IndraLab

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USP46 ubiquitinates PHLPP1. 4 / 4
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"USP46 directly regulates the ubiquitination of PHLPP1."
22391563
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"Here, we investigated whether USP46 directly regulates the level of PHLPP1 ubiquitination in vitro and in cells."
22391563
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"Previous research has shown that USP46 antagonized AKT activity by deubiquitinating PHLPP1 in colorectal cancer (15)."
37576883
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"In general, USP46 can inhibits AKT activity by deubiquitinating PHLPP1, inhibits cell proliferation and DNA damage, thus, it increases the radiation sensitivity (19) ( Figure 3 and Table 1 ).4.2.3 Transcriptional regulation."
37576883