IndraLab

Statements

USP46 leads to the ubiquitination of GRIA. 3 / 3
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"Given the same type of deubiquitinating enzyme (USP46) is able to deubiquitinate AMPA receptors, and knockdown of USP46 elevated AMPA receptor ubiquitination and reduced AMPA receptor expression in hi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In AD brains and neurons incubated with Aβ, USP46 expression is downregulated, triggering ubiquitination, and clearance of AMPARs."
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"Expression of USP46 causes AMPAR ubiquitination in heterologous cells and neurons to significantly decrease, along with AMPAR decomposition rate diminution and surface AMPAR accumulation increase."
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