IndraLab

Statements


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"These recent structural and biochemical studies complement in vivo studies of the USP-46, WDR-48, and WDR-20 complex in C. elegans."

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"Total levels of WDR48 and USP46 were unchanged upon 4HT withdrawal (XREF_FIG) thus increased signal in the WDR48 ChIP at the p14 was not attributable to increased expression of the constituents of the USP46, WDR48, and WDR20 complex by EBNA3C."

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"The overall structure of the USP46-WDR48-WDR20 complex is very similar to that of the USP12-WDR48-WDR20 complex."

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"Thus, the steady-state localization of the USP46/UAF1/WDR20 complex was cytoplasmic, while the USP12/UAF1/WDR20 complex localized mainly to the plasma membrane (PM)."

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"Because USP46 and USP12 are highly homologous (~ 90% identity) and we could confirm a robust association with USP46 by Western blotting (discussed below), we chose to focus our subsequent attention on the USP46, WDR48, and WDR20 complex."

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"Because our TAP lysis procedure extracted both nuclear and cytoplasmic proteins (XREF_SUPPLEMENTARY), we wanted to ensure that the USP46, WDR48, and WDR20 complex subcellular localization was compatible with formation of a complex with EBNA3 proteins."

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"Together with data showing that co-expression of the USP-46, WDR-48, and WDR-20 complex reduces levels of ubiquitinated GLR-1, these results support a model wherein USP-46, when bound to WDR-48 and WDR-20, deubiquitinates GLR-1 and increases receptor stability and function in vivo."

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"To determine whether the USP46-UAF1-WDR20 complex regulates Wnt signaling in physiological contexts, we took a loss-of-function approach in Drosophila."

sparser
"USP46 is normally associated with its accessory proteins UAF1 and WDR20."

sparser
"These results indicate that USP46 does not associate with its accessory factor UAF1 or WDR20 when interacting with or deubiquitinating Cdt2 in high risk E6 transformed cells."

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"In contrast, the steady-state localization of the USP46/UAF1/WDR20 complex is predominantly cytoplasmic.Our finding that WDR20 differently modulates the localization of USP12 and USP46 led us to inves[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"