IndraLab

Statements

USP46 inhibits apoptotic process. 3 / 3
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"As shown in Supplementary Fig. 6e, the depletion of USP46 in genetically engineered human immortalized melanocytes (hTERT/CDK4 /p53 ) expressing NRAS Q61R induced a significant reduction of cell proliferation as assessed by Ki67 staining, and a significant increase of apoptotic cell death as assessed by cleaved caspase-3 staining."
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"The USP46 downregulation is associated with increased cell viability and inhibited apoptosis [59] ."
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"The downregulation of USP46 expression levels in SKOV3 cells significantly inhibited cell apoptosis and increased cell viability."
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