IndraLab

Statements


WDR20 activates USP46. 9 / 9
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reach
"Together, UAF1 and WDR20 are able to synergistically stimulate the enzymatic activities of USP12 and USP46 to a peak level."

reach
"Both WDR48 and WDR20 stimulate USP12 and USP46 catalytic activity (k cat) without increasing substrate binding affinity, suggesting that the WDR proteins may affect DUB activity via a novel structural mechanism."

reach
"Interestingly, the Caenorhabditis elegans homologs of WDR20 and WDR48 (also known as UAF1) can bind to and activate USP46."

reach
"We found that increased expression of WDR-48, but not WDR-20, promotes USP-46 abundance in mammalian cells in culture and in C. elegans neurons in vivo Inhibition of the proteasome increased USP-46 abundance, and this effect was non additive with increased WDR-48 expression."

reach
"Interestingly, USP12 and USP46 are activated by two β-propeller proteins, UAF1, and WDR20."

sparser
"USP12 and USP46, but not USP1, can be independently activated by another WD40-repeat-containing protein, WDR20 ()."

sparser
"Interestingly, USP12 and USP46 are activated by two β-propeller proteins, UAF1, and WDR20."

reach
"Although mammalian USP46 and USP12 DUB activity can be stimulated by two proteins UAF-1 and WDR20, the C. elegans homologs of these genes have not yet been identified."

sparser
"USP12 and USP46, but not USP1, can be independently activated by another WD40-repeat-containing protein, WDR20 (Burska et al., 2013; Dahlberg and Juo, 2014; Kee et al., 2010; McClurg et al., 2014) ."