IndraLab

Statements

USP46 deubiquitinates GLR1.1. 5 / 5
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"These findings suggest that USP-46 functions to deubiquitinate GLR-1 and to protect the receptor from degradation."
23316392
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"These data support a model in which USP-46 promotes GLR-1 abundance at synapses by deubiquitinating GLR-1 and preventing its degradation in the lysosome."
21273419
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"The abundance of GLR-1 (4KR), a mutant receptor which can not be ubiquitinated, is unaffected in usp-46 loss-of-function mutants leading to a model where USP-46 deubiquitinates GLR-1 to regulate its abundance."
29302259
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"Second, we tested whether the amount of ubiquitinated GLR-1 is increased in usp-46 mutant animals, as would be expected if USP-46 deubiquitinates GLR-1."
21273419
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"These data demonstrate that USP-46 promotes the deubiquitination of GLR-1, which in turn increases the abundance of GLR-1 in the VNC."
21273419