IndraLab

Statements

USP46 binds USP12. 25 / 25
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reach
"The more distantly related USP1 is also regulated by WDR48, but WDR20 is unique to USP12 and USP46 complexes."
25855980
sparser
"BIAcore SPR studies demonstrated a dose dependent binding of galeterone to USP12 and USP46 (Figure xref )."
29861848
reach
"Conversely, in the CWR22Rv1 cell line silencing AR FL alone decreased galeterone efficiency by 4 fold compared to SCR control and silencing USP12 or USP12 and USP46 complex members had no significant effect on galeterone efficacy."
29861848
sparser
"The unique binding mode elucidated here thus provides a framework to guide further exploration into the role of the larger USP1 insertions and the particular interactions of USP12 and USP46 in mediati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26388029
reach
"Similarly galeterone inhibition did not have a significant effect on transcript levels of USP12 and USP46 complex members UAF1 (adj. p = 0.4) and WDR20 (adj. p = 0.25)."
29861848
sparser
"UAF1 also binds and activates two other DUBs, USP12 and USP46 ( xref ), and studies that reveal how UAF1 binds and activates USP12 and USP46 suggest that UAF1 will bind to USP1 in an analogous manner ( xref , xref )."
30456385
sparser
"Biochemical and proteomic studies showed that two WDR proteins, WDR48 (also known as USP1-associated factor, UAF1) and WDR20, interact with USP46 and USP12 (Cohn et al., 2009; Sowa et al., 2009; Kee et al., 2010)."
29302259
reach
"Our data demonstrates a proof-of-principle for USP12 and USP46 complex targeting in PC and uncovers additional mechanisms of galeterone activity."
29861848
sparser
"Together, these structural studies suggest that binding of the WDR proteins to USP12 or USP46 relatively far from the active site results in the rearrangement of several structural elements, which propagates to the catalytic triad increasing enzyme catalysis."
29302259
reach
"We therefore tested C527 for its ability to inhibit the purified USP12 and USP46 complex or other DUBs."
24130053
reach
"The mode of interaction of USP12 and USP46 with UAF1 is still unclear."
23797609
sparser
"WDR48, a WD40 repeat-containing protein, interacts with USP12 and USP46 and is required for the histone deubiquitination activity."
21183687
biogrid
No evidence text available
19615732
reach
"Although the PHLLP1 and PHLLP2 phosphatases have been reported to be components of the USP46 and USP12 complexes, they were not detectably associated with EBNA3 complexes, likely because these phosphatases are predominantly membrane associated [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25855980
reach
"C527 inhibited the DUB activity of the USP12 and USP46 complex and other DUB enzymes in vitro."
24130053
sparser
"Three recent studies provide crystal structures of the WDR proteins in complex with USP12 and USP46."
29302259
reach
"To understand further the nature of the USP12 and USP46 complexes, we attempted to identify proteins that interact with the USP12 and USP46 deubiquitinating enzyme complexes."
20147737
sparser
"Galeterone binds to USP12 and USP46."
29861848
reach
"We did not detect any USP1 peptides in our complexes, suggesting that the even though the EBNA3 proteins interact strongly with WDR48, they are selective for USP12 and USP46 complexes, possibly due to stabilizing interactions with WDR20 or the enzymes themselves."
25855980
sparser
"It also lacks the binding site for another activator, WDR20, which binds USP12 and USP46, leading to further activation (Kee et al , xref )."
33619839
sparser
"To understand further the nature of the USP12 and USP46 complexes, we attempted to identify proteins that interact with the USP12 and USP46 deubiquitinating enzyme complexes."
20147737
sparser
"Biochemical and proteomic studies showed that two WDR proteins, WDR48 (also known as USP1-associated factor, UAF1) and WDR20, interact with USP46 and USP12 (Cohn et al., xref ; Sowa et al., xref ; Kee et al., xref )."
29302259
reach
"Membrane associated USP46 and USP12 complexes have been implicated in regulating membrane trafficking of receptors, including Notch1 and GLR1 [XREF_BIBR, XREF_BIBR]."
25855980
biogrid
No evidence text available
26811477
reach
"EBNA3A and EBNA3B target the USP46 and USP12 complexes in LCLs."
25855980