48 interacts with USP1, USP12, and USP46 to activate their DUB activity ( Cohn et al., 2009; Yin et al., 2015 )."
27880911
sparser
"HPV E1 helicase, which possesses DNA unwinding activity and enhances viral DNA replication, could form a complex with UAF1 and any one of USP1, USP12 and USP46."
35283827
sparser
"For example, WDR48 interacts with USP1, USP12 and USP46 to activate their DUB activity ( xref ; xref )."
27880911
sparser
"UAF1 constitutively binds to USP1, USP12, and USP46, and this binding greatly enhances their deubiquitinase activity."
33247121
sparser
"For example, USP1, USP12 and USP46 can interact with WD40-repeat protein USP1-associated factor 1 (UAF1), and UAF1 stimulates the catalytic activity of human USP1 through the formation of a tight complex [ xref ]."
29386062
WDR20 binds USP46, USP12, and WDR48. 2 / 2
| 2
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., xref ; Kee et al., xref ) and further enhances their catalytic activity in vitro (Kee et al., xref ; Faesen et al., xref )."
29302259
USP1 binds USP46 and USP12. 2 / 2
| 2
sparser
"UAF1 is a WD40 repeat protein, which binds and activates three important DUBs, USP1, USP12 and USP46."
27650958
sparser
"Although the exact function of p80/Uaf1 in viral DNA replication remains unclear, this WD40 repeats-containing protein is known to interact with the de-ubiquitinating enzymes Usp1, Usp12 and Usp46, whose substrates include PCNA, histones H2A and H2B and Fanconi anaemia complementation group D type 2, a component of the Fanconi anaemia pathway [ xref , xref ]."
23615820
WDR20 binds USP46 and USP12. 2 / 2
| 2
sparser
"Further analysis showed that WDR20 associates exclusively with USP12 and USP46, not with USP1."
20147737
sparser
"WDR20 binding to USP12 and USP46 showed a significant increase in the catalytic activity in vitro [ xref , xref ]."
32512887
USP46 binds USP12, WDR48, and USPs. 1 / 1
| 1
sparser
"As stated earlier, UAF1 interacts with two other USPs, USP12 and USP46."
23797609
USP46 binds USP12 and DMWD. 1 / 1
| 1
sparser
"Experimentally, we first confirmed that DMWD binds both USP12 and USP46 through direct co-immunoprecipitation of epitope-tagged proteins."
33844468
TBK1 binds USP46 and USP12. 1 / 1
| 1
sparser
"In addition, USP12 and USP46 were not associated with TBK1 ( xref )."
29138248
USP46 activates USP12.
| 1
USP46 bound to WDR48 activates USP12. 1 / 1
| 1
reach
"In C. elegans, USP46 and USP12 both bind to USP1 associated factor 1 (UAF1 and WDR48) and the binding dramatically enhances the activity of USP12 and USP46."
26077708
E6 affects USP46
| 41
E6 binds USP46.
| 40
USP46 binds E6. 10 / 36
| 36
sparser
"To determine if the stabilization of Cdt2 by E6-USP46 alters Cdt2 substrates in cervical cancers, we checked the expression of Set8 in cancer biopsies."
35008200
sparser
"Turning to the mechanism by which E6 stabilizes Cdt2, we find that a purified E6:USP46 complex has significantly more de-ubiquitinase activity in vitro than USP46 alone, demonstrating that E6 can directly interact with USP46 in the absence of other proteins and that it can substitute for the known activators of USP46, UAF1 and WDR20."
35008200
sparser
"In conclusion, we find that the HPV E6 protein uses the E6-USP46-Cdt2-Set8 pathway to effect epigenetic and gene expression changes in HPV-induced cervical cancers and cell line ( xref ), that the E6 substitutes for the critical role of UAF1 in activating the USP46 deubiquitinase, and that specific regions of Cdt2 are necessary for its stabilization by E6-USP46, ruling out non-specific modes by which Cdt2 might have been deubiquitinated and stabilized."
35008200
sparser
"Collectively, these results suggest that the high risk E6 proteins, but not the low risk E6 proteins, selectively interact with USP46 in cells in situ ."
30415951
sparser
"Recently, it was demonstrated that HR HPV-16, -18 and -31 E6 bind to USP46, but that no interactions were seen with the LR HPV types [ xref ]."
32085533
sparser
"Thus in vitro , E6 interacts with USP46 and promotes the latter’s interaction with Cdt2."
30415951
sparser
"The activation of recombinant USP46 deubiquitinase by recombinant HPV-E6 suggests that E6-USP46 complex also stabilizes the conformational changes in the catalytic center necessary for activation of the deubiquitinase."
35008200
sparser
"USP46 is enzymatically inactive by itself and requires cofactors like UAF1 and WDR20 for its activity, but co-immunoprecipitation experiments suggested that the E6:USP46 complex does not contain UAF1 or WDR20 [ xref , xref , xref ]."
35008200
sparser
"These findings set the stage for screening of inhibitors of USP46 (particularly E6:USP46) that could be of therapeutic value in HPV-induced cancers."
35008200
sparser
"Therefore, a specific modification on either protein or a cellular or viral chaperone may be necessary for the formation of the complex, but once formed, such an E6:USP46 complex is stable and catalytically active."
35008200
USP46 binds DTL and E6. 3 / 3
| 3
sparser
"In Hela cells, E6 is associates with E6AP and p53, and now we find that the E6 protein also associates with USP46 and Cdt2."
30415951
sparser
"The elution profile also suggests that the Cdt2 associates with E6-USP46, as a low-affinity substoichiometric substrate rather than as a core member of the E6-USP46 complex."
30415951
sparser
"We propose that the E6-USP46 interaction promotes the tripartite E6-USP46-Cdt2 complex either due to allosteric changes in USP46, or because Cdt2 interacts simultaneously with sites on E6 and USP46 ( xref )."
30415951
TP53 binds UBE3A, USP46, and E6. 1 / 1
| 1
sparser
"E6 associates specifically with USP46+Cdt2 independent of E6AP, p53 and USP46 accessory proteins."
30415951
E6 activates USP46.
| 1
E6 activates USP46. 1 / 1
| 1
sparser
"Third, does pure recombinant E6 activate recombinant USP46 in the complete absence of known cellular activators of USP46 like UAF1 and WDR20?"
35008200
USP46 affects PHLPP1
9 1 | 18 10
USP46 binds PHLPP1.
9 | 6 10
USP46 binds PHLPP1. 10 / 22
9 | 4 9
sparser
"To determine if the interaction of PHLPP and USP46 is required for USP46-mediated increase of PHLPP expression, the full-length PHLPP1 or the USP46 binding-deficient Δ1139 mutant was co-expressed with USP46."
22391563
biogrid
No evidence text available
19615732
reach
"To determine if the interaction of PHLPP and USP46 is required for USP46 mediated increase of PHLPP expression, the full-length PHLPP1 or the USP46 binding deficient Delta1139 mutant was co-expressed with USP46."
22391563
sparser
"Hence, we checked physical interaction between USP46 and PHLPP1 by coimmunoprecipitation (co-IP)."
33029497
biogrid
No evidence text available
27880917
biogrid
No evidence text available
22391563
biogrid
No evidence text available
22391563
sparser
"Co-immunoprecipitation experiments showed that only USP46 specifically interacted with PHLPP1 in transfected 293T cells whereas other DUBs including USP7 and USP16 failed to binding PHLPP1, thus, demonstrating the specificity of USP46-mediated interaction ( xref )."
22391563
biogrid
No evidence text available
27880917
reach
"To further determine the functional interaction between USP46 and PHLPP, we generated four stable HCT116 cell lines expressing control vector, USP46 alone, PHLPP1 alone, or PHLPP1 plus USP46."
22391563
USP46 binds PHLPP1 and PHLPP2. 1 / 1
| 1
sparser
"We found that USP46 interacted with the C-terminus of PHLPP1 and PHLPP2 ( xref )."
22391563
USP46 binds PHLPP1 and leucine. 1 / 1
| 1
reach
"Recently, a proteomic study on deubiquitinating enzymes and their associated protein complexes demonstrated that USP46 interacts with PHLPP and SCOP (PH-domain leucine rich repeat protein phosphatase and suprachiasmatic nucleus circadian oscillatory protein), which are members of the of Ser/Thr family of protein phosphatases XREF_BIBR."
23472206
USP46 binds PHLPP1 and 293T. 1 / 1
| 1
reach
"Co-immunoprecipitation experiments showed that only USP46 specifically interacted with PHLPP1 in transfected 293T cells whereas other DUBs including USP7 and USP16 failed to binding PHLPP1, thus, demonstrating the specificity of USP46 mediated interaction (XREF_FIG)."
22391563
USP46 activates PHLPP1.
| 6
USP46 activates PHLPP1. 6 / 6
| 6
reach
"If USP46 enhances the stability of PHLPP1, then human tumors with downregulation of PHLPP1 protein might also have decreased expression of USP46."
22391563
reach
"Functionally, USP46 mediated stabilization of PHLPP and the subsequent inhibition of Akt result in a decrease in cell proliferation and tumorigenesis of colon cancer cells in vivo."
22391563
reach
"More importantly, co-expression of USP46 markedly enhanced the ability of PHLPP1 to suppress tumor formation (XREF_FIG)."
22391563
reach
"USP46 potentiates the tumor suppressor function of PHLPP1 in vivo."
22391563
reach
"USP46 enhances PHLPP mediated negative regulation of Akt in cells."
22391563
reach
"Furthermore, knockdown of USP46 attenuated the ability of PHLPP1 to dephosphorylate Akt and to inhibit cell proliferation (XREF_FIG)."
22391563
USP46 ubiquitinates PHLPP1.
| 2
USP46 leads to the ubiquitination of PHLPP1. 2 / 2
| 2
reach
"USP46 directly regulates the ubiquitination of PHLPP1."
22391563
reach
"Here, we investigated whether USP46 directly regulates the level of PHLPP1 ubiquitination in vitro and in cells."
22391563
USP46 increases the amount of PHLPP1.
| 2
Modified USP46 increases the amount of PHLPP1. 1 / 1
| 1
reach
"When a low concentration of PHLPP1 plasmid was transfected into cells alone, the level of PHLPP1 was not sufficient to significantly reduce the rate of cell proliferation, whereas co-expression of USP46 allowed the expression of PHLPP1 to surpass the threshold needed to induce the significant effect (XREF_FIG)."
22391563
USP46 increases the amount of PHLPP1. 1 / 1
| 1
reach
"To determine if the interaction of PHLPP and USP46 is required for USP46 mediated increase of PHLPP expression, the full-length PHLPP1 or the USP46 binding deficient Delta1139 mutant was co-expressed with USP46."
22391563
USP46 deubiquitinates PHLPP1.
1 | 1
Modified USP46 leads to the deubiquitination of PHLPP1. 1 / 1
| 1
reach
"Overexpression of WT USP46 significantly decreased the amount of ubiquitination of PHLPP1 both basally and after MG-132 treatment, while the catalytically inactive mutant USP46 had no effect (XREF_FIG)."
22391563
USP46 deubiquitinates PHLPP1. 1 / 1
1 |
ubibrowser
"SP1 [137] and USP46 [138] are other DUBs known to deubiquitinate PHLPP1"
25121098
USP46 decreases the amount of PHLPP1.
| 1
USP46 decreases the amount of PHLPP1. 1 / 1
| 1
reach
"By stabilizing the expression of PHLPP, USP46 negatively regulates Akt activity in cells and in vivo."
22391563
WDR20 affects USP46
6 | 19 11
WDR20 binds USP46.
6 | 11 8
WDR20 binds USP46 and WDR48. 10 / 11
| 7 4
sparser
"These results indicate that USP46 does not associate with its accessory factor UAF1 or WDR20 when interacting with or deubiquitinating Cdt2 in high risk E6 transformed cells."
30415951
sparser
"USP46 is normally associated with its accessory proteins UAF1 and WDR20."
30415951
sparser
"Figure 1: Model of USP46 bound to WDR48 and WDR20."
29302259
reach
"Together with data showing that co-expression of the USP-46, WDR-48, and WDR-20 complex reduces levels of ubiquitinated GLR-1, these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo."
29302259
reach
"Because USP46 and USP12 are highly homologous (~ 90% identity) and we could confirm a robust association with USP46 by Western blotting (discussed below), we chose to focus our subsequent attention on the USP46, WDR48, and WDR20 complex."
25855980
reach
"Total levels of WDR48 and USP46 were unchanged upon 4HT withdrawal (XREF_FIG) thus increased signal in the WDR48 ChIP at the p14 was not attributable to increased expression of the constituents of the USP46, WDR48, and WDR20 complex by EBNA3C."
25855980
sparser
"USP12 and USP46 exhibit the conserved USP fold structure comprised of Fingers, Palm and Thumb subdomains, with the catalytic triad of cysteine, histidine and aspartic acid, nestled in between the Palm and Thumb FIGURE 1 | Model of USP46 bound to WDR48 and WDR20."
29302259
reach
"These recent structural and biochemical studies complement in vivo studies of the USP-46, WDR-48, and WDR-20 complex in C. elegans."
29302259
reach
"Together with data showing that co-expression of the USP-46/WDR-48/WDR-20 complex reduces levels of ubiquitinated GLR-1 (Dahlberg and Juo, 2014), these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo.Interestingly, Huo et al. (2015) showed that knock-down of mammalian USP46 has a greater effect on reducing surface GluA1 (42% decrease) and mEPSC amplitude (32% decrease) than overexpression of USP46 (18%–20% increase in surface GluA1 and mEPSC amplitudes; Huo et al., 2015)."
29302259
reach
"Because our TAP lysis procedure extracted both nuclear and cytoplasmic proteins (XREF_SUPPLEMENTARY), we wanted to ensure that the USP46, WDR48, and WDR20 complex subcellular localization was compatible with formation of a complex with EBNA3 proteins."
25855980
WDR20 binds USP46. 10 / 10
6 | 4
biogrid
No evidence text available
21183687
reach
"Mechanistically, USP46 can bind with WD40-repeat (WDR) proteins WDR-20 and WDR-48 to stimulate USP46 catalytic activity and increase GLR-1 levels."
26528125
reach
"We propose that WDR-20 and WDR-48 form a complex with USP-46 and stimulate the DUB to deubiquitinate and stabilize GLR-1 in vivo."
24356955
reach
"The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans."
24356955
biogrid
No evidence text available
20147737
reach
"WDR20 binding to USP12 and USP46 showed a significant increase in the catalytic activity in vitro [71,76]."
32512887
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
WDR20 binds USP46, USP12, and WDR48. 2 / 2
| 2
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., xref ; Kee et al., xref ) and further enhances their catalytic activity in vitro (Kee et al., xref ; Faesen et al., xref )."
29302259
WDR20 binds USP46 and USP12. 2 / 2
| 2
sparser
"Further analysis showed that WDR20 associates exclusively with USP12 and USP46, not with USP1."
20147737
sparser
"WDR20 binding to USP12 and USP46 showed a significant increase in the catalytic activity in vitro [ xref , xref ]."
32512887
WDR20 activates USP46.
| 8 3
WDR20 activates USP46. 9 / 9
| 6 3
reach
"Together, UAF1 and WDR20 are able to synergistically stimulate the enzymatic activities of USP12 and USP46 to a peak level."
27373336
reach
"Both WDR48 and WDR20 stimulate USP12 and USP46 catalytic activity (k cat) without increasing substrate binding affinity, suggesting that the WDR proteins may affect DUB activity via a novel structural mechanism."
29302259
reach
"Interestingly, the Caenorhabditis elegans homologs of WDR20 and WDR48 (also known as UAF1) can bind to and activate USP46."
33483467
reach
"We found that increased expression of WDR-48, but not WDR-20, promotes USP-46 abundance in mammalian cells in culture and in C. elegans neurons in vivo Inhibition of the proteasome increased USP-46 abundance, and this effect was non additive with increased WDR-48 expression."
32587090
reach
"Interestingly, USP12 and USP46 are activated by two β-propeller proteins, UAF1, and WDR20."
32512887
sparser
"USP12 and USP46, but not USP1, can be independently activated by another WD40-repeat-containing protein, WDR20 ()."
27373336
sparser
"Interestingly, USP12 and USP46 are activated by two β-propeller proteins, UAF1, and WDR20."
32512887
reach
"Although mammalian USP46 and USP12 DUB activity can be stimulated by two proteins UAF-1 and WDR20, the C. elegans homologs of these genes have not yet been identified."
21273419
sparser
"USP12 and USP46, but not USP1, can be independently activated by another WD40-repeat-containing protein, WDR20 (Burska et al., 2013; Dahlberg and Juo, 2014; Kee et al., 2010; McClurg et al., 2014) ."
27373336
WDR20 bound to WDR48 activates USP46. 2 / 2
| 2
reach
"Indeed, it has been demonstrated that the binding of WDR20 and WDR48 synergistically activates USP46 39."
33483467
reach
"We found that the WD40-repeat proteins WDR-20 and WDR-48 bind and stimulate the catalytic activity of USP-46."
32587090
PHLPP1 affects USP46
9 | 7 10
PHLPP1 binds USP46.
9 | 6 10
USP46 binds PHLPP1. 10 / 22
9 | 4 9
sparser
"To determine if the interaction of PHLPP and USP46 is required for USP46-mediated increase of PHLPP expression, the full-length PHLPP1 or the USP46 binding-deficient Δ1139 mutant was co-expressed with USP46."
22391563
biogrid
No evidence text available
19615732
reach
"To determine if the interaction of PHLPP and USP46 is required for USP46 mediated increase of PHLPP expression, the full-length PHLPP1 or the USP46 binding deficient Delta1139 mutant was co-expressed with USP46."
22391563
sparser
"Hence, we checked physical interaction between USP46 and PHLPP1 by coimmunoprecipitation (co-IP)."
33029497
biogrid
No evidence text available
27880917
biogrid
No evidence text available
22391563
biogrid
No evidence text available
22391563
sparser
"Co-immunoprecipitation experiments showed that only USP46 specifically interacted with PHLPP1 in transfected 293T cells whereas other DUBs including USP7 and USP16 failed to binding PHLPP1, thus, demonstrating the specificity of USP46-mediated interaction ( xref )."
22391563
biogrid
No evidence text available
27880917
reach
"To further determine the functional interaction between USP46 and PHLPP, we generated four stable HCT116 cell lines expressing control vector, USP46 alone, PHLPP1 alone, or PHLPP1 plus USP46."
22391563
USP46 binds PHLPP1 and PHLPP2. 1 / 1
| 1
sparser
"We found that USP46 interacted with the C-terminus of PHLPP1 and PHLPP2 ( xref )."
22391563
USP46 binds PHLPP1 and leucine. 1 / 1
| 1
reach
"Recently, a proteomic study on deubiquitinating enzymes and their associated protein complexes demonstrated that USP46 interacts with PHLPP and SCOP (PH-domain leucine rich repeat protein phosphatase and suprachiasmatic nucleus circadian oscillatory protein), which are members of the of Ser/Thr family of protein phosphatases XREF_BIBR."
23472206
USP46 binds PHLPP1 and 293T. 1 / 1
| 1
reach
"Co-immunoprecipitation experiments showed that only USP46 specifically interacted with PHLPP1 in transfected 293T cells whereas other DUBs including USP7 and USP16 failed to binding PHLPP1, thus, demonstrating the specificity of USP46 mediated interaction (XREF_FIG)."
22391563
PHLPP1 inhibits USP46.
| 1
PHLPP1 inhibits USP46. 1 / 1
| 1
reach
"The rate of cell proliferation followed the pattern of Akt phosphorylation that WT PHLPP1 was unable to significantly inhibit cell growth in USP46 knockdown cells (XREF_FIG)."
22391563
USP46 affects WDR20
6 | 11 8
WDR20 binds USP46 and WDR48. 10 / 11
| 7 4
sparser
"These results indicate that USP46 does not associate with its accessory factor UAF1 or WDR20 when interacting with or deubiquitinating Cdt2 in high risk E6 transformed cells."
30415951
sparser
"USP46 is normally associated with its accessory proteins UAF1 and WDR20."
30415951
sparser
"Figure 1: Model of USP46 bound to WDR48 and WDR20."
29302259
reach
"Together with data showing that co-expression of the USP-46, WDR-48, and WDR-20 complex reduces levels of ubiquitinated GLR-1, these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo."
29302259
reach
"Because USP46 and USP12 are highly homologous (~ 90% identity) and we could confirm a robust association with USP46 by Western blotting (discussed below), we chose to focus our subsequent attention on the USP46, WDR48, and WDR20 complex."
25855980
reach
"Total levels of WDR48 and USP46 were unchanged upon 4HT withdrawal (XREF_FIG) thus increased signal in the WDR48 ChIP at the p14 was not attributable to increased expression of the constituents of the USP46, WDR48, and WDR20 complex by EBNA3C."
25855980
sparser
"USP12 and USP46 exhibit the conserved USP fold structure comprised of Fingers, Palm and Thumb subdomains, with the catalytic triad of cysteine, histidine and aspartic acid, nestled in between the Palm and Thumb FIGURE 1 | Model of USP46 bound to WDR48 and WDR20."
29302259
reach
"These recent structural and biochemical studies complement in vivo studies of the USP-46, WDR-48, and WDR-20 complex in C. elegans."
29302259
reach
"Together with data showing that co-expression of the USP-46/WDR-48/WDR-20 complex reduces levels of ubiquitinated GLR-1 (Dahlberg and Juo, 2014), these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo.Interestingly, Huo et al. (2015) showed that knock-down of mammalian USP46 has a greater effect on reducing surface GluA1 (42% decrease) and mEPSC amplitude (32% decrease) than overexpression of USP46 (18%–20% increase in surface GluA1 and mEPSC amplitudes; Huo et al., 2015)."
29302259
reach
"Because our TAP lysis procedure extracted both nuclear and cytoplasmic proteins (XREF_SUPPLEMENTARY), we wanted to ensure that the USP46, WDR48, and WDR20 complex subcellular localization was compatible with formation of a complex with EBNA3 proteins."
25855980
WDR20 binds USP46. 10 / 10
6 | 4
biogrid
No evidence text available
21183687
reach
"Mechanistically, USP46 can bind with WD40-repeat (WDR) proteins WDR-20 and WDR-48 to stimulate USP46 catalytic activity and increase GLR-1 levels."
26528125
reach
"We propose that WDR-20 and WDR-48 form a complex with USP-46 and stimulate the DUB to deubiquitinate and stabilize GLR-1 in vivo."
24356955
reach
"The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans."
24356955
biogrid
No evidence text available
20147737
reach
"WDR20 binding to USP12 and USP46 showed a significant increase in the catalytic activity in vitro [71,76]."
32512887
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
WDR20 binds USP46, USP12, and WDR48. 2 / 2
| 2
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., xref ; Kee et al., xref ) and further enhances their catalytic activity in vitro (Kee et al., xref ; Faesen et al., xref )."
29302259
WDR20 binds USP46 and USP12. 2 / 2
| 2
sparser
"Further analysis showed that WDR20 associates exclusively with USP12 and USP46, not with USP1."
20147737
sparser
"WDR20 binding to USP12 and USP46 showed a significant increase in the catalytic activity in vitro [ xref , xref ]."
32512887
USP46 affects AS1
| 25
USP46 binds AS1. 10 / 25
| 25
sparser
"Additionally, five adaptive lncRNAs, LINC01138, LINC00942, AL031985.3, AC015908.3 and USP46-AS1, were selected according to the performance of multivariate Cox regression analysis to construct the prognostic signature."
33764367
sparser
"We found 24 overlaps between the two lists of ncRNAs, and three ncRNA signatures, namely USP46‐AS1 , PON2 and LOC441179 , as shown in Table  xref , remained after subjecting the 24 overlaps to the random survival forest model and were used for the establishment of a prognostic signature."
30984542
sparser
"Survival rate is an important indicator of prognosis after treatment, and the significant association of survival rate with the expression levels of USP46‐AS1 , PON2 and LOC441179 suggests that those three ncRNAs should be important indicators for prognosis prediction for glioma patients."
30984542
sparser
"Results of the log-rank test showed that the high expression groups of AC112220.2, AL391121.1, USP46-AS1, AL450326.1, SUCLG2-AS1, RAP2C-AS1, FGD5-AS1, AC018647.2 and AC015922.2 had significantly longer OS than their respective low expression groups (Figure xref )."
33854630
sparser
"Meanwhile high AC112220.2, USP46-AS1, AL450326.1, SUCLG2-AS1, FGD5-AS1, AC018647.2 and AC015922.2 expression groups had remarkably longer DFS (Disease Free Survival) than their respective low expression groups."
33854630
sparser
"Then the expression data of these 2697 lncRNAs and VHL was performed to WGCNA, results showed that 12 lncRNAs (FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, RP11-10C24.1, AC112220.2, AC018647.2, AC015922.2, MID1IP1-AS1, AL731577.2 and AL450326.1) were co-expressed with VHL (Table xref )."
33854630
sparser
"We established the prognostic signature as a risk score formula by subjecting the three ncRNA expression values to multivariate Cox regression analysis in the training set as follows: risk score = −3.1563 × expression level of USP46‐AS1  + 0.3846 × expression level of PON2  + 0.4144 × expression level of LOC441179 ."
30984542
sparser
"Meanwhile, results of the log-rank test also showed that the high AC112220.2, USP46-AS1, AL450326.1, SUCLG2-AS1, FGD5-AS1, AC018647.2 and AC015922.2 expression groups had remarkably longer DFS than their respective low expression groups (Figure xref )."
33854630
sparser
"However, the relative expression of USP46‐AS1 in glioma cells was markedly decreased compared to the control cells ( P  <   0.05)."
30984542
sparser
"Besides, the analysis results of catRAPID showed that AC112220.2, AL391121.1, USP46-AS1, AL450326.1, MID1IP1-AS1, SUCLG2-AS1, RAP2C-AS1, FGD5-AS1, AC018647.2 and AC015922.2 have a certain binding potential with VHL protein."
33854630
USP46 affects GLR1.1
| 20 2
USP46 activates GLR1.1.
| 7
USP46 activates GLR1.1. 6 / 6
| 6
reach
"Furthermore, the co-localization of mCherry : : USP-46 and the endosomal marker Venus : : RAB-5 in the cell body and VNC (XREF_SUPPLEMENTARY) support a model in which USP-46 functions at an endosomal compartment to prevent the targeting of GLR-1 for degradation."
21273419
reach
"Taken together with our previous data, these results suggest that USP-46 prevents the degradation of GLR-1 and promotes its surface expression in the VNC."
21273419
reach
"These data suggest a model whereby USP-46 promotes the abundance of GLR-1 at synapses by acting in a pre-MVB compartment (i.e. endosome) to deubiquitinate GLR-1 and thus prevent its lysosomal degradation (XREF_FIG)."
21273419
reach
"This result suggests that the deubiquitinating activity of USP-46 is required in glr-1-expressing interneurons to promote GLR-1 abundance."
21273419
reach
"Together with data showing that USP-46 partially colocalizes with endosomes, Kowalski et al. (2011) proposed a model where USP-46 acts at endosomes to promote GLR-1 stability and recycling to the cell surface."
29302259
reach
"Several lines of evidence indicate that USP-46 negatively regulates GLR-1 degradation by deubiquitinating the receptor."
21273419
Mutated USP46 activates ubiquitinated GLR1.1. 1 / 1
| 1
reach
"Conversely, mutant USP46 increases ubiquitinated GLR-1."
26528125
USP46 deubiquitinates GLR1.1.
| 5
USP46 deubiquitinates GLR1.1. 5 / 5
| 5
reach
"These findings suggest that USP-46 functions to deubiquitinate GLR-1 and to protect the receptor from degradation."
23316392
reach
"These data support a model in which USP-46 promotes GLR-1 abundance at synapses by deubiquitinating GLR-1 and preventing its degradation in the lysosome."
21273419
reach
"The abundance of GLR-1 (4KR), a mutant receptor which can not be ubiquitinated, is unaffected in usp-46 loss-of-function mutants leading to a model where USP-46 deubiquitinates GLR-1 to regulate its abundance."
29302259
reach
"Second, we tested whether the amount of ubiquitinated GLR-1 is increased in usp-46 mutant animals, as would be expected if USP-46 deubiquitinates GLR-1."
21273419
reach
"These data demonstrate that USP-46 promotes the deubiquitination of GLR-1, which in turn increases the abundance of GLR-1 in the VNC."
21273419
USP46 binds GLR1.1.
| 3 2
USP46 binds GLR1.1. 4 / 4
| 2 2
sparser
"In the ventral nerve cord of C. elegans it was found that USP46 binds to GLR-1, and negatively regulates the levels of its ubiquitination."
26528125
reach
"First, we tested whether USP-46 could interact with GLR-1, as might be expected if GLR-1 were a deubiquitination target of USP-46."
21273419
reach
"In the ventral nerve cord of C. elegans it was found that USP46 binds to GLR-1, and negatively regulates the levels of its ubiquitination."
26528125
sparser
"Biochemical results indicate that although bacterially-expressed recombinant USP46 can interact with GLR-1 from worm extracts, it only exhibits a low level of DUB activity [ xref ]."
23316392
USP46 binds ubiquitinated GLR1.1. 1 / 1
| 1
reach
"Since recombinant GST-GLR-1C is not ubiquitinated, these data are consistent with the idea that USP-46 binds to ubiquitinated GLR-1, which has previously been shown to make up less than 0.5% of total GLR-1 in worms."
21273419
USP46 increases the amount of GLR1.1.
| 3
USP46 increases the amount of GLR1.1. 1 / 1
| 1
reach
"Usp-46 loss-of-function mutants exhibit increased levels of ubiquitinated GLR-1 and decreased levels of GLR-1 at synapses (Kowalski et al., 2011)."
29302259
USP46 bound to WDR48 increases the amount of GLR1.1. 1 / 1
| 1
reach
"Mechanistically, USP46 can bind with WD40-repeat (WDR) proteins WDR-20 and WDR-48 to stimulate USP46 catalytic activity and increase GLR-1 levels."
26528125
USP46 bound to WDR20 increases the amount of GLR1.1. 1 / 1
| 1
reach
"Mechanistically, USP46 can bind with WD40-repeat (WDR) proteins WDR-20 and WDR-48 to stimulate USP46 catalytic activity and increase GLR-1 levels."
26528125
USP46 decreases the amount of GLR1.1.
| 2
USP46 decreases the amount of GLR1.1. 1 / 1
| 1
reach
"Usp-46 loss-of-function mutants exhibit increased levels of ubiquitinated GLR-1 and decreased levels of GLR-1 at synapses (Kowalski et al., 2011) ."
29302259
USP46 decreases the amount of ubiquitinated GLR1.1. 1 / 1
| 1
reach
"Taken together, these data indicate that USP-46 negatively regulates the amount of ubiquitinated GLR-1 in vivo."
21273419
WDR48 affects USP12
| 17
USP46 binds USP12 and WDR48. 9 / 9
| 9
sparser
"In addition to USP1, two other DUBs, USP12 and USP46 interact with UAF1 [ xref ], but the UAF1-binding sites in these DUBs have not yet been mapped."
25744535
sparser
"In C. elegans , USP46 and USP12 both bind to USP1-associated factor 1 (UAF1/WDR48) and the binding dramatically enhances the activity of USP12 and USP46 ( xref , xref ; xref )."
26077708
sparser
"UAF1 also binds and activates two other DUBs, USP12 and USP46 ( xref ), and studies that reveal how UAF1 binds and activates USP12 and USP46 suggest that UAF1 will bind to USP1 in an analogous manner ( xref , xref )."
30456385
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"UAF1 also interacts with DUBs USP12 and USP46 ( García-Santisteban et al., 2013 ) and, thus, both genes also could be involved in senescence."
27160904
sparser
"Recent crystallographic studies demonstrate that UAF1 binds to a distinct site on USP12 or USP46 and, through an allosteric interaction, stimulates DUB activity ( xref ; xref )."
30576655
sparser
"The mode of interaction of USP12 and USP46 with UAF1 is still unclear."
23797609
sparser
"Recent structural work revealed how the WD-repeat protein UAF1 interacted with the catalytic domain of USP46 and USP12, which is facilitated predominantly through the “fingers” subdomain of the USP core, mediating long-range allosteric interactions eventually leading to enhanced enzyme efficiency ( xref , xref )."
27591049
sparser
"P65 interacted with USP12, USP46 and UAF1 in both resting and LPS-stimulated macrophages, but exhibited no association with USP1 (Fig.  xref )."
33247121
USP1 binds USP46, USP12, and WDR48. 5 / 5
| 5
sparser
"For example, WDR48 interacts with USP1, USP12, and USP46 to activate their DUB activity ( Cohn et al., 2009; Yin et al., 2015 )."
27880911
sparser
"HPV E1 helicase, which possesses DNA unwinding activity and enhances viral DNA replication, could form a complex with UAF1 and any one of USP1, USP12 and USP46."
35283827
sparser
"For example, WDR48 interacts with USP1, USP12 and USP46 to activate their DUB activity ( xref ; xref )."
27880911
sparser
"UAF1 constitutively binds to USP1, USP12, and USP46, and this binding greatly enhances their deubiquitinase activity."
33247121
sparser
"For example, USP1, USP12 and USP46 can interact with WD40-repeat protein USP1-associated factor 1 (UAF1), and UAF1 stimulates the catalytic activity of human USP1 through the formation of a tight complex [ xref ]."
29386062
WDR20 binds USP46, USP12, and WDR48. 2 / 2
| 2
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., xref ; Kee et al., xref ) and further enhances their catalytic activity in vitro (Kee et al., xref ; Faesen et al., xref )."
29302259
USP46 binds USP12, WDR48, and USPs. 1 / 1
| 1
sparser
"As stated earlier, UAF1 interacts with two other USPs, USP12 and USP46."
23797609
USP46 affects Ubiquitin
| 7 10
USP46 binds Ubiquitin.
| 5 10
Ubiquitin binds USP46. 10 / 12
| 5 7
sparser
"Binding of WDR20 to the UAF1-USP12 complex induces multiple structural changes in the enzyme, converting it into a compact form similar to Ub-bound USP46."
27373336
reach
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB (Figures 2A and 2B) ."
27373336
reach
"Binding of WDR20 to the UAF1 and USP12 complex induces multiple structural changes in the enzyme, converting it into a compact form similar to Ub bound USP46."
27373336
sparser
"UAF1 activation of USP12 requires structural fine-tuning at the ubiquitin-binding site, while WDR20 directly regulates the catalytic center of the enzyme remotely, transforming USP12 into a compact structure similar to USP46-Ub [ xref ]."
33498168
sparser
"Stabilization of a malleable apo USP46 to favor an active conformation would shift the equilibrium of association and promote productive interaction between ubiquitin and USP46."
26388029
sparser
"The USP46-bound ubiquitin is closer, however, sheltered adjacent to the concave inner face of the WDR48 ancillary domain."
26388029
sparser
"In addition, WDR48 has a novel ancillary domain and a C-terminal SUMO-like domain encircling the USP46-bound ubiquitin."
26388029
reach
"Binding of WDR20 to the UAF1-USP12 complex induces multiple structural changes in the enzyme, converting it into a compact form similar to Ub-bound USP46."
27373336
sparser
"We superimposed the crystal structures of USP46 in a non-covalent complex with WDR20 and WDR48 together with the covalent USP46–ubiquitin complex."
33483467
reach
"Reminiscent of the Ub bound UAF1 and USP46 complex, the UAF1-USP12 structure features an L shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB."
27373336
Ubiquitin binds USP46 and WDR48. 3 / 3
| 3
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB enzyme ( xref and xref )."
27373336
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB (Figures 2A and 2B) ."
27373336
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB (A and 2B)."
27373336
USP46 activates Ubiquitin.
| 2
USP46 activates Ubiquitin. 2 / 2
| 2
reach
"For example, in contrast to the USP46 BL1 residue F258, which supports the tail of Ub, the corresponding USP12 residue F262 is pushed into the catalytic cleft and would collide with the substrate.Using ubiquitin-7-amido-4-methylcoumarin (Ub-AMC) as a substrate, we have previously shown that UAF1 activates USP1 mainly by increasing its catalytic turnover (k cat ), instead of its affinity toward the substrate (K M ) (Cohn et al., 2007) ."
27373336
reach
"Initially, we hypothesized that mHTT was a substrate of Usp12 deubiquitinating activity, which could be a potential mechanism for regulating stability, localization, or other ubiquitin related signaling activity of ubiquitin conjugated mHTT."
30266909
USP12 affects WDR48
| 17
USP46 binds USP12 and WDR48. 9 / 9
| 9
sparser
"In addition to USP1, two other DUBs, USP12 and USP46 interact with UAF1 [ xref ], but the UAF1-binding sites in these DUBs have not yet been mapped."
25744535
sparser
"In C. elegans , USP46 and USP12 both bind to USP1-associated factor 1 (UAF1/WDR48) and the binding dramatically enhances the activity of USP12 and USP46 ( xref , xref ; xref )."
26077708
sparser
"UAF1 also binds and activates two other DUBs, USP12 and USP46 ( xref ), and studies that reveal how UAF1 binds and activates USP12 and USP46 suggest that UAF1 will bind to USP1 in an analogous manner ( xref , xref )."
30456385
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"UAF1 also interacts with DUBs USP12 and USP46 ( García-Santisteban et al., 2013 ) and, thus, both genes also could be involved in senescence."
27160904
sparser
"Recent crystallographic studies demonstrate that UAF1 binds to a distinct site on USP12 or USP46 and, through an allosteric interaction, stimulates DUB activity ( xref ; xref )."
30576655
sparser
"The mode of interaction of USP12 and USP46 with UAF1 is still unclear."
23797609
sparser
"Recent structural work revealed how the WD-repeat protein UAF1 interacted with the catalytic domain of USP46 and USP12, which is facilitated predominantly through the “fingers” subdomain of the USP core, mediating long-range allosteric interactions eventually leading to enhanced enzyme efficiency ( xref , xref )."
27591049
sparser
"P65 interacted with USP12, USP46 and UAF1 in both resting and LPS-stimulated macrophages, but exhibited no association with USP1 (Fig.  xref )."
33247121
USP1 binds USP46, USP12, and WDR48. 5 / 5
| 5
sparser
"For example, WDR48 interacts with USP1, USP12, and USP46 to activate their DUB activity ( Cohn et al., 2009; Yin et al., 2015 )."
27880911
sparser
"HPV E1 helicase, which possesses DNA unwinding activity and enhances viral DNA replication, could form a complex with UAF1 and any one of USP1, USP12 and USP46."
35283827
sparser
"For example, WDR48 interacts with USP1, USP12 and USP46 to activate their DUB activity ( xref ; xref )."
27880911
sparser
"UAF1 constitutively binds to USP1, USP12, and USP46, and this binding greatly enhances their deubiquitinase activity."
33247121
sparser
"For example, USP1, USP12 and USP46 can interact with WD40-repeat protein USP1-associated factor 1 (UAF1), and UAF1 stimulates the catalytic activity of human USP1 through the formation of a tight complex [ xref ]."
29386062
WDR20 binds USP46, USP12, and WDR48. 2 / 2
| 2
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., xref ; Kee et al., xref ) and further enhances their catalytic activity in vitro (Kee et al., xref ; Faesen et al., xref )."
29302259
USP46 binds USP12, WDR48, and USPs. 1 / 1
| 1
sparser
"As stated earlier, UAF1 interacts with two other USPs, USP12 and USP46."
23797609
Ubiquitin affects USP46
| 5 10
Ubiquitin binds USP46. 10 / 12
| 5 7
sparser
"Binding of WDR20 to the UAF1-USP12 complex induces multiple structural changes in the enzyme, converting it into a compact form similar to Ub-bound USP46."
27373336
reach
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB (Figures 2A and 2B) ."
27373336
reach
"Binding of WDR20 to the UAF1 and USP12 complex induces multiple structural changes in the enzyme, converting it into a compact form similar to Ub bound USP46."
27373336
sparser
"UAF1 activation of USP12 requires structural fine-tuning at the ubiquitin-binding site, while WDR20 directly regulates the catalytic center of the enzyme remotely, transforming USP12 into a compact structure similar to USP46-Ub [ xref ]."
33498168
sparser
"Stabilization of a malleable apo USP46 to favor an active conformation would shift the equilibrium of association and promote productive interaction between ubiquitin and USP46."
26388029
sparser
"The USP46-bound ubiquitin is closer, however, sheltered adjacent to the concave inner face of the WDR48 ancillary domain."
26388029
sparser
"In addition, WDR48 has a novel ancillary domain and a C-terminal SUMO-like domain encircling the USP46-bound ubiquitin."
26388029
reach
"Binding of WDR20 to the UAF1-USP12 complex induces multiple structural changes in the enzyme, converting it into a compact form similar to Ub-bound USP46."
27373336
sparser
"We superimposed the crystal structures of USP46 in a non-covalent complex with WDR20 and WDR48 together with the covalent USP46–ubiquitin complex."
33483467
reach
"Reminiscent of the Ub bound UAF1 and USP46 complex, the UAF1-USP12 structure features an L shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB."
27373336
Ubiquitin binds USP46 and WDR48. 3 / 3
| 3
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB enzyme ( xref and xref )."
27373336
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB (Figures 2A and 2B) ."
27373336
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB (A and 2B)."
27373336
USP46 affects DTL
| 14
USP46 binds DTL. 9 / 9
| 9
sparser
"If the interaction of USP46 with Cdt2 is essential for the stabilization of Cdt2, we would expect that the residues of E6 required to stabilize Cdt2 are also essential to promote the interaction of USP46 with Cdt2."
30415951
sparser
"Only high risk but not low risk E6 proteins could promote Cdt2 interaction with USP46 and stabilize Cdt2."
30415951
sparser
"In contrast, Flag-Cdt2 alone from cells without E6 did not co-immunoprecipitate endogenous USP46 ( xref , lane 1), suggesting that Cdt2 and USP46 do not interact with each other in the absence of E6."
30415951
sparser
"Immunoprecipitation of Cdt2 and immunoblotting of the precipitate for USP46 showed that high risk 16E6 and the 1–43 fragment of 16E6, but not low risk 6E6 or 16E6-F2V/P5R, promoted the interaction of USP46 and Cdt2 ( xref ), demonstrating the correlation expected above."
30415951
sparser
"Thus, HPV E6 binds directly to USP46, and this facilitates the interaction of USP46 with its potential substrate Cdt2."
30415951
sparser
"Immunoprecipitation of endogenous cellular Cdt2 coimmunoprecipitated cellular USP46 and E6 only from HeLa cell lysates (that contain HPV E6) but not from U2OS cell lysates (that do not contain E6) ( xref ; xref ), suggesting that E6 is necessary to promote the interaction of Cdt2 with USP46."
30415951
sparser
"E6 protein promotes the interaction of USP46 with Cdt2."
30415951
sparser
"Therefore although our co-immunoprecipitation experiments showed that DDB1 is present in the USP46:Cdt2 complex [ xref ], neither DDB1 nor a substrate of the CRL4-Cdt2 complex is required for the E6:USP46:Cdt2 interaction and subsequent Cdt2 stabilization"
35008200
sparser
"Thus there was a perfect correlation between an E6 variant’s ability to bind USP46 and promote the interaction of USP46 with Cdt2, and the ability of the variant to stabilize Cdt2."
30415951
USP46 binds DTL and E6. 3 / 3
| 3
sparser
"In Hela cells, E6 is associates with E6AP and p53, and now we find that the E6 protein also associates with USP46 and Cdt2."
30415951
sparser
"The elution profile also suggests that the Cdt2 associates with E6-USP46, as a low-affinity substoichiometric substrate rather than as a core member of the E6-USP46 complex."
30415951
sparser
"We propose that the E6-USP46 interaction promotes the tripartite E6-USP46-Cdt2 complex either due to allosteric changes in USP46, or because Cdt2 interacts simultaneously with sites on E6 and USP46 ( xref )."
30415951
USP6 binds USP46 and DTL. 1 / 1
| 1
sparser
"Moreover, miR-3680-5p was associated with the USP6 , USP32 , USP46 , and DTL genes, which have roles in the ubiquitin (deubiquitin) proteolysis system."
28152049
IL17RB binds USP46 and DTL. 1 / 1
| 1
sparser
"Immunoprecipitates of myc-USP46 contained Cdt2 and DDB1 indicating that USP46 associates with CRL4-Cdt2 complex ( xref )."
30415951
WDR48 affects WDR20
| 7 6
WDR20 binds USP46 and WDR48. 10 / 11
| 7 4
sparser
"These results indicate that USP46 does not associate with its accessory factor UAF1 or WDR20 when interacting with or deubiquitinating Cdt2 in high risk E6 transformed cells."
30415951
sparser
"USP46 is normally associated with its accessory proteins UAF1 and WDR20."
30415951
sparser
"Figure 1: Model of USP46 bound to WDR48 and WDR20."
29302259
reach
"Together with data showing that co-expression of the USP-46, WDR-48, and WDR-20 complex reduces levels of ubiquitinated GLR-1, these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo."
29302259
reach
"Because USP46 and USP12 are highly homologous (~ 90% identity) and we could confirm a robust association with USP46 by Western blotting (discussed below), we chose to focus our subsequent attention on the USP46, WDR48, and WDR20 complex."
25855980
reach
"Total levels of WDR48 and USP46 were unchanged upon 4HT withdrawal (XREF_FIG) thus increased signal in the WDR48 ChIP at the p14 was not attributable to increased expression of the constituents of the USP46, WDR48, and WDR20 complex by EBNA3C."
25855980
sparser
"USP12 and USP46 exhibit the conserved USP fold structure comprised of Fingers, Palm and Thumb subdomains, with the catalytic triad of cysteine, histidine and aspartic acid, nestled in between the Palm and Thumb FIGURE 1 | Model of USP46 bound to WDR48 and WDR20."
29302259
reach
"These recent structural and biochemical studies complement in vivo studies of the USP-46, WDR-48, and WDR-20 complex in C. elegans."
29302259
reach
"Together with data showing that co-expression of the USP-46/WDR-48/WDR-20 complex reduces levels of ubiquitinated GLR-1 (Dahlberg and Juo, 2014), these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo.Interestingly, Huo et al. (2015) showed that knock-down of mammalian USP46 has a greater effect on reducing surface GluA1 (42% decrease) and mEPSC amplitude (32% decrease) than overexpression of USP46 (18%–20% increase in surface GluA1 and mEPSC amplitudes; Huo et al., 2015)."
29302259
reach
"Because our TAP lysis procedure extracted both nuclear and cytoplasmic proteins (XREF_SUPPLEMENTARY), we wanted to ensure that the USP46, WDR48, and WDR20 complex subcellular localization was compatible with formation of a complex with EBNA3 proteins."
25855980
WDR20 binds USP46, USP12, and WDR48. 2 / 2
| 2
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., xref ; Kee et al., xref ) and further enhances their catalytic activity in vitro (Kee et al., xref ; Faesen et al., xref )."
29302259
USP46 affects GRIA1
1 1 | 11
USP46 deubiquitinates GRIA1.
1 | 3
USP46 deubiquitinates GRIA1. 4 / 4
1 | 3
reach
"Mammalian USP46 can deubiquitinate both GluA1 and GluA2 subunits and protect AMPARs from degradation (Huo et al., 2015)."
29302259
reach
"We observed that USP46 is able to deubiquitinate not only GluA1 but also GluA2, indicating a relative stringency in contrast to the distinct E3 ligases that are employed for GluA1 and GluA2."
26077708
reach
"Mammalian USP46 can deubiquitinate both GluA1 and GluA2 subunits and protect AMPARs from degradation."
29302259
ubibrowser
"This Editorial Highlight discusses the relevance of a study published in the current issue of Journal of Neurochemistry, in which the authors Huo and collaborators now identified ubiquitin-specific peptidase 46 (USP46) as a specific AMPAR deubiquitinase."
26237995
USP46 decreases the amount of GRIA1.
| 3
USP46 decreases the amount of GRIA1. 2 / 2
| 2
reach
"Knock-down of USP46, but not USP12, results in increased levels of ubiquitinated GluA1, decreased surface and total levels of GluA1, and reduced mEPSC amplitudes, consistent with a role for USP46 in deubiquitinating mammalian AMPARs."
29302259
reach
"Knock-down of USP46, but not USP12, results in increased levels of ubiquitinated GluA1, decreased surface and total levels of GluA1, and reduced mEPSC amplitudes, consistent with a role for USP46 in deubiquitinating mammalian AMPARs (Huo et al., 2015)."
29302259
Modified USP46 decreases the amount of GRIA1. 1 / 1
| 1
reach
"In infected cortical neurons, over-expression of USP46 significantly reduced the ubiquitination level of GluA1, whereas over-expression of USP12 showed no effect (XREF_FIG), again indicating the specificity of USP46 toward GluA1."
26077708
USP46 inhibits GRIA1.
| 2
USP46 inhibits GRIA1. 2 / 2
| 2
reach
"We showed that in HEK cells USP46 over-expression negatively regulates the turnover rate of GluA1 and thus stabilizes GluA1 from degradation."
26077708
reach
"Internalized GluA1 puncta density was also significantly reduced by USP46 over-expression (XREF_FIG) (Control : 6.42 +/- 0.40 puncta per 10 mum, n = 12 neurons; USP46 : 4.73 +/- 0.61 puncta per 10 mum, n = 12 neurons, p = 0.03)."
26077708
USP46 activates GRIA1.
| 2
USP46 activates GRIA1. 2 / 2
| 2
reach
"We found that the surface GluA1 was significantly enhanced by USP46 over-expression."
26077708
reach
"Recently, invivo and invitro studies demonstrated that the DUB USP46 also targets GluA1, regulating AMPAR surface expression, endocytosis, and the strength of synaptic transmission (Huo etal."
27365114
USP46 ubiquitinates GRIA1.
| 1
USP46 leads to the ubiquitination of GRIA1. 1 / 1
| 1
reach
"These include : (a) overexpression of Nedd4-1 in neurons, which enhances GluA1 ubiquitination, causes a reduction in the number of AMPARs on the plasma membrane; (b) shRNA mediated knockdown of Nedd4-1 increases the rate of GluA1 internalization; (c) overexpression of USP46, which downregulates GluA1 ubiquitination, decreases the accumulation of internalized GluA1 in neurons; and (d) overexpression of GluA1-4KR ubiquitin deficient mutants (where all four C-terminal lysine residues have been substituted with arginines) blocks AMPA induced GluA1 internalization."
29123470
USP46 binds GRIA1.
1 |
USP46 binds GRIA1. 1 / 1
1 |
biogrid
No evidence text available
26077708
trips
"USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway."
33029497
reach
"To determine if PHLPP and USP46 function together to negatively regulate cell proliferation, increasing amount of PHLPP1 plasmids was transfected into HCT116 cells alone or in combination with USP46."
22391563
reach
"USP46 is downregulated in lung cancer and suppresses the proliferation of lung cancer cells by inhibiting the PHLPP1 and AKT pathway."
33029497
eidos
"In functional experiments , overexpression of USP46 impaired proliferation and metastasis of HCC cells , whereas knockdown of USP46 enhanced cell proliferation and invasiveness in vitro and in vivo ."
34029571
reach
"In functional experiments, overexpression of USP46 impaired proliferation and metastasis of HCC cells, whereas knockdown of USP46 enhanced cell proliferation and invasiveness in vitro and in vivo."
34029571
reach
"Furthermore, we found that USP46 suppresses HCC cell proliferation and metastasis by inhibiting YAP1."
34029571
reach
"MiR-27a-3p targets USP46 to inhibit the cell proliferation of hepatocellular carcinoma."
35637630
reach
"USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1 and AKT Pathway."
33029497
USP46 activates cell population proliferation. 3 / 3
| 3
reach
"Ectopic expression of YAP1 rescued the inhibition of cell proliferation and metastasis caused by USP46 overexpression."
34029571
reach
"Collectively, our results indicated that miR-27a targets USP46 to promote EC cell proliferation and migration, suggesting an oncogene role of miR-27a in EC."
34239673
reach
"AKT inhibition slows the proliferation of lung cancer cells that have been downregulated by USP46 and exposed to radiation."
33029497
USP46 affects WDR20, and WDR48
| 7 4
WDR20 binds USP46 and WDR48. 10 / 11
| 7 4
sparser
"These results indicate that USP46 does not associate with its accessory factor UAF1 or WDR20 when interacting with or deubiquitinating Cdt2 in high risk E6 transformed cells."
30415951
sparser
"USP46 is normally associated with its accessory proteins UAF1 and WDR20."
30415951
sparser
"Figure 1: Model of USP46 bound to WDR48 and WDR20."
29302259
reach
"Together with data showing that co-expression of the USP-46, WDR-48, and WDR-20 complex reduces levels of ubiquitinated GLR-1, these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo."
29302259
reach
"Because USP46 and USP12 are highly homologous (~ 90% identity) and we could confirm a robust association with USP46 by Western blotting (discussed below), we chose to focus our subsequent attention on the USP46, WDR48, and WDR20 complex."
25855980
reach
"Total levels of WDR48 and USP46 were unchanged upon 4HT withdrawal (XREF_FIG) thus increased signal in the WDR48 ChIP at the p14 was not attributable to increased expression of the constituents of the USP46, WDR48, and WDR20 complex by EBNA3C."
25855980
sparser
"USP12 and USP46 exhibit the conserved USP fold structure comprised of Fingers, Palm and Thumb subdomains, with the catalytic triad of cysteine, histidine and aspartic acid, nestled in between the Palm and Thumb FIGURE 1 | Model of USP46 bound to WDR48 and WDR20."
29302259
reach
"These recent structural and biochemical studies complement in vivo studies of the USP-46, WDR-48, and WDR-20 complex in C. elegans."
29302259
reach
"Together with data showing that co-expression of the USP-46/WDR-48/WDR-20 complex reduces levels of ubiquitinated GLR-1 (Dahlberg and Juo, 2014), these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo.Interestingly, Huo et al. (2015) showed that knock-down of mammalian USP46 has a greater effect on reducing surface GluA1 (42% decrease) and mEPSC amplitude (32% decrease) than overexpression of USP46 (18%–20% increase in surface GluA1 and mEPSC amplitudes; Huo et al., 2015)."
29302259
reach
"Because our TAP lysis procedure extracted both nuclear and cytoplasmic proteins (XREF_SUPPLEMENTARY), we wanted to ensure that the USP46, WDR48, and WDR20 complex subcellular localization was compatible with formation of a complex with EBNA3 proteins."
25855980
USP1 affects USP46
| 2 9
USP1 binds USP46.
| 1 9
USP1 binds USP46, USP12, and WDR48. 5 / 5
| 5
sparser
"For example, WDR48 interacts with USP1, USP12, and USP46 to activate their DUB activity ( Cohn et al., 2009; Yin et al., 2015 )."
27880911
sparser
"HPV E1 helicase, which possesses DNA unwinding activity and enhances viral DNA replication, could form a complex with UAF1 and any one of USP1, USP12 and USP46."
35283827
sparser
"For example, WDR48 interacts with USP1, USP12 and USP46 to activate their DUB activity ( xref ; xref )."
27880911
sparser
"UAF1 constitutively binds to USP1, USP12, and USP46, and this binding greatly enhances their deubiquitinase activity."
33247121
sparser
"For example, USP1, USP12 and USP46 can interact with WD40-repeat protein USP1-associated factor 1 (UAF1), and UAF1 stimulates the catalytic activity of human USP1 through the formation of a tight complex [ xref ]."
29386062
USP1 binds USP46 and WDR48. 2 / 2
| 2
sparser
"Homologous amino acid motifs, mapping to the Fingers sub-domain, mediate binding of USP1 and USP46 to UAF1."
25744535
sparser
"Also, UAF1 can interact with USP1 and USP46 in addition to USP12 [ xref ]."
33498168
USP1 binds USP46 and USP12. 2 / 2
| 2
sparser
"UAF1 is a WD40 repeat protein, which binds and activates three important DUBs, USP1, USP12 and USP46."
27650958
sparser
"Although the exact function of p80/Uaf1 in viral DNA replication remains unclear, this WD40 repeats-containing protein is known to interact with the de-ubiquitinating enzymes Usp1, Usp12 and Usp46, whose substrates include PCNA, histones H2A and H2B and Fanconi anaemia complementation group D type 2, a component of the Fanconi anaemia pathway [ xref , xref ]."
23615820
USP1 binds USP46. 1 / 1
| 1
reach
"Homologous amino acid motifs, mapping to the Fingers sub-domain, mediate binding of USP1 and USP46 to UAF1."
25744535
USP1 activates USP46.
| 1
USP1 activates USP46. 1 / 1
| 1
reach
"The WD-repeat protein WDR48 (USP1 associated factor UAF-1) stimulates activity of ubiquitin specific proteases USP1, USP12, and USP46."
26388029
USP46 affects GRIA
| 9 1
USP46 deubiquitinates GRIA.
| 6
USP46 deubiquitinates GRIA. 5 / 5
| 5
reach
"Together, these data reveal a conserved mechanism where USP46 deubiquitinates AMPARs at synapses to protect them from degradation and promote their recycling to the cell surface to affect synapse function."
29302259
reach
"Endogenous USP46 suppresses AMPAR ubiquitination in neurons."
26077708
reach
"We found that USP46 suppressed AMPAR ubiquitination leading to an increase in receptor protein amount as well as in receptor synaptic localization."
26077708
reach
"Given the same type of deubiquitinating enzyme (USP46) is able to deubiquitinate AMPA receptors, and knockdown of USP46 elevated AMPA receptor ubiquitination and reduced AMPA receptor expression in hi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29501527
reach
"USP46 over-expression leads to a reduction in AMPAR ubiquitination, whereas knockdown of USP46 by either siRNAs or shRNAs causes a significant increase in AMPAR ubiquitination."
26077708
USP46 deubiquitinates GRIA on K48. 1 / 1
| 1
reach
"In contrast, Huo et al. (2015) showed that USP46 preferentially deubiquitinates AMPARs with Lys63- but not Lys48-linked chains in HEK293 cells, suggesting that USP46 chain specificity is controlled by other factors in vivo."
29302259
USP46 ubiquitinates GRIA.
| 1
USP46 ubiquitinates GRIA. 1 / 1
| 1
sparser
"Given the same type of deubiquitinating enzyme (USP46) is able to deubiquitinate AMPA receptors, and knockdown of USP46 elevated AMPA receptor ubiquitination and reduced AMPA receptor expression in hi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29501527
USP46 inhibits GRIA.
| 1
USP46 inhibits GRIA. 1 / 1
| 1
reach
"USP46 over-expression suppresses AMPAR internalization."
26077708
USP46 decreases the amount of GRIA.
| 1
USP46 decreases the amount of GRIA. 1 / 1
| 1
reach
"Given the same type of deubiquitinating enzyme (USP46) is able to deubiquitinate AMPA receptors, and knockdown of USP46 elevated AMPA receptor ubiquitination and reduced AMPA receptor expression in hi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29501527
USP46 activates GRIA.
| 1
USP46 activates GRIA. 1 / 1
| 1
reach
"These functions of CYLD were implied in a study on another K63-DUB, USP46, which can cleave K63-linked ubiquitination chains from AMPARs and modulate AMPAR internalization and turnover in cultured rat cortical and hippocampal neurons; in this way, USP46 is thought to regulate AMPAR-mediated excitatory synaptic transmission (Huo et al., 2015)."
34602983
USP12 affects USP46, and WDR48
| 9
USP46 binds USP12 and WDR48. 9 / 9
| 9
sparser
"In addition to USP1, two other DUBs, USP12 and USP46 interact with UAF1 [ xref ], but the UAF1-binding sites in these DUBs have not yet been mapped."
25744535
sparser
"In C. elegans , USP46 and USP12 both bind to USP1-associated factor 1 (UAF1/WDR48) and the binding dramatically enhances the activity of USP12 and USP46 ( xref , xref ; xref )."
26077708
sparser
"UAF1 also binds and activates two other DUBs, USP12 and USP46 ( xref ), and studies that reveal how UAF1 binds and activates USP12 and USP46 suggest that UAF1 will bind to USP1 in an analogous manner ( xref , xref )."
30456385
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"UAF1 also interacts with DUBs USP12 and USP46 ( García-Santisteban et al., 2013 ) and, thus, both genes also could be involved in senescence."
27160904
sparser
"Recent crystallographic studies demonstrate that UAF1 binds to a distinct site on USP12 or USP46 and, through an allosteric interaction, stimulates DUB activity ( xref ; xref )."
30576655
sparser
"The mode of interaction of USP12 and USP46 with UAF1 is still unclear."
23797609
sparser
"Recent structural work revealed how the WD-repeat protein UAF1 interacted with the catalytic domain of USP46 and USP12, which is facilitated predominantly through the “fingers” subdomain of the USP core, mediating long-range allosteric interactions eventually leading to enhanced enzyme efficiency ( xref , xref )."
27591049
sparser
"P65 interacted with USP12, USP46 and UAF1 in both resting and LPS-stimulated macrophages, but exhibited no association with USP1 (Fig.  xref )."
33247121
WDR48 affects USP1
| 7
USP1 binds USP46, USP12, and WDR48. 5 / 5
| 5
sparser
"For example, WDR48 interacts with USP1, USP12, and USP46 to activate their DUB activity ( Cohn et al., 2009; Yin et al., 2015 )."
27880911
sparser
"HPV E1 helicase, which possesses DNA unwinding activity and enhances viral DNA replication, could form a complex with UAF1 and any one of USP1, USP12 and USP46."
35283827
sparser
"For example, WDR48 interacts with USP1, USP12 and USP46 to activate their DUB activity ( xref ; xref )."
27880911
sparser
"UAF1 constitutively binds to USP1, USP12, and USP46, and this binding greatly enhances their deubiquitinase activity."
33247121
sparser
"For example, USP1, USP12 and USP46 can interact with WD40-repeat protein USP1-associated factor 1 (UAF1), and UAF1 stimulates the catalytic activity of human USP1 through the formation of a tight complex [ xref ]."
29386062
USP1 binds USP46 and WDR48. 2 / 2
| 2
sparser
"Homologous amino acid motifs, mapping to the Fingers sub-domain, mediate binding of USP1 and USP46 to UAF1."
25744535
sparser
"Also, UAF1 can interact with USP1 and USP46 in addition to USP12 [ xref ]."
33498168
USP12 affects USP1
| 7
USP1 binds USP46, USP12, and WDR48. 5 / 5
| 5
sparser
"For example, WDR48 interacts with USP1, USP12, and USP46 to activate their DUB activity ( Cohn et al., 2009; Yin et al., 2015 )."
27880911
sparser
"HPV E1 helicase, which possesses DNA unwinding activity and enhances viral DNA replication, could form a complex with UAF1 and any one of USP1, USP12 and USP46."
35283827
sparser
"For example, WDR48 interacts with USP1, USP12 and USP46 to activate their DUB activity ( xref ; xref )."
27880911
sparser
"UAF1 constitutively binds to USP1, USP12, and USP46, and this binding greatly enhances their deubiquitinase activity."
33247121
sparser
"For example, USP1, USP12 and USP46 can interact with WD40-repeat protein USP1-associated factor 1 (UAF1), and UAF1 stimulates the catalytic activity of human USP1 through the formation of a tight complex [ xref ]."
29386062
USP1 binds USP46 and USP12. 2 / 2
| 2
sparser
"UAF1 is a WD40 repeat protein, which binds and activates three important DUBs, USP1, USP12 and USP46."
27650958
sparser
"Although the exact function of p80/Uaf1 in viral DNA replication remains unclear, this WD40 repeats-containing protein is known to interact with the de-ubiquitinating enzymes Usp1, Usp12 and Usp46, whose substrates include PCNA, histones H2A and H2B and Fanconi anaemia complementation group D type 2, a component of the Fanconi anaemia pathway [ xref , xref ]."
23615820
USP1 affects WDR48
| 7
USP1 binds USP46, USP12, and WDR48. 5 / 5
| 5
sparser
"For example, WDR48 interacts with USP1, USP12, and USP46 to activate their DUB activity ( Cohn et al., 2009; Yin et al., 2015 )."
27880911
sparser
"HPV E1 helicase, which possesses DNA unwinding activity and enhances viral DNA replication, could form a complex with UAF1 and any one of USP1, USP12 and USP46."
35283827
sparser
"For example, WDR48 interacts with USP1, USP12 and USP46 to activate their DUB activity ( xref ; xref )."
27880911
sparser
"UAF1 constitutively binds to USP1, USP12, and USP46, and this binding greatly enhances their deubiquitinase activity."
33247121
sparser
"For example, USP1, USP12 and USP46 can interact with WD40-repeat protein USP1-associated factor 1 (UAF1), and UAF1 stimulates the catalytic activity of human USP1 through the formation of a tight complex [ xref ]."
29386062
USP1 binds USP46 and WDR48. 2 / 2
| 2
sparser
"Homologous amino acid motifs, mapping to the Fingers sub-domain, mediate binding of USP1 and USP46 to UAF1."
25744535
sparser
"Also, UAF1 can interact with USP1 and USP46 in addition to USP12 [ xref ]."
33498168
USP1 affects USP12
| 7
USP1 binds USP46, USP12, and WDR48. 5 / 5
| 5
sparser
"For example, WDR48 interacts with USP1, USP12, and USP46 to activate their DUB activity ( Cohn et al., 2009; Yin et al., 2015 )."
27880911
sparser
"HPV E1 helicase, which possesses DNA unwinding activity and enhances viral DNA replication, could form a complex with UAF1 and any one of USP1, USP12 and USP46."
35283827
sparser
"For example, WDR48 interacts with USP1, USP12 and USP46 to activate their DUB activity ( xref ; xref )."
27880911
sparser
"UAF1 constitutively binds to USP1, USP12, and USP46, and this binding greatly enhances their deubiquitinase activity."
33247121
sparser
"For example, USP1, USP12 and USP46 can interact with WD40-repeat protein USP1-associated factor 1 (UAF1), and UAF1 stimulates the catalytic activity of human USP1 through the formation of a tight complex [ xref ]."
29386062
USP1 binds USP46 and USP12. 2 / 2
| 2
sparser
"UAF1 is a WD40 repeat protein, which binds and activates three important DUBs, USP1, USP12 and USP46."
27650958
sparser
"Although the exact function of p80/Uaf1 in viral DNA replication remains unclear, this WD40 repeats-containing protein is known to interact with the de-ubiquitinating enzymes Usp1, Usp12 and Usp46, whose substrates include PCNA, histones H2A and H2B and Fanconi anaemia complementation group D type 2, a component of the Fanconi anaemia pathway [ xref , xref ]."
23615820
GLR1.1 affects USP46
| 5 2
GLR1.1 binds USP46.
| 3 2
USP46 binds GLR1.1. 4 / 4
| 2 2
sparser
"In the ventral nerve cord of C. elegans it was found that USP46 binds to GLR-1, and negatively regulates the levels of its ubiquitination."
26528125
reach
"First, we tested whether USP-46 could interact with GLR-1, as might be expected if GLR-1 were a deubiquitination target of USP-46."
21273419
reach
"In the ventral nerve cord of C. elegans it was found that USP46 binds to GLR-1, and negatively regulates the levels of its ubiquitination."
26528125
sparser
"Biochemical results indicate that although bacterially-expressed recombinant USP46 can interact with GLR-1 from worm extracts, it only exhibits a low level of DUB activity [ xref ]."
23316392
USP46 binds ubiquitinated GLR1.1. 1 / 1
| 1
reach
"Since recombinant GST-GLR-1C is not ubiquitinated, these data are consistent with the idea that USP-46 binds to ubiquitinated GLR-1, which has previously been shown to make up less than 0.5% of total GLR-1 in worms."
21273419
GLR1.1 activates USP46.
| 2
GLR1.1 activates USP46. 2 / 2
| 2
reach
"First, we tested whether USP-46 could interact with GLR-1, as might be expected if GLR-1 were a deubiquitination target of USP-46."
21273419
reach
"To further test whether USP-46 regulation of reversal frequencies is mediated by GLR-1, we examined if usp-46 mutation could suppress the effects of a dominant-active version of GLR-1 (GLR-1 (A/T)), on locomotion behavior."
21273419
USP46 affects PHLPP2
5 | 1
USP46 binds PHLPP2. 5 / 5
5 |
biogrid
No evidence text available
27880917
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
USP46 binds PHLPP1 and PHLPP2. 1 / 1
| 1
sparser
"We found that USP46 interacted with the C-terminus of PHLPP1 and PHLPP2 ( xref )."
22391563
USP46 affects Histone_H2B
| 6
USP46 deubiquitinates Histone_H2B. 6 / 6
| 6
reach
"Usp12 and Usp46 deubiquitinate both H2A and H2B and Uaf-1 is required for this reaction [XREF_BIBR]."
25962961
reach
"Joo et al. demonstrated that USP46 and USP12 containing fractions from HeLa cells can deubiquitinate histones H2A and H2B to control cell fate and gastrulation during Xenopus development [XREF_BIBR]."
23316392
reach
"In other species, USP46 deubiquitinates deubiquitinate histones H2A and H2B associated to USP12 and WDR48 proteins, reinforcing its epigenetic function [40]."
32078636
reach
"USP12 and USP46 prefer nucleosomal substrates and deubiquitinate both histone H2A and H2B in vitro and in vivo."
21183687
reach
"Both USP12 and USP46 deubiquitinate histone H2A and H2B, affecting Xenopus development (Joo et al., 2011), and, unlike USP1, these smaller USPs can simultaneously bind WDR20 in addition to WDR48 (Joo [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26388029
reach
"It has also been reported that USP12 and USP46 deubiquitinate histone H2A and H2B thereby playing a role in Xenopus development."
27650958
USP46 affects DMWD
5 | 1
USP46 binds DMWD. 5 / 5
5 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
21183687
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
USP46 binds USP12 and DMWD. 1 / 1
| 1
sparser
"Experimentally, we first confirmed that DMWD binds both USP12 and USP46 through direct co-immunoprecipitation of epitope-tagged proteins."
33844468
PUM2 affects USP46
| 4 2
PUM2 binds USP46.
| 3 2
PUM2 binds USP46. 5 / 5
| 3 2
sparser
"As shown in xref , the results of the RIP experiments revealed that PUM2 could bind to USP46 in SKOV3 and SKOV3/DDP cells."
33576437
reach
"The association between USP46 and PUM2 was assessed by RNA immunoprecipitation."
33576437
sparser
"The results of the RNA immunoprecipitation chip assay demonstrated that PUM2 bound to USP46 and regulated its expression."
33576437
reach
"As shown in XREF_FIG, the results of the RIP experiments revealed that PUM2 could bind to USP46 in SKOV3 and SKOV3 and DDP cells."
33576437
reach
"The results of the RNA immunoprecipitation chip assay demonstrated that PUM2 bound to USP46 and regulated its expression."
33576437
PUM2 inhibits USP46.
| 1
PUM2 inhibits USP46. 1 / 1
| 1
reach
"Further experiments revealed that PUM2 attenuated the effects of USP46 on the expression levels of apoptosis related proteins and p-AKT and mTOR expression."
33576437
PHLPP2 affects USP46
5 | 1
USP46 binds PHLPP2. 5 / 5
5 |
biogrid
No evidence text available
27880917
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
USP46 binds PHLPP1 and PHLPP2. 1 / 1
| 1
sparser
"We found that USP46 interacted with the C-terminus of PHLPP1 and PHLPP2 ( xref )."
22391563
DMWD affects USP46
5 | 1
USP46 binds DMWD. 5 / 5
5 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
21183687
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
USP46 binds USP12 and DMWD. 1 / 1
| 1
sparser
"Experimentally, we first confirmed that DMWD binds both USP12 and USP46 through direct co-immunoprecipitation of epitope-tagged proteins."
33844468
WDR proteins affects USP46
| 5
USP46 binds WDR proteins. 5 / 5
| 5
reach
"We highlight recent structural insights into how WDR proteins interact with and regulate USP46, and discuss functions for the USP46/WDR protein complex in the nervous system and across phylogeny.AMPA-type glutamate receptors (AMPARs) mediate the majority of fast excitatory transmission in the brain, and regulation of synaptic AMPAR levels is important for controlling synapse development and function."
29302259
reach
"We highlight recent structural insights into how WDR proteins interact with and regulate USP46, and discuss functions for the USP46 and WDR protein complex in the nervous system and across phylogeny."
29302259
reach
"Together, these structural studies suggest that binding of the WDR proteins to USP12 or USP46 relatively far from the active site results in the rearrangement of several structural elements, which propagates to the catalytic triad increasing enzyme catalysis."
29302259
reach
"Biochemical and proteomic studies showed that two WDR proteins, WDR48 (also known as USP1 associated factor, UAF1) and WDR20, interact with USP46 and USP12."
29302259
reach
"Together, these structural studies suggest that binding of the WDR proteins to USP12 or USP46 relatively far from the active site results in the rearrangement of several structural elements, which propagates to the catalytic triad increasing enzyme catalysis.These recent structural and biochemical studies complement in vivo studies of the USP-46/WDR-48/WDR-20 complex in C. elegans."
29302259
USP46 affects PUM2
| 3 2
PUM2 binds USP46. 5 / 5
| 3 2
sparser
"As shown in xref , the results of the RIP experiments revealed that PUM2 could bind to USP46 in SKOV3 and SKOV3/DDP cells."
33576437
reach
"The association between USP46 and PUM2 was assessed by RNA immunoprecipitation."
33576437
sparser
"The results of the RNA immunoprecipitation chip assay demonstrated that PUM2 bound to USP46 and regulated its expression."
33576437
reach
"As shown in XREF_FIG, the results of the RIP experiments revealed that PUM2 could bind to USP46 in SKOV3 and SKOV3 and DDP cells."
33576437
reach
"The results of the RNA immunoprecipitation chip assay demonstrated that PUM2 bound to USP46 and regulated its expression."
33576437
USP46 affects AKT
| 4 1
USP46 inhibits AKT.
| 3
USP46 inhibits AKT. 3 / 3
| 3
reach
"USP46 activates the Bcl-2 and caspase-3 apoptotic signaling pathway and inactivates AKT activity."
33576437
reach
"Here, we show that USP46 and PHLPP function together to suppress Akt signaling in a mutually dependent manner."
22391563
reach
"Functionally, USP46 mediated stabilization of PHLPP and the subsequent inhibition of Akt result in a decrease in cell proliferation and tumorigenesis of colon cancer cells in vivo."
22391563
USP46 phosphorylates AKT.
| 1
USP46 leads to the phosphorylation of AKT. 1 / 1
| 1
reach
"In the present study, it was revealed that downregulation of USP46 expression levels could also promote the phosphorylation of AKT and mTOR, while the overexpression of USP46 could inhibit the phosphorylation levels."
33576437
USP46 dephosphorylates AKT.
| 1
USP46 dephosphorylates AKT. 1 / 1
| 1
sparser
"Loss of USP46-induced upregulation of Akt dephosphorylation is similar as that observed by knocking down of PHLPP directly ( xref , xref )."
22391563
USP1 affects USP12, USP46, and WDR48
| 5
USP1 binds USP46, USP12, and WDR48. 5 / 5
| 5
sparser
"For example, WDR48 interacts with USP1, USP12, and USP46 to activate their DUB activity ( Cohn et al., 2009; Yin et al., 2015 )."
27880911
sparser
"HPV E1 helicase, which possesses DNA unwinding activity and enhances viral DNA replication, could form a complex with UAF1 and any one of USP1, USP12 and USP46."
35283827
sparser
"For example, WDR48 interacts with USP1, USP12 and USP46 to activate their DUB activity ( xref ; xref )."
27880911
sparser
"UAF1 constitutively binds to USP1, USP12, and USP46, and this binding greatly enhances their deubiquitinase activity."
33247121
sparser
"For example, USP1, USP12 and USP46 can interact with WD40-repeat protein USP1-associated factor 1 (UAF1), and UAF1 stimulates the catalytic activity of human USP1 through the formation of a tight complex [ xref ]."
29386062
Valproic acid affects USP46
4 |
Valproic acid decreases the amount of USP46.
3 |
Valproic acid decreases the amount of USP46. 3 / 3
3 |
ctd
No evidence text available
23179753
ctd
No evidence text available
25192806
ctd
No evidence text available
28001369
Valproic acid methylates USP46.
1 |
Valproic acid methylates USP46. 1 / 1
1 |
ctd
No evidence text available
29154799
WDR20 affects USP12
| 4
WDR20 binds USP46, USP12, and WDR48. 2 / 2
| 2
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., xref ; Kee et al., xref ) and further enhances their catalytic activity in vitro (Kee et al., xref ; Faesen et al., xref )."
29302259
WDR20 binds USP46 and USP12. 2 / 2
| 2
sparser
"Further analysis showed that WDR20 associates exclusively with USP12 and USP46, not with USP1."
20147737
sparser
"WDR20 binding to USP12 and USP46 showed a significant increase in the catalytic activity in vitro [ xref , xref ]."
32512887
USP46 affects USP46
| 4
USP46 ubiquitinates USP46.
| 1
USP46 leads to the ubiquitination of USP46. 1 / 1
| 1
reach
"Stabilization of a malleable apo USP46 to favor an active conformation would shift the equilibrium of association and promote productive interaction between ubiquitin and USP46."
26388029
USP46 inhibits USP46.
| 1
USP46 inhibits USP46. 1 / 1
| 1
reach
"In addition, the expression of USP46 was significantly decreased in 60% of colorectal cancer samples (P < 0.01) indicating a potential tumor suppressor role of USP46."
22391563
USP46 deubiquitinates USP46.
| 1
USP46 deubiquitinates USP46. 1 / 1
| 1
reach
"Given the same type of deubiquitinating enzyme (USP46) is able to deubiquitinate AMPA receptors, and knockdown of USP46 elevated AMPA receptor ubiquitination and reduced AMPA receptor expression in hi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29501527
USP46 activates USP46.
| 1
USP46 bound to WDR48 activates USP46. 1 / 1
| 1
reach
"In C. elegans, USP46 and USP12 both bind to USP1 associated factor 1 (UAF1 and WDR48) and the binding dramatically enhances the activity of USP12 and USP46."
26077708
USP46 affects Neoplasm Metastasis
| 1 3
USP46 inhibits Neoplasm Metastasis.
| 1 1
reach
"Furthermore, we found that USP46 suppresses HCC cell proliferation and metastasis by inhibiting YAP1."
34029571
eidos
"Furthermore , we found that USP46 suppresses HCC cell proliferation and metastasis by inhibiting YAP1 ."
34029571
USP46 activates Neoplasm Metastasis.
| 2
reach
"Ectopic expression of YAP1 rescued the inhibition of cell proliferation and metastasis caused by USP46 overexpression."
34029571
reach
"Moreover, USP46 enhances the migration and invasion of ESCC cells by mediating the EMT process in vitro, and promotes lymph nodes and lung metastasis of ESCC in vivo."
32707136
USP12 affects WDR20
| 4
WDR20 binds USP46, USP12, and WDR48. 2 / 2
| 2
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., xref ; Kee et al., xref ) and further enhances their catalytic activity in vitro (Kee et al., xref ; Faesen et al., xref )."
29302259
WDR20 binds USP46 and USP12. 2 / 2
| 2
sparser
"Further analysis showed that WDR20 associates exclusively with USP12 and USP46, not with USP1."
20147737
sparser
"WDR20 binding to USP12 and USP46 showed a significant increase in the catalytic activity in vitro [ xref , xref ]."
32512887
Bisphenol A affects USP46
3 |
Bisphenol A increases the amount of USP46.
2 |
Bisphenol A increases the amount of USP46. 2 / 2
2 |
ctd
No evidence text available
29275510
ctd
No evidence text available
25181051
Bisphenol A methylates USP46.
1 |
Bisphenol A methylates USP46. 1 / 1
1 |
ctd
No evidence text available
28505145
WDR48 affects Ubiquitin
| 3
Ubiquitin binds USP46 and WDR48. 3 / 3
| 3
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB enzyme ( xref and xref )."
27373336
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB (Figures 2A and 2B) ."
27373336
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB (A and 2B)."
27373336
USP46 affects apoptotic process
| 3
USP46 activates apoptotic process.
| 2
reach
"Furthermore, the overexpression of PUM2 in SKOV3 and DDP cells partially recovered the suppressive effect over proliferation and the increased levels of apoptosis induced by the overexpression of USP46."
33576437
reach
"In SKOV3 and DDP cells, the upregulation of USP46 expression levels notably suppressed cell viability and increased cell apoptosis."
33576437
USP46 inhibits apoptotic process.
| 1
USP46 inhibits apoptotic process. 1 / 1
| 1
reach
"The downregulation of USP46 expression levels in SKOV3 cells significantly inhibited cell apoptosis and increased cell viability."
33576437
USP46 affects YAP1
| 1 2
USP46 inhibits YAP1.
| 1 1
USP46 inhibits YAP1. 2 / 2
| 1 1
eidos
"Mechanistically , USP46 promotes the degradation of YAP1 by increasing expression of MST1 , and the increase in MST1 protein antagonizes YAP1 to suppress HCC progression ."
34029571
reach
"Mechanistically, USP46 promotes the degradation of YAP1 by increasing expression of MST1, and the increase in MST1 protein antagonizes YAP1 to suppress HCC progression."
34029571
USP46 activates YAP1.
| 1
USP46 activates YAP1. 1 / 1
| 1
reach
"Furthermore, we found that USP46 suppresses HCC cell proliferation and metastasis by inhibiting YAP1."
34029571
USP46 affects Ubiquitin, and WDR48
| 3
Ubiquitin binds USP46 and WDR48. 3 / 3
| 3
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB enzyme ( xref and xref )."
27373336
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB (Figures 2A and 2B) ."
27373336
sparser
"Reminiscent of the Ub-bound UAF1-USP46 complex, the UAF1-USP12 structure features an L-shaped architecture, in which the elongated UAF1 protein packs perpendicularly against the DUB (A and 2B)."
27373336
USP46 affects RAD51AP1
3 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP46 inhibits Neoplasm Invasiveness.
| 1 1
USP46 inhibits Neoplasm Invasiveness. 2 / 2
| 1 1
reach
"In functional experiments, overexpression of USP46 impaired proliferation and metastasis of HCC cells, whereas knockdown of USP46 enhanced cell proliferation and invasiveness in vitro and in vivo."
34029571
eidos
"In functional experiments , overexpression of USP46 impaired proliferation and metastasis of HCC cells , whereas knockdown of USP46 enhanced cell proliferation and invasiveness in vitro and in vivo ."
34029571
USP46 activates Neoplasm Invasiveness.
| 1
reach
"Moreover, USP46 enhances the migration and invasion of ESCC cells by mediating the EMT process in vitro, and promotes lymph nodes and lung metastasis of ESCC in vivo."
32707136
USP46 affects Histone
| 3
USP46 deubiquitinates Histone-H2A. 3 / 3
| 3
reach
"Joo et al. demonstrated that USP46 and USP12 containing fractions from HeLa cells can deubiquitinate histones H2A and H2B to control cell fate and gastrulation during Xenopus development [XREF_BIBR]."
23316392
reach
"Several DUBs have been implicated in histone deubiquitination, including USP3, USP12, USP22, and USP46, which deubiquitinate both histones H2A and histones H2B [XREF_BIBR]."
33327527
reach
"In other species, USP46 deubiquitinates deubiquitinate histones H2A and H2B associated to USP12 and WDR48 proteins, reinforcing its epigenetic function [40]."
32078636
USP46 affects GRIA2
| 3
USP46 deubiquitinates GRIA2. 3 / 3
| 3
reach
"Mammalian USP46 can deubiquitinate both GluA1 and GluA2 subunits and protect AMPARs from degradation."
29302259
reach
"We observed that USP46 is able to deubiquitinate not only GluA1 but also GluA2, indicating a relative stringency in contrast to the distinct E3 ligases that are employed for GluA1 and GluA2."
26077708
reach
"Mammalian USP46 can deubiquitinate both GluA1 and GluA2 subunits and protect AMPARs from degradation (Huo et al., 2015)."
29302259
sparser
"In this study, we found that several lncRNAs, including FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, ENSG00000271020, AC112220.2, AC018647.2, AC015922.2, MID1IP1-AS1, AL731577.2 and AL450326.1 were co-expressed with VHL, and their expression were positively correlated with VHL expression."
33854630
sparser
"Lower expression of FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 were associated with advanced tumor stage (Figure xref A); lower expression of RAP2C-AS1 was related to lymphatic invasion (Figure xref B); lower expression of RAP2C-AS1, USP46-AS1, AC112220.2 and AC015922.2 tended to promote tumor metastasis (Figure xref C); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 expression levels were correlated with higher pathological stage (Figure xref D); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2 and AC015922.2 expression levels were also correlated with higher histological grade (Figure xref E)."
33854630
USP46 binds PON2 and Delta-actitoxin-Avd1a. 1 / 1
| 1
sparser
"In this study, we explored the association between ncRNA expression and glioma OS, and obtained a prognostic signature containing three ncRNAs, including USP46‐AS1 , PON2 and LOC441179 , based on which we could accurately separate glioma patients with better prognosis from those with a worse prognosis."
30984542
USP46 affects Cell Survival
| 1 2
USP46 inhibits Cell Survival.
| 1 1
USP46 inhibits Cell Survival. 2 / 2
| 1 1
eidos
"In SKOV3 / DDP cells , the upregulation of USP46 expression levels notably suppressed cell viability and increased cell apoptosis ."
33576437
reach
"In SKOV3 and DDP cells, the upregulation of USP46 expression levels notably suppressed cell viability and increased cell apoptosis."
33576437
USP46 activates Cell Survival.
| 1
USP46 activates Cell Survival. 1 / 1
| 1
reach
"The downregulation of USP46 expression levels in SKOV3 cells significantly inhibited cell apoptosis and increased cell viability."
33576437
USP46 affects CASP3
| 3
USP46 increases the amount of CASP3.
| 1
USP46 increases the amount of CASP3. 1 / 1
| 1
reach
"The present experimental results demonstrated that the knockdown of USP46 upregulated Bcl-2 expression levels and downregulated the expression levels of Bax, caspase-3 and caspase-9."
33576437
USP46 decreases the amount of CASP3.
| 1
USP46 decreases the amount of CASP3. 1 / 1
| 1
reach
"The present experimental results demonstrated that the knockdown of USP46 upregulated Bcl-2 expression levels and downregulated the expression levels of Bax, caspase-3 and caspase-9."
33576437
USP46 activates CASP3.
| 1
USP46 activates CASP3. 1 / 1
| 1
reach
"USP46 activates the Bcl-2 and caspase-3 apoptotic signaling pathway and inactivates AKT activity."
33576437
RAD51AP1 affects USP46
3 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
EBNA3 affects USP46
| 2 1
EBNA3 binds USP46.
| 1 1
USP46 binds EBNA3. 1 / 1
| 1
sparser
"They found that EBNA3 proteins can interact with USP46 deubiquitinating enzyme (DUB) as well as its associated chaperones WDR48 and WDR20 [ xref ]."
35158879
USP46 binds EBNA3. 1 / 1
| 1
reach
"The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46 and USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth."
25855980
EBNA3 activates USP46.
| 1
EBNA3 activates USP46. 1 / 1
| 1
reach
"Because we did not find peptides corresponding to other EBNA proteins in these complexes, each EBNA3 protein appears to target RBPJ and the USP46 and USP12 DUB complexes independently."
25855980
E6 affects DTL
| 3
USP46 binds DTL and E6. 3 / 3
| 3
sparser
"In Hela cells, E6 is associates with E6AP and p53, and now we find that the E6 protein also associates with USP46 and Cdt2."
30415951
sparser
"The elution profile also suggests that the Cdt2 associates with E6-USP46, as a low-affinity substoichiometric substrate rather than as a core member of the E6-USP46 complex."
30415951
sparser
"We propose that the E6-USP46 interaction promotes the tripartite E6-USP46-Cdt2 complex either due to allosteric changes in USP46, or because Cdt2 interacts simultaneously with sites on E6 and USP46 ( xref )."
30415951
sparser
"In this study, we found that several lncRNAs, including FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, ENSG00000271020, AC112220.2, AC018647.2, AC015922.2, MID1IP1-AS1, AL731577.2 and AL450326.1 were co-expressed with VHL, and their expression were positively correlated with VHL expression."
33854630
sparser
"Lower expression of FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 were associated with advanced tumor stage (Figure xref A); lower expression of RAP2C-AS1 was related to lymphatic invasion (Figure xref B); lower expression of RAP2C-AS1, USP46-AS1, AC112220.2 and AC015922.2 tended to promote tumor metastasis (Figure xref C); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 expression levels were correlated with higher pathological stage (Figure xref D); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2 and AC015922.2 expression levels were also correlated with higher histological grade (Figure xref E)."
33854630
USP46 binds PON2 and Delta-actitoxin-Avd1a. 1 / 1
| 1
sparser
"In this study, we explored the association between ncRNA expression and glioma OS, and obtained a prognostic signature containing three ncRNAs, including USP46‐AS1 , PON2 and LOC441179 , based on which we could accurately separate glioma patients with better prognosis from those with a worse prognosis."
30984542
DTL affects E6, and USP46
| 3
USP46 binds DTL and E6. 3 / 3
| 3
sparser
"In Hela cells, E6 is associates with E6AP and p53, and now we find that the E6 protein also associates with USP46 and Cdt2."
30415951
sparser
"The elution profile also suggests that the Cdt2 associates with E6-USP46, as a low-affinity substoichiometric substrate rather than as a core member of the E6-USP46 complex."
30415951
sparser
"We propose that the E6-USP46 interaction promotes the tripartite E6-USP46-Cdt2 complex either due to allosteric changes in USP46, or because Cdt2 interacts simultaneously with sites on E6 and USP46 ( xref )."
30415951
Propeller affects USP46
| 2
Propeller activates USP46. 2 / 2
| 2
reach
"Given the distinct binding mode elucidated here, it is less straightforward to reconcile this structure with direct active-site modulation, yet we propose a mechanism centered on WDR48 dependent USP s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26388029
reach
"In this in vitro setting, a construct consisting of only the WDR48 beta propeller (27-359) was able to stimulate USP46 almost as well as the full-length WT WDR48 construct, again corroborating the imp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26388029
Muscimol affects USP46
| 2
Muscimol inhibits mutated USP46. 2 / 2
| 2
reach
"The muscimol induced current in the hippocampal CA1 pyramidal neurons and hippocampal expression of the 67-kDa isoform of glutamic acid decarboxylase significantly decreased in the Usp46 mutant mice compared to control mice."
20297739
reach
"The muscimol induced current in the hippocampal CA1 pyramidal neurons and hippocampal expression of the 67-kDa isoform of glutamic acid decarboxylase were significantly decreased in the Usp46 mutant mice compared to control mice."
19465912
Hsa-miR-873-5p affects USP46
2 |
Hsa-miR-873-5p decreases the amount of USP46. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6893-3p affects USP46
2 |
Hsa-miR-6893-3p decreases the amount of USP46. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6765-3p affects USP46
2 |
Hsa-miR-6765-3p decreases the amount of USP46. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-5585-5p affects USP46
2 |
Hsa-miR-5585-5p decreases the amount of USP46. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548ax affects USP46
2 |
Hsa-miR-548ax decreases the amount of USP46. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548ao-5p affects USP46
2 |
Hsa-miR-548ao-5p decreases the amount of USP46. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4797-5p affects USP46
2 |
Hsa-miR-4797-5p decreases the amount of USP46. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4722-5p affects USP46
2 |
Hsa-miR-4722-5p decreases the amount of USP46. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-370-3p affects USP46
2 |
Hsa-miR-370-3p decreases the amount of USP46. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-3622b-3p affects USP46
2 |
Hsa-miR-3622b-3p decreases the amount of USP46. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-3622a-3p affects USP46
2 |
Hsa-miR-3622a-3p decreases the amount of USP46. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-1286 affects USP46
2 |
Hsa-miR-1286 decreases the amount of USP46. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-1205 affects USP46
2 |
Hsa-miR-1205 decreases the amount of USP46. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
reach
"Therefore, in the present study, we examined whether the immobility time is influenced by drugs affecting the action mediated by GABA A receptor using both 3-bp deleted (the Usp46 mutant) and null Usp46 (Usp46 KO) mice."
22720038
Gamma-aminobutyric acid activates mutated USP46. 1 / 1
| 1
reach
"Therefore, in the present study, we examined whether the immobility time is influenced by drugs affecting the action mediated by GABA A receptor using both 3-bp deleted (the Usp46 mutant) and null Usp46 (Usp46 KO) mice."
22720038
Aflatoxin B1 affects USP46
2 |
Aflatoxin B1 methylates USP46.
1 |
Aflatoxin B1 methylates USP46. 1 / 1
1 |
ctd
No evidence text available
30157460
Aflatoxin B1 demethylates USP46.
1 |
Aflatoxin B1 demethylates USP46. 1 / 1
1 |
ctd
No evidence text available
27153756
WDR protein affects USP46
| 2
USP46 binds WDR protein. 2 / 2
| 2
reach
"We highlight recent structural insights into how WDR proteins interact with and regulate USP46, and discuss functions for the USP46 and WDR protein complex in the nervous system and across phylogeny."
29302259
reach
"We highlight recent structural insights into how WDR proteins interact with and regulate USP46, and discuss functions for the USP46/WDR protein complex in the nervous system and across phylogeny.AMPA-type glutamate receptors (AMPARs) mediate the majority of fast excitatory transmission in the brain, and regulation of synaptic AMPAR levels is important for controlling synapse development and function."
29302259
USP46 affects mHTT
| 2
USP46 inhibits mHTT. 2 / 2
| 2
reach
"When transfected at a similar gene dose as that at which Usp12 rescues mHTT toxicity, Usp46 did not block degeneration of mHTT expressing neurons."
30266909
reach
"The neuroprotective role of Usp12 may be specific amongst related deubiquitinases, as the closely related homolog Usp46 does not suppress mHTT mediated toxicity."
30266909
USP46 affects lung cancer cells
| 2
USP46 inhibits lung cancer cells.
| 1
USP46 inhibits lung cancer cells. 1 / 1
| 1
eidos
"AKT inhibition slows the proliferation of lung cancer cells that have been downregulated by USP46 and exposed to radiation ."
33029497
USP46 activates lung cancer cells.
| 1
USP46 activates lung cancer cells. 1 / 1
| 1
eidos
"USP46 is downregulated in lung cancer and suppresses the proliferation of lung cancer cells by inhibiting the PHLPP1 / AKT pathway ."
33029497
USP46 deubiquitinates gamma-aminobutyric acid.
| 1
reach
"It will be important in the future to test if USP46 functions in GABA neurons and whether it directly deubiquitinates components of the GABA system.WDR proteins are involved in protein-protein interactions that mediate diverse cellular processes."
29302259
reach
"It is thought that Usp46 deficiency causes dysfunction of gamma-aminobutyric acid A (GABA A) receptor activity [XREF_BIBR, XREF_BIBR]."
26284364
USP46 affects WDR protein
| 2
USP46 binds WDR protein. 2 / 2
| 2
reach
"We highlight recent structural insights into how WDR proteins interact with and regulate USP46, and discuss functions for the USP46 and WDR protein complex in the nervous system and across phylogeny."
29302259
reach
"We highlight recent structural insights into how WDR proteins interact with and regulate USP46, and discuss functions for the USP46/WDR protein complex in the nervous system and across phylogeny.AMPA-type glutamate receptors (AMPARs) mediate the majority of fast excitatory transmission in the brain, and regulation of synaptic AMPAR levels is important for controlling synapse development and function."
29302259
USP46 affects SUCLG2
| 2
sparser
"In this study, we found that several lncRNAs, including FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, ENSG00000271020, AC112220.2, AC018647.2, AC015922.2, MID1IP1-AS1, AL731577.2 and AL450326.1 were co-expressed with VHL, and their expression were positively correlated with VHL expression."
33854630
sparser
"Lower expression of FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 were associated with advanced tumor stage (Figure xref A); lower expression of RAP2C-AS1 was related to lymphatic invasion (Figure xref B); lower expression of RAP2C-AS1, USP46-AS1, AC112220.2 and AC015922.2 tended to promote tumor metastasis (Figure xref C); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 expression levels were correlated with higher pathological stage (Figure xref D); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2 and AC015922.2 expression levels were also correlated with higher histological grade (Figure xref E)."
33854630
USP46 affects SNX6
2 |
SNX6 binds USP46. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP46 affects SNX2
2 |
SNX2 binds USP46. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
USP46 affects IFI30
2 |
USP46 binds IFI30. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP46 affects HSPA8
2 |
USP46 binds HSPA8. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP46 affects H2BC21
1 1 |
USP46 deubiquitinates H2BC21.
1 |
USP46 deubiquitinates H2BC21. 1 / 1
1 |
ubibrowser
"Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46."
21183687
USP46 binds H2BC21.
1 |
USP46 binds H2BC21. 1 / 1
1 |
biogrid
No evidence text available
21183687
USP46 affects H2AC20
1 1 |
USP46 deubiquitinates H2AC20.
1 |
USP46 deubiquitinates H2AC20. 1 / 1
1 |
ubibrowser
"Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46."
21183687
USP46 binds H2AC20.
1 |
USP46 binds H2AC20. 1 / 1
1 |
biogrid
No evidence text available
21183687
USP46 affects EBNA3
| 1 1
USP46 binds EBNA3. 1 / 1
| 1
sparser
"They found that EBNA3 proteins can interact with USP46 deubiquitinating enzyme (DUB) as well as its associated chaperones WDR48 and WDR20 [ xref ]."
35158879
USP46 binds EBNA3. 1 / 1
| 1
reach
"The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46 and USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth."
25855980
USP46 affects CASP9
| 2
USP46 increases the amount of CASP9.
| 1
USP46 increases the amount of CASP9. 1 / 1
| 1
reach
"The present experimental results demonstrated that the knockdown of USP46 upregulated Bcl-2 expression levels and downregulated the expression levels of Bax, caspase-3 and caspase-9."
33576437
USP46 decreases the amount of CASP9.
| 1
USP46 decreases the amount of CASP9. 1 / 1
| 1
reach
"The present experimental results demonstrated that the knockdown of USP46 upregulated Bcl-2 expression levels and downregulated the expression levels of Bax, caspase-3 and caspase-9."
33576437
USP46 affects BCL2
| 2
USP46 decreases the amount of BCL2.
| 1
USP46 decreases the amount of BCL2. 1 / 1
| 1
reach
"The present experimental results demonstrated that the knockdown of USP46 upregulated Bcl-2 expression levels and downregulated the expression levels of Bax, caspase-3 and caspase-9."
33576437
USP46 activates BCL2.
| 1
USP46 activates BCL2. 1 / 1
| 1
reach
"USP46 activates the Bcl-2 and caspase-3 apoptotic signaling pathway and inactivates AKT activity."
33576437
USP46 affects BAX
| 2
USP46 increases the amount of BAX.
| 1
USP46 increases the amount of BAX. 1 / 1
| 1
reach
"The present experimental results demonstrated that the knockdown of USP46 upregulated Bcl-2 expression levels and downregulated the expression levels of Bax, caspase-3 and caspase-9."
33576437
USP46 decreases the amount of BAX.
| 1
USP46 decreases the amount of BAX. 1 / 1
| 1
reach
"The present experimental results demonstrated that the knockdown of USP46 upregulated Bcl-2 expression levels and downregulated the expression levels of Bax, caspase-3 and caspase-9."
33576437
USP46 affects AR
1 | 1
USP46 deubiquitinates AR. 2 / 2
1 | 1
reach
"Furthermore, overexpressed USP46 was able to deubiquitinate AR, similarly to our previous observations for USP12 [XREF_BIBR]."
29861848
ubibrowser
"Here we report that the novel small molecule anti-androgen, galeterone targets USP12 and USP46, two highly homologous deubiquitinating enzymes that control the AR-AKT-MDM2-P53 signalling pathway."
29861848
USP46 affects ACTB
2 |
ACTB binds USP46. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP12 affects USP46, WDR20, and WDR48
| 2
WDR20 binds USP46, USP12, and WDR48. 2 / 2
| 2
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., 2009; Kee et al., 2010) and further enhances their catalytic activity in vitro (Kee et al., 2010; Faesen et al., 2011)."
29302259
sparser
"WDR20 forms a unique ternary complex with WDR48 and either USP12 or USP46 (Sowa et al., xref ; Kee et al., xref ) and further enhances their catalytic activity in vitro (Kee et al., xref ; Faesen et al., xref )."
29302259
USP12 affects USP46, and WDR20
| 2
WDR20 binds USP46 and USP12. 2 / 2
| 2
sparser
"Further analysis showed that WDR20 associates exclusively with USP12 and USP46, not with USP1."
20147737
sparser
"WDR20 binding to USP12 and USP46 showed a significant increase in the catalytic activity in vitro [ xref , xref ]."
32512887
USP1 affects USP46, and WDR48
| 2
USP1 binds USP46 and WDR48. 2 / 2
| 2
sparser
"Homologous amino acid motifs, mapping to the Fingers sub-domain, mediate binding of USP1 and USP46 to UAF1."
25744535
sparser
"Also, UAF1 can interact with USP1 and USP46 in addition to USP12 [ xref ]."
33498168
USP1 affects USP12, and USP46
| 2
USP1 binds USP46 and USP12. 2 / 2
| 2
sparser
"UAF1 is a WD40 repeat protein, which binds and activates three important DUBs, USP1, USP12 and USP46."
27650958
sparser
"Although the exact function of p80/Uaf1 in viral DNA replication remains unclear, this WD40 repeats-containing protein is known to interact with the de-ubiquitinating enzymes Usp1, Usp12 and Usp46, whose substrates include PCNA, histones H2A and H2B and Fanconi anaemia complementation group D type 2, a component of the Fanconi anaemia pathway [ xref , xref ]."
23615820
TCF3 affects USP46
2 |
TCF3 decreases the amount of USP46. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
SUCLG2 affects USP46
| 2
sparser
"In this study, we found that several lncRNAs, including FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, ENSG00000271020, AC112220.2, AC018647.2, AC015922.2, MID1IP1-AS1, AL731577.2 and AL450326.1 were co-expressed with VHL, and their expression were positively correlated with VHL expression."
33854630
sparser
"Lower expression of FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 were associated with advanced tumor stage (Figure xref A); lower expression of RAP2C-AS1 was related to lymphatic invasion (Figure xref B); lower expression of RAP2C-AS1, USP46-AS1, AC112220.2 and AC015922.2 tended to promote tumor metastasis (Figure xref C); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 expression levels were correlated with higher pathological stage (Figure xref D); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2 and AC015922.2 expression levels were also correlated with higher histological grade (Figure xref E)."
33854630
SPI1 affects USP46
2 |
SPI1 decreases the amount of USP46. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
SNX6 affects USP46
2 |
SNX6 binds USP46. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
SNX2 affects USP46
2 |
SNX2 binds USP46. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
Particulate Matter increases the amount of USP46.
1 |
Particulate Matter increases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
29883952
Particulate Matter decreases the amount of USP46.
1 |
Particulate Matter decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
29883952
IFI30 affects USP46
2 |
USP46 binds IFI30. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
HSPA8 affects USP46
2 |
USP46 binds HSPA8. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
sparser
"In this study, we found that several lncRNAs, including FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, ENSG00000271020, AC112220.2, AC018647.2, AC015922.2, MID1IP1-AS1, AL731577.2 and AL450326.1 were co-expressed with VHL, and their expression were positively correlated with VHL expression."
33854630
sparser
"Lower expression of FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 were associated with advanced tumor stage (Figure xref A); lower expression of RAP2C-AS1 was related to lymphatic invasion (Figure xref B); lower expression of RAP2C-AS1, USP46-AS1, AC112220.2 and AC015922.2 tended to promote tumor metastasis (Figure xref C); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2, AC015922.2 and AL450326.1 expression levels were correlated with higher pathological stage (Figure xref D); lower FGD5-AS1, RAP2C-AS1, SUCLG2-AS1, USP46-AS1, AL391121.1, AC112220.2, AC018647.2 and AC015922.2 expression levels were also correlated with higher histological grade (Figure xref E)."
33854630
Air Pollutants affects USP46
2 |
Air Pollutants increases the amount of USP46.
1 |
Air Pollutants increases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
29883952
Air Pollutants decreases the amount of USP46.
1 |
Air Pollutants decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
29883952
ACTB affects USP46
2 |
ACTB binds USP46. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
Vinclozolin affects USP46
1 |
Vinclozolin increases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
23034163
Trifluoperazine affects USP46
| 1
reach
"Pimozide, flupenthixol and trifluoperazine did not inhibit USP46 and UAF1 at the highest inhibitor concentrations tested (114 muM), while low level of inhibition by GW7647 was observed (IC 50 = 12 muM, XREF_TABLE)."
22118673
Topotecan affects USP46
1 |
Topotecan decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
25729387
Silver(0) affects USP46
1 |
Silver(0) decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
27131904
SiRNA-mediated wdr48 affects USP46
| 1
SiRNA-mediated wdr48 activates USP46. 1 / 1
| 1
eidos
"Finally , siRNA-mediated knockdown of wdr48 destabilizes USP46 in mammalian cells ."
32587090
Quercetin affects USP46
1 |
Quercetin decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
21632981
Potassium dichromate increases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
23608068
Polyubiquitin chains affects USP46
| 1
USP46 binds polyubiquitin chains. 1 / 1
| 1
reach
"USP46 binds to PHLPP and directly removes the polyubiquitin chains from PHLPP in vitro and in cells."
22391563
Piroxicam affects USP46
1 |
Piroxicam decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
21858171
Pimozide affects USP46
| 1
Pimozide inhibits USP46. 1 / 1
| 1
reach
"Pimozide, flupenthixol and trifluoperazine did not inhibit USP46 and UAF1 at the highest inhibitor concentrations tested (114 muM), while low level of inhibition by GW7647 was observed (IC 50 = 12 muM, XREF_TABLE)."
22118673
Phlorizin affects USP46
1 |
Phlorizin decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
22538082
Oxaliplatin affects USP46
1 |
Oxaliplatin decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
25729387
Nitrazepam affects USP46
| 1
Nitrazepam activates mutated USP46. 1 / 1
| 1
reach
"The Usp46 KO mice exhibited short immobility times comparable to the Usp46 mutant mice, which was also increased by nitrazepam administration."
22720038
Mono(2-ethylhexyl) phthalate decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
31059758
Methylmercury chloride decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
28001369
Methyl methanesulfonate increases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
23649840
Leucine affects USP46
| 1
USP46 binds PHLPP1 and leucine. 1 / 1
| 1
reach
"Recently, a proteomic study on deubiquitinating enzymes and their associated protein complexes demonstrated that USP46 interacts with PHLPP and SCOP (PH-domain leucine rich repeat protein phosphatase and suprachiasmatic nucleus circadian oscillatory protein), which are members of the of Ser/Thr family of protein phosphatases XREF_BIBR."
23472206
Hsa-miR-6815-3p affects USP46
1 |
Hsa-miR-6815-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-6807-5p affects USP46
1 |
Hsa-miR-6807-5p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23708386
Hsa-miR-6751-3p affects USP46
1 |
Hsa-miR-6751-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23708386
Hsa-miR-513c-3p affects USP46
1 |
Hsa-miR-513c-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-513b-5p affects USP46
1 |
Hsa-miR-513b-5p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-513a-5p affects USP46
1 |
Hsa-miR-513a-5p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-513a-3p affects USP46
1 |
Hsa-miR-513a-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-489-3p affects USP46
1 |
Hsa-miR-489-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4795-3p affects USP46
1 |
Hsa-miR-4795-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-4766-3p affects USP46
1 |
Hsa-miR-4766-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4670-3p affects USP46
1 |
Hsa-miR-4670-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-4459 affects USP46
1 |
Hsa-miR-4459 decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4457 affects USP46
1 |
Hsa-miR-4457 decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4433b-3p affects USP46
1 |
Hsa-miR-4433b-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23708386
Hsa-miR-4303 affects USP46
1 |
Hsa-miR-4303 decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23708386
Hsa-miR-4294 affects USP46
1 |
Hsa-miR-4294 decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23708386
Hsa-miR-4282 affects USP46
1 |
Hsa-miR-4282 decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4280 affects USP46
1 |
Hsa-miR-4280 decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-3920 affects USP46
1 |
Hsa-miR-3920 decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-375 affects USP46
1 |
Hsa-miR-375 decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20215506
Hsa-miR-374b-3p affects USP46
1 |
Hsa-miR-374b-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3688-3p affects USP46
1 |
Hsa-miR-3688-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-3681-3p affects USP46
1 |
Hsa-miR-3681-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-3606-3p affects USP46
1 |
Hsa-miR-3606-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-338-5p affects USP46
1 |
Hsa-miR-338-5p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3065-5p affects USP46
1 |
Hsa-miR-3065-5p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3064-3p affects USP46
1 |
Hsa-miR-3064-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-27b-3p affects USP46
1 |
Hsa-miR-27b-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-27a-3p affects USP46
1 |
Hsa-miR-27a-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-216a-3p affects USP46
1 |
Hsa-miR-216a-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-195-3p affects USP46
1 |
Hsa-miR-195-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-16-2-3p affects USP46
1 |
Hsa-miR-16-2-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-140-3p affects USP46
1 |
Hsa-miR-140-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-128-3p affects USP46
1 |
Hsa-miR-128-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-125b-2-3p affects USP46
1 |
Hsa-miR-125b-2-3p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-1199-5p affects USP46
1 |
Hsa-miR-1199-5p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23708386
Hsa-miR-1179 affects USP46
1 |
Hsa-miR-1179 decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23708386
Hsa-miR-106b-5p affects USP46
1 |
Hsa-miR-106b-5p decreases the amount of USP46. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
17242205
Hexabromocyclododecane increases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
29177809
HUAF1 affects USP46
| 1
USP46 binds hUAF1. 1 / 1
| 1
reach
"These may suggested that the activation of USP1 upon binding to UAF1 may be due to an increase in k cat with no drastic change in the K M, that was similar to what were observed on activation of human USP12 and USP46 binding to hUAF1 [XREF_BIBR] Besides hUSP1, hUAF1 stimulates hUSP12 and hUSP46 activity as well."
29091922
Endosulfan affects USP46
1 |
Endosulfan decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
29391264
Cocaine affects USP46
1 |
Cocaine increases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
27506785
Cobalt dichloride affects USP46
1 |
Cobalt dichloride decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
19320972
Cholesterol affects USP46
| 1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
19260141
Calcitriol affects USP46
1 |
Calcitriol decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
14996990
Bun107 affects USP46
| 1
Bun107 activates USP46. 1 / 1
| 1
reach
"Moreover, the human ortholog of Bun107 activates USP12 and USP46 XREF_BIBR."
20838651
Bis(2-ethylhexyl) phthalate decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
21318169
Benzo[a]pyrene affects USP46
1 |
Benzo[a]pyrene decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
22228805
Atrazine affects USP46
1 |
Atrazine decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
25929836
All-trans-retinoic acid increases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
20488242
Albumin affects USP46
| 1
USP46 binds albumin. 1 / 1
| 1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
19260141
Acrylamide affects USP46
1 |
Acrylamide decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
28959563
ZEB1 affects USP46
1 |
ZEB1 decreases the amount of USP46. 1 / 1
1 |
biopax:msigdb
No evidence text available
YWHAH affects USP46
1 |
YWHAH binds USP46. 1 / 1
1 |
biogrid
No evidence text available
19615732
XPO1 affects USP46
1 |
XPO1 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
26673895
WDR77 affects USP46
1 |
USP46 binds WDR77. 1 / 1
1 |
biogrid
No evidence text available
21183687
WDR48 affects USPs
| 1
USP46 binds USP12, WDR48, and USPs. 1 / 1
| 1
sparser
"As stated earlier, UAF1 interacts with two other USPs, USP12 and USP46."
23797609
WDR26 affects USP46
1 |
USP46 binds WDR26. 1 / 1
1 |
biogrid
No evidence text available
21183687
WD40-repeat-containing protein affects USP46
| 1
WD40-repeat-containing protein activates USP46. 1 / 1
| 1
eidos
"USP12 and USP46 , but not USP1 , can be independently activated by another WD40-repeat-containing protein , WDR20 ( Burska et al ., 2013 ; Dahlberg and Juo , 2014 ; Kee et al ., 2010 ; McClurg et al ., 2014 ) ."
27373336
WD40-repeat (WDR) proteins affects USP46
| 1
USP46 binds WD40-repeat (WDR) proteins. 1 / 1
| 1
reach
"Mechanistically, USP46 can bind with WD40-repeat (WDR) proteins WDR-20 and WDR-48 to stimulate USP46 catalytic activity and increase GLR-1 levels."
26528125
WD40 affects USP46
| 1
WD40 activates USP46. 1 / 1
| 1
reach
"For example, GMP synthetase (GMPS) interacts and activates USP7 (Faesen et al., 2011; Sarkari et al., 2009; van der Knaap et al., 2005), whereas the WD40 repeat containing UAF1 (WDR48) activates USP1,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22195557
USPs affects WDR48
| 1
USP46 binds USP12, WDR48, and USPs. 1 / 1
| 1
sparser
"As stated earlier, UAF1 interacts with two other USPs, USP12 and USP46."
23797609
USP8 affects USP46
| 1
USP8 deubiquitinates USP46. 1 / 1
| 1
reach
"In addition to USP46, USP8 can also deubiquitinate mammalian AMPARs indicating that multiple regulatory mechanisms exist to control AMPAR ubiquitination levels (Scudder et al., 2014)."
29302259
USP6 affects USP46
| 1
USP6 binds USP46 and DTL. 1 / 1
| 1
sparser
"Moreover, miR-3680-5p was associated with the USP6 , USP32 , USP46 , and DTL genes, which have roles in the ubiquitin (deubiquitin) proteolysis system."
28152049
USP46
| 1
USP46 translocates to the nucleus. 1 / 1
| 1
sparser
"We could not determine whether the E6 translocated USP46 to the nucleus of the cancer cells, because contrary to the well-known cytoplasmic localization of USP46 in cell lines in culture, IHC with the USP46 antibody revealed that USP46 is nuclear in both normal and malignant areas of cervical squamous epithelium ( xref )."
30415951
USP46 affects ubiquitinated receptors
| 1
USP46 activates ubiquitinated receptors. 1 / 1
| 1
reach
"In addition, GLR-1 accumulates in the VNC of usp-46 mutants when trafficking to the MVB is blocked, suggesting that USP-46 is required to prevent the degradation of ubiquitinated receptors in the MVB and lysosome pathway."
23316392
USP46 affects resistance ovarian cancer cisplatin
| 1
USP46 inhibits resistance ovarian cancer cisplatin. 1 / 1
| 1
eidos
"Downregulated expression levels of USP46 promote the resistance of ovarian cancer to cisplatin and are regulated by PUM2 ."
33576437
USP46 affects receptor stability
| 1
USP46 activates receptor stability. 1 / 1
| 1
eidos
"Together with data showing that co-expression of the USP-46 / WDR-48 / WDR-20 complex reduces levels of ubiquitinated GLR-1 ( Dahlberg and Juo , 2014 ) , these results support a model wherein USP-46 , when bound to WDR-48 and WDR-20 , deubiquitinates GLR-1 and increases receptor stability and function in vivo ."
29302259
USP46 affects polyubiquitin chains
| 1
USP46 binds polyubiquitin chains. 1 / 1
| 1
reach
"USP46 binds to PHLPP and directly removes the polyubiquitin chains from PHLPP in vitro and in cells."
22391563
USP46 affects pevonedistat
| 1
USP46 activates pevonedistat. 1 / 1
| 1
reach
"USP1, USP46, and WDR20 are candidate ubiquitylation targets (XREF_FIG), as they are either only detected or APSMs increase in the presence of MLN4924 and/or Btz."
24035498
USP46 affects nodes lung metastasis ESCC
| 1
USP46 activates nodes lung metastasis ESCC. 1 / 1
| 1
eidos
"Moreover , USP46 enhances the migration and invasion of ESCC cells by mediating the EMT process in vitro , and promotes lymph nodes and lung metastasis of ESCC in vivo ."
32707136
USP46 affects migration invasion ESCC cells
| 1
USP46 activates migration invasion ESCC cells. 1 / 1
| 1
eidos
"Moreover , USP46 enhances the migration and invasion of ESCC cells by mediating the EMT process in vitro , and promotes lymph nodes and lung metastasis of ESCC in vivo ."
32707136
USP46 affects lung cancer cell
| 1
USP46 inhibits lung cancer cell. 1 / 1
| 1
eidos
"USP46 was further shown to inhibit lung cancer cell proliferation under conditions of normal growth and during radiation-induced DNA damage by antagonizing the ubiquitination of PHLPP1 resulting in the inhibition of AKT signaling ."
33029497
USP46 affects leucine
| 1
USP46 binds PHLPP1 and leucine. 1 / 1
| 1
reach
"Recently, a proteomic study on deubiquitinating enzymes and their associated protein complexes demonstrated that USP46 interacts with PHLPP and SCOP (PH-domain leucine rich repeat protein phosphatase and suprachiasmatic nucleus circadian oscillatory protein), which are members of the of Ser/Thr family of protein phosphatases XREF_BIBR."
23472206
USP46 affects histones H2B
| 1
USP46 deubiquitinates histones H2B. 1 / 1
| 1
reach
"Several DUBs have been implicated in histone deubiquitination, including USP3, USP12, USP22, and USP46, which deubiquitinate both histones H2A and histones H2B [XREF_BIBR]."
33327527
USP46 affects hUAF1
| 1
USP46 binds hUAF1. 1 / 1
| 1
reach
"These may suggested that the activation of USP1 upon binding to UAF1 may be due to an increase in k cat with no drastic change in the K M, that was similar to what were observed on activation of human USP12 and USP46 binding to hUAF1 [XREF_BIBR] Besides hUSP1, hUAF1 stimulates hUSP12 and hUSP46 activity as well."
29091922
reach
"Importantly, USP46 stimulated the glycolysis and promoted the malignant growth of TNBC cells through upregulation of PGAM1."
36335636
USP46 affects function
| 1
USP46 activates function. 1 / 1
| 1
eidos
"Together with data showing that co-expression of the USP-46 / WDR-48 / WDR-20 complex reduces levels of ubiquitinated GLR-1 ( Dahlberg and Juo , 2014 ) , these results support a model wherein USP-46 , when bound to WDR-48 and WDR-20 , deubiquitinates GLR-1 and increases receptor stability and function in vivo ."
29302259
USP46 affects endocytosis
| 1
USP46 activates endocytosis. 1 / 1
| 1
reach
"We propose that USP-46 functions, in part, by acting prior to clathrin mediated endocytosis to prevent the degradation of newly synthesized GLR-1 delivered to an internal compartment en route to the plasma membrane."
21273419
USP46 affects cholesterol
| 1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
19260141
USP46 activates cellular senescence. 1 / 1
| 1
reach
"Transient depletion of USP12, USP46, and USP53 did not induce a senescence arrest."
27160904
USP46 affects cell
| 1
USP46 inhibits cell. 1 / 1
| 1
eidos
"Furthermore , we found that USP46 suppresses HCC cell proliferation and metastasis by inhibiting YAP1 ."
34029571
USP46 affects cell high-risk HPV
| 1
USP46 activates cell high-risk HPV. 1 / 1
| 1
eidos
"USP46 is selectively recruited by the high-risk HPV and promotes cell proliferation in high-risk HPV caused cervical cancer 13 ."
32226309
USP46 affects cell apoptosis
| 1
USP46 activates cell apoptosis. 1 / 1
| 1
eidos
"In SKOV3 / DDP cells , the upregulation of USP46 expression levels notably suppressed cell viability and increased cell apoptosis ."
33576437
USP46 affects albumin
| 1
USP46 binds albumin. 1 / 1
| 1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
19260141
USP46 affects YWHAH
1 |
YWHAH binds USP46. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP46 affects XPO1
1 |
XPO1 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
26673895
USP46 affects WDR77
1 |
USP46 binds WDR77. 1 / 1
1 |
biogrid
No evidence text available
21183687
USP46 affects WDR26
1 |
USP46 binds WDR26. 1 / 1
1 |
biogrid
No evidence text available
21183687
USP46 affects WD40-repeat (WDR) proteins
| 1
USP46 binds WD40-repeat (WDR) proteins. 1 / 1
| 1
reach
"Mechanistically, USP46 can bind with WD40-repeat (WDR) proteins WDR-20 and WDR-48 to stimulate USP46 catalytic activity and increase GLR-1 levels."
26528125
USP46 affects USPs
| 1
USP46 binds USP12, WDR48, and USPs. 1 / 1
| 1
sparser
"As stated earlier, UAF1 interacts with two other USPs, USP12 and USP46."
23797609
USP46 affects USP6
| 1
USP6 binds USP46 and DTL. 1 / 1
| 1
sparser
"Moreover, miR-3680-5p was associated with the USP6 , USP32 , USP46 , and DTL genes, which have roles in the ubiquitin (deubiquitin) proteolysis system."
28152049
USP46 affects USH1C
1 |
USH1C binds USP46. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP46 affects UBE3A
| 1
TP53 binds UBE3A, USP46, and E6. 1 / 1
| 1
sparser
"E6 associates specifically with USP46+Cdt2 independent of E6AP, p53 and USP46 accessory proteins."
30415951
USP46 affects UBB
1 |
UBB binds USP46. 1 / 1
1 |
biogrid
No evidence text available
27650958
USP46 affects UBA52
1 |
UBA52 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
22043315
USP46 affects TST
| 1
USP46 inhibits TST. 1 / 1
| 1
reach
"Importantly, the decreased TST and FST immobility and the defects in the GABA system observed in CS mice could be rescued by expression of Usp46 from a BAC transgene [XREF_BIBR]."
23316392
USP46 affects TSPYL6
1 |
TSPYL6 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP46 affects TP53
| 1
TP53 binds UBE3A, USP46, and E6. 1 / 1
| 1
sparser
"E6 associates specifically with USP46+Cdt2 independent of E6AP, p53 and USP46 accessory proteins."
30415951
USP46 affects TIMM8A
| 1
USP46 activates TIMM8A. 1 / 1
| 1
reach
"Similarly, in SKOV3 and DDP cells, the overexpression of PUM2 could reverse DDP sensitivity induced by the overexpression of USP46."
33576437
USP46 affects THUMPD3
1 |
USP46 binds THUMPD3. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP46 affects TBK1
| 1
TBK1 binds USP46 and USP12. 1 / 1
| 1
sparser
"In addition, USP12 and USP46 were not associated with TBK1 ( xref )."
29138248
USP46 affects STK4
| 1
USP46 activates STK4. 1 / 1
| 1
reach
"Moreover, USP46 acts as a deubiquitinating enzyme of MST1 to potentiate MST1 kinase activity to suppress tumor growth and metastasis, indicating that USP46 activation may represent a potential treatment strategy for HCC."
34029571
USP46 affects SET
1 |
SET binds USP46. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP46 affects RNF19B
1 |
USP46 binds RNF19B. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP46 affects RCC
| 1
USP46 inhibits RCC. 1 / 1
| 1
reach
"We thus revealed a novel mechanism of USP46 regulation in RCC, and our data indicate that USP46 is a tumor suppressor in RCC via AKT signaling pathway inactivation."
31542232
USP46 affects RAP1GDS1
| 1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
19260141
USP46 affects PTGER3
1 |
USP46 binds PTGER3. 1 / 1
1 |
biogrid
No evidence text available
26186194
USP46 affects PPP1R9B
1 |
USP46 binds PPP1R9B. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP46 affects PPM1B
| 1
USP46 increases the amount of PPM1B. 1 / 1
| 1
reach
"We found that USP46 could be co-immunoprecipitated with PPM1B (Supplementary Fig. 3f) and that USP46 overexpression increased levels of PPM1B protein to some extent (Supplementary Fig. 3g), whereas silencing USP46 resulted in a slight decrease in PPM1B expression (Supplementary Fig. 3h)."
34381028
USP46 affects PON2
| 1
USP46 binds PON2 and Delta-actitoxin-Avd1a. 1 / 1
| 1
sparser
"In this study, we explored the association between ncRNA expression and glioma OS, and obtained a prognostic signature containing three ncRNAs, including USP46‐AS1 , PON2 and LOC441179 , based on which we could accurately separate glioma patients with better prognosis from those with a worse prognosis."
30984542
USP46 affects PJA2
1 |
PJA2 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP46 affects PGAM1
| 1
USP46 activates PGAM1. 1 / 1
| 1
reach
"Mechanistically, USP46 enhanced the protein stability of phosphoglycerate mutase 1 (PGAM1) via direct interaction."
36335636
USP46 affects PEMT
| 1
USP46 binds PEMT. 1 / 1
| 1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
19260141
USP46 affects NR3C2
| 1
USP46 binds NR3C2. 1 / 1
| 1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
19260141
USP46 affects MYL6
1 |
USP46 binds MYL6. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP46 affects MVD1
| 1
USP46 binds MVD1. 1 / 1
| 1
sparser
"Firstly, the association of USP46 gene with MDD patients may be due to biased samples, such as small sample sizes or unmatched age."
21663972
USP46 affects MTOR
| 1
USP46 leads to the phosphorylation of MTOR. 1 / 1
| 1
reach
"In the present study, it was revealed that downregulation of USP46 expression levels could also promote the phosphorylation of AKT and mTOR, while the overexpression of USP46 could inhibit the phosphorylation levels."
33576437
USP46 affects MAPK8IP2
1 |
USP46 binds MAPK8IP2. 1 / 1
1 |
biogrid
No evidence text available
25814554
USP46 affects Lys63-
| 1
USP46 deubiquitinates Lys63- on K48. 1 / 1
| 1
reach
"In contrast, Huo et al. (2015) showed that USP46 preferentially deubiquitinates AMPARs with Lys63- but not Lys48-linked chains in HEK293 cells, suggesting that USP46 chain specificity is controlled by other factors in vivo."
29302259
USP46 affects K63
| 1
USP46 binds K63. 1 / 1
| 1
sparser
"These functions of CYLD were implied in a study on another K63-DUB, USP46, which can cleave K63-linked ubiquitination chains from AMPARs and modulate AMPAR internalization and turnover in cultured rat cortical and hippocampal neurons; in this way, USP46 is thought to regulate AMPAR-mediated excitatory synaptic transmission ( xref )."
34602983
USP46 affects IQGAP1
1 |
USP46 binds IQGAP1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP46 affects IL17RB
| 1
IL17RB binds USP46 and DTL. 1 / 1
| 1
sparser
"Immunoprecipitates of myc-USP46 contained Cdt2 and DDB1 indicating that USP46 associates with CRL4-Cdt2 complex ( xref )."
30415951
USP46 affects IGFBP1
1 |
USP46 binds IGFBP1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP46 affects GRIK2
| 1
USP46 binds GRIK2. 1 / 1
| 1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
19260141
USP46 affects GPR15
| 1
CCR4 binds CCR8, USP46, and GPR15. 1 / 1
| 1
sparser
"GPR15, RTKN2 , USP46, CCR4, and CCR8 formed a cluster of genes up-regulated in smokers ( Figure 3 )."
26348578
USP46 affects GORASP1
1 |
GORASP1 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP46 affects GAD1
1 |
USP46 deubiquitinates GAD1. 1 / 1
1 |
ubibrowser
No evidence text available
USP46 affects Fibrinogen
| 1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
19260141
USP46 affects FST
| 1
USP46 activates FST. 1 / 1
| 1
reach
"Importantly, the decreased TST and FST immobility and the defects in the GABA system observed in CS mice could be rescued by expression of Usp46 from a BAC transgene [XREF_BIBR]."
23316392
USP46 affects ESCC
| 1
USP46 activates ESCC. 1 / 1
| 1
reach
"Moreover, USP46 enhances the migration and invasion of ESCC cells by mediating the EMT process in vitro, and promotes lymph nodes and lung metastasis of ESCC in vivo."
32707136
USP46 affects ERP44
1 |
ERP44 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP46 affects EIF2AK4
1 |
EIF2AK4 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP46 affects EC
| 1
USP46 activates EC. 1 / 1
| 1
reach
"Collectively, our results indicated that miR-27a targets USP46 to promote EC cell proliferation and migration, suggesting an oncogene role of miR-27a in EC."
34239673
USP46 affects EBNA3 family
| 1
USP46 binds EBNA3 family. 1 / 1
| 1
reach
"The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46 and USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth."
25855980
USP46 affects EAF2
| 1
USP46 binds EAF2. 1 / 1
| 1
sparser
"The objective of the present study was to investigate the association of USP46 polymorphisms with affective temperamental traits in healthy subjects."
30605993
USP46 affects E1
1 |
USP46 binds E1. 1 / 1
1 |
virhostnet
No evidence text available
30209081
USP46 affects Death
| 1
USP46 activates Death. 1 / 1
| 1
reach
"However, Usp46 overexpression appeared to increase the risk of death in neurons co-transfected with a non pathogenic form of HTT, HTT-N586 Q17."
30266909
USP46 affects DDP resistance OC
| 1
USP46 inhibits DDP resistance OC. 1 / 1
| 1
eidos
"In conclusion , the findings of the present study suggested that the downregulation of USP46 expression levels may promote DDP resistance in OC , which may be regulated by PUM2 ."
33576437
reach
"MiR-27a-3p targets USP46 to inhibit the cell proliferation of hepatocellular carcinoma."
35637630
USP46 affects CHRM3
1 |
CHRM3 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP46 affects CCR8
| 1
CCR4 binds CCR8, USP46, and GPR15. 1 / 1
| 1
sparser
"GPR15, RTKN2 , USP46, CCR4, and CCR8 formed a cluster of genes up-regulated in smokers ( Figure 3 )."
26348578
USP46 affects CASC3
| 1
USP46 activates CASC3. 1 / 1
| 1
reach
"USP1, USP46, and WDR20 are candidate ubiquitylation targets (XREF_FIG), as they are either only detected or APSMs increase in the presence of MLN4924 and/or Btz."
24035498
USP46 affects AS
| 1
USP46 binds AS. 1 / 1
| 1
sparser
"Lei et al. identified a five angiogenesis-related lncRNA signature (LINC01138, LINC00942, AL031985.3, AC015908.3 and USP46-AS) as an independent prognostic biomarker for predicting hepatocellular carcinoma patient survival [ xref ]."
34876056
USP46 affects AMPA receptors
| 1
USP46 deubiquitinates AMPA receptors. 1 / 1
| 1
reach
"Given the same type of deubiquitinating enzyme (USP46) is able to deubiquitinate AMPA receptors, and knockdown of USP46 elevated AMPA receptor ubiquitination and reduced AMPA receptor expression in hi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29501527
USP46 affects ALDH9A1
1 |
USP46 binds ALDH9A1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP46 affects 293T
| 1
USP46 binds PHLPP1 and 293T. 1 / 1
| 1
reach
"Co-immunoprecipitation experiments showed that only USP46 specifically interacted with PHLPP1 in transfected 293T cells whereas other DUBs including USP7 and USP16 failed to binding PHLPP1, thus, demonstrating the specificity of USP46 mediated interaction (XREF_FIG)."
22391563
USP12 affects USPs
| 1
USP46 binds USP12, WDR48, and USPs. 1 / 1
| 1
sparser
"As stated earlier, UAF1 interacts with two other USPs, USP12 and USP46."
23797609
USP12 affects TBK1
| 1
TBK1 binds USP46 and USP12. 1 / 1
| 1
sparser
"In addition, USP12 and USP46 were not associated with TBK1 ( xref )."
29138248
USP12 affects DMWD
| 1
USP46 binds USP12 and DMWD. 1 / 1
| 1
sparser
"Experimentally, we first confirmed that DMWD binds both USP12 and USP46 through direct co-immunoprecipitation of epitope-tagged proteins."
33844468
USH1C affects USP46
1 |
USH1C binds USP46. 1 / 1
1 |
biogrid
No evidence text available
27173435
UBE3A affects USP46
| 1
TP53 binds UBE3A, USP46, and E6. 1 / 1
| 1
sparser
"E6 associates specifically with USP46+Cdt2 independent of E6AP, p53 and USP46 accessory proteins."
30415951
UBB affects USP46
1 |
UBB binds USP46. 1 / 1
1 |
biogrid
No evidence text available
27650958
UBA52 affects USP46
1 |
UBA52 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
22043315
UAF1 elusive affects USP46
| 1
UAF1 elusive activates USP46. 1 / 1
| 1
eidos
"However , a structural comparison of the enzyme in these two post-reaction forms revealed few conformational differences , leaving the mechanism of USP46 activation by UAF1 elusive ."
27373336
TSPYL6 affects USP46
1 |
TSPYL6 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
28514442
TP53 affects USP46
| 1
TP53 binds UBE3A, USP46, and E6. 1 / 1
| 1
sparser
"E6 associates specifically with USP46+Cdt2 independent of E6AP, p53 and USP46 accessory proteins."
30415951
THUMPD3 affects USP46
1 |
USP46 binds THUMPD3. 1 / 1
1 |
biogrid
No evidence text available
28514442
TBK1 affects USP46
| 1
TBK1 binds USP46 and USP12. 1 / 1
| 1
sparser
"In addition, USP12 and USP46 were not associated with TBK1 ( xref )."
29138248
SET affects USP46
1 |
SET binds USP46. 1 / 1
1 |
biogrid
No evidence text available
19615732
Rimonabant affects USP46
1 |
Rimonabant increases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
19030233
RNF19B affects USP46
1 |
USP46 binds RNF19B. 1 / 1
1 |
biogrid
No evidence text available
28514442
RNAi affects USP46
| 1
RNAi inhibits USP46. 1 / 1
| 1
reach
"By contrast, knockdown of USP46 by RNAi leads to elevated AMPAR ubiquitination and a reduction in surface AMPARs at synapses in neurons."
26077708
RAP1GDS1 affects USP46
| 1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
19260141
Proteasome affects USP46
| 1
Proteasome inhibits USP46. 1 / 1
| 1
reach
"We found that increased expression of WDR-48, but not WDR-20, promotes USP-46 abundance in mammalian cells in culture and in C. elegans neurons in vivo Inhibition of the proteasome increased USP-46 abundance, and this effect was non additive with increased WDR-48 expression."
32587090
PTGER3 affects USP46
1 |
USP46 binds PTGER3. 1 / 1
1 |
biogrid
No evidence text available
26186194
PPP1R9B affects USP46
1 |
USP46 binds PPP1R9B. 1 / 1
1 |
biogrid
No evidence text available
19615732
PON2 affects USP46
| 1
USP46 binds PON2 and Delta-actitoxin-Avd1a. 1 / 1
| 1
sparser
"In this study, we explored the association between ncRNA expression and glioma OS, and obtained a prognostic signature containing three ncRNAs, including USP46‐AS1 , PON2 and LOC441179 , based on which we could accurately separate glioma patients with better prognosis from those with a worse prognosis."
30984542
PJA2 affects USP46
1 |
PJA2 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
19615732
PHLPP2 affects PHLPP1
| 1
USP46 binds PHLPP1 and PHLPP2. 1 / 1
| 1
sparser
"We found that USP46 interacted with the C-terminus of PHLPP1 and PHLPP2 ( xref )."
22391563
PHLPP1 affects leucine
| 1
USP46 binds PHLPP1 and leucine. 1 / 1
| 1
reach
"Recently, a proteomic study on deubiquitinating enzymes and their associated protein complexes demonstrated that USP46 interacts with PHLPP and SCOP (PH-domain leucine rich repeat protein phosphatase and suprachiasmatic nucleus circadian oscillatory protein), which are members of the of Ser/Thr family of protein phosphatases XREF_BIBR."
23472206
PHLPP1 affects PHLPP2, and USP46
| 1
USP46 binds PHLPP1 and PHLPP2. 1 / 1
| 1
sparser
"We found that USP46 interacted with the C-terminus of PHLPP1 and PHLPP2 ( xref )."
22391563
PHLPP1 affects 293T
| 1
USP46 binds PHLPP1 and 293T. 1 / 1
| 1
reach
"Co-immunoprecipitation experiments showed that only USP46 specifically interacted with PHLPP1 in transfected 293T cells whereas other DUBs including USP7 and USP16 failed to binding PHLPP1, thus, demonstrating the specificity of USP46 mediated interaction (XREF_FIG)."
22391563
PEMT affects USP46
| 1
USP46 binds PEMT. 1 / 1
| 1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
19260141
NR3C2 affects USP46
| 1
USP46 binds NR3C2. 1 / 1
| 1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
19260141
NEDD4 affects USP46
| 1
NEDD4 decreases the amount of USP46. 1 / 1
| 1
reach
"These include : (a) overexpression of Nedd4-1 in neurons, which enhances GluA1 ubiquitination, causes a reduction in the number of AMPARs on the plasma membrane; (b) shRNA mediated knockdown of Nedd4-1 increases the rate of GluA1 internalization; (c) overexpression of USP46, which downregulates GluA1 ubiquitination, decreases the accumulation of internalized GluA1 in neurons; and (d) overexpression of GluA1-4KR ubiquitin deficient mutants (where all four C-terminal lysine residues have been substituted with arginines) blocks AMPA induced GluA1 internalization."
29123470
MYL6 affects USP46
1 |
USP46 binds MYL6. 1 / 1
1 |
biogrid
No evidence text available
19615732
MVD1 affects USP46
| 1
USP46 binds MVD1. 1 / 1
| 1
sparser
"Firstly, the association of USP46 gene with MDD patients may be due to biased samples, such as small sample sizes or unmatched age."
21663972
MIR106B affects USP46
1 |
MIR106B decreases the amount of USP46. 1 / 1
1 |
bel
"Microarray profiling uncovers multiple targets of the family, including the cyclin-dependent kinase inhibitor p21/CDKN1A. (See supplemental Table 1: Supplementary Table 1. miR-106b family signature. A consensus set of genes that were significantly down-regulated by miR-106a, miR-106b, miR-17-5p, and miR-20)"
18212054
MIR106A affects USP46
1 |
MIR106A decreases the amount of USP46. 1 / 1
1 |
bel
"Microarray profiling uncovers multiple targets of the family, including the cyclin-dependent kinase inhibitor p21/CDKN1A. (See supplemental Table 1: Supplementary Table 1. miR-106b family signature. A consensus set of genes that were significantly down-regulated by miR-106a, miR-106b, miR-17-5p, and miR-20)"
18212054
MAPK8IP2 affects USP46
1 |
USP46 binds MAPK8IP2. 1 / 1
1 |
biogrid
No evidence text available
25814554
K92 mutation affects USP46
| 1
K92 mutation inhibits USP46. 1 / 1
| 1
eidos
"The magnitude of behavioral effects in the USP46 ( K92 ) mutant mice were not as strong as those observed in USP46 KO mice ( Imai et al ., 2013 ) , suggesting that the K92 mutation does not completely eliminate USP46 activity ."
29302259
K63 affects USP46
| 1
USP46 binds K63. 1 / 1
| 1
sparser
"These functions of CYLD were implied in a study on another K63-DUB, USP46, which can cleave K63-linked ubiquitination chains from AMPARs and modulate AMPAR internalization and turnover in cultured rat cortical and hippocampal neurons; in this way, USP46 is thought to regulate AMPAR-mediated excitatory synaptic transmission ( xref )."
34602983
IQGAP1 affects USP46
1 |
USP46 binds IQGAP1. 1 / 1
1 |
biogrid
No evidence text available
19615732
IL17RB affects USP46
| 1
IL17RB binds USP46 and DTL. 1 / 1
| 1
sparser
"Immunoprecipitates of myc-USP46 contained Cdt2 and DDB1 indicating that USP46 associates with CRL4-Cdt2 complex ( xref )."
30415951
IGFBP1 affects USP46
1 |
USP46 binds IGFBP1. 1 / 1
1 |
biogrid
No evidence text available
28514442
H2BC21 affects USP46
1 |
USP46 binds H2BC21. 1 / 1
1 |
biogrid
No evidence text available
21183687
H2AC20 affects USP46
1 |
USP46 binds H2AC20. 1 / 1
1 |
biogrid
No evidence text available
21183687
GSK-J4 affects USP46
1 |
GSK-J4 increases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
29301935
GRIK2 affects USP46
| 1
USP46 binds GRIK2. 1 / 1
| 1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
19260141
GRIA1 affects USP46
1 |
USP46 binds GRIA1. 1 / 1
1 |
biogrid
No evidence text available
26077708
GPR15 affects USP46
| 1
CCR4 binds CCR8, USP46, and GPR15. 1 / 1
| 1
sparser
"GPR15, RTKN2 , USP46, CCR4, and CCR8 formed a cluster of genes up-regulated in smokers ( Figure 3 )."
26348578
GORASP1 affects USP46
1 |
GORASP1 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
28514442
Fibrinogen affects USP46
| 1
reach
"The remaining 9 findings implied possible associations between phosphatidylethanolamine N-methyltransferase (PEMT) gene and total cholesterol; USP46, RAP1GDS1, and ZCCHC16 genes and triglycerides; BCAT1 and SLC14A2 genes and albumin; and NR3C2, GRIK2, and PCSK2 genes and fibrinogen."
19260141
FAM126A affects USP46
| 1
FAM126A activates USP46. 1 / 1
| 1
reach
"When knocking down USP46, the proliferation activity of HCC cells was significantly enhanced, while it was significantly inhibited after over-expressing USP4."
35637630
ERP44 affects USP46
1 |
ERP44 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF2AK4 affects USP46
1 |
EIF2AK4 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
19615732
EBNA6 affects USP46
| 1
EBNA6 activates USP46. 1 / 1
| 1
reach
"Thus, EBNA3C also appears to target the USP46 complex; however, this complex appears to be less stably associated with EBNA3C-F-HA than it is with either EBNA3A-F-HA or EBNA3B-F-HA."
25855980
EBNA3 proteins affects USP46
| 1
EBNA3 proteins activates USP46. 1 / 1
| 1
reach
"We speculated that the EBNA3 proteins may target the USP46 complex primarily via interactions with WDR48 and that, in our overexpression assay, only a small portion of the WDR20 or USP46 was complexed by endogenous WDR48."
25855980
EBNA3 family affects USP46
| 1
USP46 binds EBNA3 family. 1 / 1
| 1
reach
"The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46 and USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth."
25855980
EAF2 affects USP46
| 1
USP46 binds EAF2. 1 / 1
| 1
sparser
"The objective of the present study was to investigate the association of USP46 polymorphisms with affective temperamental traits in healthy subjects."
30605993
E6 affects UBE3A
| 1
TP53 binds UBE3A, USP46, and E6. 1 / 1
| 1
sparser
"E6 associates specifically with USP46+Cdt2 independent of E6AP, p53 and USP46 accessory proteins."
30415951
E1 affects USP46
1 |
USP46 binds E1. 1 / 1
1 |
virhostnet
No evidence text available
30209081
Dietary Fats affects USP46
1 |
Dietary Fats increases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
19030233
Delta-actitoxin-Avd1a affects PON2, and USP46
| 1
USP46 binds PON2 and Delta-actitoxin-Avd1a. 1 / 1
| 1
sparser
"In this study, we explored the association between ncRNA expression and glioma OS, and obtained a prognostic signature containing three ncRNAs, including USP46‐AS1 , PON2 and LOC441179 , based on which we could accurately separate glioma patients with better prognosis from those with a worse prognosis."
30984542
DTL affects USP6
| 1
USP6 binds USP46 and DTL. 1 / 1
| 1
sparser
"Moreover, miR-3680-5p was associated with the USP6 , USP32 , USP46 , and DTL genes, which have roles in the ubiquitin (deubiquitin) proteolysis system."
28152049
DTL affects IL17RB, and USP46
| 1
IL17RB binds USP46 and DTL. 1 / 1
| 1
sparser
"Immunoprecipitates of myc-USP46 contained Cdt2 and DDB1 indicating that USP46 associates with CRL4-Cdt2 complex ( xref )."
30415951
DMWD affects USP12, and USP46
| 1
USP46 binds USP12 and DMWD. 1 / 1
| 1
sparser
"Experimentally, we first confirmed that DMWD binds both USP12 and USP46 through direct co-immunoprecipitation of epitope-tagged proteins."
33844468
Cuprizone affects USP46
1 |
Cuprizone decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
26577399
Circ-NNT affects USP46
| 1
Circ-NNT activates USP46. 1 / 1
| 1
reach
"Circ-NNT promotes pyroptosis and myocardial I/R injury by acting as a miR-33a-5p sponge to regulate USP46."
34845193
Caenorhabditis elegans homologs WDR20 WDR48 known UAF1 affects USP46
| 1
Caenorhabditis elegans homologs WDR20 WDR48 known UAF1 activates USP46. 1 / 1
| 1
eidos
"Interestingly , the Caenorhabditis elegans homologs of WDR20 and WDR48 ( also known as UAF1 ) can bind to and activate USP46 ."
33483467
CPVL affects FKBP5, FOSL2, GADD45B, PTGS1, USP46, and ZNF423
| 1
sparser
"Some hub genes with high interactions such as USP46, CPVL, FKBP5, FOSL2, GADD45B, PTGS1, and ZNF423 were identified in the PPI and TFs network."
29922448
CHRM3 affects USP46
1 |
CHRM3 binds USP46. 1 / 1
1 |
biogrid
No evidence text available
28514442
CCR8 affects USP46
| 1
CCR4 binds CCR8, USP46, and GPR15. 1 / 1
| 1
sparser
"GPR15, RTKN2 , USP46, CCR4, and CCR8 formed a cluster of genes up-regulated in smokers ( Figure 3 )."
26348578
CAT affects USP46
| 1
CAT activates USP46. 1 / 1
| 1
reach
"Given the distinct binding mode elucidated here, it is less straightforward to reconcile this structure with direct active-site modulation, yet we propose a mechanism centered on WDR48 dependent USP s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26388029
Antirheumatic Agents increases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
24449571
Alzheimer Disease affects USP46
| 1
Alzheimer Disease decreases the amount of USP46. 1 / 1
| 1
reach
"Furthermore, AD brain lysates and Abeta incubated neurons show increased expression of the AMPAR E3 ligase Nedd4 and decreased expression of AMPAR deubiquitinase USP46."
29614651
AS affects USP46
| 1
USP46 binds AS. 1 / 1
| 1
sparser
"Lei et al. identified a five angiogenesis-related lncRNA signature (LINC01138, LINC00942, AL031985.3, AC015908.3 and USP46-AS) as an independent prognostic biomarker for predicting hepatocellular carcinoma patient survival [ xref ]."
34876056
APP affects USP46
| 1
APP decreases the amount of USP46. 1 / 1
| 1
reach
"Furthermore, AD brain lysates and Abeta incubated neurons show increased expression of the AMPAR E3 ligase Nedd4 and decreased expression of AMPAR deubiquitinase USP46."
29614651
ALDH9A1 affects USP46
1 |
USP46 binds ALDH9A1. 1 / 1
1 |
biogrid
No evidence text available
19615732
4-hydroxyphenyl retinamide decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
28973697
293T affects USP46
| 1
USP46 binds PHLPP1 and 293T. 1 / 1
| 1
reach
"Co-immunoprecipitation experiments showed that only USP46 specifically interacted with PHLPP1 in transfected 293T cells whereas other DUBs including USP7 and USP16 failed to binding PHLPP1, thus, demonstrating the specificity of USP46 mediated interaction (XREF_FIG)."
22391563
2,6-dinitrotoluene increases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
20406850
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
19933214
2',3,3',4',5-pentachloro-4-hydroxybiphenyl decreases the amount of USP46. 1 / 1
1 |
ctd
No evidence text available
19114083